Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2AQ5N)

Drug Name
Spironolactone Drug Info
Synonyms
Abbolactone; Acelat; Aldace; Aldactazide; Aldactide; Aldactone; Alderon; Aldopur; Almatol; Altex; Aquareduct; Deverol; Diatensec; Dira; Duraspiron; Espironolactona; Euteberol; Flumach; Frumikal; Jenaspiron; Lacalmin; Lacdene; Laractone; Melarcon; Nefurofan; NovoSpiroton; Osyrol; Practon; SNL; Sagisal; Sincomen; Spiractin; Spiresis; Spiretic; Spiridon; Spirobeta; Spiroctan; Spiroctanie; Spiroderm; Spirogamma; Spirolactone; Spirolakton; Spirolang; Spirolone; Spirone; Spironocompren; Spironolactonum; Spironolattone; Spironone; Spirospare; Sprioderm; Suracton; Uractone; Urusonin; Veroshpiron; Verospiron; Verospirone; Xenalon; Aldactone A; Alphapharm Brand of Spironolactone; Alpharma Brand of Spironolactone; Alter Brand of Spironolactone; Ashbourne Brand of Spironolactone; Azupharma Brand of Spironolactone; Betapharm Brand of Spironolactone; Cardel Brand of Spironolactone; Ct Arzneimittel Brand of Spironolactone; Dexo Brand of Spironolactone; Espironolactona Alter; Espironolactona Mundogen; Generosan Brand of Spironolactone; Hormosan Brand of Spironolactone; Jenapharm Brand of Spironolactone; Merck dura Brand of Spironolactone; Mundogen Brand of Spironolactone; Novo Spiroton; Novopharm Brand of Spironolactone; Pfizer Brand of Spironolactone; Pharmafrid Brand of Spironolactone; Roche Brand of Spironolactone; Searle Brand of Spironolactone; Spiro von ct; Spirono Isis; Spironolactone A; Spironolattone [DCIT]; Verospirone Opianin; Worwag Brand of Spironolactone; LT00772287; SC 9420; SC9420; Aldactazide (TN); Aldactone (TN); Berlactone (TN); Ct-Arzneimittel Brand of Spironolactone; Espironolactona [INN-Spanish]; Mayoly-Spindler Brand of Spironolactone; Novo-Spiroton; SC-9420; Spiractin (TN); Spiro-Tablinen; Spirono-Isis; Spironolactonum [INN-Latin]; Spirotone (TN); Supra-puren; Verospiron (TN); Von ct, spiro; Novo-Spiroton (TN); Spironolactone [BAN:INN:JAN]; Spironolactone [INN:BAN:JAN]; Spiro L.U.T.; Spironolactone (JP15/USP/INN); Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]; Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan); 4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate; 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone; 7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Congestive heart failure BD10 Approved [2]
Edema MG29 Approved [1]
Hyperaldosteronism 5A72 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Therapeutic Class
Diuretics
Cross-matching ID
PubChem CID
5833
ChEBI ID
CHEBI:9241
CAS Number
CAS 52-01-7
TTD Drug ID
DM2AQ5N
VARIDT Drug ID
DR00609
ACDINA Drug ID
D00638

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Mineralocorticoid receptor (MR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [14]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [4]
Fludrocortisone DMUDIR8 Addison disease 5A74.0 Approved [15]
Desoxycorticosterone Acetate DMS0AFE Discovery agent N.A. Approved [4]
Desoxycorticosterone Pivalate DMSA4B3 Addison disease 5A74.0 Approved [16]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [17]
Finerenone DMM4FJ3 Chronic kidney disease GB61 Approved [18]
ZK-91587 DMJ94L0 Cardiovascular disease BA00-BE2Z Phase 2 [19]
Nerenone DMBJ3GL Diabetic nephropathy GB61.Z Phase 2 [20]
LY-2623091 DMFGNB4 Chronic kidney disease GB61 Phase 2 [21]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [22]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [24]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [25]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [26]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [26]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [27]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [28]
Capsaicin DMGMF6V Back pain ME84.Z Approved [29]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [30]
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Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [11]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [31]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [11]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [31]
Sulfinpyrazone DMEV954 Gout FA25 Approved [32]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [11]
Zafirlukast DMHNQOG Asthma CA23 Approved [11]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [11]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [33]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [34]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [35]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [8]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [8]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [36]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [35]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [8]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [37]
Gefitinib DM15F0X Colon adenocarcinoma Approved [35]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [38]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [35]
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Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [44]
Estrone DM5T6US Acne vulgaris ED80 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [46]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [47]
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Drug(s) Affected By Tissue-type plasminogen activator (PLAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Etretinate DM2CZFA Keratosis ED56 Approved [49]
Prednisone DM2HG4X Acute asthma CA23 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [53]
Fructose DM43AN2 Vomiting MD90 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [55]
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Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [56]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [59]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [60]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [62]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [63]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [64]
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Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [65]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [68]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [62]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [72]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [73]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [76]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [77]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [79]
Selenium DM25CGV N. A. N. A. Approved [80]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [81]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [82]
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Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [88]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [90]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
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Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
Estrone DM5T6US Acne vulgaris ED80 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [97]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [90]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [104]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [105]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [106]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [46]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [108]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [109]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [110]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [111]
Cepharanthine DM9Y5JB N. A. N. A. Approved [112]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [113]
Clozapine DMFC71L Schizophrenia 6A20 Approved [114]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [115]
Trifluoperazine DMKBYWI Anxiety Approved [116]
Olanzapine DMPFN6Y Bipolar depression Approved [114]
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Drug(s) Affected By Mineralocorticoid receptor (NR3C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [117]
Triamcinolone DM98IXF Acute adrenal insufficiency Approved [118]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [119]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [118]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [118]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [121]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [118]
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Drug(s) Affected By Myb-related protein A (MYBL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Estrone DM5T6US Acne vulgaris ED80 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [123]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [126]
Folic Acid DMEMBJC Colorectal carcinoma Approved [127]
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Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [128]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [128]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [128]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [129]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [130]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [131]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [132]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
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Drug(s) Affected By Natriuretic peptides B (NPPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [138]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [139]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [141]
Ethanol DMDRQZU Chronic pain MG30 Approved [142]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [143]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [146]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [147]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [148]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [149]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [151]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [152]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [153]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [154]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [157]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [9]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [158]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [159]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [160]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [161]
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Drug(s) Affected By Protein GREB1 (GREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Testosterone DM7HUNW Hot flushes GA30 Approved [163]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [126]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [97]
Mestranol DMG3F94 Contraception QA21 Approved [126]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [167]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [168]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [169]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [170]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [171]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [172]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [61]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [173]
Epinephrine DM3KJBC Acute asthma CA23 Approved [174]
Chlorthalidone DM4DMBT Edema MG29 Approved [175]
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Drug(s) Affected By Serum paraoxonase/lactonase 3 (PON3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [176]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [177]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Clozapine DMFC71L Schizophrenia 6A20 Approved [178]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [58]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [179]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [176]
Phenylacetic acid DMQ95GE Hepatic encephalopathy DB99.5 Approved [180]
RTR-003632 DM45NHF N. A. N. A. Phase 2 [181]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mineralocorticoid receptor (MR) TT26PHO MCR_HUMAN Modulator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Protein Interaction/Cellular Processes [5]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Gene/Protein Processing [6]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [7]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [8]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [9]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [9]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Gene/Protein Processing [10]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Gene/Protein Processing [11]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [12]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [13]

References

1 Spironolactone FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2875).
3 Spironolactone in Covid-19 Induced ARDS
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals. Toxicology. 2004 Feb 15;195(2-3):177-86. doi: 10.1016/j.tox.2003.09.012.
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