Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM47CO1)

• Drug Name: Okadaic acid Drug Info
• Synonyms: 78111-17-8; CHEMBL280487; CHEBI:44658; C44H68O13; 9,10-Deepithio-9,10-didehydroacanthifolicin; Ocadaic Acid; OKA; (2R)-3-[(2S,5R,6R,8S)-8-[(2R,3E)-4-[(2R,4'aR,5R,6'S,8'R,8'aS)-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-7'-methylidene-hexahydro-3'H-spiro[oxolane-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl]-5-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-hydroxy-2-methylpropanoic acid; UNII-1W21G5Q4N2; CCRIS 3329; HSDB 7243; 1W21G5Q4N2; 1jk7

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 446512
  ChEBI ID: CHEMBL280487
  CAS Number: CAS 78111-17-8
  TTD Drug ID: DM47CO1
  VARIDT Drug ID: DR01345

Molecule-Related Drug Atlas

Drug(s) Targeting Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[9]
ADOCIAQUINONE B	DMPOU86	Discovery agent	N.A.	Investigative	[9]
4-ethoxynaphthalene-1,2-dione	DMUN7KC	Discovery agent	N.A.	Investigative	[9]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[10]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[12]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[13]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[16]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[17]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[19]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[20]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[21]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[22]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[23]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[24]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[25]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[23]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[34]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[35]

Drug(s) Affected By Semenogelin-1 (SEMG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[36]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[37]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Haloperidol	DM96SE0	Delirium		Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[52]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[51]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Haloperidol	DM96SE0	Delirium		Approved	[52]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[60]

Drug(s) Affected By ATP synthase subunit alpha, mitochondrial (ATP5F1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[65]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[66]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[67]

Drug(s) Affected By Peroxiredoxin-5, mitochondrial (PRDX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[73]

Drug(s) Affected By ATP synthase subunit delta, mitochondrial (ATP5F1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[75]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By Methylosome subunit pICln (CLNS1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[39]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[81]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Destrin (DSTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[85]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[87]

Drug(s) Affected By LRP chaperone MESD (MESD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[89]

Drug(s) Affected By Poly(rC)-binding protein 1 (PCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[52]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[90]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[93]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[35]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]

Drug(s) Affected By Calcyclin-binding protein (CACYBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[98]

Drug(s) Affected By Sialic acid synthase (NANS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By MICOS complex subunit MIC19 (CHCHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[103]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[81]

Drug(s) Affected By Glutathione S-transferase 3, mitochondrial (MGST3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[67]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[97]

Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[110]
Bortezomib	DMNO38U	Leukemia		Approved	[111]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[112]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[115]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[125]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[126]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[123]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[127]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Haloperidol	DM96SE0	Delirium		Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[131]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[121]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[131]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[139]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[148]
Fructose	DM43AN2	Vomiting	MD90	Approved	[149]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[150]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[151]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]

Drug(s) Affected By Bisphosphoglycerate mutase (BPGM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[156]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[87]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[158]

Drug(s) Affected By Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[159]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[160]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By Histone H1.4 (H1-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[164]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[165]

Drug(s) Affected By Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[167]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[101]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[177]

Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[183]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[186]

Drug(s) Affected By T-complex protein 1 subunit alpha (TCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[165]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[188]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[190]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[75]

Drug(s) Affected By DnaJ homolog subfamily B member 2 (DNAJB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[199]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[45]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[204]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[121]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[205]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[206]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[207]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[150]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[213]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[214]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[153]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[215]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]

Drug(s) Affected By T-complex protein 1 subunit delta (CCT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[218]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[81]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[158]

Drug(s) Affected By Ataxin-3 (ATXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[224]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[226]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[228]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]

Drug(s) Affected By E3 ubiquitin-protein ligase RBX1 (RBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[233]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase A (PPIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[222]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[177]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[67]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[236]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[237]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[238]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[239]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]

Drug(s) Affected By Elongin-C (ELOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[133]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[242]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[243]

Drug(s) Affected By Elongin-B (ELOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[244]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[158]

Drug(s) Affected By DnaJ homolog subfamily C member 10 (DNAJC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[199]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[247]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[199]

Drug(s) Affected By ATP-dependent RNA helicase DDX1 (DDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[235]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[219]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[249]

Drug(s) Affected By Histone H2A type 1-C (H2AC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[229]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[222]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[250]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[251]

Drug(s) Affected By StAR-related lipid transfer protein 4 (STARD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By Dynein regulatory complex protein 10 (IQCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[253]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[255]

Drug(s) Affected By Prefoldin subunit 5 (PFDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[257]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[259]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[259]

Drug(s) Affected By T-complex protein 1 subunit eta (CCT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[52]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[260]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[218]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[86]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[81]

Drug(s) Affected By Oxysterol-binding protein-related protein 11 (OSBPL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[255]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[81]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[242]

Drug(s) Affected By Egl nine homolog 1 (EGLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[263]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]

Drug(s) Affected By Prolyl hydroxylase EGLN3 (EGLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[264]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[265]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]

Drug(s) Affected By DnaJ homolog subfamily C member 4 (DNAJC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Bortezomib	DMNO38U	Leukemia		Approved	[266]
Indomethacin	DMSC4A7	Bursitis		Approved	[267]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[268]
L-serine	DM6WPIS	Pulmonary tuberculosis	1B10.Z	Investigative	[269]

Drug(s) Affected By Translocation protein SEC63 homolog (SEC63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Indomethacin	DMSC4A7	Bursitis		Approved	[267]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By Prefoldin subunit 2 (PFDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[233]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[271]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[273]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[276]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[277]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[278]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[284]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[285]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[286]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[287]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[288]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]

Drug(s) Affected By Regulator of G-protein signaling 5 (RGS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[290]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]

Drug(s) Affected By Nuclear receptor corepressor 1 (NCOR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[291]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[294]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[295]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[296]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[296]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[297]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[298]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[299]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[296]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[296]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[296]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[300]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[301]

Drug(s) Affected By Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[302]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[305]

Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[306]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[308]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[309]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[310]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[311]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[109]

Drug(s) Affected By Claudin-7 (CLDN7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[308]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[314]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]

Drug(s) Affected By Securin (PTTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[109]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[317]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]

Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[226]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[74]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[319]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[294]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[319]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[320]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[321]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[322]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[324]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[325]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[326]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]

Drug(s) Affected By Serotransferrin (TF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[328]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[329]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[330]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[331]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Selenium	DM25CGV	N. A.	N. A.	Approved	[332]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[334]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[335]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[336]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[337]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[340]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[341]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[343]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[344]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[347]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[345]

Drug(s) Affected By ADP/ATP translocase 1 (SLC25A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[348]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By DNA-directed RNA polymerase II subunit RPB1 (POLR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[350]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[230]
Deferasirox	DM6ETS0	Beta thalassemia	3A50.2	Approved	[351]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[353]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[355]
Fructose	DM43AN2	Vomiting	MD90	Approved	[356]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[357]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[358]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[359]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[360]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[361]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[362]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[364]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[365]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[368]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[359]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[369]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[370]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[371]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[358]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[149]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[361]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[362]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[372]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[373]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[374]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[87]

Drug(s) Affected By Neurotensin/neuromedin N (NTS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[375]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[376]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[377]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[378]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[290]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[379]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[376]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[383]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[384]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[385]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[386]

Drug(s) Affected By Solute carrier organic anion transporter family member 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[387]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[388]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[389]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[390]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[262]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[391]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[392]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]

Drug(s) Affected By Glutamine--tRNA ligase (QARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[393]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[394]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[395]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[396]

Drug(s) Affected By Claudin-2 (CLDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[397]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[398]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[397]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[399]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[400]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[401]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[403]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[405]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[406]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[223]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[407]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Cyclin-A1 (CCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[409]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[410]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[314]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[412]

Drug(s) Affected By Disabled homolog 2 (DAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[413]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[414]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[263]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[415]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[416]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[417]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[419]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[420]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[421]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[422]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[423]

Drug(s) Affected By Protein AF1q (MLLT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[424]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Bortezomib	DMNO38U	Leukemia		Approved	[266]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[425]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 2 (MAPRE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[337]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[337]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[35]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[81]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[426]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[427]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[429]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[430]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[431]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[432]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[433]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[436]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[437]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[308]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[422]

Drug(s) Affected By Tax1-binding protein 1 (TAX1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[438]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[439]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[87]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[158]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[440]

Drug(s) Affected By Mitochondrial import receptor subunit TOM5 homolog (TOMM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[160]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[67]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[243]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[441]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[442]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[443]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[445]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[446]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[271]

Drug(s) Affected By Anaphase-promoting complex subunit 13 (ANAPC13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[447]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[447]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[448]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[222]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[449]

Drug(s) Affected By Tight junction protein ZO-2 (TJP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[450]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[67]

Drug(s) Affected By Jupiter microtubule associated homolog 1 (JPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[295]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[451]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[451]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[452]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[149]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[453]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[454]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[455]

Drug(s) Affected By Axin-2 (AXIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[456]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[457]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[200]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[458]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[459]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[460]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[461]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[462]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[463]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[464]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[464]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[389]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[465]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[466]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[467]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[389]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[387]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[468]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[306]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[468]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[469]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dual specificity protein phosphatase 1 (DUSP1)	TTG8HIM	DUS1_HUMAN	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ADP/ATP translocase 1 (SLC25A4)	OTKYLK2J	ADT1_HUMAN	Gene/Protein Processing	[4]
Anaphase-promoting complex subunit 13 (ANAPC13)	OTQWXHEJ	APC13_HUMAN	Gene/Protein Processing	[5]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[6]
Aryl hydrocarbon receptor nuclear translocator (ARNT)	OTMSIEZY	ARNT_HUMAN	Gene/Protein Processing	[7]
Ataxin-3 (ATXN3)	OTJVVGKT	ATX3_HUMAN	Gene/Protein Processing	[7]
ATP synthase subunit alpha, mitochondrial (ATP5F1A)	OT3FZDLX	ATPA_HUMAN	Gene/Protein Processing	[8]
ATP synthase subunit delta, mitochondrial (ATP5F1D)	OTXTAG2V	ATPD_HUMAN	Gene/Protein Processing	[8]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[6]
ATP-dependent RNA helicase DDX1 (DDX1)	OT3U8FD0	DDX1_HUMAN	Gene/Protein Processing	[7]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[6]

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