Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHEAGL)

• Drug Name: Epanova Drug Info
• Synonyms: Omefas; Anti-hypertriglycemic (oral/capsule, hypertriglyceridemia/crohn's disease), Omthera

Indication

Disease Entry	ICD 11	Status	REF
Hypertriglyceridemia	5C80.1	Approved	[1]

• Cross-matching ID:
  PubChem CID: 56842239
  TTD Drug ID: DMHEAGL
  INTEDE Drug ID: DR1194
  ACDINA Drug ID: D00488

Molecule-Related Drug Atlas

Drug(s) Metabolized By Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[9]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[10]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[10]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[10]
Omega-6-FA	DMBWY8V	N. A.	N. A.	Phase 3	[11]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[12]
alpha-linolenic acid	DMY64HE	Discovery agent	N.A.	Investigative	[10]
Eicosadienoic acid	DMVJK9W	N. A.	N. A.	Investigative	[10]
Icosapentum	DMF1CM7	N. A.	N. A.	Investigative	[10]

Drug(s) Metabolized By Arachidonate 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Omega-6-FA	DMBWY8V	N. A.	N. A.	Phase 3	[11]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 11 (PSMD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[22]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[23]

Drug(s) Affected By Butyrophilin subfamily 3 member A1 (BTN3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By Heparan sulfate glucosamine 3-O-sulfotransferase 1 (HS3ST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[34]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[38]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[39]

Drug(s) Affected By Pendrin (SLC26A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[40]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[42]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[44]
IODIDE	DM3FZ6P	Discovery agent	N.A.	Investigative	[45]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[46]

Drug(s) Affected By Chromosome-associated kinesin KIF4A (KIF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]

Drug(s) Affected By RNA-binding protein RO60 (RO60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[55]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[56]

Drug(s) Affected By Integrin beta-4 (ITGB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[57]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[58]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[65]

Drug(s) Affected By Syndecan-4 (SDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[32]

Drug(s) Affected By Sterol O-acyltransferase 1 (SOAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[34]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[78]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[79]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[85]

Drug(s) Affected By Gap junction gamma-1 protein (GJC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[86]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[34]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[44]

Drug(s) Affected By Glycine--tRNA ligase (GARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[56]

Drug(s) Affected By Excitatory amino acid transporter 4 (SLC1A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Indomethacin	DMSC4A7	Bursitis		Approved	[94]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[44]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[18]

Drug(s) Affected By Diacylglycerol kinase epsilon (DGKE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Bortezomib	DMNO38U	Leukemia		Approved	[97]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[34]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[99]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[100]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[86]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[87]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]

Drug(s) Affected By Protocadherin-1 (PCDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[106]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]

Drug(s) Affected By Mesothelin (MSLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[44]
TAK-114	DMTXE19	Ulcerative colitis	DD71	Phase 1	[111]

Drug(s) Affected By Interleukin-27 subunit beta (EBI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[115]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[68]

Drug(s) Affected By Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[44]

Drug(s) Affected By NudC domain-containing protein 3 (NUDCD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[117]

Drug(s) Affected By Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[54]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Carboxypeptidase B2 (CPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[123]

Drug(s) Affected By Interleukin-1 receptor accessory protein (IL1RAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[126]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]

Drug(s) Affected By Poly(U)-binding-splicing factor PUF60 (PUF60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[129]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[101]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]

Drug(s) Affected By SLAM family member 5 (CD84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[130]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[131]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[130]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[132]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[44]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Phospholipid-transporting ATPase IA (ATP8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[136]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[138]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[139]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[140]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[144]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[148]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[149]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[152]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[155]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[155]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[156]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[158]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[159]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[154]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[160]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[110]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 2 (COX-2)	DE492CE	PGH2_HUMAN	Substrate	[2]
Arachidonate 5-lipoxygenase (ALOX5)	DE87OZS	LOX5_HUMAN	Substrate	[3]
Cytochrome P450 147G1 (cyp147)	DEIPST6	B2HE89_MYCMM	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 11 (PSMD11)	OT8KO67V	PSD11_HUMAN	Gene/Protein Processing	[5]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[6]
Butyrophilin subfamily 3 member A1 (BTN3A1)	OTGZADIX	BT3A1_HUMAN	Gene/Protein Processing	[5]
Carboxypeptidase B2 (CPB2)	OTPIL8IE	CBPB2_HUMAN	Gene/Protein Processing	[5]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Drug Response	[7]
Chromosome-associated kinesin KIF4A (KIF4A)	OT3UWL7D	KIF4A_HUMAN	Gene/Protein Processing	[5]
Diacylglycerol kinase epsilon (DGKE)	OTWS86AS	DGKE_HUMAN	Gene/Protein Processing	[5]
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3)	OTPOL1QW	ALG3_HUMAN	Gene/Protein Processing	[5]
Dual specificity protein phosphatase 2 (DUSP2)	OTH54FMR	DUS2_HUMAN	Gene/Protein Processing	[5]
Excitatory amino acid transporter 4 (SLC1A6)	OTRSPH8U	EAA4_HUMAN	Gene/Protein Processing	[5]

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