Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2QHZU)

• Drug Name: Sulindac Drug Info
• Synonyms: Aclin; Aflodac; Arthrobid; Arthrocine; Chibret; Clinoril; Copal; Copals; Kenalin; Klinoril; Mobilin; Sulindaco; Sulindacum; Sulindal; Alphapharm Brand of Sulindac; Apo Sulin; Apotex Brand of Sulindac; Cahill May Roberts Brand of Sulindac; Chemia Brand of Sulindac; Copal resin; Copal rosin varnish; Gum copal; KendrickBrand of Sulindac; Merck Brand of Sulindac; Novo Sundac; Novopharm Brand of Sulindac; Nu Pharm Brand of Sulindac; Nu Sulindac; Resin copal; Sulindac sulfoxide; MK 231; MK231; S 8139; Apo-Sulin; Clinoril (TN); MK-231; Merck Sharp & Dohme Brand of Sulindac; Novo-Sundac; Nu-Pharm Brand of Sulindac; Nu-Sulindac; Sulindaco [INN-Spanish]; Sulindacum [INN-Latin]; Sulindac (JAN/USP/INN); Sulindac [USAN:BAN:INN:JAN]; Z-5-Fluoro-2-methyl-1-[p-(methlsulfinyl)benzylidene]indene-3-acetic acid; Cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid; {5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1h-inden-3-yl}acetic acid; Cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; [(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfinyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid; {(1E)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid; {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid; (E)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-[[4-(methyl-sulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid; 2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[1]
Bursitis		Approved	[1]
Osteoarthritis	FA00-FA05	Approved	[1]
Rheumatoid arthritis	FA20	Approved	[2]
Colon cancer	2B90.Z	Investigative	[1]

• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 1548887
  ChEBI ID: CHEBI:9352
  CAS Number: CAS 38194-50-2
  TTD Drug ID: DM2QHZU
  VARIDT Drug ID: DR00715
  ACDINA Drug ID: D00644

Molecule-Related Drug Atlas

Drug(s) Targeting Aldose reductase (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[9]
Fidarestat	DMZL1I8	Diabetic complication	5A2Y	Phase 3	[10]
Ranirestat	DMD5QRS	Diabetic neuropathy	8C0Z	Phase 3	[11]
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[12]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[11]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[13]
LIDORESTAT	DMA0RI9	Diabetic complication	5A2Y	Phase 2	[14]
QR-333	DMKVIWM	Diabetic neuropathy	8C0Z	Phase 2	[15]
ADMVA	DM819CO	Diabetic complication	5A2Y	Phase 2	[11]
M-16209	DMZ7YX3	Diabetic complication	5A2Y	Phase 2	[16]

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[18]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[19]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[20]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[22]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[23]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[25]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[21]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX15 (ALOX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[30]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[31]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[32]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[33]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[34]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[35]

Drug(s) Affected By Arylamine N-acetyltransferase 1 (NAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[40]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[41]

Drug(s) Affected By Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[46]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 (ELAPOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[31]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[55]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[57]

Drug(s) Affected By Protocadherin-17 (PCDH17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[63]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[64]

Drug(s) Affected By Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Bortezomib	DMNO38U	Leukemia		Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[75]

Drug(s) Affected By NPC intracellular cholesterol transporter 1 (NPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[79]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]

Drug(s) Affected By T-box transcription factor TBX3 (TBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[82]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[87]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]

Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[94]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[96]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[97]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[98]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]

Drug(s) Affected By Origin recognition complex subunit 4 (ORC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[102]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[103]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[57]

Drug(s) Affected By Bromodomain-containing protein 4 (BRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[63]

Drug(s) Affected By Transmembrane protein 127 (TMEM127)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Hyaluronan mediated motility receptor (HMMR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]

Drug(s) Affected By Stanniocalcin-2 (STC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[112]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]

Drug(s) Affected By Ribonuclease pancreatic (RNASE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[31]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[116]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[94]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[117]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[98]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[119]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[121]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[119]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[120]

Drug(s) Affected By Calmodulin-1 (CALM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[104]

Drug(s) Affected By Lysosomal acid phosphatase (ACP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[124]

Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[88]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[130]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]

Drug(s) Affected By Protein C-ets-1 (ETS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[138]

Drug(s) Affected By Integrin alpha-2 (ITGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[141]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[153]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[154]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[145]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[157]

Drug(s) Affected By Casein kinase II subunit alpha' (CSNK2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[158]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[158]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[164]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[166]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[167]

Drug(s) Affected By DNA excision repair protein ERCC-5 (ERCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[168]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[171]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[172]

Drug(s) Affected By High affinity cationic amino acid transporter 1 (SLC7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[98]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]

Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[178]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[179]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[180]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[158]

Drug(s) Affected By Biotin--protein ligase (HLCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[182]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]

Drug(s) Affected By Plexin-A3 (PLXNA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[184]

Drug(s) Affected By Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (NDST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[184]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]

Drug(s) Affected By Small ubiquitin-related modifier 3 (SUMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[190]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[111]

Drug(s) Affected By Casein kinase II subunit alpha (CSNK2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[197]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[158]

Drug(s) Affected By Polycystin-1 (PKD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[198]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[55]

Drug(s) Affected By Transcription initiation factor IIB (GTF2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[199]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[200]

Drug(s) Affected By Cyclin-dependent kinase 3 (CDK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[201]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[63]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[63]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[202]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[203]

Drug(s) Affected By Cdc42 effector protein 1 (CDC42EP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[206]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[31]

Drug(s) Affected By Growth factor receptor-bound protein 10 (GRB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[208]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[210]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[145]

Drug(s) Affected By Krueppel-like factor 5 (KLF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]

Drug(s) Affected By Dihydropyrimidinase (DPYS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By Four and a half LIM domains protein 2 (FHL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[217]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[218]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[219]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]

Drug(s) Affected By Kinesin-like protein KIF14 (KIF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]

Drug(s) Affected By Syntaxin-binding protein 2 (STXBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[223]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[224]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]

Drug(s) Affected By Nuclear factor interleukin-3-regulated protein (NFIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[226]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[228]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[229]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[151]

Drug(s) Affected By TBC1 domain family member 10B (TBC1D10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[204]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Migration and invasion-inhibitory protein (MIIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[225]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[204]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[103]

Drug(s) Affected By Cyclin-J (CCNJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[95]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[230]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[231]

Drug(s) Affected By OTU domain-containing protein 1 (OTUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[232]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[31]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]

Drug(s) Affected By Tensin-3 (TNS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[104]

Drug(s) Affected By F-box only protein 42 (FBXO42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[204]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[235]

Drug(s) Affected By Metal transporter CNNM4 (CNNM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[184]

Drug(s) Affected By Ankyrin repeat domain-containing protein 11 (ANKRD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[238]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[63]

Drug(s) Affected By La-related protein 4 (LARP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[63]

Drug(s) Affected By LIM domain-binding protein 1 (LDB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[241]

Drug(s) Affected By Transmembrane protein adipocyte-associated 1 (TPRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[242]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[243]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[245]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[243]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[246]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[247]

Drug(s) Affected By UPF0690 protein C1orf52 (C1ORF52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[204]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[248]

Drug(s) Affected By Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (LFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Osteoclast-stimulating factor 1 (OSTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[243]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[204]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[250]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]

Drug(s) Affected By Caveolae-associated protein 3 (CAVIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[252]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]

Drug(s) Affected By Sorting nexin-21 (SNX21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]

Drug(s) Affected By Arrestin domain-containing protein 3 (ARRDC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[241]

Drug(s) Affected By Splicing factor ESS-2 homolog (ESS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[48]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[204]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[257]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]

Drug(s) Affected By Histone-lysine N-methyltransferase EHMT2 (EHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[262]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[263]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[167]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[266]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[111]

Drug(s) Affected By Sodium-coupled neutral amino acid symporter 2 (SLC38A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[267]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[94]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[268]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[95]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 15 (MED15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[204]

Drug(s) Affected By Pleckstrin homology domain-containing family F member 1 (PLEKHF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[270]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[269]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[269]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Sialidase-1 (NEU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[274]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]

Drug(s) Affected By Translin-associated protein X (TSNAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[275]

Drug(s) Affected By Copine-1 (CPNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[276]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[111]

Drug(s) Affected By Allograft inflammatory factor 1-like (AIF1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[281]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[47]

Drug(s) Affected By Ferroptosis suppressor protein 1 (AIFM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[96]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[98]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[98]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[234]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]

Drug(s) Affected By Transmembrane emp24 domain-containing protein 9 (TMED9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[282]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[283]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[284]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF26 (RNF26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[285]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Tripartite motif-containing protein 2 (TRIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[66]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[252]

Drug(s) Affected By Sorting nexin-25 (SNX25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[134]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[282]

Drug(s) Affected By tRNA dimethylallyltransferase (TRIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[286]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]

Drug(s) Affected By PDZ and LIM domain protein 7 (PDLIM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[157]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]

Drug(s) Affected By Phosphatidylinositol polyphosphate 5-phosphatase type IV (INPP5E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By Transmembrane protein 39A (TMEM39A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[282]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[287]

Drug(s) Affected By Arginine and glutamate-rich protein 1 (ARGLU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[241]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[242]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[63]

Drug(s) Affected By SUN domain-containing protein 2 (SUN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[241]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[289]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[202]

Drug(s) Affected By B-cell receptor-associated protein 29 (BCAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[282]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]

Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[291]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[292]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[292]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[293]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[294]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[293]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[295]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[296]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Indomethacin	DMSC4A7	Bursitis		Approved	[297]

Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[296]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[291]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[295]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[298]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[294]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[299]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[300]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[301]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[297]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[297]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[302]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[297]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[303]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[297]
Ketoprofen	DMRKXPT	Bursitis		Approved	[297]

Drug(s) Affected By Organic anion transporter 7 (SLC22A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[94]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[268]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[297]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[151]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[297]

Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[297]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[297]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[297]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[304]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[297]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[305]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[297]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[306]
Ketoprofen	DMRKXPT	Bursitis		Approved	[297]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[297]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[94]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[307]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[307]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[307]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[307]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[307]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[307]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[293]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[309]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[309]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[310]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[312]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[313]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[314]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[315]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[316]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[317]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[318]

Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[319]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[320]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[321]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[319]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[321]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[322]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[104]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[323]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[324]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[321]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[325]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[326]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[327]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[328]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[330]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[331]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[332]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[334]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[335]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[335]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[335]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[336]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[337]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[338]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[339]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[340]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[341]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[314]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[342]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[343]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[344]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[347]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[348]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[349]
Herbimycin A	DM6YWBF	Solid tumour/cancer	2A00-2F9Z	Approved	[350]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[351]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[352]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[353]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[354]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[355]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[356]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[357]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[358]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[6]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[359]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[360]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[360]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[363]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[6]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[6]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[366]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[363]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[367]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[6]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[363]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[331]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[6]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[366]

Drug(s) Affected By Ladinin-1 (LAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[269]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[368]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[370]
Selenium	DM25CGV	N. A.	N. A.	Approved	[371]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[372]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[373]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[374]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[375]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[374]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[376]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[377]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[378]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[379]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[8]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[8]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[8]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[8]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[382]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[383]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[386]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[387]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[388]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[390]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[391]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[153]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[154]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[392]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[394]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[395]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[397]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[398]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[399]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[400]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[401]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[402]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[403]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[404]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[405]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[406]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[314]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[407]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[408]
Selenium	DM25CGV	N. A.	N. A.	Approved	[409]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[410]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[411]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[412]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[413]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[414]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[415]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[416]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[417]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[419]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[420]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[314]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[421]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[422]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[423]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[424]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[428]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[429]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[430]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[429]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[431]
Selenium	DM25CGV	N. A.	N. A.	Approved	[432]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[433]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[434]

Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[435]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[436]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[437]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[438]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[439]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[440]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[441]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[442]

Drug(s) Affected By Apolipoprotein C-III (APOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[5]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[443]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[5]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[444]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[446]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[448]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[5]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[449]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[450]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[451]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[452]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[454]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[455]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[456]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[458]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[459]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[460]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[460]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[314]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[407]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[461]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[462]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[464]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[465]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[466]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[467]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[468]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[469]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[470]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[417]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[471]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[472]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[473]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[474]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[473]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]

Drug(s) Affected By Protein disulfide-isomerase (P4HB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[5]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[475]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[476]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Decorin (DCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[477]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[478]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[479]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase receptor Ret (RET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[408]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[480]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[216]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[408]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[481]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[482]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[483]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[358]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[484]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[485]
Selenium	DM25CGV	N. A.	N. A.	Approved	[486]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[466]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[487]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[488]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[489]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[87]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[490]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[130]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[490]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[491]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[492]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[493]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[408]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[494]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[495]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[408]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[494]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[496]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[497]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[498]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[499]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[473]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[500]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[430]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[501]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[502]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[503]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[504]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[494]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[505]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[506]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[507]
Bortezomib	DMNO38U	Leukemia		Approved	[508]

Drug(s) Affected By Neuromodulin (GAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[509]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[408]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[510]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[408]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[511]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[153]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[512]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[145]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[392]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[513]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[514]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[483]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[515]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[419]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[516]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[517]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[518]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[519]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[520]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[521]

Drug(s) Affected By Galanin peptides (GAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[408]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[408]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[522]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[523]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[318]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[524]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[525]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[470]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[526]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[416]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[527]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[519]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[521]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[474]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[528]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[529]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[530]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[527]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[531]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[532]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[498]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[473]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[314]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[533]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[485]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[374]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[387]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[534]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[330]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[535]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[536]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[537]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[317]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[538]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[539]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[540]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[541]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[542]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]

Drug(s) Affected By Protein-lysine 6-oxidase (LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[543]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[544]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[545]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[536]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[546]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[547]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[548]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[535]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[314]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[317]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[538]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[494]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[494]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[178]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[550]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[550]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]

Drug(s) Affected By Leukocyte elastase inhibitor (SERPINB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[475]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[551]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[552]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[553]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[318]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[554]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[555]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[556]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[174]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[416]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[557]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[558]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[559]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[560]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[561]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[245]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[562]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[563]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[564]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[564]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[565]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[566]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[567]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[568]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[569]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[570]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[571]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[572]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[573]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[574]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[575]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[576]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[577]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[578]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[579]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[580]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[342]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[429]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[581]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[582]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[152]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[583]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[584]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[524]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[585]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[164]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[584]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[530]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[586]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[85]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[470]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[88]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[587]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[130]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[269]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[314]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[579]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[588]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[589]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[590]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[591]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[592]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[494]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[593]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[594]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[595]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[454]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[596]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[597]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[598]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[599]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[600]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[533]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[485]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[601]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[602]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[603]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[604]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[605]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[606]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[607]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[174]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[608]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[609]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[610]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[611]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[612]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[613]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[469]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[614]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[615]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[517]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[616]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[152]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[617]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[618]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[532]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[619]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[566]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[620]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[621]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[479]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[622]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[5]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[5]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[623]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[5]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[623]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[624]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[625]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]

Drug(s) Affected By Nucleosome assembly protein 1-like 1 (NAP1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[626]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[627]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[219]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[628]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[629]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[316]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[630]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[631]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[87]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[632]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[633]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[634]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[497]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[459]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[469]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[517]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[635]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[636]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[637]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[637]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[638]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[637]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[637]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[637]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[637]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[639]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[640]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[527]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[641]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[269]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]

Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[234]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[642]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[643]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[134]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[644]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[645]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[645]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[645]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[645]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[645]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[646]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[647]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[648]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[649]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[650]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[318]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[516]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[534]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[651]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[652]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[653]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[654]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[655]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[656]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[517]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[657]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[429]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[429]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[429]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[429]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[429]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[566]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[611]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[612]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[658]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[659]

Drug(s) Affected By Integrin-linked protein kinase (ILK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[157]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[660]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]

Drug(s) Affected By Endonuclease G, mitochondrial (ENDOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[517]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[661]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[158]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[145]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[662]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[663]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[664]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[223]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[665]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[666]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[495]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[667]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[668]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[669]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[670]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[671]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[672]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[673]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[673]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[674]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[675]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[566]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[267]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[676]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By Carbonic anhydrase 9 (CA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[677]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[678]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Bortezomib	DMNO38U	Leukemia		Approved	[679]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[680]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[681]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[681]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[241]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[681]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[477]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[682]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[609]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[208]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[683]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[533]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[685]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[686]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[530]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[446]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[687]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[8]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[8]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[8]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[8]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[8]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[8]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[8]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[8]

Drug(s) Affected By Transmembrane 7 superfamily member 3 (TM7SF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[649]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[242]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[688]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[689]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[153]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[154]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[392]

Drug(s) Affected By Serine/threonine-protein kinase TBK1 (TBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[690]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[691]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[692]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[693]
Flavonoid derivative 1	DMCQP0B	N. A.	N. A.	Patented	[691]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[204]

Drug(s) Affected By Angiopoietin-related protein 3 (ANGPTL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[5]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[623]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[5]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[623]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[694]
Indomethacin	DMSC4A7	Bursitis		Approved	[5]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]

Drug(s) Affected By eIF5-mimic protein 1 (BZW2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[695]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[56]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[204]

Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[696]
Almogran	DM7I64Z	Migraine	8A80	Approved	[697]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[698]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[699]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[700]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[701]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[702]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[703]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[258]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[704]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[705]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[60]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[706]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[77]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[310]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[533]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[315]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[617]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[630]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[470]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[707]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[130]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[6]
Allograft inflammatory factor 1-like (AIF1L)	OTDEOB80	AIF1L_HUMAN	Gene/Protein Processing	[7]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[7]
Angiopoietin-related protein 3 (ANGPTL3)	OTCD5Z9W	ANGL3_HUMAN	Gene/Protein Processing	[5]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Gene/Protein Processing	[8]
Ankyrin repeat domain-containing protein 11 (ANKRD11)	OTV0V70M	ANR11_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Protein Interaction/Cellular Processes	[5]

References

• [1] Sulindac FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5425).
• [3] Inhibition of human lens aldose reductase by flavonoids, sulindac and indomethacin. Biochem Pharmacol. 1983 Jul 1;32(13):1995-8.
• [4] Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus. J Neurochem. 2010 Oct;115(1):200-8.
• [5] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [6] Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
• [7] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [8] Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
• [9] Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients. J Diabetes Complications. 2001 Sep-Oct;15(5):241-4.
• [10] Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care. 2001 Oct;24(10):1776-82.
• [11] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768).
• [12] Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes. J Nat Prod. 1996 Apr;59(4):443-5.
• [13] ClinicalTrials.gov (NCT02332005) 12-Month Efficacy and Safety of Diepalrestat in Adults With Diabetic Peripheral Neuropathy, a DB, Placebo-Controlled Study (DE-DPN). U.S. National Institutes of Health.
• [14] Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors ... J Med Chem. 2005 May 5;48(9):3141-52.
• [15] A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. J Diabetes Complications. 2005 Sep-Oct;19(5):247-53.
• [16] Effects of novel aldose reductase inhibitors, M16209 and M16287, on streptozotocin-induced diabetic neuropathy in rats. Eur J Pharmacol. 1991 Feb 7;193(2):185-91.
• [17] Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35.
• [18] Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50.
• [19] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [20] The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9.
• [21] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [22] Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7.
• [23] P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201.
• [24] Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6.
• [25] Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503.
• [26] Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. Chem Biol Interact. 2018 Oct 1;294:158-166.
• [27] Expression of 15-lipoxygenase-1 in human nasal epithelium: its implication in mucociliary differentiation. Prostaglandins Leukot Essent Fatty Acids. 2005 Aug;73(2):77-83. doi: 10.1016/j.plefa.2005.05.023.
• [28] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [29] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [30] The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells. Cancer Res. 2004 Dec 1;64(23):8778-81.
• [31] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [32] Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. Cancer Res. 2001 Jun 15;61(12):4879-84.
• [33] GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells. Cancer Res. 2002 Feb 15;62(4):1178-83.
• [34] Evaluation of the antioxidative properties of lipoxygenase inhibitors. Pharmacol Rep. 2012;64(5):1179-88.
• [35] Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. Cancer Res. 2005 Sep 15;65(18):8442-7.
• [36] Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. Protein J. 2005 Feb;24(2):65-77.
• [37] The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol Pharmacol. 2005 Apr;67(4):1299-306.
• [38] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [39] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [40] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [41] Paclitaxel inhibits N-acetyltransferase activity and gene expression in human stomach tumor cells (SC-M1). Res Commun Mol Pathol Pharmacol. 2004;115-116:21-38.
• [42] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [43] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [44] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [45] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [46] Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
• [47] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [48] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [49] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [50] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [51] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [52] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [53] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [54] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [55] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [56] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [57] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [58] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [59] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [60] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [61] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [62] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [63] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [64] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [65] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [66] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [67] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [68] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [69] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [70] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [71] Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Lett. 2006 Sep 8;241(1):93-101. doi: 10.1016/j.canlet.2005.10.014. Epub 2005 Dec 9.
• [72] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [73] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [74] Preferential cytotoxicity of bortezomib toward highly malignant human liposarcoma cells via suppression of MDR1 expression and function. Toxicol Appl Pharmacol. 2015 Feb 15;283(1):1-8. doi: 10.1016/j.taap.2014.12.015. Epub 2015 Jan 6.
• [75] Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men. PLoS One. 2017 Jun 5;12(6):e0178535. doi: 10.1371/journal.pone.0178535. eCollection 2017.
• [76] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [77] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [78] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [79] Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
• [80] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [81] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [82] The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
• [83] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [84] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [85] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [86] Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
• [87] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [88] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [89] Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
• [90] Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
• [91] Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
• [92] Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
• [93] CyclinB2 and BIRC5 genes as surrogate biomarkers for neurite outgrowth in SH-SY5Y subclonal cells. Neuropharmacology. 2006 Jun;50(8):1041-7. doi: 10.1016/j.neuropharm.2006.02.004. Epub 2006 Mar 30.
• [94] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [95] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [96] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [97] Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
• [98] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [99] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [100] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [101] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [102] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [103] Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
• [104] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [105] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [106] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [107] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [108] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [109] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [110] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [111] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [112] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [113] Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study. J Nutrigenet Nutrigenomics. 2008;1(1-2):30-48. doi: 10.1159/000109873. Epub 2007 Oct 16.
• [114] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [115] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [116] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [117] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [118] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [119] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [120] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [121] Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
• [122] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [123] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [124] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [125] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [126] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [127] G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
• [128] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [129] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [130] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [131] Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines. ChemMedChem. 2011 May 2;6(5):859-68. doi: 10.1002/cmdc.201100019. Epub 2011 Apr 6.
• [132] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [133] Resveratrol inhibits hydrogen peroxide-induced apoptosis in endothelial cells via the activation of PI3K/Akt by miR-126. J Atheroscler Thromb. 2014;21(2):108-18. doi: 10.5551/jat.19257. Epub 2013 Oct 10.
• [134] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [135] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [136] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [137] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [138] Transcriptional repression of IKK by p53 in arsenite-induced GADD45 accumulation and apoptosis. Oncogene. 2019 Jan;38(5):731-746. doi: 10.1038/s41388-018-0478-7. Epub 2018 Sep 3.
• [139] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [140] Altered oxidative status and integrin expression in cyclosporine A-treated oral epithelial cells. Toxicol Mech Methods. 2015 Feb;25(2):98-104. doi: 10.3109/15376516.2014.990595. Epub 2015 Jan 22.
• [141] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [142] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [143] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [144] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [145] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [146] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [147] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [148] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [149] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [150] Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
• [151] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [152] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [153] Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
• [154] NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
• [155] Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicol In Vitro. 2016 Oct;36:186-196. doi: 10.1016/j.tiv.2016.07.017. Epub 2016 Jul 26.
• [156] Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
• [157] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [158] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [159] Silencing of the CKII alpha and CKII alpha' genes during cellular senescence is mediated by DNA methylation. Gene. 2009 Feb 15;431(1-2):55-60. doi: 10.1016/j.gene.2008.10.020. Epub 2008 Nov 6.
• [160] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [161] Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
• [162] A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
• [163] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [164] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [165] The Effect of GADD45a on Furazolidone-Induced S-Phase Cell-Cycle Arrest in Human Hepatoma G2 Cells. J Biochem Mol Toxicol. 2015 Oct;29(10):489-495. doi: 10.1002/jbt.21719. Epub 2015 Jun 11.
• [166] Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. Oncogene. 2004 Jun 3;23(26):4614-23. doi: 10.1038/sj.onc.1207598.
• [167] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [168] Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
• [169] Pharmacological inhibition of Rho-kinase (ROCK) signaling enhances cisplatin resistance in neuroblastoma cells. Int J Oncol. 2010 Nov;37(5):1297-305. doi: 10.3892/ijo_00000781.
• [170] A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy. Genes Dev. 2015 Sep 15;29(18):1891-6. doi: 10.1101/gad.261867.115. Epub 2015 Sep 3.
• [171] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [172] Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci. 2010 Aug;116(2):422-32.
• [173] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [174] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [175] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [176] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [177] A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):291-4.
• [178] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [179] Glucocorticoid programming mechanism for hypercholesterolemia in prenatal ethanol-exposed adult offspring rats. Toxicol Appl Pharmacol. 2019 Jul 15;375:46-56.
• [180] Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis. 2008 Feb;13(2):259-71. doi: 10.1007/s10495-007-0165-6.
• [181] Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. J Nutr Biochem. 2015 Nov;26(11):1379-84. doi: 10.1016/j.jnutbio.2015.07.004. Epub 2015 Jul 26.
• [182] Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. Toxicol Lett. 2011 Aug 28;205(2):140-5. doi: 10.1016/j.toxlet.2011.05.1032. Epub 2011 May 27.
• [183] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [184] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [185] Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
• [186] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [187] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [188] Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24.
• [189] Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry. Cells. 2019 Jul 31;8(8):806. doi: 10.3390/cells8080806.
• [190] Effect of endosulfan and bisphenol A on the expression of SUMO and UBC9. Drug Chem Toxicol. 2020 Nov;43(6):637-644. doi: 10.1080/01480545.2018.1526179. Epub 2018 Nov 14.
• [191] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [192] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [193] A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):904-12. doi: 10.1016/j.ijrobp.2008.10.032.
• [194] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [195] Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study. Arch Toxicol. 2020 Jun;94(6):2225-2237. doi: 10.1007/s00204-020-02746-x. Epub 2020 Apr 23.
• [196] Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. J Med Chem. 2011 Jan 27;54(2):635-54.
• [197] Capsaicin, a component of red peppers, stimulates protein kinase CKII activity. BMB Rep. 2010 May;43(5):325-9. doi: 10.5483/bmbrep.2010.43.5.325.
• [198] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [199] Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
• [200] Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
• [201] Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells. Mol Cancer. 2009 Apr 22;8:26. doi: 10.1186/1476-4598-8-26.
• [202] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [203] Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. Int J Oncol. 2008 Oct;33(4):767-76.
• [204] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [205] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [206] Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
• [207] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [208] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [209] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [210] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [211] Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
• [212] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [213] Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
• [214] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [215] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [216] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [217] Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
• [218] Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
• [219] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [220] Chronic exposure to arsenic causes increased cell survival, DNA damage, and increased expression of mitochondrial transcription factor A (mtTFA) in human prostate epithelial cells. Chem Res Toxicol. 2011 Mar 21;24(3):340-9. doi: 10.1021/tx1003112. Epub 2011 Jan 14.
• [221] Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis. J Biochem Mol Toxicol. 2014 Dec;28(12):529-38.
• [222] Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
• [223] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [224] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [225] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [226] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [227] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [228] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [229] In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer. Mol Cancer. 2006 Mar 28;5:13.
• [230] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [231] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [232] Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
• [233] The RET oncogene is a critical component of transcriptional programs associated with retinoic acid-induced differentiation in neuroblastoma. Mol Cancer Ther. 2007 Apr;6(4):1300-9.
• [234] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [235] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [236] The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
• [237] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [238] Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
• [239] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [240] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [241] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [242] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [243] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [244] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [245] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [246] Glyphosate-based herbicides at low doses affect canonical pathways in estrogen positive and negative breast cancer cell lines. PLoS One. 2019 Jul 11;14(7):e0219610. doi: 10.1371/journal.pone.0219610. eCollection 2019.
• [247] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [248] Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
• [249] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [250] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [251] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [252] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [253] SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
• [254] The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis. Cell Physiol Biochem. 2015;35(6):2192-202. doi: 10.1159/000374024. Epub 2015 Apr 7.
• [255] AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
• [256] Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
• [257] Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions. Aging (Albany NY). 2009 Mar 31;1(4):412-24. doi: 10.18632/aging.100035.
• [258] Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS. Toxicol Lett. 2016 Sep 30;259:133-142. doi: 10.1016/j.toxlet.2016.08.006. Epub 2016 Aug 8.
• [259] Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis. Toxicology. 2022 Jan 15;465:153050. doi: 10.1016/j.tox.2021.153050. Epub 2021 Nov 23.
• [260] Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases. J Biol Chem. 2013 May 31;288(22):16004-15. doi: 10.1074/jbc.M112.432294. Epub 2013 Apr 1.
• [261] In vitro hydroquinone-induced instauration of histone bivalent mark on human retroelements (LINE-1) in HL60 cells. Toxicol In Vitro. 2017 Apr;40:1-10. doi: 10.1016/j.tiv.2016.12.007. Epub 2016 Dec 13.
• [262] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [263] Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes. Anticancer Drugs. 2007 Aug;18(7):763-72. doi: 10.1097/CAD.0b013e3280adc905.
• [264] Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
• [265] Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
• [266] Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
• [267] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [268] Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
• [269] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [270] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [271] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [272] Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
• [273] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [274] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [275] Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A. Arch Toxicol. 2018 Feb;92(2):995-1014.
• [276] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [277] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [278] Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J Biol Chem. 2004 Feb 20;279(8):6883-92. doi: 10.1074/jbc.M305295200. Epub 2003 Dec 8.
• [279] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [280] Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol. 2009 Jan;144(2):251-62. doi: 10.1111/j.1365-2141.2008.07441.x. Epub 2008 Nov 19.
• [281] Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
• [282] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [283] Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
• [284] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [285] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [286] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [287] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [288] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [289] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [290] Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
• [291] Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives. Toxicol Lett. 2020 Mar 15;321:114-121. doi: 10.1016/j.toxlet.2019.12.012. Epub 2019 Dec 9.
• [292] Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients. Food Chem Toxicol. 2012 Jul;50(7):2289-93. doi: 10.1016/j.fct.2012.03.077. Epub 2012 Apr 16.
• [293] A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
• [294] Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther. 2009 Apr;329(1):252-61. doi: 10.1124/jpet.108.146225. Epub 2009 Jan 13.
• [295] Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.
• [296] Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36.
• [297] Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
• [298] Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J Pharmacol Exp Ther. 2005 Dec;315(3):1288-97.
• [299] The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator. Br J Pharmacol. 2016 May;173(10):1703-15. doi: 10.1111/bph.13472. Epub 2016 Apr 8.
• [300] P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate. Toxicol Appl Pharmacol. 2016 Sep 1;306:27-35. doi: 10.1016/j.taap.2016.06.030. Epub 2016 Jul 1.
• [301] Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020 Jun 1;175(2):279-291. doi: 10.1093/toxsci/kfaa033.
• [302] Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol. Toxicol Lett. 2023 Apr 15;379:48-55. doi: 10.1016/j.toxlet.2023.03.007. Epub 2023 Mar 22.
• [303] Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate. Toxicol In Vitro. 2017 Oct;44:27-35.
• [304] Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
• [305] Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379. doi: 10.1002/jbt.22379. Epub 2019 Jul 31.
• [306] Multiple drug transporters mediate the placental transport of sulpiride. Arch Toxicol. 2017 Dec;91(12):3873-3884. doi: 10.1007/s00204-017-2008-8. Epub 2017 Jun 9.
• [307] Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8.
• [308] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [309] Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.
• [310] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [311] Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
• [312] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [313] Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
• [314] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [315] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [316] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [317] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [318] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [319] Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
• [320] Methotrexate induction of human sulfotransferases in Hep G2 and Caco-2 cells. J Appl Toxicol. 2005 Sep-Oct;25(5):354-60.
• [321] Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Anal Biochem. 2006 Oct 1;357(1):85-92.
• [322] Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro. Drug Metab Dispos. 2003 Nov;31(11):1300-5.
• [323] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [324] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [325] Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
• [326] Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
• [327] Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
• [328] Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
• [329] Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
• [330] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [331] Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
• [332] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [333] The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
• [334] Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
• [335] In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
• [336] Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
• [337] Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
• [338] Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
• [339] Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
• [340] Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60.
• [341] Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
• [342] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [343] Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
• [344] Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chem Biol Interact. 2014 Feb 5;208:64-76. doi: 10.1016/j.cbi.2013.11.018. Epub 2013 Dec 6.
• [345] Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab. 2006 Apr;7(3):301-13. doi: 10.2174/138920006776359310.
• [346] Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells. Phytother Res. 2012 Nov;26(11):1746-52.
• [347] Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
• [348] Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
• [349] Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
• [350] The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells. Biosci Biotechnol Biochem. 2010;74(1):36-43. doi: 10.1271/bbb.90438. Epub 2010 Jan 7.
• [351] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [352] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [353] In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
• [354] Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
• [355] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
• [356] Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
• [357] Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
• [358] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [359] Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
• [360] Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chem Biol Interact. 2011 May 30;191(1-3):227-33.
• [361] In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
• [362] AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44.
• [363] Initro inhibition of AKR1Cs by sulphonylureas and the structural basis. Chem Biol Interact. 2015 Oct 5;240:310-5.
• [364] A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
• [365] Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
• [366] Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
• [367] Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
• [368] Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis. Oncol Rep. 2007 Sep;18(3):523-9.
• [369] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [370] Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
• [371] Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
• [372] Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1;96(23):1769-80. doi: 10.1093/jnci/djh322.
• [373] Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells. Carcinogenesis. 2007 Oct;28(10):2114-21. doi: 10.1093/carcin/bgm133. Epub 2007 Jun 4.
• [374] Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
• [375] Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol. 2007 Feb 15;178(4):2507-16. doi: 10.4049/jimmunol.178.4.2507.
• [376] Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem. 2005 Dec 9;280(49):41047-56. doi: 10.1074/jbc.M503713200. Epub 2005 Sep 30.
• [377] Blockade of oncogenic IB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11365-70. doi: 10.1073/pnas.1411701111. Epub 2014 Jul 21.
• [378] Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology. 2005 Mar;146(3):1491-7. doi: 10.1210/en.2004-0809. Epub 2004 Nov 24.
• [379] Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes. Biochem Biophys Res Commun. 2015 Aug 14;464(1):221-228. doi: 10.1016/j.bbrc.2015.06.120. Epub 2015 Jun 23.
• [380] Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
• [381] Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol. 2009 Apr 15;77(8):1410-7.
• [382] Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. World J Gastroenterol. 2005 May 14;11(18):2748-53. doi: 10.3748/wjg.v11.i18.2748.
• [383] Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
• [384] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [385] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [386] Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
• [387] Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
• [388] Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
• [389] Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer. Cell Death Dis. 2019 Nov 7;10(11):846. doi: 10.1038/s41419-019-2001-7.
• [390] Asbestos-induced alveolar epithelial cell apoptosis. The role of endoplasmic reticulum stress response. Am J Respir Cell Mol Biol. 2013 Dec;49(6):892-901. doi: 10.1165/rcmb.2013-0053OC.
• [391] Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway. Cancer Sci. 2014 May;105(5):520-7. doi: 10.1111/cas.12395. Epub 2014 Apr 11.
• [392] Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Exp Eye Res. 2007 Dec;85(6):825-35. doi: 10.1016/j.exer.2007.08.018. Epub 2007 Aug 29.
• [393] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [394] Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53. Clin Cancer Res. 2004 May 1;10(9):3179-88. doi: 10.1158/1078-0432.ccr-03-0309.
• [395] Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway. Toxicol Sci. 2017 Mar 1;156(1):252-260. doi: 10.1093/toxsci/kfw249.
• [396] Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
• [397] Effects of histamine H2-receptor blockade on the cardiovascular reflex response to lower-body negative pressure in man. Acta Physiol Scand. 1990 May;139(1):161-72. doi: 10.1111/j.1748-1716.1990.tb08909.x.
• [398] Addition of acebutolol to diuretics in hypertension. Clin Pharmacol Ther. 1981 Dec;30(6):739-44. doi: 10.1038/clpt.1981.232.
• [399] Relative potency of a beta-blocking and a calcium entry blocking agent as antihypertensive drugs in black patients. Eur J Clin Pharmacol. 1986;29(5):523-7. doi: 10.1007/BF00635887.
• [400] Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans. Hypertension. 2006 Jul;48(1):120-6. doi: 10.1161/01.HYP.0000225424.13138.5d. Epub 2006 May 22.
• [401] Effects of an angiotensin converting enzyme inhibitor, ramipril, on intracranial circulation in healthy volunteers. off. Br J Clin Pharmacol. 1992 Sep;34(3):224-30. doi: 10.1111/j.1365-2125.1992.tb04128.x.
• [402] Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites. Am J Physiol Renal Physiol. 2005 May;288(5):F1044-52. doi: 10.1152/ajprenal.00142.2004. Epub 2004 Dec 21.
• [403] beta-Endorphin and essential hypertension: importance of the clonidine-naloxone interaction. Acta Physiol Hung. 1985;65(2):217-26.
• [404] Hypokalemia from beta2-receptor stimulation by circulating epinephrine. N Engl J Med. 1983 Dec 8;309(23):1414-9. doi: 10.1056/NEJM198312083092303.
• [405] Detection of low-renin hypertension; evaluation of out-patient renin-stimulating methods. Clin Sci Mol Med. 1975 Feb;48(2):91-6. doi: 10.1042/cs0480091.
• [406] Dosage dependent hormonal counter regulation to combination therapy in patients with left ventricular dysfunction. J Clin Pharm Ther. 2006 Apr;31(2):139-47. doi: 10.1111/j.1365-2710.2006.00606.x.
• [407] Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
• [408] Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
• [409] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [410] Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation. Mutat Res. 2001 Sep 1;480-481:269-76. doi: 10.1016/s0027-5107(01)00184-1.
• [411] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [412] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [413] R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. J Pharmacol Exp Ther. 2006 Mar;316(3):1219-28.
• [414] Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
• [415] ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
• [416] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [417] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [418] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [419] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [420] Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
• [421] Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res. 2010 Feb 15;70(4):1314-22. doi: 10.1158/0008-5472.CAN-09-3292. Epub 2010 Feb 9.
• [422] PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells. Antioxid Redox Signal. 2002 Dec;4(6):877-84. doi: 10.1089/152308602762197416.
• [423] Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
• [424] Cytokine abnormalities in a patient with eosinophilic fasciitis. Ann Allergy Asthma Immunol. 2003 Apr;90(4):452-5. doi: 10.1016/S1081-1206(10)61832-7.
• [425] Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil. Br J Pharmacol. 2009 Jun;157(3):362-70. doi: 10.1111/j.1476-5381.2009.00161.x. Epub 2009 Apr 9.
• [426] Influence of quercetin and x-ray on collagen synthesis of cultured human keloid-derived fibroblasts. Chin Med Sci J. 2006 Sep;21(3):179-83.
• [427] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [428] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [429] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [430] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [431] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [432] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [433] Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
• [434] Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
• [435] Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations. Pharmacogenomics. 2008 Oct;9(10):1543-6. doi: 10.2217/14622416.9.10.1543.
• [436] Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics. 2010 Mar;11(3):349-56. doi: 10.2217/pgs.09.162.
• [437] HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9. doi: 10.1073/pnas.0409500102. Epub 2005 Mar 2.
• [438] HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese. Epilepsia. 2013 Jul;54(7):1307-14. doi: 10.1111/epi.12217. Epub 2013 May 20.
• [439] Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
• [440] Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet. 2002 Mar 30;359(9312):1121-2. doi: 10.1016/S0140-6736(02)08158-8.
• [441] HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009 Jul;41(7):816-9. doi: 10.1038/ng.379. Epub 2009 May 31.
• [442] HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity. PLoS One. 2013 Jul 9;8(7):e68111. doi: 10.1371/journal.pone.0068111. Print 2013.
• [443] Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
• [444] Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017 May 16;37(11):e00079-17. doi: 10.1128/MCB.00079-17. Print 2017 Jun 1.
• [445] [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
• [446] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [447] Effect of simvastatin treatment on the electronegative low-density lipoprotein present in patients with heterozygous familial hypercholesterolemia. Am J Cardiol. 1999 Sep 15;84(6):655-9. doi: 10.1016/s0002-9149(99)00411-7.
• [448] Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):571-7. doi: 10.1161/01.ATV.0000154142.61859.94. Epub 2004 Dec 23.
• [449] Aluminum-induced mitochondrial dysfunction leads to lipid accumulation in human hepatocytes: a link to obesity. Cell Physiol Biochem. 2007;20(5):627-38. doi: 10.1159/000107546.
• [450] Relation between dose of bendrofluazide, antihypertensive effect, and adverse biochemical effects. BMJ. 1990 Apr 14;300(6730):975-8. doi: 10.1136/bmj.300.6730.975.
• [451] p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
• [452] Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
• [453] Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
• [454] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [455] Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
• [456] Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
• [457] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [458] Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
• [459] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [460] Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis. J Antimicrob Chemother. 2004 Feb;53(2):174-9. doi: 10.1093/jac/dkh056. Epub 2004 Jan 16.
• [461] The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils. Allergy Asthma Proc. 2005 Jul-Aug;26(4):292-8.
• [462] Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. doi: 10.1034/j.1398-9995.2000.00803.x.
• [463] Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. J Dermatol Sci. 2001 Jun;26(2):85-93. doi: 10.1016/s0923-1811(00)00165-1.
• [464] Correlation of sICAM-1 and sVCAM-1 level with biochemical, histological and viral findings in chronic hepatitis C after interferon-alpha + ribavirin therapy. Rom J Gastroenterol. 2003 Jun;12(2):91-5.
• [465] Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J Toxicol Sci. 2019;44(3):213-224. doi: 10.2131/jts.44.213.
• [466] Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
• [467] Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Exp Biol Med (Maywood). 2008 Nov;233(11):1433-40. doi: 10.3181/0804-RM-127. Epub 2008 Sep 12.
• [468] Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
• [469] Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
• [470] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [471] Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
• [472] HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
• [473] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [474] Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
• [475] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [476] Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
• [477] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [478] Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study. J Nutr Sci. 2016 Apr 26;5:e17. doi: 10.1017/jns.2016.8. eCollection 2016.
• [479] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [480] Hypotensive shock and angio-oedema from angiotensin II receptor blocker: a class effect in spite of tripled tryptase values. J Intern Med. 2005 Oct;258(4):385-7. doi: 10.1111/j.1365-2796.2005.01547.x.
• [481] Dual inhibition of RET and FGFR4 restrains medullary thyroid cancer cell growth. Clin Cancer Res. 2005 Feb 1;11(3):1336-41.
• [482] A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
• [483] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [484] Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
• [485] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [486] High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8.
• [487] Ammonia promotes endothelial cell survival via the heme oxygenase-1-mediated release of carbon monoxide. Free Radic Biol Med. 2017 Jan;102:37-46. doi: 10.1016/j.freeradbiomed.2016.11.029. Epub 2016 Nov 17.
• [488] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [489] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [490] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [491] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [492] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [493] Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
• [494] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [495] Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
• [496] p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells. Neuro Oncol. 2012 Jul;14(7):870-81. doi: 10.1093/neuonc/nos114. Epub 2012 Jun 18.
• [497] In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells. Food Chem Toxicol. 2022 Jan;159:112722. doi: 10.1016/j.fct.2021.112722. Epub 2021 Dec 3.
• [498] Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int J Mol Med. 2010 Nov;26(5):735-41. doi: 10.3892/ijmm_00000520.
• [499] A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
• [500] Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
• [501] Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
• [502] Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
• [503] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [504] Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.
• [505] Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun. 2005 Mar 4;328(1):227-34. doi: 10.1016/j.bbrc.2004.12.151.
• [506] Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
• [507] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [508] Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
• [509] Arsenic trioxide inhibits neuroblastoma growth in vivo and promotes apoptotic cell death in vitro. Biochem Biophys Res Commun. 2000 Oct 14;277(1):179-85. doi: 10.1006/bbrc.2000.3651.
• [510] Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP. Mol Cell Biochem. 2010 Dec;345(1-2):1-11. doi: 10.1007/s11010-010-0553-z. Epub 2010 Aug 9.
• [511] Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells. PLoS One. 2011;6(11):e27265. doi: 10.1371/journal.pone.0027265. Epub 2011 Nov 11.
• [512] Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res. 2009 Sep;50(9):1814-23. doi: 10.1194/jlr.M800343-JLR200. Epub 2009 Apr 21.
• [513] Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
• [514] 9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts. Reprod Toxicol. 2019 Aug;87:21-31. doi: 10.1016/j.reprotox.2019.04.008. Epub 2019 May 1.
• [515] Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
• [516] Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
• [517] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [518] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [519] Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
• [520] CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
• [521] Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
• [522] The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
• [523] Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
• [524] Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
• [525] Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
• [526] Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
• [527] Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
• [528] Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells. Exp Cell Res. 2004 Jul 1;297(1):68-81. doi: 10.1016/j.yexcr.2004.02.017.
• [529] [P27(Kip1), cyclin E and endogenous TGF-beta1 changes in apoptosis of NB4 cells induced by As(2)O(3) and/or TGF-beta1 and their significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Feb;17(1):74-9.
• [530] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [531] Down-regulation and decreased activity of cyclin-dependent kinase 2 in H2O2-induced premature senescence. Int J Biochem Cell Biol. 2003 Feb;35(2):246-54. doi: 10.1016/s1357-2725(02)00129-2.
• [532] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [533] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [534] Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
• [535] Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
• [536] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [537] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [538] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
• [539] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [540] Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
• [541] Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
• [542] Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
• [543] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [544] Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. Chin Med J (Engl). 2007 Sep 20;120(18):1626-31.
• [545] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [546] A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
• [547] The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
• [548] Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
• [549] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [550] Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood. 2010 Jan 14;115(2):326-30. doi: 10.1182/blood-2009-07-235051. Epub 2009 Nov 2.
• [551] 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
• [552] Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
• [553] Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
• [554] Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
• [555] Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
• [556] Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
• [557] Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.
• [558] Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
• [559] Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
• [560] Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46.
• [561] Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
• [562] Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23. doi: 10.1016/j.cbi.2015.08.023. Epub 2015 Sep 1.
• [563] Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
• [564] Functional analysis of MRP1 cloned from bovine. FEBS Lett. 2002 Jun 19;521(1-3):211-3. doi: 10.1016/s0014-5793(02)02816-8.
• [565] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [566] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [567] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [568] Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
• [569] Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
• [570] Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
• [571] Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
• [572] Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
• [573] Chemoprevention of chemically-induced mammary and colon carcinogenesis by 1alpha-hydroxyvitamin D5. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):129-36. doi: 10.1016/j.jsbmb.2005.06.008. Epub 2005 Jul 26.
• [574] Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
• [575] Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
• [576] Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
• [577] COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
• [578] Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
• [579] Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
• [580] Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
• [581] A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
• [582] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
• [583] High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
• [584] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [585] Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
• [586] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [587] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [588] Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L422-9. doi: 10.1152/ajplung.00204.2006. Epub 2006 Oct 6.
• [589] Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicol Appl Pharmacol. 2020 Dec 1;408:115273. doi: 10.1016/j.taap.2020.115273. Epub 2020 Oct 6.
• [590] Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. Biocell. 2009 Aug;33(2):107-14.
• [591] Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer. 2011 Jun 16;11:255. doi: 10.1186/1471-2407-11-255.
• [592] Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.
• [593] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [594] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [595] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [596] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [597] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [598] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [599] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [600] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [601] Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
• [602] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [603] Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med. 2002 Mar 1;32(5):386-93. doi: 10.1016/s0891-5849(01)00812-7.
• [604] Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
• [605] Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
• [606] Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013 Oct 4;288(40):28792-800. doi: 10.1074/jbc.M113.491365. Epub 2013 Aug 12.
• [607] Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
• [608] Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
• [609] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [610] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [611] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
• [612] Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
• [613] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [614] The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Chem Biol Interact. 2019 Sep 1;310:108688. doi: 10.1016/j.cbi.2019.06.001. Epub 2019 Jun 4.
• [615] Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
• [616] Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chem Biol Interact. 2010 Oct 6;188(1):75-85. doi: 10.1016/j.cbi.2010.06.001. Epub 2010 Jun 9.
• [617] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [618] Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. J Biol Chem. 2003 May 16;278(20):18092-100. doi: 10.1074/jbc.M300265200. Epub 2003 Mar 13.
• [619] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [620] Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies. Arch Toxicol. 2018 Sep;92(9):2829-2844. doi: 10.1007/s00204-018-2263-3. Epub 2018 Jul 13.
• [621] Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBP-SIRT1 pathway. Toxicology. 2019 Apr 1;417:23-34. doi: 10.1016/j.tox.2019.02.008. Epub 2019 Feb 15.
• [622] Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer. Environ Toxicol. 2023 Oct;38(10):2352-2360. doi: 10.1002/tox.23871. Epub 2023 Jun 22.
• [623] Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
• [624] Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicol Sci. 2018 Aug 1;164(2):477-488.
• [625] Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin. J Lipid Res. 1999 Jun;40(6):1078-89.
• [626] Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells. J Steroid Biochem Mol Biol. 2003 May;85(1):1-8. doi: 10.1016/s0960-0760(03)00142-0.
• [627] Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
• [628] Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
• [629] Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
• [630] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [631] The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
• [632] Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
• [633] Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
• [634] Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
• [635] Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
• [636] NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11.
• [637] A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
• [638] Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
• [639] Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
• [640] Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat Med. 2004 Jan;10(1):40-7. doi: 10.1038/nm969. Epub 2003 Dec 14.
• [641] Antiproliferative effects of gefitinib are associated with suppression of E2F-1 expression and telomerase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3387-91.
• [642] Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
• [643] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [644] Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine. Toxicol In Vitro. 2009 Oct;23(7):1259-67.
• [645] Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
• [646] Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta. Mol Cell Biochem. 2004 Nov;266(1-2):57-63. doi: 10.1023/b:mcbi.0000049138.67699.7b.
• [647] (9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.
• [648] Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. Anticancer Res. 2009 Sep;29(9):3647-58.
• [649] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [650] On the mechanism for PPAR agonists to enhance ABCA1 gene expression. Atherosclerosis. 2009 Aug;205(2):413-9. doi: 10.1016/j.atherosclerosis.2009.01.008. Epub 2009 Jan 19.
• [651] Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
• [652] Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
• [653] Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression. Signal Transduct Target Ther. 2023 Jan 9;8(1):14. doi: 10.1038/s41392-022-01248-9.
• [654] Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
• [655] Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
• [656] Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
• [657] Distinct role and functional mode of TR3 and RARalpha in mediating ATRA-induced signalling pathway in breast and gastric cancer cells. Int J Biochem Cell Biol. 2004 Jan;36(1):98-113. doi: 10.1016/s1357-2725(03)00143-2.
• [658] Comparative effects of fructose and glucose on lipogenic gene expression and intermediary metabolism in HepG2 liver cells. PLoS One. 2011;6(11):e26583. doi: 10.1371/journal.pone.0026583. Epub 2011 Nov 11.
• [659] Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
• [660] Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. J Biochem Mol Toxicol. 2020 Oct;34(10):e22547. doi: 10.1002/jbt.22547. Epub 2020 Jun 26.
• [661] Anticancer effects of cantharidin in A431 human skin cancer (Epidermoid carcinoma) cells in vitro and in vivo. Environ Toxicol. 2017 Mar;32(3):723-738. doi: 10.1002/tox.22273. Epub 2016 Apr 25.
• [662] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [663] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [664] Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
• [665] Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. Biochem Pharmacol. 2012 May 1;83(9):1172-82. doi: 10.1016/j.bcp.2012.01.017. Epub 2012 Jan 21.
• [666] Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos. 2006 Feb;34(2):296-304. doi: 10.1124/dmd.105.005280. Epub 2005 Nov 9.
• [667] Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
• [668] Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis. 2001 Sep;22(9):1393-7. doi: 10.1093/carcin/22.9.1393.
• [669] AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
• [670] Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells. Blood Cancer J. 2019 Jan 15;9(2):4. doi: 10.1038/s41408-018-0165-5.
• [671] Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
• [672] AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 2004 Dec;25(12):2497-507. doi: 10.1093/carcin/bgh253. Epub 2004 Aug 5.
• [673] Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci. 2009 Nov;112(1):153-63.
• [674] Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J Cardiovasc Pharmacol. 2008 Mar;51(3):267-73. doi: 10.1097/FJC.0b013e3181624b44.
• [675] Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
• [676] SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
• [677] Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. J Med Chem. 2011 Oct 13;54(19):6905-18.
• [678] Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line. Neurochem Res. 2012 Feb;37(2):370-80. doi: 10.1007/s11064-011-0620-1. Epub 2011 Oct 4.
• [679] A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. Clin Cancer Res. 2005 Aug 1;11(15):5526-33. doi: 10.1158/1078-0432.CCR-05-0081.
• [680] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [681] Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chem Biol Interact. 2019 May 25;305:12-20. doi: 10.1016/j.cbi.2019.03.026. Epub 2019 Mar 26.
• [682] Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec 2;286(48):41413-41424. doi: 10.1074/jbc.M111.287052. Epub 2011 Oct 5.
• [683] Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ. 2000 Jun;7(6):574-86. doi: 10.1038/sj.cdd.4400688.
• [684] Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation. 2002 Oct 27;74(8):1063-9. doi: 10.1097/00007890-200210270-00001.
• [685] Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
• [686] Down regulation of N-acetylglucosaminyltransferase V facilitates all-transretinoic acid to induce apoptosis of human hepatocarcinoma cells. Mol Cell Biochem. 2006 Mar;284(1-2):103-10. doi: 10.1007/s11010-005-9022-5. Epub 2006 Jan 13.
• [687] Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women. Clin Pharmacol Ther. 2007 Aug;82(2):187-96. doi: 10.1038/sj.clpt.6100214. Epub 2007 May 2.
• [688] Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells. Toxicology. 2015 Feb 3;328:102-11. doi: 10.1016/j.tox.2014.12.018. Epub 2014 Dec 18.
• [689] Effect of quercetin on apoptosis of PANC-1 cells. J Korean Surg Soc. 2013 Dec;85(6):249-60. doi: 10.4174/jkss.2013.85.6.249. Epub 2013 Nov 26.
• [690] Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery. J Interferon Cytokine Res. 2015 Mar;35(3):143-56. doi: 10.1089/jir.2014.0038. Epub 2014 Oct 16.
• [691] Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochem Pharmacol. 2009 Apr 15;77(8):1391-400. doi: 10.1016/j.bcp.2009.01.009. Epub 2009 Jan 23.
• [692] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [693] Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers. J Allergy Clin Immunol. 2016 Dec;138(6):1690-1700. doi: 10.1016/j.jaci.2016.02.038. Epub 2016 Apr 24.
• [694] Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. Life Sci. 2016 Jul 1;156:47-56.
• [695] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [696] Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Psychopharmacology (Berl). 2000 Sep;151(4):312-20.
• [697] Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11.
• [698] Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. Drug Metab Dispos. 2004 Nov;32(11):1247-53. doi: 10.1124/dmd.104.000026. Epub 2004 Jul 30.
• [699] Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants. J Pharmacol Exp Ther. 2007 Jan;320(1):266-73. doi: 10.1124/jpet.106.112268. Epub 2006 Oct 18.
• [700] Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries. OMICS. 2013 Jul;17(7):353-67. doi: 10.1089/omi.2013.0019. Epub 2013 Jun 11.
• [701] Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. Drug Metab Dispos. 2008 Dec;36(12):2547-55. doi: 10.1124/dmd.108.023671. Epub 2008 Sep 22.
• [702] Cytotoxicity of simvastatin to pancreatic adenocarcinoma cells containing mutant ras gene. Jpn J Cancer Res. 1994 Jun;85(6):633-8. doi: 10.1111/j.1349-7006.1994.tb02406.x.
• [703] Regulation of the signal transduction program by drugs. Adv Enzyme Regul. 1997;37:35-55. doi: 10.1016/s0065-2571(96)00025-8.
• [704] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [705] Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol. 2005 Sep;130(6):912-25. doi: 10.1111/j.1365-2141.2005.05696.x.
• [706] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [707] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.