Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM78XFG)

• Drug Name: Tibolone Drug Info
• Synonyms: Livial (TN)

Indication

Disease Entry	ICD 11	Status	REF
Anabolic metabolism	5C50-5C8Z	Approved	[1]

• Cross-matching ID:
  PubChem CID: 444008
  ChEBI ID: CHEBI:32223
  CAS Number: CAS 5630-53-5
  TTD Drug ID: DM78XFG
  INTEDE Drug ID: DR1590

Molecule-Related Drug Atlas

Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Premature labour	JB00	Approved	[4]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[5]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[6]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[7]
Aspirin	DM672AH	Myocardial infarction	BA41-BA43	Approved	[8]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[9]
Cholic acid	DM7OKQV	Peroxisomal disorder	5C57	Approved	[10]
Liothyronine	DM6IR3P	Hypothyroidism	5A00	Approved	[11]
Epinephrine	DM3KJBC	Allergy	4A80-4A85	Approved	[12]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[13]

Drug(s) Metabolized By Dihydrotestosterone oxidoreductase (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[14]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[15]
HE2100	DMCP2KH	Thrombocytopenia	3B64	Discontinued in Phase 1	[16]
17alpha-hydroxypregnenolone	DMT2EPG	Discovery agent	N.A.	Investigative	[15]

Drug(s) Metabolized By Beta-HSD adrenal and gonadal type (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[14]
Norethindrone acetate	DMDGCQP	Menorrhagia	GA20.50	Approved	[17]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[15]
17alpha-hydroxypregnenolone	DMT2EPG	Discovery agent	N.A.	Investigative	[15]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-HSD adrenal and gonadal type (HSD3B2)	DEN0GVQ	3BHS2_HUMAN	Substrate	[2]
Sulfotransferase 1A1 (SULT1A1)	DEYWLRK	ST1A1_HUMAN	Substrate	[3]
Dihydrotestosterone oxidoreductase (HSD3B1)	DERDQWN	3BHS1_HUMAN	Substrate	[2]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Tibolone: a unique version of hormone replacement therapy. Ann Pharmacother. 2004 May;38(5):874-81.
• [3] Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Steroids. 2006 May;71(5):343-51.
• [4] Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.
• [5] Tamoxifen-induced adduct formation and cell stress in human endometrial glands. Drug Metab Dispos. 2010 Jan;38(1):200-7.
• [6] Proposed role of the sulfotransferase/sulfatase pathway in modulating yolk steroid effects. Integr Comp Biol. 2008 Sep;48(3):419-27.
• [7] Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65.
• [8] Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
• [9] Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1. Phytomedicine. 2001 Nov;8(6):481-8.
• [10] Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010 Mar;40(3):184-94.
• [11] Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
• [12] Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005 Sep 23;335(2):417-23.
• [13] Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
• [14] Selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer. J Steroid Biochem Mol Biol. 2011 May;125(1-2):57-65.
• [15] Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801.
• [16] Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.
• [17] Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.