Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRK8OT)

Drug Name
Candesartan Drug Info
Synonyms
candesartan; 139481-59-7; Blopress; Ratacand; CV-11974; 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid; CV 11974; UNII-S8Q36MD2XX; 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid; CHEMBL1016; S8Q36MD2XX; 2-Ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylic acid; CHEBI:3347; C24H20N6O3; 2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid; NCGC00167474-01; AK-57139; Blopress; Candesartan [BAN]; CV11974; Amias (TN); Atacand (TN); Blopress (TN); Candesartan [USAN:INN]; KS-5003; Ratacand (TN); Candesartan (USAN/INN); Atacand, Blopress, Amias, Ratacand,Candesartan; 2-(ethyloxy)-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl] methyl]-3H-benzoimidazole-4-carboxylic acid; 2-ethoxy-1-({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylic acid; 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4ethyl}-1H-benzimidazole-7-carboxylic acid; 2-ethoxy-7-carboxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylbenzimidazole; [3H]candesartan
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
2541
ChEBI ID
CHEBI:3347
CAS Number
CAS 139481-59-7
TTD Drug ID
DMRK8OT
VARIDT Drug ID
DR00601
INTEDE Drug ID
DR0264

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiotensin II receptor type-1 (AGTR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [16]
Olmesartan medoxomil DMWBHRY High blood pressure BA00 Approved [17]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [16]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [16]
Telmisartan DMS3GX2 Hypertension BA00-BA04 Approved [18]
ANGIOTENSIN II DMLWQ27 Increase blood pressure BA04 Approved [19]
SARALASIN DMKS1DV Hypertension BA00-BA04 Approved [20]
Tasosartan DMM13DI Hypertension BA00-BA04 Approved [21]
Eprosartan DM07K2I Hypertension BA00-BA04 Approved [22]
Sparsentan DMMP51W IgA nephropathy MF8Y Approved [23]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [27]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [30]
Metronidazole DMTIVEN Abscess Approved [31]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [32]
Ethanol DMDRQZU Chronic pain MG30 Approved [33]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [34]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [35]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [38]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Verapamil DMA7PEW Angina pectoris BA40 Approved [39]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [40]
Estrone DM5T6US Acne vulgaris ED80 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A3 (UGT1A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [44]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [45]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [46]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [47]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [48]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [49]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [6]
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Drug(s) Metabolized By Carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [50]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [51]
Salbutamol DMN9CWF Acute asthma CA23 Approved [52]
Methylphenidate DM7SJD6 Attention deficit hyperactivity disorder 6A05.Z Approved [53]
PSI-7977 DMLSUWZ HCV 1-6 infection 1E51 Approved [54]
Rufinamide DMWE60C Epilepsy 8A60-8A68 Approved [55]
Dexmethylphenidate DMUQE2A Attention deficit hyperactivity disorder 6A05.Z Approved [56]
MK-4827 DMLYGH4 Ovarian cancer 2C73 Phase 3 [57]
Dabigatran etexilate DMRDZ4X Venous thromboembolism BD72 Phase 3 [58]
Pradaxa DM2ZYX9 Stroke 8B20 Phase 3 [59]
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Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [6]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [6]
Diazepam DM08E9O Alcohol withdrawal Approved [6]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [6]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [6]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [6]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [6]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [61]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [62]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [63]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [66]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [67]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [68]
Epinephrine DM3KJBC Acute asthma CA23 Approved [69]
Chlorthalidone DM4DMBT Edema MG29 Approved [70]
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Drug(s) Affected By Carbonic anhydrase 1 (CA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [71]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [10]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [72]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [73]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [74]
Indomethacin DMSC4A7 Bursitis Approved [75]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [77]
GUAIACOL DMN4E7T N. A. N. A. Phase 3 [73]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [78]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [79]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [80]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [83]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [84]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [85]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [86]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [87]
Testosterone DM7HUNW Hot flushes GA30 Approved [88]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [89]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [90]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [92]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [93]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [94]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [97]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [95]
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Drug(s) Affected By Cytochrome b-245 light chain (CYBA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Testosterone DM7HUNW Hot flushes GA30 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Testosterone enanthate DMB6871 N. A. N. A. Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
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Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [110]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [111]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [113]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [114]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [115]
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Drug(s) Affected By CD40 ligand (CD40LG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [110]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [118]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [115]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [8]
Menthol DMG2KW7 Back pain ME84.Z Approved [119]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [120]
Eptifibatide DMQXTJS Acute cardiac ischemic events BA40.Z Approved [121]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [122]
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Drug(s) Affected By Leptin (LEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [123]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [124]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [123]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [123]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [126]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [127]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [128]
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Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [123]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [123]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [123]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [123]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [126]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [133]
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Drug(s) Affected By NADPH oxidase 4 (NOX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [135]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Capsaicin DMGMF6V Back pain ME84.Z Approved [137]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [138]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [139]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [141]
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Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [142]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [143]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [145]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [146]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [147]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [144]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [148]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [149]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin II receptor type-1 (AGTR1) TT8DBY3 AGTR1_HUMAN Antagonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [5]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [6]
Carboxylesterase 1 (CES1) DEB30C5 EST1_HUMAN Substrate [7]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [8]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [9]
Carbonic anhydrase 1 (CA1) OTNFBVVQ CAH1_HUMAN Gene/Protein Processing [10]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Gene/Protein Processing [8]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Gene/Protein Processing [11]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Drug Response [12]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [13]
Leptin (LEP) OT5Q7ODW LEP_HUMAN Gene/Protein Processing [14]
NADPH oxidase 4 (NOX4) OTTYQ097 NOX4_HUMAN Gene/Protein Processing [11]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Gene/Protein Processing [15]

References

1 Candesartan FDA Label
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3 Candesartan: widening indications for this angiotensin II receptor blocker Expert Opin Pharmacother. 2009 Aug;10(12):1995-2007.
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5 The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72.
6 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
7 Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1. Drug Metab Dispos. 2013 Nov;41(11):1888-95.
8 Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients. Diabetes Care. 2006 Feb;29(2):195-201. doi: 10.2337/diacare.29.02.06.dc05-1418.
9 Candesartan reduces oxidative stress and inflammation in patients with essential hypertension. Hypertens Res. 2003 Sep;26(9):691-7. doi: 10.1291/hypres.26.691.
10 The mechanism of action of angiotensin II is dependent on direct activation of vascular smooth muscle carbonic anhydrase I. Int J Clin Lab Res. 2000;30(3):119-25. doi: 10.1007/s005990070010.
11 Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies. J Hypertens. 2008 Jul;26(7):1435-45. doi: 10.1097/HJH.0b013e3283013b6e.
12 Variants of the CYP11B2 gene predict response to therapy with candesartan. Eur J Pharmacol. 2002 Jun 7;445(1-2):151-2. doi: 10.1016/s0014-2999(02)01766-1.
13 Angiotensin II type 1 receptor antagonist candesartan as an angiogenic inhibitor in a xenograft model of bladder cancer. Clin Cancer Res. 2006 May 1;12(9):2888-93. doi: 10.1158/1078-0432.CCR-05-2213.
14 Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs. Int J Cardiol. 2010 Apr 1;140(1):73-81. doi: 10.1016/j.ijcard.2008.11.017. Epub 2008 Dec 6.
15 Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor- activation in human monocytes. J Hypertens. 2012 Jan;30(1):87-96. doi: 10.1097/HJH.0b013e32834dde5f.
16 Radioligand binding assays: application of [(125)I]angiotensin II receptor binding. Methods Mol Biol. 2009;552:131-41.
17 Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers. J Cardiovasc Pharmacol. 2009 Jul;54(1):47-56.
18 Deletion of angiotensin II type I receptor reduces hepatic steatosis. J Hepatol. 2009 Jun;50(6):1226-35.
19 The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75.
20 Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69.
21 Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding. J Pharmacol Exp Ther. 2000 Nov;295(2):649-54.
22 Clinical profile of eprosartan: a different angiotensin II receptor blocker. Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):253-7.
23 Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43.
24 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
25 Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8.
26 Effect of UDP-glucuronosyltransferase (UGT) 1A polymorphism (rs8330 and rs10929303) on glucuronidation status of acetaminophen. Dose Response. 2017 Sep 11;15(3):1559325817723731.
27 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
28 Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. J Clin Pharmacol. 2009 Sep;49(9):1079-90.
29 Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36.
30 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
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32 Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes. Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):211-4.
33 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
34 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
35 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
36 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
37 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
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