General Information of Drug (ID: DMSE8NU)

Drug Name
4-ANDROSTENE-3-17-DIONE Drug Info
Synonyms
Androstenedione; androstenedione; 4-Androstene-3,17-dione; Androst-4-ene-3,17-dione; 1963/5/8; 4-Androstenedione; Androtex; 3,17-Dioxoandrost-4-ene; delta-4-Androstenedione; SKF 2170; Fecundin; delta-4-Androsten-3,17-dione; delta-4-Androstene-3,17-dione; Androstendione; 4-Androsten-3,17-dione; NSC 9563; delta-(sup4)-Androsten-3,17-dione; delta(sup 4)-Androstene-3,17-dione; UNII-409J2J96VR; 17-Ketotestosterone; d4-androstenedione; CHEBI:16422; Androstenedione [JAN]; HSDB 7335; EINECS 200-554-5; MLS000028510; NSC9563; ANDROSTENEDIONE
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6128
ChEBI ID
CHEBI:16422
CAS Number
CAS 63-05-8
TTD Drug ID
DMSE8NU
VARIDT Drug ID
DR00943
INTEDE Drug ID
DR0116

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Drug(s) Targeting Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anastrozole DMNP60F Breast cancer 2C60-2C65 Approved [13]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [14]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [14]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [15]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [16]
Testolactone DMVY4GN Breast cancer 2C60-2C65 Approved [17]
LIAROZOLE DM4OYXE Dermatological disease DA24.Y Phase 2/3 [18]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [19]
BGS-649 DMO4MNQ Endometriosis GA10 Phase 2 [20]
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [18]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [150]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [151]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [152]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [152]
Methotrexate DM2TEOL Anterior urethra cancer Approved [146]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [32]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [154]
Fluoxetine DM3PD2C Bipolar depression Approved [152]
⏷ Show the Full List of 20 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [2]
Equilenin DMHO56W Discovery agent N.A. Investigative [2]
5alpha-Androstan-3,17-Dione DMHI7Y2 Discovery agent N.A. Investigative [2]
4-MA DMNCVIP Discovery agent N.A. Investigative [21]
17 beta-N,N-diethylcarbamoyl-4-aza-5 alpha-androstan-3-one (4MA) DMDR1M6 Discovery agent N.A. Investigative [22]
Epostane DMV8PB4 Abortion JA00 Investigative [23]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [24]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [2]
2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M Discovery agent N.A. Investigative [2]
APIGENIN DMI3491 Discovery agent N.A. Investigative [24]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [24]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 Discovery agent N.A. Investigative [25]
7-(3-Hydroxy-phenyl)-naphthalen-2-ol DM2I91C Discovery agent N.A. Investigative [26]
NSC-94258 DM6VY3P Discovery agent N.A. Investigative [24]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol DM7ERYJ Discovery agent N.A. Investigative [27]
6-(4-Hydroxy-phenyl)-naphthalen-1-ol DM2V9XI Discovery agent N.A. Investigative [26]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [28]
ASP-9521 DM8V0UL Prostate cancer 2C82.0 Phase 1/2 [29]
N-(benzimidazole/indole) benzoic acid derivative 2 DMOPUFM N. A. N. A. Patented [30]
N-(phenylamino)-benzoate derivative 1 DMNIWVG N. A. N. A. Patented [30]
Indomethacin analog 3 DM53JXE N. A. N. A. Patented [30]
Indomethacin analog 2 DMKFPJ7 N. A. N. A. Patented [30]
Beta-naphthylacetic acids derivative 1 DM5KTDY N. A. N. A. Patented [30]
Indomethacin analog 1 DM3E5V6 N. A. N. A. Patented [30]
N-(naphthylamino)-benzoate derivative 1 DM310ES N. A. N. A. Patented [30]
N-(benzimidazolylcarbonyl)-piperidine derivative 1 DM541QW N. A. N. A. Patented [30]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [31]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [35]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [36]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [37]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [37]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [40]
Selenium DM25CGV N. A. N. A. Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [51]
Gefitinib DM15F0X Colon adenocarcinoma Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [54]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [60]
Testosterone DM7HUNW Hot flushes GA30 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [61]
Benzatropine DMF7EXL Parkinsonian disorder Approved [62]
Clozapine DMFC71L Schizophrenia 6A20 Approved [62]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CREB-binding protein (CREBBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [69]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [70]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [71]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [8]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [8]
Gefitinib DM15F0X Colon adenocarcinoma Approved [73]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [74]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [75]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [79]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Estrone DM5T6US Acne vulgaris ED80 Approved [83]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [84]
Leflunomide DMR8ONJ Arthritis FA20 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [71]
Bortezomib DMNO38U Leukemia Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [4]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [92]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [93]
Testosterone DM7HUNW Hot flushes GA30 Approved [94]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lutropin subunit beta (LHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [96]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [99]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [100]
Alprazolam DMC7XDN Anxiety Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Norethindrone acetate DMDGCQP N. A. N. A. Approved [97]
Metoclopramide DMFA5MY Nausea MD90 Approved [99]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [103]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [12]
Thiotepa DMIZKOP Breast cancer 2C60-2C65 Approved [104]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [105]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [106]
Ethacrynic acid DM60QMR Edema MG29 Approved [107]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [89]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [61]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [112]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [115]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [118]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [88]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [116]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [119]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
Testosterone DM7HUNW Hot flushes GA30 Approved [94]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [123]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [124]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [125]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [126]
Hexachlorophene DMLKSE0 Bacterial infection 1A00-1C4Z Approved [127]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [129]
Panobinostat DM58WKG Chronic graft versus host disease Approved [130]
Testosterone DM7HUNW Hot flushes GA30 Approved [94]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [132]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [5]
Diazepam DM08E9O Alcohol withdrawal Approved [134]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [135]
Desogestrel DM27U4Y Contraception QA21 Approved [135]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [5]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [10]
Quercetin DM3NC4M Obesity 5B81 Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [140]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [133]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [61]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [71]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [143]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [144]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [145]
Methotrexate DM2TEOL Anterior urethra cancer Approved [146]
Leflunomide DMR8ONJ Arthritis FA20 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [148]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [88]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [119]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [149]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [1]
Dihydrodiol dehydrogenase type I (AKR1C3) TT5ZWB6 AK1C3_HUMAN Inhibitor [2]
Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) TTIWB6L DHB1_HUMAN Inhibitor [2]
Hydroxysteroid dehydrogenase 3-beta (HSD3B) TTZT9R2 3BHS1_HUMAN; 3BHS2_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Testicular 17-beta-hydroxysteroid dehydrogenase (HSD17B3) Main DME DEX8J7E DHB3_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Biotransformations [4]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Biotransformations [4]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Regulation of Drug Effects [5]
Aldo-keto reductase family 1 member D1 (AKR1D1) OTBDJ6RL AK1D1_HUMAN Biotransformations [6]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Regulation of Drug Effects [7]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [8]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Gene/Protein Processing [9]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Biotransformations [10]
Dehydrogenase/reductase SDR family member 7 (DHRS7) OTV729DT DHRS7_HUMAN Biotransformations [11]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Biotransformations [12]

References

1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 17beta-hydroxysteroid dehydrogenase-3 deficiency: a rare endocrine cause of male-to-female sex reversal. Gynecol Endocrinol. 2006 Sep;22(9):488-94.
4 Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.
5 Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
6 Human and murine steroid 5-reductases (AKR1D1 and AKR1D4): insights into the role of the catalytic glutamic acid. Chem Biol Interact. 2019 May 25;305:163-170. doi: 10.1016/j.cbi.2019.03.025. Epub 2019 Mar 28.
7 A comparison of two human cell lines and two rat gonadal cell primary cultures as in vitro screening tools for aromatase modulation. Toxicol In Vitro. 2012 Feb;26(1):107-18.
8 Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res. 2012 Aug;349(2):551-63. doi: 10.1007/s00441-012-1417-5. Epub 2012 May 13.
9 ErbB receptor signaling and therapeutic resistance to aromatase inhibitors. Clin Cancer Res. 2006 Feb 1;12(3 Pt 2):1008s-1012s. doi: 10.1158/1078-0432.CCR-05-2352.
10 Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chem Biol Interact. 2019 May 25;305:12-20. doi: 10.1016/j.cbi.2019.03.026. Epub 2019 Mar 26.
11 Biochemical properties of human dehydrogenase/reductase (SDR family) member 7. Chem Biol Interact. 2014 Jan 25;207:52-7. doi: 10.1016/j.cbi.2013.11.003. Epub 2013 Nov 16.
12 Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis. FASEB J. 2013 Aug;27(8):3198-208. doi: 10.1096/fj.12-222745. Epub 2013 May 6.
13 Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome. J Pediatr Endocrinol Metab. 2002;15 Suppl 3:945-8.
14 Aromatase inhibitors--theoretical concept and present experiences in the treatment of endometriosis. Zentralbl Gynakol. 2003 Jul-Aug;125(7-8):247-51.
15 Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2007 Jul;20(7):1038-45.
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