Details of Disease

General Information of Disease (ID: DISD06OF)

Disease Name Abdominal aortic aneurysm
Synonyms aortic aneurysm, familial abdominal 1
Disease Class BD50: Aneurysm/dissection
Definition Enlargement and ballooning of the vessel that supplies arterial blood to the abdomen, pelvis and legs.
Disease Hierarchy
DISQ5KRA: Aortic aneurysm
DISD06OF: Abdominal aortic aneurysm
ICD Code
ICD-11
ICD-11: BD50.4
ICD-10
ICD-10: I71.3, I71.4
Expand ICD-11
'BD50.4
Expand ICD-10
'I71.3; 'I71.4
Disease Identifiers
MONDO ID
MONDO_0005350
MESH ID
D017544
UMLS CUI
C0162871
MedGen ID
56524
HPO ID
HP:0005112
SNOMED CT ID
233985008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
EVANS BLUE DM5GT1M Approved Small molecular drug [1]
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This Disease is Treated as An Indication in 1 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
PMID27998201-Compound-7 DMU4QYR Patented Small molecular drug [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 83 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ACR TTAHE2N Limited Biomarker [3]
ADM2 TTM642F Limited Biomarker [4]
CAD TT2YT1K Limited Genetic Variation [5]
CASP5 TTWR48J Limited Altered Expression [6]
CETP TTFQAYR Limited Genetic Variation [7]
CTSS TTUMQVO Limited Biomarker [8]
CYSLTR1 TTGKOY9 Limited Biomarker [9]
F10 TTCIHJA Limited Biomarker [10]
LOX TTQHNAM Limited Biomarker [11]
MMP10 TTXLEG7 Limited Genetic Variation [12]
MMP8 TTGA1IV Limited Altered Expression [13]
PDGFA TTSM78N Limited Biomarker [14]
PLA2G7 TTDNFMT Limited Biomarker [15]
PTGS2 TTVKILB Limited Altered Expression [16]
RALBP1 TTVSRUA Limited Biomarker [17]
RENBP TTZCG0Q Limited Altered Expression [18]
SERPINE1 TTTO43N Limited Genetic Variation [19]
SMYD2 TT7YJFO Limited Biomarker [20]
TGFBR2 TTZE3P7 moderate Genetic Variation [21]
ACLY TT0Z6Y2 Strong Biomarker [22]
ADAM8 TTQWYMD Strong Altered Expression [23]
ADAMTS1 TTS2TEI Strong Biomarker [24]
ADAMTS5 TTXSU2Y Strong Altered Expression [25]
AGTR1 TT8DBY3 Strong Biomarker [26]
AHCY TTE2KUJ Strong Biomarker [27]
ALOX5AP TTDMBF5 Strong Genetic Variation [28]
APOE TTKS9CB Strong Biomarker [29]
APOH TT2OUI9 Strong Biomarker [30]
BAK1 TTFM7V0 Strong Altered Expression [31]
BGN TT0JPVF Strong Altered Expression [32]
BLVRA TTJBPN3 Strong Altered Expression [33]
CASP1 TTCQIBE Strong Biomarker [34]
CCL2 TTNAY0P Strong Altered Expression [29]
CD22 TTM6QSK Strong Biomarker [35]
CTSA TT5NILS Strong Biomarker [36]
CTSC TT4H0V2 Strong Biomarker [37]
CTSH TT3G406 Strong Biomarker [38]
CTSK TTDZN01 Strong Biomarker [39]
CYP2J2 TTNE1C7 Strong Altered Expression [40]
DCN TTB3XAN Strong Biomarker [41]
DHFR TTYZVDJ Strong Biomarker [42]
EGLN2 TTMHFRY Strong Biomarker [43]
FCGRT TTKLPHO Strong Genetic Variation [44]
GAA TTLPC70 Strong Biomarker [45]
HCAR2 TTWNV8U Strong Genetic Variation [46]
HPN TT25MVL Strong Biomarker [47]
KAT6A TT6O1J0 Strong Biomarker [48]
KAT6B TTH4VJL Strong Biomarker [48]
KYNU TTWQM3J Strong Biomarker [49]
LANCL1 TTZW8NS Strong Biomarker [50]
LDLR TTH0DUS Strong Biomarker [51]
LPA TTU9LGY Strong Genetic Variation [52]
LRP5 TT7VMG4 Strong Genetic Variation [53]
LTA4H TTXZEAJ Strong Biomarker [54]
LTB TTHQ6US Strong Biomarker [54]
LTC4S TTW7OTG Strong Altered Expression [54]
MMP12 TTXZ0KQ Strong Biomarker [55]
MMP14 TTJ4QE7 Strong Biomarker [56]
MMP3 TTUZ2L5 Strong Biomarker [57]
MYLK TT18ETS Strong Biomarker [38]
NOX4 TTQRBSJ Strong Genetic Variation [43]
P2RY12 TTZ1DT0 Strong Biomarker [58]
PCSK9 TTNIZ2B Strong Genetic Variation [7]
PDE3B TTN34SQ Strong Biomarker [59]
PEPD TTLZXI0 Strong Biomarker [35]
RIPK1 TTVJHX8 Strong Biomarker [17]
SELL TT2IYXF Strong Altered Expression [60]
SLC30A8 TTXIGT7 Strong Genetic Variation [61]
SMAD3 TTHQZV7 Strong Biomarker [62]
SOD2 TT9O4C5 Strong Genetic Variation [63]
SORT1 TTRX9AV Strong Genetic Variation [64]
SRD5A1 TTTU72V Strong Biomarker [65]
TAGLN TTDRZ9H Strong Biomarker [66]
TGFB2 TTI0KH6 Strong Biomarker [67]
TGFB3 TTWOMY8 Strong Genetic Variation [68]
TGFBR1 TTP4520 Strong Genetic Variation [69]
THBD TTAPV67 Strong Biomarker [70]
TIRAP TTKU0LS Strong Biomarker [71]
TK1 TTP3QRF Strong Altered Expression [72]
UTS2R TTW5UDX Strong Altered Expression [73]
ACE2 TTUI5H7 Definitive Biomarker [74]
NCF1 TTZ4JC3 Definitive Genetic Variation [43]
REN TTB2MXP Definitive Biomarker [75]
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⏷ Show the Full List of 83 DTT(s)
This Disease Is Related to 4 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCC11 DTWN7FC Strong Altered Expression [76]
SLC25A37 DTLBGTZ Strong Altered Expression [77]
SLC28A3 DT4YL5R Strong Biomarker [72]
SLC29A2 DTW78DQ Strong Biomarker [72]
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This Disease Is Related to 3 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ACSS2 DEE76VW Strong Biomarker [78]
EGLN3 DEMQTKH Strong Biomarker [43]
PCYT1A DEQYXD4 Strong Biomarker [79]
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This Disease Is Related to 90 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACCS OTHIHI9D Limited Biomarker [80]
CCN3 OTOW5YL4 Limited Biomarker [81]
CSTB OT3U0JF8 Limited Biomarker [82]
DAB2IP OTF456VC Limited Altered Expression [83]
DUOX1 OTQ2AEW0 Limited Biomarker [84]
DUOX2 OTU14HCN Limited Biomarker [84]
FOXO4 OT90X9LN Limited Biomarker [85]
HLA-DRB3 OT5PM9N7 Limited Genetic Variation [86]
ITGAX OTOGIMHE Limited Biomarker [87]
LTBP4 OTC8WL2V Limited Genetic Variation [88]
MFAP4 OT5W64QY Limited Biomarker [89]
MPRIP OT5FV5NS Limited Genetic Variation [17]
NHS OTKE8QAT Limited Biomarker [90]
PLA2G15 OT6VJTPA Limited Biomarker [80]
RIPK3 OTL1D484 Limited Genetic Variation [17]
TIMP2 OT8S1RRP Disputed Altered Expression [91]
AAAS OTJT9T23 Strong Biomarker [92]
ACTA2 OTEDLG8E Strong Altered Expression [60]
ADAMTS8 OT2KFY1S Strong Altered Expression [25]
ADCY10 OTYSTB0R Strong Genetic Variation [93]
AEBP1 OTBI1RZ6 Strong Altered Expression [94]
AIM2 OT86QUI8 Strong Biomarker [95]
ANKRD44 OTUI0WOO Strong Genetic Variation [96]
AP2A1 OTEFZB21 Strong Biomarker [97]
ARMH1 OTTJC0D6 Strong Biomarker [50]
ARSI OTIANNWW Strong Genetic Variation [98]
CARD8 OTXXZYWU Strong Genetic Variation [99]
CCL4L2 OTDBSXOU Strong Altered Expression [100]
CCL8 OTCTWYN8 Strong Altered Expression [101]
CD8A OTDWQJXK Strong Altered Expression [102]
CNN2 OTH3CSXA Strong Genetic Variation [93]
CNTN3 OTC1274J Strong Genetic Variation [103]
COL5A2 OT5VOSQE Strong Biomarker [104]
CORT OTX3GUHB Strong Biomarker [105]
DHX40 OTOL02QN Strong Genetic Variation [106]
DYM OTQ670WI Strong Biomarker [107]
E2F4 OTB3JFH4 Strong Altered Expression [108]
EBNA1BP2 OTBRVMZH Strong Biomarker [50]
EFNA5 OTOH4DRR Strong Genetic Variation [32]
EHF OTY6TPWD Strong Therapeutic [109]
FAM3D OTM3GWFP Strong Biomarker [110]
FBLN2 OTEHR7N7 Strong Biomarker [111]
FBN1 OTYCJT63 Strong Genetic Variation [112]
FCER1A OTIRUOHF Strong Biomarker [113]
FCN3 OTPRENLS Strong Biomarker [114]
GNG2 OT05Z3MC Strong Biomarker [78]
GYPA OTABU4YV Strong Biomarker [115]
GYPB OTESHUIX Strong Biomarker [115]
GYPE OTBHAG6A Strong Biomarker [115]
HCST OTILCB4K Strong Biomarker [116]
HEY2 OTU4J3ZI Strong Biomarker [117]
IARS1 OT9WXH5N Strong Altered Expression [66]
IARS2 OTDX4SCA Strong Altered Expression [66]
ICAM2 OT3E070F Strong Biomarker [118]
KAT8 OT5LPQTR Strong Biomarker [48]
KLHL35 OT1DL3FY Strong Biomarker [93]
LRP10 OT8490HT Strong Genetic Variation [119]
MBD4 OTWR9YXE Strong Biomarker [120]
MCF2L2 OTOGFMIH Strong Genetic Variation [121]
MNDA OTCTKR47 Strong Biomarker [38]
MYH11 OTVNVWY3 Strong Altered Expression [122]
MYO9B OTQ94R5K Strong Biomarker [123]
MYRF OTKF6AEB Strong Altered Expression [124]
NCOR1 OT04XNOU Strong Biomarker [108]
NFIB OTX94PD0 Strong Biomarker [22]
NKTR OTIADJNW Strong Biomarker [102]
NONO OTN36Q6U Strong Altered Expression [125]
OSCP1 OTZ4IFGJ Strong Biomarker [126]
PCIF1 OTXFGK9H Strong Genetic Variation [20]
PHC1 OT1JMX8U Strong Biomarker [43]
PLA2G10 OTRZ2L5A Strong Biomarker [127]
PPP1R12A OT4AVU95 Strong Posttranslational Modification [128]
PSMD7 OT7PZZ4K Strong Biomarker [50]
PXDN OTFGGM9R Strong Biomarker [129]
RABEPK OTCZSREH Strong Biomarker [50]
SELENOP OT02B8IR Strong Genetic Variation [63]
SERPINF2 OTZGAF8B Strong Genetic Variation [130]
SPARCL1 OT74DWMV Strong Biomarker [22]
STARD7 OTDUZ296 Strong Biomarker [131]
TAF1 OTDYS5G4 Strong Altered Expression [132]
TDRD10 OT5WIRLE Strong Genetic Variation [61]
TIMP4 OT8A68SW Strong Biomarker [133]
TNFAIP6 OT1SLUZH Strong Altered Expression [134]
TRIP13 OTFM3TI9 Strong Biomarker [135]
TSHZ1 OTYQ9ECW Strong Genetic Variation [136]
TSPYL2 OTGGW2EF Strong Altered Expression [137]
COL3A1 OTT1EMLM Definitive Genetic Variation [138]
ELN OTFSO7PG Definitive Biomarker [139]
ERG OTOTX9VU Definitive Genetic Variation [20]
IL6R OTCQL07Z Definitive Genetic Variation [140]
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⏷ Show the Full List of 90 DOT(s)

References

1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
3 ACR Appropriateness Criteria() Abdominal Aortic Aneurysm Follow-up (Without Repair).J Am Coll Radiol. 2019 May;16(5S):S2-S6. doi: 10.1016/j.jacr.2019.02.005.
4 Inhibition of endoplasmic reticulum stress by intermedin1-53 attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE KO Mice.Endocrine. 2018 Oct;62(1):90-106. doi: 10.1007/s12020-018-1657-6. Epub 2018 Jun 26.
5 Primary results of abdominal aortic aneurysm screening in the at-risk residents in middle China.BMC Cardiovasc Disord. 2018 Apr 3;18(1):60. doi: 10.1186/s12872-018-0793-5.
6 Inflammasome activity in leucocytes decreases with abdominal aortic aneurysm progression.Int J Mol Med. 2019 Oct;44(4):1299-1308. doi: 10.3892/ijmm.2019.4307. Epub 2019 Aug 7.
7 Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis.JAMA Cardiol. 2018 Jan 1;3(1):26-33. doi: 10.1001/jamacardio.2017.4293.
8 Plasma Cathepsin S is Associated with High-density Lipoprotein Cholesterol and Bilirubin in Patients with Abdominal Aortic Aneurysms.J Med Biochem. 2019 May 11;38(3):268-275. doi: 10.2478/jomb-2018-0039. eCollection 2019 Jul.
9 Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm.Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1907-1912. doi: 10.1073/pnas.1717906115. Epub 2018 Feb 5.
10 Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity.Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8038-8047. doi: 10.1073/pnas.1814409116. Epub 2019 Apr 3.
11 High-frequency murine ultrasound provides enhanced metrics of BAPN-induced AAA growth.Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H981-H990. doi: 10.1152/ajpheart.00300.2019. Epub 2019 Sep 27.
12 The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: a systematic review and meta-analysis.Heart. 2014 Feb;100(4):295-302. doi: 10.1136/heartjnl-2013-304129. Epub 2013 Jun 27.
13 Association of Matrix Metalloproteinase Levels with Collagen Degradation in the Context of Abdominal Aortic Aneurysm.Eur J Vasc Endovasc Surg. 2017 Apr;53(4):549-558. doi: 10.1016/j.ejvs.2016.12.030. Epub 2017 Feb 10.
14 Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset.BMC Cardiovasc Disord. 2018 Feb 13;18(1):34. doi: 10.1186/s12872-018-0766-8.
15 Lp-PLA(2) activity and mass for prediction of incident abdominal aortic aneurysms: A prospective longitudinal cohort study.Atherosclerosis. 2017 Jul;262:14-18. doi: 10.1016/j.atherosclerosis.2017.04.014. Epub 2017 Apr 21.
16 Regulatory T cells protected against abdominal aortic aneurysm by suppression of the COX-2 expression.J Cell Mol Med. 2019 Oct;23(10):6766-6774. doi: 10.1111/jcmm.14554. Epub 2019 Jul 21.
17 Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models.Cell Death Dis. 2019 Mar 6;10(3):226. doi: 10.1038/s41419-019-1468-6.
18 Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-Benzopyrene/Angiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm.Stem Cells Int. 2017;2017:9495739. doi: 10.1155/2017/9495739. Epub 2017 Oct 18.
19 The study of t-PA, u-PA and PAI-1 genes polymorphisms in patients with abdominal aortic aneurysm.Mol Biol Rep. 2014 May;41(5):2859-64. doi: 10.1007/s11033-014-3141-6. Epub 2014 Jan 23.
20 Replication of Newly Identified Genetic Associations Between Abdominal Aortic Aneurysm and SMYD2, LINC00540, PCIF1/MMP9/ZNF335, and ERG.Eur J Vasc Endovasc Surg. 2020 Jan;59(1):92-97. doi: 10.1016/j.ejvs.2019.02.017. Epub 2019 Nov 1.
21 Abdominal aortic aneurysm: novel mechanisms and therapies.Curr Opin Cardiol. 2015 Nov;30(6):566-73. doi: 10.1097/HCO.0000000000000216.
22 Microarray analysis to identify the similarities and differences of pathogenesis between aortic occlusive disease and abdominal aortic aneurysm.Vascular. 2018 Jun;26(3):301-314. doi: 10.1177/1708538117736695. Epub 2017 Oct 31.
23 Expression of a disintegrin and metalloprotease in human abdominal aortic aneurysms.J Vasc Res. 2012;49(3):198-206. doi: 10.1159/000332959. Epub 2012 Mar 14.
24 ADAMTS-1 in abdominal aortic aneurysm.PLoS One. 2017 Jun 1;12(6):e0178729. doi: 10.1371/journal.pone.0178729. eCollection 2017.
25 Alterations in phenotype and gene expression of adult human aneurysmal smooth muscle cells by exogenous nitric oxide.Exp Cell Res. 2019 Nov 1;384(1):111589. doi: 10.1016/j.yexcr.2019.111589. Epub 2019 Aug 29.
26 Metformin prescription status and abdominal aortic aneurysm disease progression in the U.S. veteran population.J Vasc Surg. 2019 Mar;69(3):710-716.e3. doi: 10.1016/j.jvs.2018.06.194. Epub 2018 Sep 6.
27 Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm.J Med Genet. 2008 Nov;45(11):721-30. doi: 10.1136/jmg.2008.057851. Epub 2008 Jul 17.
28 The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms.Atherosclerosis. 2012 Feb;220(2):425-8. doi: 10.1016/j.atherosclerosis.2011.10.040. Epub 2011 Nov 9.
29 Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice.Br J Pharmacol. 2020 Apr;177(8):1719-1734. doi: 10.1111/bph.14906. Epub 2020 Mar 2.
30 B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinaemia-aggravated abdominal aortic aneurysm.Cardiovasc Res. 2020 Sep 1;116(11):1897-1909. doi: 10.1093/cvr/cvz288.
31 Atorvastatin mediates increases in intralesional BAX and BAK expression in human end-stage abdominal aortic aneurysms. Can J Physiol Pharmacol. 2009 Nov;87(11):915-22. doi: 10.1139/y09-085.
32 Differential gene expression in human abdominal aorta: aneurysmal versus occlusive disease.J Vasc Surg. 2002 Feb;35(2):346-55. doi: 10.1067/mva.2002.121071.
33 Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.Arch Biochem Biophys. 2019 Dec 15;678:108182. doi: 10.1016/j.abb.2019.108182. Epub 2019 Nov 5.
34 High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation.J Biol Chem. 2018 Aug 24;293(34):13257-13269. doi: 10.1074/jbc.RA118.002428. Epub 2018 Jul 5.
35 Analysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19.BMC Med Genet. 2011 Jan 19;12:14. doi: 10.1186/1471-2350-12-14.
36 The Relationship between the Concentration of Cathepsin A, D, and E and the Concentration of Copper and Zinc, and the Size of the Aneurysmal Enlargement in the Wall of the Abdominal Aortic Aneurysm.Ann Vasc Surg. 2019 Feb;55:182-188. doi: 10.1016/j.avsg.2018.07.043. Epub 2018 Sep 29.
37 Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1660-1669. doi: 10.1161/ATVBAHA.116.307786. Epub 2016 Jun 9.
38 Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array.J Vasc Surg. 2001 Jul;34(1):143-50. doi: 10.1067/mva.2001.113310.
39 Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms.J Vasc Surg. 2017 Apr;65(4):1171-1179.e1. doi: 10.1016/j.jvs.2015.12.056. Epub 2016 Mar 6.
40 CYP2J2 overexpression increases EETs and protects against angiotensin II-induced abdominal aortic aneurysm in mice.J Lipid Res. 2013 May;54(5):1448-56. doi: 10.1194/jlr.M036533. Epub 2013 Feb 26.
41 Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture.Sci Rep. 2017 Nov 20;7(1):15857. doi: 10.1038/s41598-017-16194-8.
42 Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction.Redox Biol. 2019 Jun;24:101185. doi: 10.1016/j.redox.2019.101185. Epub 2019 Mar 29.
43 NOX isoforms in the development of abdominal aortic aneurysm.Redox Biol. 2017 Apr;11:118-125. doi: 10.1016/j.redox.2016.11.002. Epub 2016 Nov 19.
44 Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA-->stop TAA).Blood. 1992 Oct 15;80(8):1972-9.
45 Identification of a new point mutation in hypoxanthine phosphoribosyl transferase responsible for hyperuricemia in a female patient.Metabolism. 2004 Nov;53(11):1500-2. doi: 10.1016/j.metabol.2004.04.016.
46 Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide.Cardiovasc Res. 2020 Dec 1;116(14):2226-2238. doi: 10.1093/cvr/cvz303.
47 Genes involved in the transforming growth factor beta signalling pathway and the risk of intracranial aneurysms.J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):722-4. doi: 10.1136/jnnp.2007.128041.
48 Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm.Clin Epigenetics. 2016 Jan 13;8:3. doi: 10.1186/s13148-016-0169-6. eCollection 2016.
49 Tryptophan-Derived 3-Hydroxyanthranilic Acid Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice In Vivo.Circulation. 2017 Dec 5;136(23):2271-2283. doi: 10.1161/CIRCULATIONAHA.117.030972. Epub 2017 Oct 4.
50 Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm.Sci Rep. 2019 Jul 18;9(1):10447. doi: 10.1038/s41598-019-46909-y.
51 H19 Induces Abdominal Aortic Aneurysm Development and Progression.Circulation. 2018 Oct 9;138(15):1551-1568. doi: 10.1161/CIRCULATIONAHA.117.032184.
52 Lipoprotein(a) and abdominal aortic aneurysm risk: The Atherosclerosis Risk in Communities study.Atherosclerosis. 2018 Jan;268:63-67. doi: 10.1016/j.atherosclerosis.2017.10.017. Epub 2017 Nov 26.
53 Editor's Choice - High Annual Hospital Volume is Associated with Decreased in Hospital Mortality and Complication Rates Following Treatment of Abdominal Aortic Aneurysms: Secondary Data Analysis of the Nationwide German DRG Statistics from 2005 to 2013.Eur J Vasc Endovasc Surg. 2018 Feb;55(2):185-194. doi: 10.1016/j.ejvs.2017.11.016. Epub 2017 Dec 27.
54 Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21093-7. doi: 10.1073/pnas.1015166107. Epub 2010 Nov 15.
55 Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging.J Med Chem. 2019 Nov 14;62(21):9743-9752. doi: 10.1021/acs.jmedchem.9b01186. Epub 2019 Oct 25.
56 Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo.J Biol Chem. 2009 Jan 16;284(3):1765-71. doi: 10.1074/jbc.M806239200. Epub 2008 Nov 14.
57 Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells.Nat Commun. 2018 Nov 27;9(1):5022. doi: 10.1038/s41467-018-07495-1.
58 Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model.J Vasc Surg. 2009 Mar;49(3):719-27. doi: 10.1016/j.jvs.2008.09.057. Epub 2008 Nov 22.
59 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.Nat Genet. 2018 Nov;50(11):1514-1523. doi: 10.1038/s41588-018-0222-9. Epub 2018 Oct 1.
60 Identification of key microRNAs and genes associated with abdominal aortic aneurysm based on the gene expression profile.Exp Physiol. 2020 Jan;105(1):160-173. doi: 10.1113/EP087705. Epub 2019 Dec 16.
61 Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients.J Vasc Surg. 2015 Mar;61(3):787-92. doi: 10.1016/j.jvs.2013.10.090. Epub 2014 Jan 11.
62 MiR-195 promotes abdominal aortic aneurysm media remodeling by targeting Smad3.Cardiovasc Ther. 2017 Dec;35(6). doi: 10.1111/1755-5922.12286.
63 Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure.PLoS One. 2018 Sep 6;13(9):e0203350. doi: 10.1371/journal.pone.0203350. eCollection 2018.
64 A DAB2IP genotype: sex interaction is associated with abdominal aortic aneurysm expansion.J Investig Med. 2017 Oct;65(7):1077-1082. doi: 10.1136/jim-2016-000404. Epub 2017 Jul 11.
65 A population-based study of polymorphisms in genes related to sex hormones and abdominal aortic aneurysm.Eur J Hum Genet. 2011 Mar;19(3):363-6. doi: 10.1038/ejhg.2010.182. Epub 2010 Dec 1.
66 Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways.Life Sci. 2019 May 1;224:51-57. doi: 10.1016/j.lfs.2019.03.052. Epub 2019 Mar 21.
67 Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization.Sci Rep. 2019 May 29;9(1):7999. doi: 10.1038/s41598-019-44266-4.
68 Mutations in a TGF- ligand, TGFB3, cause syndromic aortic aneurysms and dissections.J Am Coll Cardiol. 2015 Apr 7;65(13):1324-1336. doi: 10.1016/j.jacc.2015.01.040.
69 The transforming growth factor- receptor genes and the risk of intracranial aneurysms.Int J Stroke. 2012 Dec;7(8):645-8. doi: 10.1111/j.1747-4949.2011.00615.x. Epub 2011 Oct 6.
70 The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm.Biomed Res Int. 2017;2017:2791082. doi: 10.1155/2017/2791082. Epub 2017 Apr 3.
71 TRIF adaptor signaling is important in abdominal aortic aneurysm formation.Atherosclerosis. 2015 Aug;241(2):561-8. doi: 10.1016/j.atherosclerosis.2015.06.014. Epub 2015 Jun 12.
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115 Blood groups and HLA antigens in patients with abdominal aortic aneurysms.Hum Hered. 1984;34(1):9-13. doi: 10.1159/000153411.
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126 Deletion of the NR4A nuclear receptor NOR1 in hematopoietic stem cells reduces inflammation but not abdominal aortic aneurysm formation.BMC Cardiovasc Disord. 2017 Oct 18;17(1):271. doi: 10.1186/s12872-017-0701-4.
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139 Mechanisms underlying the inhibitory effects of probucol on elastase-induced abdominal aortic aneurysm in mice.Br J Pharmacol. 2020 Jan;177(1):204-216. doi: 10.1111/bph.14857. Epub 2019 Nov 3.
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