Details of the Drug

General Information of Drug (ID: DMHFJDT)

Drug Name
Procyclidine
Synonyms
Arpicolin; Elorine; Kemadrin; Kemadrine; Lergine; Metanin; Osnervan; Prociclidina; Procidlidina; Procyclid; Procyclidinum; Procyklidin; Prosyklidin; Spamol; Triciclidina; Triciloid; Tricoloid; Tricyclamol; Vagosin; Prociclidina [INN-Spanish]; Procyclidine (INN); Procyclidine [INN:BAN]; Procyclidinum [INN-Latin]; 1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol; 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol; 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Approved [1], [2]
Therapeutic Class
Antiparkinson Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 287.4
Topological Polar Surface Area (xlogp) 4.1
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 2
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 0.86 mL/min/kg [4]
Half-life
The concentration or amount of drug in body reduced by one-half in 12 hours [4]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.15847 micromolar/kg/day [5]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 0.74 L/kg [4]
Chemical Identifiers
Formula
C19H29NO
IUPAC Name
1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
Canonical SMILES
C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O
InChI
InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
InChIKey
WYDUSKDSKCASEF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4919
ChEBI ID
CHEBI:8448
CAS Number
77-37-2
DrugBank ID
DB00387
TTD ID
D0R1WR

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M5 (CHRM5) TTH18TF ACM5_HUMAN Antagonist [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Procyclidine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Biperiden DME78OA Moderate Additive anticholinergic effects by the combination of Procyclidine and Biperiden. Parkinsonism [8A00] [17]
Levodopa DMN3E57 Moderate Altered absorption of Procyclidine due to GI dynamics variation caused by Levodopa. Parkinsonism [8A00] [18]
Orphenadrine DMW542E Moderate Additive anticholinergic effects by the combination of Procyclidine and Orphenadrine. Parkinsonism [8A00] [19]
Coadministration of a Drug Treating the Disease Different from Procyclidine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Bethanechol DMCLHO0 Moderate Antagonize the effect of Procyclidine when combined with Bethanechol. Abnormal micturition [MF50] [20]
Oliceridine DM6MDCF Moderate Additive CNS depression effects by the combination of Procyclidine and Oliceridine. Acute pain [MG31] [21]
Scopolamine DMOM8AL Moderate Additive anticholinergic effects by the combination of Procyclidine and Scopolamine. Addictive disorder [6C50-6C5Z] [19]
Mepyramine DMB4SFH Moderate Additive anticholinergic effects by the combination of Procyclidine and Mepyramine. Allergic/hypersensitivity disorder [4A80-4A8Z] [17]
Phenyltoloxamine DMKAEQW Moderate Additive anticholinergic effects by the combination of Procyclidine and Phenyltoloxamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [17]
Tripelennamine DMZBU15 Moderate Additive anticholinergic effects by the combination of Procyclidine and Tripelennamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [17]
Memantine DMD9WSC Moderate Additive anticholinergic effects by the combination of Procyclidine and Memantine. Alzheimer disease [8A20] [19]
Galantamine DMEO794 Moderate Antagonize the effect of Procyclidine when combined with Galantamine. Alzheimer disease [8A20] [22]
Rivastigmine DMG629M Moderate Antagonize the effect of Procyclidine when combined with Rivastigmine. Alzheimer disease [8A20] [22]
Donepezil DMIYG7Z Moderate Antagonize the effect of Procyclidine when combined with Donepezil. Alzheimer disease [8A20] [22]
Marinol DM70IK5 Moderate Additive CNS depression effects by the combination of Procyclidine and Marinol. Anorexia nervosa [6B80] [21]
Methylphenobarbital DMDSWAG Moderate Additive CNS depression effects by the combination of Procyclidine and Methylphenobarbital. Anxiety disorder [6B00-6B0Z] [21]
Hydroxyzine DMF8Y74 Moderate Additive anticholinergic effects by the combination of Procyclidine and Hydroxyzine. Anxiety disorder [6B00-6B0Z] [19]
Promazine DMZAL7W Moderate Antagonize the effect of Procyclidine when combined with Promazine. Appearance/behaviour symptom [MB23] [23]
Desipramine DMT2FDC Moderate Additive anticholinergic effects by the combination of Procyclidine and Desipramine. Attention deficit hyperactivity disorder [6A05] [19]
Cariprazine DMJYDVK Moderate Additive anticholinergic effects by the combination of Procyclidine and Cariprazine. Bipolar disorder [6A60] [19]
Loperamide DMOJZQ9 Moderate Additive antimotility effects by the combination of Procyclidine and Loperamide. Bowel habit change [ME05] [24]
Sotalol DML60TN Moderate Antagonize the effect of Procyclidine when combined with Sotalol. Cardiac arrhythmia [BC9Z] [25]
Acetylcholine DMDF79Z Moderate Antagonize the effect of Procyclidine when combined with Acetylcholine. Cataract [9B10] [26]
Secobarbital DM14RF5 Moderate Additive CNS depression effects by the combination of Procyclidine and Secobarbital. Chronic insomnia [7A00] [21]
Umeclidinium DM4E8O9 Moderate Additive anticholinergic effects by the combination of Procyclidine and Umeclidinium. Chronic obstructive pulmonary disease [CA22] [27]
Tiotropium DMFDC0Q Moderate Additive anticholinergic effects by the combination of Procyclidine and Tiotropium. Chronic obstructive pulmonary disease [CA22] [27]
Revefenacin DMMP5SI Moderate Additive anticholinergic effects by the combination of Procyclidine and Revefenacin. Chronic obstructive pulmonary disease [CA22] [27]
Dihydrocodeine DMB0FWL Moderate Additive CNS depression effects by the combination of Procyclidine and Dihydrocodeine. Chronic pain [MG30] [21]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Procyclidine and Olopatadine. Conjunctiva disorder [9A60] [28]
Methohexital DM7YMIT Moderate Additive CNS depression effects by the combination of Procyclidine and Methohexital. Corneal disease [9A76-9A78] [21]
Thiopental DMGP8AX Moderate Additive CNS depression effects by the combination of Procyclidine and Thiopental. Corneal disease [9A76-9A78] [21]
Alfentanil DMVO0UB Moderate Additive CNS depression effects by the combination of Procyclidine and Alfentanil. Corneal disease [9A76-9A78] [21]
Remifentanil DMZTXCH Moderate Additive CNS depression effects by the combination of Procyclidine and Remifentanil. Corneal disease [9A76-9A78] [21]
Arbutamine DMCY8AF Moderate Increased risk of rapid heart rate by the combination of Procyclidine and Arbutamine. Coronary atherosclerosis [BA80] [29]
Ethanol DMDRQZU Moderate Additive CNS depression effects by the combination of Procyclidine and Ethanol. Cystitis [GC00] [30]
Trimipramine DM1SC8M Moderate Additive anticholinergic effects by the combination of Procyclidine and Trimipramine. Depression [6A70-6A7Z] [19]
Cyclobenzaprine DM1YBRM Moderate Additive anticholinergic effects by the combination of Procyclidine and Cyclobenzaprine. Depression [6A70-6A7Z] [19]
Imipramine DM2NUH3 Moderate Additive anticholinergic effects by the combination of Procyclidine and Imipramine. Depression [6A70-6A7Z] [19]
Nortriptyline DM4KDYJ Moderate Additive anticholinergic effects by the combination of Procyclidine and Nortriptyline. Depression [6A70-6A7Z] [19]
Isocarboxazid DMAF1NB Minor Additive anticholinergic effects by the combination of Procyclidine and Isocarboxazid. Depression [6A70-6A7Z] [21]
Tranylcypromine DMGB5RE Minor Additive anticholinergic effects by the combination of Procyclidine and Tranylcypromine. Depression [6A70-6A7Z] [21]
OPC-34712 DMHG57U Moderate Antagonize the effect of Procyclidine when combined with OPC-34712. Depression [6A70-6A7Z] [31]
Phenelzine DMHIDUE Minor Additive anticholinergic effects by the combination of Procyclidine and Phenelzine. Depression [6A70-6A7Z] [21]
Clomipramine DMINRKW Moderate Additive anticholinergic effects by the combination of Procyclidine and Clomipramine. Depression [6A70-6A7Z] [19]
Amoxapine DMKITQE Moderate Additive anticholinergic effects by the combination of Procyclidine and Amoxapine. Depression [6A70-6A7Z] [19]
Doxepin DMPI98T Moderate Additive anticholinergic effects by the combination of Procyclidine and Doxepin. Depression [6A70-6A7Z] [19]
Maprotiline DMPWB7T Moderate Additive anticholinergic effects by the combination of Procyclidine and Maprotiline. Depression [6A70-6A7Z] [19]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Procyclidine and Esketamine. Depression [6A70-6A7Z] [32]
Nitroglycerin DMQ2491 Minor Decreased dissolution of Procyclidine taken sublingually caused by Nitroglycerin. Diabetic foot ulcer [BD54] [33]
Hyoscyamine DM804UR Moderate Additive anticholinergic effects by the combination of Procyclidine and Hyoscyamine. Digestive system disease [DE2Z] [19]
Mepenzolate DM8YU2F Moderate Additive anticholinergic effects by the combination of Procyclidine and Mepenzolate. Digestive system disease [DE2Z] [17]
Oxybutynine DMJPBAX Moderate Additive anticholinergic effects by the combination of Procyclidine and Oxybutynine. Discovery agent [N.A.] [19]
Heroin diacetylmorphine DMDBWHY Moderate Additive CNS depression effects by the combination of Procyclidine and Heroin diacetylmorphine. Dissociative neurological symptom disorder [6B60] [21]
Meclizine DMS7T13 Moderate Additive anticholinergic effects by the combination of Procyclidine and Meclizine. Dizziness and giddiness [MB48] [19]
Zonisamide DM0DTF7 Major Increased risk of hyperpyrexia by the combination of Procyclidine and Zonisamide. Epilepsy/seizure [8A61-8A6Z] [34]
Primidone DM0WX6I Moderate Additive CNS depression effects by the combination of Procyclidine and Primidone. Epilepsy/seizure [8A61-8A6Z] [21]
Phenobarbital DMXZOCG Moderate Additive CNS depression effects by the combination of Procyclidine and Phenobarbital. Epilepsy/seizure [8A61-8A6Z] [21]
Cannabidiol DM0659E Moderate Additive CNS depression effects by the combination of Procyclidine and Cannabidiol. Epileptic encephalopathy [8A62] [21]
Diphenhydramine DMKQTBA Moderate Additive anticholinergic effects by the combination of Procyclidine and Diphenhydramine. Episodic vestibular syndrome [AB31] [19]
Bendroflumethiazide DM7EVLC Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Bendroflumethiazide. Essential hypertension [BA00] [35]
Benzthiazide DMQWZ0H Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Benzthiazide. Essential hypertension [BA00] [35]
Nadolol DMW6GVL Moderate Altered absorption of Procyclidine due to GI dynamics variation caused by Nadolol. Essential hypertension [BA00] [25]
Solifenacin DMG592Q Moderate Additive anticholinergic effects by the combination of Procyclidine and Solifenacin. Functional bladder disorder [GC50] [19]
Darifenacin DMWXLYZ Moderate Additive anticholinergic effects by the combination of Procyclidine and Darifenacin. Functional bladder disorder [GC50] [19]
Ketoconazole DMPZI3Q Moderate Decreased absorption of Procyclidine due to altered gastric pH caused by Ketoconazole. Fungal infection [1F29-1F2F] [36]
Propantheline DM2EN6G Moderate Additive anticholinergic effects by the combination of Procyclidine and Propantheline. Gastric ulcer [DA60] [19]
Isoflurophate DMBSK7X Moderate Antagonize the effect of Procyclidine when combined with Isoflurophate. Glaucoma [9C61] [26]
Carteolol DMFMDOB Moderate Antagonize the effect of Procyclidine when combined with Carteolol. Glaucoma [9C61] [37]
Brimonidine DMQLT4N Moderate Additive CNS depression effects by the combination of Procyclidine and Brimonidine. Glaucoma [9C61] [38]
Pilocarpine DMV9ADG Moderate Antagonize the effect of Procyclidine when combined with Pilocarpine. Glaucoma [9C61] [20]
Carvedilol DMHTEAO Moderate Altered absorption of Procyclidine due to GI dynamics variation caused by Carvedilol. Heart failure [BD10-BD1Z] [25]
Chlorothiazide DMLHESP Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Chlorothiazide. Heart failure [BD10-BD1Z] [35]
Digoxin DMQCTIH Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Digoxin. Heart failure [BD10-BD1Z] [39]
Hydroflumethiazide DMVPUQI Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Hydroflumethiazide. Heart failure [BD10-BD1Z] [35]
Acebutolol DM0TI4U Moderate Antagonize the effect of Procyclidine when combined with Acebutolol. Hypertension [BA00-BA04] [25]
Bisoprolol DM3UZ95 Moderate Antagonize the effect of Procyclidine when combined with Bisoprolol. Hypertension [BA00-BA04] [25]
Penbutolol DM4ES8F Moderate Antagonize the effect of Procyclidine when combined with Penbutolol. Hypertension [BA00-BA04] [40]
Nebivolol DM7F1PA Moderate Antagonize the effect of Procyclidine when combined with Nebivolol. Hypertension [BA00-BA04] [25]
Pindolol DMD2NV7 Moderate Antagonize the effect of Procyclidine when combined with Pindolol. Hypertension [BA00-BA04] [25]
Indapamide DMGN1PW Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Indapamide. Hypertension [BA00-BA04] [35]
Trichlormethiazide DMHAQCO Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Trichlormethiazide. Hypertension [BA00-BA04] [35]
Labetalol DMK8U72 Moderate Altered absorption of Procyclidine due to GI dynamics variation caused by Labetalol. Hypertension [BA00-BA04] [25]
Hydrochlorothiazide DMUSZHD Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Hydrochlorothiazide. Hypertension [BA00-BA04] [35]
Belladonna DM2RBWK Moderate Additive anticholinergic effects by the combination of Procyclidine and Belladonna. Infectious gastroenteritis/colitis [1A40] [19]
Amantadine DMS3YE9 Moderate Additive anticholinergic effects by the combination of Procyclidine and Amantadine. Influenza [1E30-1E32] [41]
Amobarbital DM0GQ8N Moderate Additive CNS depression effects by the combination of Procyclidine and Amobarbital. Insomnia [7A00-7A0Z] [21]
Propiomazine DMKY8V1 Moderate Additive anticholinergic effects by the combination of Procyclidine and Propiomazine. Insomnia [7A00-7A0Z] [17]
ITI-007 DMUQ1DO Moderate Antagonize the effect of Procyclidine when combined with ITI-007. Insomnia [7A00-7A0Z] [31]
Nabilone DMVRYT2 Moderate Additive CNS depression effects by the combination of Procyclidine and Nabilone. Insomnia [7A00-7A0Z] [21]
R0-93877 DMM4U9G Moderate Antagonize the effect of Procyclidine when combined with R0-93877. Irritable bowel syndrome [DD91] [42]
Clidinium DMUMQZ0 Moderate Additive anticholinergic effects by the combination of Procyclidine and Clidinium. Irritable bowel syndrome [DD91] [19]
Dicyclomine DMZSDGX Moderate Additive anticholinergic effects by the combination of Procyclidine and Dicyclomine. Irritable bowel syndrome [DD91] [19]
Physostigmine DM2N0TO Moderate Antagonize the effect of Procyclidine when combined with Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [22]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Procyclidine and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [43]
Propranolol DM79NTF Moderate Antagonize the effect of Procyclidine when combined with Propranolol. Migraine [8A80] [32]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Procyclidine and Lasmiditan. Migraine [8A80] [44]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Procyclidine and Flibanserin. Mood disorder [6A60-6E23] [45]
Neostigmine DM6T2J3 Moderate Antagonize the effect of Procyclidine when combined with Neostigmine. Myasthenia gravis [8C6Y] [46]
Pyridostigmine DM8HO1L Moderate Antagonize the effect of Procyclidine when combined with Pyridostigmine. Myasthenia gravis [8C6Y] [46]
Edrophonium DMCRQHB Moderate Antagonize the effect of Procyclidine when combined with Edrophonium. Myasthenia gravis [8C6Y] [46]
Ambenonium DMOP0BL Moderate Antagonize the effect of Procyclidine when combined with Ambenonium. Myasthenia gravis [8C6Y] [46]
Phenindamine DMDTC7R Moderate Additive anticholinergic effects by the combination of Procyclidine and Phenindamine. Nasopharyngitis [CA00] [17]
Prochlorperazine DM53SRA Moderate Antagonize the effect of Procyclidine when combined with Prochlorperazine. Nausea/vomiting [MD90] [31]
Promethazine DM6I5GR Moderate Additive anticholinergic effects by the combination of Procyclidine and Promethazine. Nausea/vomiting [MD90] [19]
Cyclizine DM9G7BS Moderate Additive anticholinergic effects by the combination of Procyclidine and Cyclizine. Nausea/vomiting [MD90] [17]
Metoclopramide DMFA5MY Moderate Antagonize the effect of Procyclidine when combined with Metoclopramide. Nausea/vomiting [MD90] [47]
Metolazone DMB39LO Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Metolazone. Oedema [MG29] [35]
Polythiazide DMCH80F Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Polythiazide. Oedema [MG29] [35]
Levomethadyl Acetate DM06HG5 Moderate Additive CNS depression effects by the combination of Procyclidine and Levomethadyl Acetate. Opioid use disorder [6C43] [21]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Procyclidine and Apraclonidine. Optic nerve disorder [9C40] [38]
Dextropropoxyphene DM23HCX Moderate Additive CNS depression effects by the combination of Procyclidine and Dextropropoxyphene. Pain [MG30-MG3Z] [21]
Butorphanol DM5KYPJ Moderate Additive CNS depression effects by the combination of Procyclidine and Butorphanol. Pain [MG30-MG3Z] [21]
Oxymorphone DM65AGJ Moderate Additive CNS depression effects by the combination of Procyclidine and Oxymorphone. Pain [MG30-MG3Z] [21]
Levorphanol DMGS80V Moderate Additive CNS depression effects by the combination of Procyclidine and Levorphanol. Pain [MG30-MG3Z] [21]
Dezocine DMJDB0Y Moderate Additive CNS depression effects by the combination of Procyclidine and Dezocine. Pain [MG30-MG3Z] [21]
Flavoxate DMKV4NL Moderate Additive anticholinergic effects by the combination of Procyclidine and Flavoxate. Pain [MG30-MG3Z] [19]
Nalbuphine DMOSQGU Moderate Additive CNS depression effects by the combination of Procyclidine and Nalbuphine. Pain [MG30-MG3Z] [21]
Buprenorphine DMPRI8G Moderate Additive CNS depression effects by the combination of Procyclidine and Buprenorphine. Pain [MG30-MG3Z] [21]
Hydrocodone DMQ2JO5 Moderate Additive CNS depression effects by the combination of Procyclidine and Hydrocodone. Pain [MG30-MG3Z] [21]
Meperidine DMX4GND Moderate Additive CNS depression effects by the combination of Procyclidine and Meperidine. Pain [MG30-MG3Z] [21]
Oxycodone DMXLKHV Moderate Additive CNS depression effects by the combination of Procyclidine and Oxycodone. Pain [MG30-MG3Z] [21]
Methylscopolamine DM5VWOB Moderate Additive anticholinergic effects by the combination of Procyclidine and Methylscopolamine. Peptic ulcer [DA61] [19]
Levomepromazine DMIKFEL Moderate Additive anticholinergic effects by the combination of Procyclidine and Levomepromazine. Psychotic disorder [6A20-6A25] [17]
Fluphenazine DMIT8LX Moderate Antagonize the effect of Procyclidine when combined with Fluphenazine. Psychotic disorder [6A20-6A25] [31]
Triflupromazine DMKFQJP Moderate Antagonize the effect of Procyclidine when combined with Triflupromazine. Psychotic disorder [6A20-6A25] [23]
Cyproheptadine DM92AH3 Moderate Additive anticholinergic effects by the combination of Procyclidine and Cyproheptadine. Rheumatoid arthritis [FA20] [19]
Quetiapine DM1N62C Moderate Antagonize the effect of Procyclidine when combined with Quetiapine. Schizophrenia [6A20] [31]
Mesoridazine DM2ZGAN Moderate Antagonize the effect of Procyclidine when combined with Mesoridazine. Schizophrenia [6A20] [23]
Thioridazine DM35M8J Moderate Antagonize the effect of Procyclidine when combined with Thioridazine. Schizophrenia [6A20] [23]
Aripiprazole DM3NUMH Moderate Antagonize the effect of Procyclidine when combined with Aripiprazole. Schizophrenia [6A20] [31]
Iloperidone DM6AUFY Moderate Antagonize the effect of Procyclidine when combined with Iloperidone. Schizophrenia [6A20] [31]
Paliperidone DM7NPJS Moderate Antagonize the effect of Procyclidine when combined with Paliperidone. Schizophrenia [6A20] [31]
Loxapine DM8AI9U Moderate Antagonize the effect of Procyclidine when combined with Loxapine. Schizophrenia [6A20] [31]
Haloperidol DM96SE0 Moderate Antagonize the effect of Procyclidine when combined with Haloperidol. Schizophrenia [6A20] [31]
Perphenazine DMA4MRX Moderate Antagonize the effect of Procyclidine when combined with Perphenazine. Schizophrenia [6A20] [31]
Molindone DMAH70G Moderate Antagonize the effect of Procyclidine when combined with Molindone. Schizophrenia [6A20] [31]
Chlorpromazine DMBGZI3 Moderate Antagonize the effect of Procyclidine when combined with Chlorpromazine. Schizophrenia [6A20] [31]
Thiothixene DMDINC4 Moderate Antagonize the effect of Procyclidine when combined with Thiothixene. Schizophrenia [6A20] [31]
Trifluoperazine DMKBYWI Moderate Antagonize the effect of Procyclidine when combined with Trifluoperazine. Schizophrenia [6A20] [31]
Risperidone DMN6DXL Moderate Antagonize the effect of Procyclidine when combined with Risperidone. Schizophrenia [6A20] [31]
Asenapine DMSQZE2 Moderate Antagonize the effect of Procyclidine when combined with Asenapine. Schizophrenia [6A20] [31]
Pimozide DMW83TP Moderate Antagonize the effect of Procyclidine when combined with Pimozide. Schizophrenia [6A20] [31]
Fentanyl DM8WAHT Moderate Additive CNS depression effects by the combination of Procyclidine and Fentanyl. Sensation disturbance [MB40] [21]
Sufentanil DMU7YEL Moderate Additive CNS depression effects by the combination of Procyclidine and Sufentanil. Sensation disturbance [MB40] [21]
Tizanidine DMR2IQ4 Moderate Additive CNS depression effects by the combination of Procyclidine and Tizanidine. Tonus and reflex abnormality [MB47] [48]
Pramlintide DM0EZ9Q Moderate Altered absorption of Procyclidine due to GI dynamics variation caused by Pramlintide. Type-1/2 diabete [5A10-5A11] [49]
Atropine DMEN6X7 Moderate Additive anticholinergic effects by the combination of Procyclidine and Atropine. Unspecific substance harmful effect [NE6Z] [19]
Nitrofurantoin DM7PQIK Minor Altered absorption of Procyclidine due to GI dynamics variation caused by Nitrofurantoin. Urinary tract infection [GC08] [50]
Chlorpheniramine DM5URA2 Moderate Additive anticholinergic effects by the combination of Procyclidine and Chlorpheniramine. Vasomotor/allergic rhinitis [CA08] [19]
Triprolidine DM7SWIA Moderate Additive anticholinergic effects by the combination of Procyclidine and Triprolidine. Vasomotor/allergic rhinitis [CA08] [19]
Methdilazine DMAUHQX Moderate Additive anticholinergic effects by the combination of Procyclidine and Methdilazine. Vasomotor/allergic rhinitis [CA08] [17]
Carbinoxamine DMCT31R Moderate Additive anticholinergic effects by the combination of Procyclidine and Carbinoxamine. Vasomotor/allergic rhinitis [CA08] [19]
Trimeprazine DMEMV9D Moderate Additive anticholinergic effects by the combination of Procyclidine and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [17]
Brompheniramine DMFOVSD Moderate Additive anticholinergic effects by the combination of Procyclidine and Brompheniramine. Vasomotor/allergic rhinitis [CA08] [19]
Dexbrompheniramine DMKVWGE Moderate Additive anticholinergic effects by the combination of Procyclidine and Dexbrompheniramine. Vasomotor/allergic rhinitis [CA08] [19]
Acrivastine DMTIGA0 Moderate Additive anticholinergic effects by the combination of Procyclidine and Acrivastine. Vasomotor/allergic rhinitis [CA08] [17]
Azatadine DMZ80SB Moderate Additive anticholinergic effects by the combination of Procyclidine and Azatadine. Vasomotor/allergic rhinitis [CA08] [17]
⏷ Show the Full List of 153 DDI Information of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7280).
2 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009818.
3 BDDCS predictions, self-correcting aspects of BDDCS assignments, BDDCS assignment corrections, and classification for more than 175 additional drugs
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
6 Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts. Toxicol Appl Pharmacol. 2004 May 1;196(3):327-36.
7 Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12.
8 Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
9 Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L340-6.
10 Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81.
11 Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. Neurotox Res. 2009 Oct;16(3):194-204.
12 Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci. 1999;64(25):2351-8.
13 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7354).
14 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
15 Comparison of pharmacological effects of L- and DL-n-butyl-scopolamine in rat uterus. Yao Xue Xue Bao. 1994;29(1):24-7.
16 Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
17 Kulik AV, Wilbur R "Delirium and stereotypy from anticholinergic antiparkinson drugs." Prog Neuropsychopharmacol Biol Psychiatry 6 (1982): 75-82. [PMID: 7202232]
18 Algeri S, Cerletti C, Curcio M, et al. "Effect of anticholinergic drugs on gastro-intestinal absorption of L-dopa in rats and man." Eur J Pharmacol 35 (1976): 293-9. [PMID: 1248506]
19 Cohen MA, Alfonso CA, Mosquera M. Development of urinary retention during treatment with clozapine and meclizine [published correction appears in Am J Psychiatry 1994 Jun;151(6):952]. Am J Psychiatry. 1994;151(4):619-620. [PMID: 8147469]
20 Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255. [PMID: 376469]
21 Product Information. Artane (trihexyphenidyl). Lederle Laboratories, Wayne, NJ.
22 Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC "Explicit criteria for determining inappropriate medication use in nursing home residents." Arch Intern Med 151 (1991): 1825-32. [PMID: 1888249]
23 Warnes H, Lehmann HE, Ban TA "Adynamic ileus during psychoactive medication: a report of three fatal and five severe cases." Can Med Assoc J 96 (1967): 1112-3. [PMID: 6021058]
24 Eronen M, Putkonen H, Hallikainen T, Vartiainen H "Lethal gastroenteritis associated with clozapine and loperamide." Am J Psychiatry 160 (2003): 2242-2243. [PMID: 14638602]
25 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
26 Multum Information Services, Inc. Expert Review Panel.
27 Cole JM, Sheehan AH, Jordan JK "Concomitant use of ipratropium and tiotropium in chronic obstructive plmonary disease." Ann Pharmacother 46 (2012): 1717-21. [PMID: 23170031]
28 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
29 Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.
30 Linnoila M "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol 6 (1973): 107-12. [PMID: 4588850]
31 Hvizdos AJ, Bennett JA, Wells BG, Rappaport KB, Mendel SA "Anticholinergic psychosis in a patient receiving usual doses of haloperidol." Clin Pharm 2 (1983): 174-8. [PMID: 6883947]
32 Cerner Multum, Inc. "Australian Product Information.".
33 Product Information. Nitrostat (nitroglycerin). Parke-Davis, Morris Plains, NJ.
34 Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
35 Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7. [PMID: 668798]
36 Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ.
37 Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
38 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
39 Binnion PF, McDermott M, LeSher D "Bioavailability of digoxin." Lancet 1 (1973): 1118. [PMID: 4122032]
40 Briant RH, Dorrington RE, Ferry DG, Paxton JW "Bioavailability of metoprolol in young adults and the elderly, with additional studies on the effects of metoclopramide and probanthine." Eur J Clin Pharmacol 25 (1983): 353-6. [PMID: 6628522]
41 Postma JU, van Tilburg W "Visual hallucinations and delirium during treatment with amantadine (Symmetrel)." J Am Geriatr Soc 23 (1975): 212-5. [PMID: 123540]
42 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
43 Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
44 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
45 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
46 Product Information. Mestinon (pyridostigmine). ICN Pharmaceuticals Inc, Cost Mesa, CA.
47 Product Information. Motilium (domperidone). Janssen-Ortho Inc, Toronto, ON.
48 Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
49 Product Information. Symlin (pramlintide). Amphastar Pharmaceuticals Inc, South El Monte, CA.
50 Jaffe JM "Effect of propantheline on nitrofurantoin absorption." J Pharm Sci 64 (1975): 1729-30. [PMID: 1185550]