Details of Disease

General Information of Disease (ID: DISX608J)

• Disease Name: Dilated cardiomyopathy
• Synonyms: familial dilated cardiomyopathy; idiopathic dilation cardiomyopathy; primary dilated cardiomyopathy; congestive cardiomyopathy; dilated cardiomyopathy
• Disease Class: BC43: Cardiomyopathy
• Definition: Cardiomyopathy which is characterized by dilation and contractile dysfunction of the left and right ventricles. It may be idiopathic, or it may result from a myocardial infarction, myocardial infection, or alcohol abuse. It is a cause of congestive heart failure.
• Disease Hierarchy:
  DISYBB39: Intrinsic cardiomyopathy
  DISX608J: Dilated cardiomyopathy
• ICD Code:
  ICD-11: ICD-11: BC43.0
  ICD-10: ICD-10: I42.0
  Expand ICD-11: 'BC43.0
  Expand ICD-10: 'I42.0
  Expand ICD-9: 359,425.4,728
• Disease Identifiers:
  MONDO ID: MONDO_0005021
  MESH ID: D002311
  UMLS CUI: C0007193
  MedGen ID: 2880
  HPO ID: HP:0001644
  Orphanet ID: 217604
  SNOMED CT ID: 195021004

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ixmyelocel-T	DMW7UL0	Phase 3	NA	[1]
PF-07265803	DM3E6Q4	Phase 3	Small molecule	[2]
ARRY-797	DMJ48AB	Phase 2	Small molecular drug	[1]
MYK-491	DM9BREJ	Phase 2	Small molecular drug	[3]
Tissue repair stem cell therapy	DME7N7O	Phase 1/2	NA	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 164 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TXNRD2	OTZQQC3T	Limited	Autosomal dominant	[5]
VCL	OTPQ0JYS	Moderate	Autosomal dominant	[6]
LRRC10	OT9V0ZBY	No Known	Autosomal recessive	[6]
MIB1	OT5C404P	No Known	Autosomal dominant	[6]
NPPA	OTMQNTNX	No Known	Autosomal recessive	[6]
TMPO	OTL68EL4	Refuted	Autosomal dominant	[5]
ABCC9	OTGAXLQN	Limited	Autosomal dominant	[6]
ABRA	OTBQ2C1J	Limited	Biomarker	[19]
ANKRD1	OTHJ7JV9	Limited	Autosomal dominant	[6]
ANO5	OTOW8R6H	Limited	Genetic Variation	[73]
ARC	OTN2QQPG	Limited	Altered Expression	[74]
AXIN2	OTRMGQNU	Limited	Biomarker	[20]
CSRNP1	OTDK1FPH	Limited	Biomarker	[19]
CSRP3	OTECBJMV	Limited	Autosomal dominant	[6]
CTF1	OT6P9QBG	Limited	Autosomal dominant	[6]
CTNNA3	OT9Z0P1E	Limited	Genetic Variation	[75]
DNAJC6	OT1P6ZIE	Limited	Biomarker	[76]
DSG2	OTJPB2TO	Limited	Autosomal dominant	[6]
DTNA	OTVBIRH2	Limited	Autosomal dominant	[6]
FBXO32	OTUE978R	Limited	Genetic Variation	[77]
FKRP	OTMUZ7GH	Limited	Genetic Variation	[78]
FOXD4	OTTY0FF2	Limited	Genetic Variation	[79]
GATA4	OTQHWAZG	Limited	Autosomal dominant	[5]
GATAD1	OT0UZ3EP	Limited	Autosomal recessive	[6]
IL18BP	OTW0LRYZ	Limited	Biomarker	[80]
ILK	OTYG2FD1	Limited	Autosomal dominant	[6]
KLHL24	OTWZSX5C	Limited	Genetic Variation	[81]
LAMA2	OTFROQWE	Limited	Genetic Variation	[82]
LAMA4	OTHI7TA0	Limited	Autosomal dominant	[6]
LDB3	OTGQL1AM	Limited	Autosomal dominant	[6]
LTBP4	OTC8WL2V	Limited	Biomarker	[83]
MTPN	OT5N60RU	Limited	Biomarker	[84]
MYBPC1	OTRPN93S	Limited	Genetic Variation	[85]
MYBPC3	OT8IG00B	Limited	Autosomal dominant	[6]
MYH6	OT3YNCH1	Limited	Autosomal dominant	[6]
MYH7B	OTCB2IJB	Limited	Altered Expression	[86]
MYL2	OT78PC0C	Limited	Autosomal dominant	[6]
MYPN	OTHTOFDU	Limited	Autosomal dominant	[6]
NEBL	OT2WH1NC	Limited	Autosomal dominant	[6]
NKX2-5	OTS1SAWM	Limited	Autosomal dominant	[6]
OBSCN	OTT14OVX	Limited	Autosomal dominant	[6]
OPA3	OT6NDC1M	Limited	Genetic Variation	[87]
PLEKHM2	OT4ZYV73	Limited	Autosomal recessive	[6]
PRDM16	OT0BGA27	Limited	Autosomal dominant	[6]
PSEN2	OTOW778B	Limited	Autosomal dominant	[6]
RNF111	OTO3QT6Q	Limited	Altered Expression	[88]
RPL3L	OTTNH7PK	Limited	Autosomal recessive	[5]
SGCD	OTRBL3NQ	Limited	Autosomal dominant	[6]
SHBG	OTPWU5IW	Limited	Biomarker	[89]
TAX1BP3	OTQ6IB4T	Limited	Genetic Variation	[90]
TBX20	OTMPU2XQ	Limited	Autosomal dominant	[6]
TCAP	OTQQMJ94	Limited	Autosomal dominant	[6]
TIMP4	OT8A68SW	Limited	Biomarker	[91]
TNNI3K	OTJ6CWUN	Limited	Autosomal dominant	[6]
ACTN2	OT9FOLD7	Disputed	Genetic Variation	[92]
EEF1A2	OT9Z23K5	Disputed	Genetic Variation	[93]
ELAC2	OTY3BOF6	Disputed	Genetic Variation	[94]
IER3	OTZJI5FZ	Disputed	Biomarker	[95]
ITPA	OTQ47WVR	Disputed	Biomarker	[96]
MYH14	OT1TZEJK	Disputed	Genetic Variation	[97]
MYL3	OTKD3RSX	Disputed	Autosomal dominant	[6]
NRAP	OTO6H3YF	Disputed	Genetic Variation	[98]
PDLIM3	OTVXQC81	Disputed	Autosomal dominant	[6]
PKP2	OTJOVF68	Disputed	Autosomal dominant	[6]
PSEN1	OTKL39RT	Disputed	Autosomal dominant	[6]
SYNM	OTOI8TRJ	Disputed	Genetic Variation	[99]
TLN2	OT10QQBC	Disputed	Biomarker	[23]
ACTC1	OTJU04B1	Moderate	Autosomal dominant	[6]
ADD2	OTRCPCD2	moderate	Genetic Variation	[29]
CEP85L	OTSHJFOT	moderate	CausalMutation	[100]
DHX16	OTW8KZAU	moderate	Genetic Variation	[101]
DOLK	OT2HTIAN	moderate	Biomarker	[102]
HADHA	OTO557N2	moderate	Genetic Variation	[103]
JPH2	OTL9YH7V	Moderate	Semidominant	[6]
NCAPH2	OTSASNX6	moderate	Genetic Variation	[104]
NEXN	OTKB0B0H	Moderate	Autosomal dominant	[6]
PPCS	OT344CQO	moderate	Genetic Variation	[105]
SCO2	OTJQQDRS	moderate	Genetic Variation	[104]
SPEG	OTQXWJR4	moderate	Biomarker	[49]
TAF1A	OTEH7OFT	moderate	Genetic Variation	[106]
TMEM43	OTM9RS9G	moderate	Genetic Variation	[107]
TNNI3	OT65E12V	Moderate	Autosomal dominant	[6]
TPM1	OTD73X6R	Moderate	Autosomal dominant	[6]
ACTA1	OTOVGLPG	Strong	Biomarker	[108]
ALMS1	OTW66JKS	Strong	Biomarker	[109]
ALPK3	OTLUYSMO	Strong	Biomarker	[110]
ATP5F1D	OTXTAG2V	Strong	CausalMutation	[111]
ATP6V1G2	OTM1DSKL	Strong	Genetic Variation	[112]
BDH1	OT62RL5P	Strong	Biomarker	[113]
BTNL2	OTTTEMZA	Strong	Genetic Variation	[114]
CA8	OT9Y8GA8	Strong	Biomarker	[115]
CAP2	OTC1WFNO	Strong	Biomarker	[116]
CASZ1	OTWJ2OR8	Strong	Genetic Variation	[117]
CAVIN4	OTB1DM2C	Strong	Biomarker	[118]
CELF1	OT6JQ5RS	Strong	Altered Expression	[119]
CNN1	OTVPG39Z	Strong	Genetic Variation	[120]
DNAJA3	OT61924T	Strong	Biomarker	[37]
DNAJC19	OTLA1V91	Strong	Biomarker	[121]
DNM1L	OTXK1Q1G	Strong	Biomarker	[122]
DNTT	OTFSEF12	Strong	Biomarker	[123]
DPM3	OTSB4XO0	Strong	Genetic Variation	[124]
DSP	OTB2MOP8	Strong	CausalMutation	[22]
E2F6	OT2PN28R	Strong	Biomarker	[113]
ELP1	OTYEWBF7	Strong	Biomarker	[125]
EMD	OTR8ZANE	Strong	Genetic Variation	[126]
ERBIN	OTNWTUA8	Strong	Biomarker	[127]
EYA4	OTINGR3Z	Strong	Biomarker	[128]
FKTN	OTQ9GCXL	Strong	Genetic Variation	[129]
FXR1	OTEMQ1SR	Strong	Altered Expression	[130]
GAB1	OTQKE6V4	Strong	Genetic Variation	[131]
HAND1	OTN4IPVV	Strong	Genetic Variation	[132]
HOPX	OTBSR6C9	Strong	Altered Expression	[133]
HSPB6	OTFPLGZI	Strong	Genetic Variation	[134]
HSPB7	OTLATAOV	Strong	Genetic Variation	[135]
ISL1	OTVNVKAX	Strong	Genetic Variation	[136]
ITGB1BP2	OTHYX9F3	Strong	Genetic Variation	[137]
JARID2	OT14UM8H	Strong	Biomarker	[138]
LMO7	OTDLY6TC	Strong	Biomarker	[139]
LTBP2	OTS88GSD	Strong	Biomarker	[140]
MDH1	OTJEO4E8	Strong	Altered Expression	[141]
MED1	OTOO24C4	Strong	Altered Expression	[142]
MEF2A	OTV2SF6E	Strong	Altered Expression	[143]
MINDY3	OT6YZPWC	Strong	Biomarker	[115]
MIPEP	OTB2IHCT	Strong	CausalMutation	[144]
MRGPRD	OTTMOJ8U	Strong	Biomarker	[145]
MYBPC2	OTCXSB6A	Strong	Genetic Variation	[146]
MYOCD	OTSJNHTH	Strong	Altered Expression	[133]
MYOZ2	OTMEIQJA	Strong	Biomarker	[147]
NCOA6	OTOMIGTV	Strong	Genetic Variation	[148]
NDUFAB1	OTF906UR	Strong	Genetic Variation	[149]
NIF3L1	OT4MP90J	Strong	Biomarker	[150]
NMU	OTW9X7BQ	Strong	Altered Expression	[151]
NOL3	OT1K0L0D	Strong	Genetic Variation	[152]
PDK4	OTCMHMBZ	Strong	Genetic Variation	[153]
PDLIM5	OTLQVV22	Strong	Biomarker	[154]
POLG	OTDUCT04	Strong	Altered Expression	[37]
PPARGC1A	OTHCDQ22	Strong	Biomarker	[155]
PRPF6	OT3U0ABN	Strong	Altered Expression	[59]
RBM24	OTQI1AR1	Strong	Biomarker	[156]
RGCC	OTYJMLWM	Strong	Biomarker	[157]
RND3	OTXMXPIH	Strong	Biomarker	[158]
RYR2	OT0PF19E	Strong	Genetic Variation	[159]
SCARB2	OTN929M8	Strong	Genetic Variation	[160]
SLMAP	OTHW3DVC	Strong	Biomarker	[161]
SRF	OTW18FQN	Strong	Biomarker	[116]
SYNE1	OTSBSLUH	Strong	Genetic Variation	[162]
TBX5	OT70PISV	Strong	Biomarker	[163]
TEAD1	OTK6971C	Strong	Genetic Variation	[164]
TJP1	OTBDCUPK	Strong	Genetic Variation	[165]
TOR1AIP1	OTTG8MAK	Strong	Biomarker	[166]
BAG3	OTVXYUDQ	Definitive	Autosomal dominant	[6]
CXADR	OT9ZP02A	Definitive	Altered Expression	[167]
DES	OTI09KBW	Definitive	Autosomal dominant	[6]
ELMO1	OTY2ORXK	Definitive	Biomarker	[168]
FLNC	OT3F8J6Y	Definitive	Autosomal dominant	[6]
LMNA	OT3SG7ZR	Definitive	Autosomal dominant	[6]
MARCKSL1	OT13J2FM	Definitive	Genetic Variation	[169]
MUC2	OT3X4QVX	Definitive	Genetic Variation	[169]
MYH7	OT4Z9T8N	Definitive	Autosomal dominant	[6]
RBM20	OTOQZNKS	Definitive	Autosomal dominant	[6]
SCN5A	OTGYZWR6	Definitive	Autosomal dominant	[6]
TNNC1	OT9A0FL4	Definitive	Autosomal dominant	[6]
TNNT2	OT80NN7R	Definitive	Autosomal dominant	[6]
TTN	OT0LZ058	Definitive	Autosomal dominant	[6]

This Disease Is Related to 85 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADORA1	TTK25J1	Limited	Altered Expression	[7]
ADRA2C	TT2NUT5	Limited	Genetic Variation	[8]
ATM	TTKBM7V	Limited	Biomarker	[9]
CRYAB	TT7RUHB	Limited	Genetic Variation	[10]
CSF3	TT5TQ2W	Limited	Therapeutic	[11]
CTF1	TTXGTZU	Limited	Autosomal dominant	[6]
FASLG	TTO7014	Limited	Biomarker	[12]
GATA4	TT1VDN2	Limited	Autosomal dominant	[5]
GJA5	TTFQKZ7	Limited	Genetic Variation	[13]
HRC	TTR4FKD	Limited	Genetic Variation	[14]
ILK	TT7ALZG	Limited	Autosomal dominant	[6]
KCNN3	TT9JH25	Limited	Biomarker	[15]
MYBPC3	TT9WOBN	Limited	Autosomal dominant	[6]
MYH7	TTNIMDP	Limited	Genetic Variation	[16]
PSEN2	TTWN3F4	Limited	Autosomal dominant	[6]
RAC1	TT2M9CG	Limited	Biomarker	[17]
SGCA	TTS9Q5V	Limited	Biomarker	[18]
SIK1	TT1H6LC	Limited	Biomarker	[19]
TCF7L2	TT80QAL	Limited	Biomarker	[20]
TNNC1	TT8RDXP	Limited	Genetic Variation	[21]
TNNI3	TTNLDK6	Limited	CausalMutation	[22]
PSEN1	TTZ3S8C	Disputed	Autosomal dominant	[6]
TLN1	TTQSMFG	Disputed	Altered Expression	[23]
TRPV2	TTBECWA	Disputed	Biomarker	[24]
ABCC9	TTEF5MJ	moderate	Biomarker	[25]
LAMP2	TTULDG7	moderate	Biomarker	[26]
PSEN1	TTZ3S8C	moderate	Genetic Variation	[27]
RAF1	TTAN5W2	moderate	Genetic Variation	[28]
RUNX1	TTWIN3H	moderate	Genetic Variation	[29]
TNNI3	TTNLDK6	Moderate	Autosomal dominant	[6]
ADRB1	TTR6W5O	Strong	Biomarker	[30]
ADRB2	TTG8ZWP	Strong	Biomarker	[31]
AGT	TT5C0UB	Strong	Biomarker	[32]
AGTR1	TT8DBY3	Strong	Genetic Variation	[33]
CD36	TTPJMCU	Strong	Biomarker	[34]
CHRM2	TTYEG6Q	Strong	Biomarker	[35]
DAG1	TT4X7PG	Strong	Biomarker	[36]
DNAJB1	TTPXAWS	Strong	Biomarker	[37]
ERBB2	TTR5TV4	Strong	Biomarker	[38]
ESRRB	TTKF0XS	Strong	Biomarker	[39]
FAS	TT7LTUJ	Strong	Biomarker	[12]
FASN	TT7AOUD	Strong	Biomarker	[40]
GPX1	TTYAHBP	Strong	Biomarker	[41]
GRK2	TTAZ3MN	Strong	Altered Expression	[42]
GRK3	TT5A4DX	Strong	Altered Expression	[42]
GRK5	TTTCXO0	Strong	Altered Expression	[42]
HRH2	TTQHJ1K	Strong	Altered Expression	[43]
ILK	TT7ALZG	Strong	Biomarker	[44]
ITGB1	TTBVIQC	Strong	Biomarker	[45]
LHCGR	TT2O4W9	Strong	Biomarker	[46]
MC4R	TTD0CIQ	Strong	Biomarker	[47]
MMP1	TTMX39J	Strong	Altered Expression	[48]
MTM1	TTY2TCU	Strong	Biomarker	[49]
MYBPC3	TT9WOBN	Strong	CausalMutation	[22]
NPPB	TTY63XT	Strong	Altered Expression	[50]
NR3C2	TT26PHO	Strong	Biomarker	[51]
PRKCE	TT57MT2	Strong	Biomarker	[52]
PSEN2	TTWN3F4	Strong	Biomarker	[53]
PTGER4	TT79WV3	Strong	Biomarker	[54]
RENBP	TTZCG0Q	Strong	Biomarker	[55]
RTN4	TT7GXMU	Strong	Biomarker	[56]
SCN5A	TTZOVE0	Strong	Genetic Variation	[57]
SGCB	TTEDCQ0	Strong	Biomarker	[58]
SLC25A4	TTU5A6Q	Strong	Altered Expression	[59]
SLC2A4	TTP6MT5	Strong	Biomarker	[60]
SOD2	TT9O4C5	Strong	Genetic Variation	[61]
TNNT2	TTWAS18	Strong	Genetic Variation	[62]
UCP1	TTI12YJ	Strong	Biomarker	[40]
WWP2	TT6TU05	Strong	Biomarker	[63]
AGTR2	TTQVOEI	Definitive	Biomarker	[64]
BAX	TTQ57WJ	Definitive	Biomarker	[65]
BCL2L1	TTRE6AX	Definitive	Biomarker	[65]
CASP3	TTPF2QI	Definitive	Biomarker	[65]
CASP8	TT6SZNG	Definitive	Biomarker	[65]
CASP9	TTB6T7O	Definitive	Biomarker	[65]
CXCL1	TTLK1RW	Definitive	Biomarker	[66]
CXCR3	TT1UCIJ	Definitive	Biomarker	[67]
EGFR	TTGKNB4	Definitive	Biomarker	[68]
MAS1	TTOISYB	Definitive	Therapeutic	[64]
MYH7	TTNIMDP	Definitive	Autosomal dominant	[6]
PLN	TTMCVJF	Definitive	Genetic Variation	[69]
RPS6KB1	TTG0U4H	Definitive	Biomarker	[70]
SCN5A	TTZOVE0	Definitive	Autosomal dominant	[6]
TNNC1	TT8RDXP	Definitive	Autosomal dominant	[6]
TNNT2	TTWAS18	Definitive	Autosomal dominant	[6]

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCC9	DT3JCE6	Limited	Autosomal dominant	[6]
SLC22A5	DT3HUVD	Strong	Biomarker	[71]
SLC25A5	DTL1TRY	Strong	Altered Expression	[59]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
FXN	DEXVHDB	Strong	Genetic Variation	[72]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] ClinicalTrials.gov (NCT03439514) A Phase 3, Multinational, Randomized, Placebo-controlled Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation (REALM-DCM). U.S.National Institutes of Health.
• [3] ClinicalTrials.gov (NCT03447990) Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491. U.S. National Institutes of Health.
• [4] Aastrom Announces First Patient Treatment With Autologous Stem Cell Therapy for Heart Failure
• [5] Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
• [6] Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen). Genet Med. 2020 Feb;22(2):245-257. doi: 10.1038/s41436-019-0686-8. Epub 2019 Nov 6.
• [7] Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.Circulation. 2006 Nov 21;114(21):2240-50. doi: 10.1161/CIRCULATIONAHA.106.620211. Epub 2006 Nov 6.
• [8] Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry.Cardiovasc J Afr. 2008 Jul-Aug;19(4):188-93.
• [9] Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis.PLoS One. 2013 Dec 16;8(12):e83513. doi: 10.1371/journal.pone.0083513. eCollection 2013.
• [10] Molecular mechanisms of -crystallinopathy and its therapeutic strategy.Biol Pharm Bull. 2011;34(11):1653-8. doi: 10.1248/bpb.34.1653.
• [11] Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy.Lab Invest. 2007 May;87(5):440-55. doi: 10.1038/labinvest.3700530. Epub 2007 Mar 5.
• [12] Myocardial Fas ligand expression increases susceptibility to AZT-induced cardiomyopathy.Cardiovasc Toxicol. 2007;7(4):255-63. doi: 10.1007/s12012-007-9004-9. Epub 2007 Oct 18.
• [13] A gene defect that causes conduction system disease and dilated cardiomyopathy maps to chromosome 1p1-1q1.Nat Genet. 1994 Aug;7(4):546-51. doi: 10.1038/ng0894-546.
• [14] Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression.Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1588-95. doi: 10.1152/ajpheart.01153.2010. Epub 2011 Jul 8.
• [15] Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction.PLoS One. 2015 Dec 28;10(12):e0145518. doi: 10.1371/journal.pone.0145518. eCollection 2015.
• [16] Congenital myopathies are mainly associated with a mild cardiac phenotype.J Neurol. 2019 Jun;266(6):1367-1375. doi: 10.1007/s00415-019-09267-3. Epub 2019 Mar 14.
• [17] Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy.Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2325-33. doi: 10.1152/ajpheart.01041.2004. Epub 2005 Sep 9.
• [18] The heart in limb girdle muscular dystrophy.Heart. 1998 Jan;79(1):73-7. doi: 10.1136/hrt.79.1.73.
• [19] Transcriptional analysis of doxorubicin-induced cardiotoxicity.Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1098-102. doi: 10.1152/ajpheart.00832.2005. Epub 2005 Oct 21.
• [20] A context-specific cardiac -catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.Nucleic Acids Res. 2018 Apr 6;46(6):2850-2867. doi: 10.1093/nar/gky049.
• [21] Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study.J Phys Chem B. 2016 Aug 25;120(33):8264-75. doi: 10.1021/acs.jpcb.6b01950. Epub 2016 May 6.
• [22] Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples.Genet Med. 2017 Feb;19(2):192-203. doi: 10.1038/gim.2016.90. Epub 2016 Aug 17.
• [23] Loss of mouse cardiomyocyte talin-1 and talin-2 leads to -1 integrin reduction, costameric instability, and dilated cardiomyopathy.Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6250-E6259. doi: 10.1073/pnas.1701416114. Epub 2017 Jul 11.
• [24] Novel inhibitor candidates of TRPV2 prevent damage of dystrophic myocytes and ameliorate against dilated cardiomyopathy in a hamster model.Oncotarget. 2018 Feb 8;9(18):14042-14057. doi: 10.18632/oncotarget.24449. eCollection 2018 Mar 6.
• [25] ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene.Int J Cardiol. 2014 Feb 15;171(3):431-42. doi: 10.1016/j.ijcard.2013.12.084. Epub 2014 Jan 4.
• [26] A novel vacuolar myopathy with dilated cardiomyopathy.Autophagy. 2007 Nov-Dec;3(6):638-9. doi: 10.4161/auto.4931. Epub 2007 Aug 23.
• [27] Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease.Hum Mol Genet. 2014 Feb 1;23(3):602-17. doi: 10.1093/hmg/ddt448. Epub 2013 Sep 18.
• [28] RAF1 mutations in childhood-onset dilated cardiomyopathy. Nat Genet. 2014 Jun;46(6):635-639. doi: 10.1038/ng.2963. Epub 2014 Apr 28.
• [29] Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy.PLoS Genet. 2010 Oct 21;6(10):e1001167. doi: 10.1371/journal.pgen.1001167.
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