General Information of Drug (ID: DMYXELH)

Drug Name
1,2-NAPHTHOQUINONE Drug Info
Synonyms
1,2-NAPHTHOQUINONE; 524-42-5; 1,2-Naphthalenedione; naphthalene-1,2-dione; o-Naphthoquinone; beta-Naphthoquinone; 1,2-Naphthaquinone; 1,2-Naftochinon; .beta.-Naphthoquinone; 1,2-Naftochinon [Czech]; CCRIS 1558; UNII-804K62F61Q; HSDB 2036; 1,2-dihydronaphthalene-1,2-dione; NSC 9831; EINECS 208-360-2; 1,2-Dihydro-1,2-diketo-naphthalene; BRN 0606546; CHEMBL52347; MLS000069467; AI3-14930; CHEBI:34055; C10H6O2; KETQAJRQOHHATG-UHFFFAOYSA-N; 804K62F61Q; SMR000059112; 1,2-Naphthoquinone, 95%, tech.; NAPHTHALENEDIONE; b-naphthoquinone
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10667
ChEBI ID
CHEBI:34055
CAS Number
CAS 524-42-5
TTD Drug ID
DMYXELH
INTEDE Drug ID
DR0006

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Drug(s) Targeting Acetylcholinesterase (AChE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [14]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [15]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [16]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [17]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [18]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [19]
YM443 DMNZCI1 Functional dyspepsia DD90.3 Approved [20]
Ambenonium DMOP0BL Myasthenia gravis 8C6Y Approved [21]
Demecarium bromide DMAYEU1 Open-angle glaucoma 9C61 Approved [22]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [23]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [24]
PACTIMIBE DM0NZDT Arteriosclerosis BD40 Phase 2/3 [25]
K-604 DMQVN6P Arteriosclerosis BD40 Phase 2 [26]
Eldacimibe DML7WP0 Hyperlipidaemia 5C80 Phase 2 [27]
GR148672X DM7W6YN Acute lymphoblastic leukaemia 2A85 Clinical trial [28]
Avasimibe DMFG4OM Peripheral vascular disease BD4Z Discontinued in Phase 3 [29]
E-5324 DM562BM Hyperlipidaemia 5C80 Discontinued in Phase 2 [30]
RP-64477 DMTQ3BS Hyperlipidaemia 5C80 Discontinued in Phase 2 [31]
CI-976 DMBO28J Hyperlipidaemia 5C80 Discontinued in Phase 2 [32]
CL-283796 DM7LIDT Hyperlipidaemia 5C80 Discontinued in Phase 2 [33]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
TRYPAN BLUE DM4NTMO Ophthalmic surgery injury PK97 Approved [35]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [36]
ISIS 113715 DMUPD4G Type-2 diabetes 5A11 Phase 2 [37]
ISIS-PTP1Brx DMJGVXT Type-2 diabetes 5A11 Phase 2 [38]
ERTIPROTAFIB DMJXEV7 Type-2 diabetes 5A11 Terminated [39]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [24]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [24]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [24]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [24]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [40]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [2]
BMS-986205 DM3MAYQ Melanoma 2C30 Phase 3 [41]
INCB24360 DMIJGT9 Urothelial carcinoma 2C92.0 Phase 3 [42]
NLG8189 DM0798Z Melanoma 2C30 Phase 2/3 [41]
DN1406131 DMQFX8R Solid tumour/cancer 2A00-2F9Z Phase 1 [43]
HTI-1090 DMI4TEC Solid tumour/cancer 2A00-2F9Z Phase 1 [44]
KHK2455 DMLSUQ8 Solid tumour/cancer 2A00-2F9Z Phase 1 [41]
LY3381916 DMONZ1L Solid tumour/cancer 2A00-2F9Z Phase 1 [41]
PF-06840003 DMOX6EJ Glioma 2A00.0 Phase 1 [45]
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Drug(s) Targeting Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hexafluronium bromide DMFY307 Spasm MB47.3 Approved [46]
MEPTAZINOL DMPSB8F Pain MG30-MG3Z Approved [47]
Eptastigmine DMTV7ZM Cognitive impairment 6D71 Phase 3 [48]
(-)-Phenserine DMNCY1I Alzheimer disease 8A20 Phase 3 [49]
Plasma derived human butyrylcholinesterase DMF3IBC Neurotoxicity NE61 Phase 1 [50]
Protexia DME1Y9W Alzheimer disease 8A20 Phase 1 [51]
JES-9501 DMYR3IE Alzheimer disease 8A20 Phase 1 [52]
Tetra-hydro-isoquinoline derivative 3 DMCZA45 N. A. N. A. Patented [53]
Tetra-hydro-isoquinoline derivative 1 DML86IO N. A. N. A. Patented [53]
Tetra-hydro-isoquinoline derivative 2 DM5CKVF N. A. N. A. Patented [53]
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Drug(s) Metabolized By NADPH:quinone reductase (CRYZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [54]
4-hydroxy-2-nonenal DM2LJFZ Discovery agent N.A. Investigative [55]
Hexylacrolein DMBC8KM N. A. N. A. Investigative [55]
Acetyl ethylene DMUH4N7 N. A. N. A. Investigative [55]
J-009747 DMQSB6N N. A. N. A. Investigative [55]
Drug(s) Metabolized By Sepiapterin reductase (SPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [6]
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [58]
Verapamil DMA7PEW Angina pectoris BA40 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [62]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [63]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [66]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [67]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [58]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [69]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [72]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [70]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [73]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [74]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [77]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [82]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [83]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [84]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [85]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [87]
Ethacrynic acid DM60QMR Edema MG29 Approved [88]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [89]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [90]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [91]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [94]
Capsaicin DMGMF6V Back pain ME84.Z Approved [95]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [96]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [93]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [97]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [98]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [99]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [100]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [101]
Gefitinib DM15F0X Colon adenocarcinoma Approved [102]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [103]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [104]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [106]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Selenium DM25CGV N. A. N. A. Approved [109]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [110]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Verapamil DMA7PEW Angina pectoris BA40 Approved [112]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [107]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [112]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [117]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Selenium DM25CGV N. A. N. A. Approved [118]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [120]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [123]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [124]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [125]
Clozapine DMFC71L Schizophrenia 6A20 Approved [126]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [127]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [128]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [129]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [139]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [125]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [140]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [141]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [142]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [143]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [144]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [145]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [146]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [147]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [149]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [150]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [151]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [152]
Gefitinib DM15F0X Colon adenocarcinoma Approved [153]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [155]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [156]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [147]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [157]
Paclitaxel DMLB81S Breast carcinoma Approved [158]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [159]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [146]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [160]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [149]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [150]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [128]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [162]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [94]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [125]
Menthol DMG2KW7 Back pain ME84.Z Approved [163]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [164]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [165]
Arsenic DMTL2Y1 N. A. N. A. Approved [166]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [167]
Verapamil DMA7PEW Angina pectoris BA40 Approved [59]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Selenium DM25CGV N. A. N. A. Approved [118]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [168]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [169]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [171]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [172]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [94]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [173]
Camphor DMWIO46 Acute or chronic pain MG30-MG31 Approved [174]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [175]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [177]
Manganese DMKT129 N. A. N. A. Investigative [178]
1,4-Naphthoquinone DMTCMH7 Discovery agent N.A. Investigative [179]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [180]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [181]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [125]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [182]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [184]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [188]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [189]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [190]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [193]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [94]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [125]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [194]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [193]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [195]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [94]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [125]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [196]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [182]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [197]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [198]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [199]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [200]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [201]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [202]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [125]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [194]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [182]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [186]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [202]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [200]
Urethane DM7NSI0 N. A. N. A. Phase 4 [203]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [1]
Cholinesterase (BCHE) TTEB0GD CHLE_HUMAN Inhibitor [1]
Indoleamine 2,3-dioxygenase 1 (IDO1) TTZJYKH I23O1_HUMAN Inhibitor [2]
Liver carboxylesterase (CES1) TTMF541 EST1_HUMAN Inhibitor [1]
PTPN1 messenger RNA (PTPN1 mRNA) TTELIN2 PTN1_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
NADPH:quinone reductase (CRYZ) DE8RYV5 QOR_HUMAN Substrate [4]
Dicarbonyl/L-xylulose reductase (DCXR) DE3FEV8 DCXR_HUMAN Substrate [5]
Sepiapterin reductase (SPR) DEJVDAT SPRE_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) OTGEDDM2 ARK72_HUMAN Biotransformations [7]
Aldo-keto reductase family 1 member A1 (AKR1A1) OTZT9NOW AK1A1_HUMAN Biotransformations [7]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Biotransformations [7]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [8]
Dehydrogenase/reductase SDR family member 7 (DHRS7) OTV729DT DHRS7_HUMAN Biotransformations [9]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Gene/Protein Processing [10]
DNA topoisomerase 2-beta (TOP2B) OTDHKQZ8 TOP2B_HUMAN Gene/Protein Processing [10]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Post-Translational Modifications [11]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Gene/Protein Processing [12]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [13]

References

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2 Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18.
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