Details of the Drug-Related molecule(s) Interaction Atlas

Pazopanib Drug Info

Pazopanib; Pazopanib (GW-786034); 444731-52-6; 5-((4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide; 5-(4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide; 5-[[4-[(2,3-dimethylindazol-6-yl)-methyl-amino]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide; 790713-33-6; 7RN5DR86CK; CHEBI:71219; DSSTox_CID_28659; DSSTox_GSID_48733; DSSTox_RID_82929; GW 78603; GW 786034; GW-786034; GW786034; MFCD11616589; NCGC00188865-01; UNII-7RN5DR86CK

Cross-matching ID

PubChem CID

10113978

ChEBI ID

CHEBI:71219

CAS Number

CAS 444731-52-6

TTD Drug ID

DMF57DM

INTEDE Drug ID

DR1248

General Information of Drug (ID: DMF57DM)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[10]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[13]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[15]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[16]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[10]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[17]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[45]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[47]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[48]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[49]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[50]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[18]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[15]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[24]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[25]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[26]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[13]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[30]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[31]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[33]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[34]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[36]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[39]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[35]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[40]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[52]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[51]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[52]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[53]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[51]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[51]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[51]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[54]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[55]
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Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[3]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[56]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[56]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[57]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[3]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[56]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[3]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[59]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[3]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[60]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[61]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[62]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[63]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[64]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[65]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[66]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[67]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[68]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[69]
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Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[72]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[73]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[75]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[77]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[78]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[79]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[4]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[80]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[81]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[86]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[87]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[88]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[89]
Methysergide	DM1EF73	Migraine	8A80	Approved	[58]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[62]
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Drug(s) Affected By Myeloblastin (PRTN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[102]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[103]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[104]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[105]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[107]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[108]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[110]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[105]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[115]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[116]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[104]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[107]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[108]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[4]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[121]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[122]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[123]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[124]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[125]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[126]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[127]
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Drug(s) Affected By HLA class I histocompatibility antigen protein P5 (HCP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[128]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[129]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[130]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)^{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[1]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[2]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[1]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[3]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[5]
HLA class I histocompatibility antigen protein P5 (HCP5)	OTV0YRI8	HCP5_HUMAN	Drug Response	[6]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Protein Interaction/Cellular Processes	[7]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[8]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[8]

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