Details of the Drug Combination

General Information of Drug Combination (ID: DCDH4ZU)

Drug Combination Name
Motexafin gadolinium Carboplatin
Indication
Disease Entry Status REF
Stage IIIA Non-small Cell Lung Cancer Phase 1 [1]
Component Drugs Motexafin gadolinium   DMEJKRF Carboplatin   DMG281S
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Motexafin gadolinium
Disease Entry ICD 11 Status REF
Brain cancer 2A00 Approved [2]
Human immunodeficiency virus infection 1C62 Phase 3 [3]
Motexafin gadolinium Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Thioredoxin reductase (PRDX5) TTLPJWH PRDX5_HUMAN Modulator [3]
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Motexafin gadolinium Interacts with 132 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [7]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [7]
Metallothionein-1F (MT1F) OTZVUYG1 MT1F_HUMAN Increases Expression [7]
Metallothionein 1H-like protein 1 (MT1HL1) OTTB2N9F M1BL1_HUMAN Increases Expression [7]
Metallothionein-1G (MT1G) OTAV1OCR MT1G_HUMAN Increases Expression [7]
Metallothionein-1H (MT1H) OT0MVBM6 MT1H_HUMAN Increases Expression [7]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase RNF19B (RNF19B) OTYCWKBP RN19B_HUMAN Increases Expression [7]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Increases Expression [7]
Activator of apoptosis harakiri (HRK) OTR4GWJ0 HRK_HUMAN Increases Expression [6]
Transcription factor E2F3 (E2F3) OT5VQMWY E2F3_HUMAN Increases Expression [6]
Programmed cell death protein 5 (PDCD5) OT6T2DDL PDCD5_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [6]
Transcription regulator protein BACH1 (BACH1) OTY8004K BACH1_HUMAN Increases Expression [6]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Increases Expression [6]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [6]
Death-associated protein kinase 3 (DAPK3) OTLV7EKW DAPK3_HUMAN Decreases Expression [6]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Increases Expression [6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [6]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) OT5GR4Z2 SMCA5_HUMAN Decreases Expression [6]
HMG box-containing protein 1 (HBP1) OTDPGGDV HBP1_HUMAN Increases Expression [6]
DnaJ homolog subfamily B member 6 (DNAJB6) OTMHIIAN DNJB6_HUMAN Increases Expression [6]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Increases Expression [6]
E3 SUMO-protein ligase PIAS1 (PIAS1) OTZVAHZI PIAS1_HUMAN Increases Expression [6]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Decreases Expression [6]
Glutaminase kidney isoform, mitochondrial (GLS) OTGOZG2M GLSK_HUMAN Decreases Expression [6]
Elongator complex protein 1 (ELP1) OTYEWBF7 ELP1_HUMAN Decreases Expression [6]
RCC1 and BTB domain-containing protein 2 (RCBTB2) OTECBF4R RCBT2_HUMAN Decreases Expression [6]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Decreases Expression [6]
NAD kinase (NADK) OTYN9GX0 NADK_HUMAN Increases Expression [6]
Heat shock 70 kDa protein 4L (HSPA4L) OT181WZB HS74L_HUMAN Increases Expression [6]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [6]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [6]
Phosphoglycerate kinase 1 (PGK1) OT6V1ICH PGK1_HUMAN Increases Expression [6]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [6]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Increases Expression [6]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [6]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Increases Expression [6]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Increases Expression [6]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [6]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Increases Expression [6]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [6]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [6]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Increases Expression [6]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Increases Expression [6]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [6]
Neurofibromin (NF1) OTC29NHH NF1_HUMAN Increases Expression [6]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Increases Expression [6]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Increases Expression [6]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [6]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Increases Expression [6]
Cell division cycle protein 27 homolog (CDC27) OTDT45XJ CDC27_HUMAN Increases Expression [6]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Increases Expression [6]
High affinity cationic amino acid transporter 1 (SLC7A1) OTR2ZVA8 CTR1_HUMAN Increases Expression [6]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [6]
Tumor necrosis factor ligand superfamily member 8 (TNFSF8) OTDYGDJ3 TNFL8_HUMAN Increases Expression [6]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [6]
Glycogen debranching enzyme (AGL) OTWBM7WY GDE_HUMAN Decreases Expression [6]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [6]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [6]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [6]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [6]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Decreases Expression [6]
Transcription activator BRG1 (SMARCA4) OT68WOPQ SMCA4_HUMAN Decreases Expression [6]
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) OTF3TBTK SSDH_HUMAN Increases Expression [6]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Increases Expression [6]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [6]
Selenoprotein W (SELENOW) OTVSKPAN SELW_HUMAN Increases Expression [6]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [6]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [6]
Transcription factor RelB (RELB) OTU3QYEF RELB_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) OT1YFEP1 TNR17_HUMAN Decreases Expression [6]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Decreases Expression [6]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Increases Expression [6]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Decreases Expression [6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [6]
Cell division cycle protein 16 homolog (CDC16) OTB914M7 CDC16_HUMAN Decreases Expression [6]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [6]
DnaJ homolog subfamily C member 3 (DNAJC3) OT7ROIJF DNJC3_HUMAN Increases Expression [6]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Expression [6]
Serine/threonine-protein kinase ATR (ATR) OTH0OP1J ATR_HUMAN Decreases Expression [6]
Cullin-3 (CUL3) OTDNOAPM CUL3_HUMAN Decreases Expression [6]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [6]
Core-binding factor subunit beta (CBFB) OTIAC6W4 PEBB_HUMAN Increases Expression [6]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) OT5VYOSM IKKE_HUMAN Increases Expression [6]
Helicase-like transcription factor (HLTF) OTRX2OSF HLTF_HUMAN Decreases Expression [6]
Protein RRP5 homolog (PDCD11) OTS1NJK2 RRP5_HUMAN Decreases Expression [6]
Nuclear receptor subfamily 1 group D member 2 (NR1D2) OT9CVF41 NR1D2_HUMAN Increases Expression [6]
Metal cation symporter ZIP14 (SLC39A14) OTGR686L S39AE_HUMAN Increases Expression [6]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [6]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) OT25JBA3 F263_HUMAN Increases Expression [6]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) OTQYEXL2 F264_HUMAN Increases Expression [6]
S-adenosylmethionine sensor upstream of mTORC1 (BMT2) OTSMVQCU SAMTR_HUMAN Increases Expression [6]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Increases Expression [6]
Cyclin-J (CCNJ) OTCR4WVV CCNJ_HUMAN Decreases Expression [6]
Rho GTPase-activating protein 17 (ARHGAP17) OTEABPLV RHG17_HUMAN Decreases Expression [6]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [6]
Interferon regulatory factor 2-binding protein 2 (IRF2BP2) OTSSRRCA I2BP2_HUMAN Increases Expression [6]
Homeodomain-interacting protein kinase 1 (HIPK1) OTSEA8RS HIPK1_HUMAN Increases Expression [6]
T-cell activation Rho GTPase-activating protein (TAGAP) OTHJNNO2 TAGAP_HUMAN Increases Expression [6]
Protein PHTF2 (PHTF2) OTBLTYRJ PHTF2_HUMAN Increases Expression [6]
TNFAIP3-interacting protein 2 (TNIP2) OTDQWTUB TNIP2_HUMAN Decreases Expression [6]
Alanine aminotransferase 2 (GPT2) OTS5VF7N ALAT2_HUMAN Increases Expression [6]
General transcription factor 3C polypeptide 2 (GTF3C2) OTWDANLJ TF3C2_HUMAN Increases Expression [6]
DNA-binding death effector domain-containing protein 2 (DEDD2) OT0WXRWT DEDD2_HUMAN Increases Expression [6]
Heat shock protein 105 kDa (HSPH1) OTVRR73T HS105_HUMAN Increases Expression [6]
Protein FAM162A (FAM162A) OT882DND F162A_HUMAN Increases Expression [6]
Probable G-protein coupled receptor 146 (GPR146) OTFDR1WJ GP146_HUMAN Increases Expression [6]
Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) OTWE5G4T P3IP1_HUMAN Increases Expression [6]
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) OTALABSK S38A2_HUMAN Increases Expression [6]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [6]
Cell division cycle 5-like protein (CDC5L) OTTPFUU5 CDC5L_HUMAN Decreases Expression [6]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Decreases Expression [6]
Cyclin-dependent kinase 19 (CDK19) OTVMM0CP CDK19_HUMAN Increases Expression [6]
Serine/threonine-protein kinase D2 (PRKD2) OTIFSVI8 KPCD2_HUMAN Decreases Expression [6]
Egl nine homolog 1 (EGLN1) OT5QODDK EGLN1_HUMAN Increases Expression [6]
MOB kinase activator 1A (MOB1A) OTSPBZ4Z MOB1A_HUMAN Increases Expression [6]
Zinc transporter ZIP9 (SLC39A9) OTBVVFSK S39A9_HUMAN Increases Expression [6]
Fas apoptotic inhibitory molecule 1 (FAIM) OTR67PGU FAIM1_HUMAN Decreases Expression [6]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [6]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Decreases Expression [6]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Increases Expression [6]
NADH-cytochrome b5 reductase 1 (CYB5R1) OTMDHMLA NB5R1_HUMAN Increases Expression [6]
Zinc transporter ZIP10 (SLC39A10) OT04411Q S39AA_HUMAN Affects Expression [6]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [6]
Nischarin (NISCH) OTTMT8UD NISCH_HUMAN Decreases Expression [6]
Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) OTBU39Q1 PTH2_HUMAN Decreases Expression [6]
Lysine-specific demethylase 3A (KDM3A) OTZYJ8VN KDM3A_HUMAN Increases Expression [6]
Hypoxia-inducible lipid droplet-associated protein (HILPDA) OTEID3ZM HLPDA_HUMAN Increases Expression [6]
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⏷ Show the Full List of 132 DOT(s)
Indication(s) of Carboplatin
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [4]
Carcinoma 2A00-2F9Z Approved [4]
Cholangiocarcinoma 2C12.10 Approved [4]
Cutaneous melanoma 2C30 Approved [4]
Epithelial ovarian cancer 2B5D Approved [4]
Fallopian tube neoplasm N.A. Approved [4]
Gastroesophageal junction adenocarcinoma 2B71 Approved [4]
Lung adenocarcinoma N.A. Approved [4]
Lung cancer 2C25.0 Approved [4]
Non-small-cell lung cancer 2C25.Y Approved [4]
Ovarian cancer 2C73 Approved [5]
Ovarian disorder N.A. Approved [4]
Ovarian neoplasm N.A. Approved [4]
Ovarian serous cystadenocarcinoma N.A. Approved [4]
Small-cell lung cancer 2C25.Y Approved [4]
Lung large cell carcinoma N.A. Investigative [4]
Neuroblastoma 2D11.2 Investigative [4]
Carboplatin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Modulator [8]
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Carboplatin Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
High affinity copper uptake protein 1 (SLC31A1) DTP8L4F COPT1_HUMAN Substrate [9]
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Carboplatin Interacts with 7 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Glutathione S-transferase pi (GSTP1) DEK6079 GSTP1_HUMAN Metabolism [10]
Glutathione S-transferase theta-1 (GSTT1) DE3PKUG GSTT1_HUMAN Metabolism [10]
Metallothionein-1A (MT1A) DE5ME8A MT1A_HUMAN Metabolism [10]
Metallothionein-2A (MT2A) DEFKGT7 MT2_HUMAN Metabolism [10]
Myeloperoxidase (MPO) DEA3U9Y PERM_HUMAN Metabolism [10]
Quinone reductase 1 (NQO1) DENP5RY NQO1_HUMAN Metabolism [10]
Glutathione S-transferase mu-1 (GSTM1) DEYZEJA GSTM1_HUMAN Metabolism [10]
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⏷ Show the Full List of 7 DME(s)

References

1 ClinicalTrials.gov (NCT00005065) Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Stage IIIA Non-small Cell Lung Cancer
2 Photodynamic therapy: applications in atherosclerotic vascular disease with motexafin lutetium. Catheter Cardiovasc Interv. 2002 Nov;57(3):387-94.
3 Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). Biochem Biophys Res Commun. 2009 Feb 13;379(3):775-9.
4 Carboplatin FDA Label
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7624).
6 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
7 Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res. 2005 May 1;65(9):3837-45.
8 Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.Clin Cancer Res.2010 Oct 1;16(19):4899-905.
9 Overcoming platinum drug resistance with copper-lowering agents. Anticancer Res. 2013 Oct;33(10):4157-61.
10 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)