Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVFK3J)

• Drug Name: PFI-1 Drug Info
• Synonyms: QCR-192; HY-16586; PF-6405761

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 71271629
  ChEBI ID: CHEBI:95079
  CAS Number: CAS 1403764-72-6
  TTD Drug ID: DMVFK3J

Molecule-Related Drug Atlas

Drug(s) Targeting Bromodomain-containing protein 4 (BRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPI-0610	DMPXOYJ	Myelofibrosis	2A20.2	Phase 3	[3]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[3]
PLX2853	DMX168L	Acute myeloid leukaemia	2A60	Phase 1/2	[4]
RVX-208	DM1LO8K	Alzheimer disease	8A20	Phase 1/2	[3]
INCB57643	DMBGU7V	Advanced malignancy	2A00-2F9Z	Phase 1/2	[4]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[4]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[5]
GSK525762	DMPAWBN	Haematological malignancy	2B33.Y	Phase 1	[3]
TEN010	DM4UOY5	Advanced solid tumour	2A00-2F9Z	Phase 1	[3]
AZD5153	DMW4GM2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[6]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[6]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[13]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[14]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[16]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[17]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[22]
Fructose	DM43AN2	Vomiting	MD90	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[27]
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[32]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[37]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[37]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[41]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[43]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[47]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[59]

Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[11]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[65]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[65]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[66]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[69]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[70]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[71]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[44]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[76]
Fructose	DM43AN2	Vomiting	MD90	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[82]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[88]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]

Drug(s) Affected By Integrin alpha-5 (ITGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[9]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[88]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[92]

Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[94]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[96]

Drug(s) Affected By Intercellular adhesion molecule 2 (ICAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[101]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]

Drug(s) Affected By Integrin alpha-4 (ITGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[106]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[107]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[108]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[24]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[11]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[111]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]

Drug(s) Affected By Collagen alpha-1(V) chain (COL5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Protein-lysine 6-oxidase (LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[121]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]

Drug(s) Affected By Thrombospondin-2 (THBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[11]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[123]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[124]

Drug(s) Affected By Fibrillin-1 (FBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[11]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[127]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[129]

Drug(s) Affected By Integrin alpha-1 (ITGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[129]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[132]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[139]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]

Drug(s) Affected By Lysyl oxidase homolog 1 (LOXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[142]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[129]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[144]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[98]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[124]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[149]

Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[88]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[150]

Drug(s) Affected By Platelet-derived growth factor C (PDGFC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[129]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[11]

Drug(s) Affected By Lysyl oxidase homolog 2 (LOXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[88]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[156]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain-containing protein 4 (BRD4)	TTRA6BO	BRD4_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[2]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[2]
Collagen alpha-1(V) chain (COL5A1)	OT24078H	CO5A1_HUMAN	Gene/Protein Processing	[2]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Gene/Protein Processing	[2]
Fibrillin-1 (FBN1)	OTYCJT63	FBN1_HUMAN	Gene/Protein Processing	[2]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Gene/Protein Processing	[2]
Integrin alpha-1 (ITGA1)	OTDITIST	ITA1_HUMAN	Gene/Protein Processing	[2]
Integrin alpha-4 (ITGA4)	OTSCAL0V	ITA4_HUMAN	Gene/Protein Processing	[2]
Integrin alpha-5 (ITGA5)	OT3RCI67	ITA5_HUMAN	Gene/Protein Processing	[2]
Integrin beta-1 (ITGB1)	OT6G1IAR	ITB1_HUMAN	Gene/Protein Processing	[2]

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