General Information of Drug (ID: DMJXQME)

Drug Name
Hydroxyestradiol Drug Info
Synonyms
4-Hydroxy-17-beta-estradiol; 4-Hydroxyestradiol-17beta; 4-OH-Estradiol; 4-hydroxy-estradiol; 4-HYDROXYESTRADIOL; 4-hydroxyestradiol-17 beta; 4OHE2; 5976-61-4; C3ZO03450E; CHEBI:62845; MLS000069567; SMR000058747; UNII-C3ZO03450E; estra-1,3,5(10)-triene-2,4,17beta-triol; 4-Hydroxyestradiol; (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol; 1,3,5(10)-Estratriene-3,4,17beta-triol; 1,3,5[10]-ESTRATRIENE-3,4,17BETA-TRIOL; 3,4,17beta-estriol; 3,4,17beta-trihydroxy-1,3,5[10]-estratriene
Cross-matching ID
PubChem CID
5282360
ChEBI ID
CHEBI:62845
CAS Number
CAS 5976-61-4
TTD Drug ID
DMJXQME
INTEDE Drug ID
DR1976

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [9]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [10]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [11]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [12]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [13]
Naproxen DMZ5RGV Bursitis Approved [14]
Deferiprone DMS2M7O Beta thalassemia 3A50.2 Approved [15]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [1]
BCP-13498 DM2BO9W N. A. N. A. Phase 2 [16]
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Drug(s) Affected By Sphingosine kinase 1 (SPHK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Panobinostat DM58WKG Chronic graft versus host disease Approved [19]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [20]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Bortezomib DMNO38U Leukemia Approved [24]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [25]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [26]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [30]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [31]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [4]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [32]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [33]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [33]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [34]
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Drug(s) Affected By ATP synthase subunit a (ATP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [30]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [4]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [32]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [39]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [40]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Gefitinib DM15F0X Colon adenocarcinoma Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [44]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [45]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [46]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
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Drug(s) Affected By Prolactin (PRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [49]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [52]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [53]
Aripiprazole DM3NUMH Bipolar I disorder Approved [54]
Fluoxetine DM3PD2C Bipolar depression Approved [55]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [56]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Gefitinib DM15F0X Colon adenocarcinoma Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [61]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [60]
Estrone DM5T6US Acne vulgaris ED80 Approved [65]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Fructose DM43AN2 Vomiting MD90 Approved [68]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [69]
Estrone DM5T6US Acne vulgaris ED80 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [70]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [70]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [70]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Gefitinib DM15F0X Colon adenocarcinoma Approved [73]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [80]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Selenium DM25CGV N. A. N. A. Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [89]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [90]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [94]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [95]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Leflunomide DMR8ONJ Arthritis FA20 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [98]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [99]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [3]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [100]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [98]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [101]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [102]
Lithium chloride DMHYLQ2 Discovery agent N.A. Investigative [103]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [104]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [107]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [108]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [110]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [111]
Panobinostat DM58WKG Chronic graft versus host disease Approved [19]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Gefitinib DM15F0X Colon adenocarcinoma Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Selenium DM25CGV N. A. N. A. Approved [82]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [115]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [116]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [119]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [120]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [121]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [122]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Gefitinib DM15F0X Colon adenocarcinoma Approved [123]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [125]
Selenium DM25CGV N. A. N. A. Approved [126]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [45]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [127]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [128]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [122]
Gefitinib DM15F0X Colon adenocarcinoma Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [126]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [74]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Panobinostat DM58WKG Chronic graft versus host disease Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [138]
Leflunomide DMR8ONJ Arthritis FA20 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [97]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [139]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Prednisone DM2HG4X Acute asthma CA23 Approved [141]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [141]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [142]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [143]
Epinephrine DM3KJBC Acute asthma CA23 Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Fluoxetine DM3PD2C Bipolar depression Approved [145]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [146]
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Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Gefitinib DM15F0X Colon adenocarcinoma Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [148]
Estrone DM5T6US Acne vulgaris ED80 Approved [149]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [150]
Testosterone DM7HUNW Hot flushes GA30 Approved [151]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [153]
Mestranol DMG3F94 Contraception QA21 Approved [154]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [155]
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Drug(s) Affected By Leptin (LEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [157]
Quercetin DM3NC4M Obesity 5B81 Approved [158]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [159]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [156]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [156]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [160]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [161]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [162]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [163]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [163]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [163]
Modafinil DMYILBE Malignant glioma 2A00.0 Approved [164]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [163]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [168]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [169]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [170]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [171]
Estrone DM5T6US Acne vulgaris ED80 Approved [172]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [173]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [174]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [175]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [176]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [177]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A6 (UGT1A6) Main DME DESD26P UD16_HUMAN Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [2]
Alkaline phosphatase, germ cell type (ALPG) OTCIM29R PPBN_HUMAN Gene/Protein Processing [3]
ATP synthase subunit a (ATP6) OTPHOGLX ATP6_HUMAN Gene/Protein Processing [4]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [2]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Biotransformations [5]
Cytochrome c oxidase subunit 3 (COX3) OTNNGBYJ COX3_HUMAN Gene/Protein Processing [4]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Biotransformations [6]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Gene/Protein Processing [7]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Gene/Protein Processing [7]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Gene/Protein Processing [7]

References

1 Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999 Nov;31(4):817-99.
2 Long-term exposure of 4-hydroxyestradiol induces the cancer cell characteristics via upregulating CYP1B1 in MCF-10A cells. Toxicol Mech Methods. 2019 Nov;29(9):686-692. doi: 10.1080/15376516.2019.1650146. Epub 2019 Aug 30.
3 Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells. Toxicol Lett. 2005 Jul 28;158(1):72-86. doi: 10.1016/j.toxlet.2005.02.011. Epub 2005 Apr 11.
4 Enhanced levels of several mitochondrial mRNA transcripts and mitochondrial superoxide production during ethinyl estradiol-induced hepatocarcinogenesis and after estrogen treatment of HepG2 cells. Carcinogenesis. 1998 Dec;19(12):2187-93. doi: 10.1093/carcin/19.12.2187.
5 Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells. Carcinogenesis. 2008 Feb;29(2):363-70.
6 Association of the CYP1B1*3 allele with survival in patients with prostate cancer receiving docetaxel. Mol Cancer Ther. 2008 Jan;7(1):19-26. doi: 10.1158/1535-7163.MCT-07-0557. Epub 2008 Jan 9.
7 Catechol estrogens induce proliferation and malignant transformation in prostate epithelial cells. Toxicol Lett. 2013 Jul 18;220(3):247-58. doi: 10.1016/j.toxlet.2013.05.002. Epub 2013 May 15.
8 UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables. Drug Metab Dispos. 2011 Sep;39(9):1650-7.
9 UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S). J Pharmacol Exp Ther. 2005 Jun;313(3):1340-6.
10 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
11 Pharmacokinetics of propofol and extrahepatic UGT1A6 gene expression in anhepatic rats. Pharmacology. 2009;84(4):219-26.
12 Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9.
13 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.
14 S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33.
15 Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants. Drug Metab Dispos. 2009 Feb;37(2):322-9.
16 Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics. 2004 Aug;14(8):487-99.
17 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
18 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
19 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
20 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
21 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
22 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
23 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
24 Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. Biochem Biophys Res Commun. 2011 Feb 4;405(1):31-6. doi: 10.1016/j.bbrc.2010.12.111. Epub 2010 Dec 30.
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