Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG2KW7)

Drug Name
Menthol Drug Info
Synonyms
Hexahydrothymol; Levomenthol; Levomentholum; Menthacamphor; Menthomenthol; Neoisomenthol; Racementhol; Racementholum; Racementol; Headache crystals; Menthol natural; Menthol racemic; Menthol racemique; Menthol racemique [French]; Menthol solution; Menthyl alcohol; Peppermint camphor; Racemic menthol; Robitussin Cough Drops; M0321; M0545; D-Menthol; D-Neomenthol; Dl-Menthol; Fisherman's friend lozenges; L-Menthol; Levomenthol [INN:BAN]; Levomentholum [INN-Latin]; Menthol (USP); Menthol (VAN); Menthol natural, brazilian; NOOLISFMXDJSKH-KXUCPTDWBX; Rac-Menthol; Racementhol [INN:BAN]; Racementholum [INN-Latin]; Racementol [INN-Spanish]; Tra-kill tracheal mite killer; D,l-Menthol; Dl-Menthol (JP15); Fisherman's friendlozenges (TN); L-Menthol (JP15); L-Menthol (TN); L-Menthol (natural); Dl-3-p-Menthanol; P-Menthan-3-ol; RACEMIC MENTHOL U.S.P.; U.S.P. Menthol; D-(-)-Menthol; D-p-Menthan-3-ol; L-(-)-Menthol; Menthol, (1alpha,2beta,5alpha)-Isomer; Cis-1 ,3-trans-1,4-(+-)-menthol; Cis-1,3-trans-1,4-(+-)-menthol; (+)-Neo-menthol; (+)-p-Menthan-3-ol; (+-)-(1R*,3R*,4S*)-Menthol; (+-)-Menthol; (+/-)-Menthol; (+/-)-p-Menthan-3-ol; (-)-(1R,3R,4S)-Menthol; (-)-Menthyl alcohol; (-)-menthol; (-)-p-Menthan-3-ol; (-)-trans-p-Menthan-cis-ol; (1R)-(-)-Menthol; (1R,2S,5R)-Menthol; (1R,3R,4S)-(-)-MENTHOL; (1S, 2S, 5R)-(+)-Neomenthol; (1S,2R,5R)-(+)-Isomenthol; (1S,2R,5S)-(+)-Menthol; (1S,2R,5S)-Menthol; (1r,2s,5r)-(-)-menthol; (L)-MENTHOL; (R)-(-)-Menthol; 2-Isopropyl-5-methylcyclohexanol; 3-p-Menthol; 4-Isopropyl-1-methylcyclohexan-3-ol; 5-Methyl-2-(1-methylethyl)-cyclohexanol; 5-Methyl-2-(1-methylethyl)cyclohexanol; 5-methyl-2-(propan-2-yl)cyclohexanol; 5-methyl-2-propan-2-ylcyclohexan-1-ol
Indication
Disease Entry ICD 11 Status REF
Back pain ME84.Z Approved [1]
Pityriasis simplex Approved [1]
Throat irritation CA0Y Approved [2]
Tinea versicolor 1F2D.0 Approved [1]
Pruritus EC90 Investigative [1]
Therapeutic Class
Antipruritics
Cross-matching ID
PubChem CID
1254
ChEBI ID
CHEBI:25187
CAS Number
CAS 89-78-1
TTD Drug ID
DMG2KW7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
D-3263 DM7V2OM Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
PF-05105679 DM4QPT0 Pain MG30-MG3Z Phase 1 [6]
2-APB DM9AKVR Discovery agent N.A. Investigative [7]
ACAA DMACYPW Discovery agent N.A. Investigative [8]
5-METHOXYTRYPTAMINE DMARCKD Discovery agent N.A. Investigative [9]
icilin DMYVOL9 Discovery agent N.A. Investigative [10]
2-(5-fluoro-1H-indol-3-yl)ethanamine DMHW5FT Discovery agent N.A. Investigative [9]
NADA DM3ORGM Discovery agent N.A. Investigative [8]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine DMD2QVO Discovery agent N.A. Investigative [9]
linalool DMGZQ5P Discovery agent N.A. Investigative [11]
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Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY3526318 DMFXNQM Chronic low-back pain MG30 Phase 2 [12]
HX-100 DMFRM15 Diabetic neuropathy 8C0Z Phase 1 [13]
NPPB DMFIWAN Discovery agent N.A. Investigative [14]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [15]
[3H]resolvin D1 DMFT0HU Discovery agent N.A. Investigative [16]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [17]
icilin DMYVOL9 Discovery agent N.A. Investigative [18]
4-oxo-nonenal DMPX1J9 Discovery agent N.A. Investigative [19]
dibutyl phthalate DMEDGKO Discovery agent N.A. Investigative [20]
prostaglandin A2 DMWC4X8 Discovery agent N.A. Investigative [21]
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Drug(s) Affected By Transient receptor potential cation channel subfamily M member 8 (TRPM8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [26]
Capsaicin DMGMF6V Back pain ME84.Z Approved [27]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [31]
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Drug(s) Affected By Deoxyribonuclease-2-alpha (DNASE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [45]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [48]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
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Drug(s) Affected By E3 SUMO-protein ligase CBX4 (CBX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [54]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
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Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Capsaicin DMGMF6V Back pain ME84.Z Approved [58]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Paclitaxel DMLB81S Breast carcinoma Approved [60]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
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Drug(s) Affected By Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [71]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
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Drug(s) Affected By TNF receptor-associated factor 5 (TRAF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ethanol DMDRQZU Chronic pain MG30 Approved [74]
Paclitaxel DMLB81S Breast carcinoma Approved [75]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [77]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [78]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [79]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
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Drug(s) Affected By Transcription factor E2F3 (E2F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [83]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [87]
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Drug(s) Affected By Etoposide-induced protein 2.4 homolog (EI24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Amifostine DM5FL14 Mucositis CA00 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [90]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
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Drug(s) Affected By Prostaglandin E synthase (PTGES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Selenium DM25CGV N. A. N. A. Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Mestranol DMG3F94 Contraception QA21 Approved [92]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [92]
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Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [99]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [102]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
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Drug(s) Affected By Programmed cell death protein 5 (PDCD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [83]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [108]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [109]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [110]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Selenium DM25CGV N. A. N. A. Approved [114]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [110]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [115]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [115]
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Drug(s) Affected By Neuropilin-1 (NRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [122]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [125]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [68]
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Drug(s) Affected By Calpain-9 (CAPN9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [126]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [126]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [72]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [126]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [126]
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Drug(s) Affected By Protein Mdm4 (MDM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [129]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
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Drug(s) Affected By Phospholipid scramblase 1 (PLSCR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
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Drug(s) Affected By Tumor protein p73 (TP73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [133]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Etretinate DM2CZFA Keratosis ED56 Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [138]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [134]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [139]
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Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [141]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [142]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [145]
Ethacrynic acid DM60QMR Edema MG29 Approved [146]
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Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [28]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [149]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death-associated protein kinase 3 (DAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [83]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [151]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [152]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Capsaicin DMGMF6V Back pain ME84.Z Approved [153]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate receptor ionotropic, delta-2 (GRID2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [155]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
Drug(s) Affected By Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [157]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [158]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [157]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [72]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
Mibefradil DMU9VDS Glioblastoma multiforme 2A00.0 Phase 1 [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 12 (TNFSF12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [160]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [161]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [162]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Arsenic DMTL2Y1 N. A. N. A. Approved [163]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [164]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [165]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 14 (TNFSF14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [170]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [169]
PF-3758309 DM36PKZ Solid tumour/cancer 2A00-2F9Z Phase 1 [171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [172]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [173]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [174]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuropilin-2 (NRP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Folic Acid DMEMBJC Colorectal carcinoma Approved [175]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [176]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [68]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [68]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [177]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipid transferase CIDEA (CIDEA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [178]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [179]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [180]
Arsenic DMTL2Y1 N. A. N. A. Approved [181]
PF-02545920 DMJPE61 Huntington disease 8A01.10 Phase 2 [182]
Delphinidin DMS2WIN Cardiovascular disease BA00-BE2Z Phase 2 [183]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [184]
Milchsaure DM462BT Pruritus EC90 Investigative [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Immunoglobulin mu Fc receptor (FCMR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [187]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [188]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [189]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [190]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polyglutamine-binding protein 1 (PQBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [191]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [192]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [193]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
Drug(s) Affected By Nucleolar protein 3 (NOL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [155]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death protein 6 (PDCD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [195]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [197]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase 6 (NME6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [198]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [199]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [201]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Syntaxin-11 (STX11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [203]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [205]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [210]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 13 (TNFSF13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [212]
Paclitaxel DMLB81S Breast carcinoma Approved [213]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [214]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [216]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [215]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal recognition particle subunit SRP72 (SRP72)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [219]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [204]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase 17B (STK17B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [222]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleckstrin homology domain-containing family G member 5 (PLEKHG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [223]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [224]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [224]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 15 (TNFSF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Clozapine DMFC71L Schizophrenia 6A20 Approved [225]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Arsenic DMTL2Y1 N. A. N. A. Approved [163]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [226]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Herbimycin A DM6YWBF Solid tumour/cancer 2A00-2F9Z Approved [227]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [228]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CUGBP Elav-like family member 2 (CELF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Selenium DM25CGV N. A. N. A. Approved [93]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [222]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [230]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [202]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Topotecan DMP6G8T Central nervous system neoplasm Approved [231]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [232]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By BAG family molecular chaperone regulator 4 (BAG4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [233]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [155]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [234]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosyl-DNA phosphodiesterase 2 (TDP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [236]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [232]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [237]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [238]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [239]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [240]
Arsenic DMTL2Y1 N. A. N. A. Approved [241]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [164]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BAG family molecular chaperone regulator 2 (BAG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [242]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [83]
Capsaicin DMGMF6V Back pain ME84.Z Approved [153]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [245]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [246]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [247]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By B-cell lymphoma/leukemia 10 (BCL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Capsaicin DMGMF6V Back pain ME84.Z Approved [153]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [249]
Haloperidol DM96SE0 Delirium Approved [250]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [251]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [252]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [253]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [255]
Epinephrine DM3KJBC Acute asthma CA23 Approved [256]
Quercetin DM3NC4M Obesity 5B81 Approved [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [258]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [259]
Fructose DM43AN2 Vomiting MD90 Approved [250]
Ketoprofen DMRKXPT Bursitis Approved [250]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [261]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [262]
Gefitinib DM15F0X Colon adenocarcinoma Approved [263]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [264]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prelamin-A/C (LMNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [266]
Quercetin DM3NC4M Obesity 5B81 Approved [267]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [268]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [269]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [270]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [271]
Quercetin DM3NC4M Obesity 5B81 Approved [272]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [273]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [99]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [274]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [275]
Testosterone DM7HUNW Hot flushes GA30 Approved [276]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [277]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [278]
Selenium DM25CGV N. A. N. A. Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [152]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [279]
Epinephrine DM3KJBC Acute asthma CA23 Approved [256]
Quercetin DM3NC4M Obesity 5B81 Approved [280]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [281]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [282]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By N-myc proto-oncogene protein (MYCN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [285]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [286]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [287]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [288]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [289]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [290]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Selenium DM25CGV N. A. N. A. Approved [93]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [292]
Quercetin DM3NC4M Obesity 5B81 Approved [293]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [294]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [295]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [296]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Clozapine DMFC71L Schizophrenia 6A20 Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [298]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [299]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [301]
Paclitaxel DMLB81S Breast carcinoma Approved [302]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [303]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [304]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor I (IGF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [306]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [265]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [307]
Quercetin DM3NC4M Obesity 5B81 Approved [308]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [309]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [310]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Testosterone DM7HUNW Hot flushes GA30 Approved [311]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [312]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [313]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [314]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [316]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [317]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [318]
Fructose DM43AN2 Vomiting MD90 Approved [250]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [319]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [320]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [251]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [321]
Methotrexate DM2TEOL Anterior urethra cancer Approved [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gelsolin (GSN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [323]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [324]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [325]
Gefitinib DM15F0X Colon adenocarcinoma Approved [326]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [327]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [328]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [329]
Methotrexate DM2TEOL Anterior urethra cancer Approved [330]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [331]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [332]
Selenium DM25CGV N. A. N. A. Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [333]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [334]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [335]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [336]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [337]
Gefitinib DM15F0X Colon adenocarcinoma Approved [338]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [307]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [339]
Quercetin DM3NC4M Obesity 5B81 Approved [340]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [341]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [342]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [344]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [345]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [346]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [346]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [347]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [332]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [228]
Selenium DM25CGV N. A. N. A. Approved [93]
Etretinate DM2CZFA Keratosis ED56 Approved [294]
Quercetin DM3NC4M Obesity 5B81 Approved [293]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c1, heme protein, mitochondrial (CYC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [349]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [350]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-3 (IL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [351]
Ethanol DMDRQZU Chronic pain MG30 Approved [351]
Betamethasone Valerate DMMIAXO Dermatological disease DA24.Y Approved [352]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [353]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [352]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [250]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [250]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A5 (ANXA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [242]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [354]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Benzatropine DMF7EXL Parkinsonian disorder Approved [297]
Clozapine DMFC71L Schizophrenia 6A20 Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Granzyme B (GZMB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [356]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [357]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [358]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [359]
Bortezomib DMNO38U Leukemia Approved [59]
Ethambutol DMR87LC Pulmonary tuberculosis 1B10.Z Approved [358]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [360]
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [250]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [361]
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Drug(s) Affected By Transcriptional activator Myb (MYB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [362]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Estrone DM5T6US Acne vulgaris ED80 Approved [92]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [274]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [363]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [364]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [365]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [366]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [367]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [250]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Verapamil DMA7PEW Angina pectoris BA40 Approved [368]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [369]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [261]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [370]
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Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [228]
Etretinate DM2CZFA Keratosis ED56 Approved [294]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [267]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [371]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [372]
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Drug(s) Affected By Clusterin (CLU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [373]
Selenium DM25CGV N. A. N. A. Approved [93]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [373]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [281]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [374]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [373]
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Drug(s) Affected By Interferon regulatory factor 1 (IRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [174]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [332]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [376]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [377]
Etretinate DM2CZFA Keratosis ED56 Approved [294]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [378]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [379]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [333]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [380]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [381]
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Drug(s) Affected By DNA topoisomerase 1 (TOP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [250]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [228]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [382]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
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Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [383]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [384]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [251]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [385]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [382]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [386]
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Drug(s) Affected By Cation-independent mannose-6-phosphate receptor (IGF2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [174]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [202]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Folic Acid DMEMBJC Colorectal carcinoma Approved [175]
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Drug(s) Affected By ADP/ATP translocase 1 (SLC25A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Folic Acid DMEMBJC Colorectal carcinoma Approved [388]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Paclitaxel DMLB81S Breast carcinoma Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [389]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [390]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [391]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [392]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [393]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [394]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Perforin-1 (PRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [356]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Bortezomib DMNO38U Leukemia Approved [59]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [250]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [396]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [165]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
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Drug(s) Affected By Endoplasmin (HSP90B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [332]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [228]
Selenium DM25CGV N. A. N. A. Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [397]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [398]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [399]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor JunB (JUNB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [320]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [400]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [401]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor JunD (JUND)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [320]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [402]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [403]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [404]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [405]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 2 (IGFBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [406]
Selenium DM25CGV N. A. N. A. Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [407]
Testosterone DM7HUNW Hot flushes GA30 Approved [311]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [408]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Arsenic DMTL2Y1 N. A. N. A. Approved [409]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [408]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein uL30 (RPL7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Selenium DM25CGV N. A. N. A. Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [411]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Bortezomib DMNO38U Leukemia Approved [413]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [126]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [126]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [414]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [179]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [405]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Gefitinib DM15F0X Colon adenocarcinoma Approved [415]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [416]
Methotrexate DM2TEOL Anterior urethra cancer Approved [255]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [292]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [415]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [417]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [418]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [418]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
Ethanol DMDRQZU Chronic pain MG30 Approved [351]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lamin-B1 (LMNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [419]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [292]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [420]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [309]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
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Drug(s) Affected By B-cell lymphoma 3 protein (BCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [421]
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [403]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [202]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [202]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
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Drug(s) Affected By Cannabinoid receptor 1 (CNR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [422]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [222]
Norepinephrine DMOUC09 Alopecia ED70 Approved [423]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [424]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [425]
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Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [426]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [426]
Ethacrynic acid DM60QMR Edema MG29 Approved [427]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [230]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [428]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [426]
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Drug(s) Affected By Cadherin-3 (CDH3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Selenium DM25CGV N. A. N. A. Approved [93]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [281]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [281]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [429]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase CBL (CBL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [430]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [431]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [223]
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Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [406]
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [433]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [434]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 4 (TNFSF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [435]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [436]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [437]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [370]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [438]
Gefitinib DM15F0X Colon adenocarcinoma Approved [439]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [327]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [440]
Selenium DM25CGV N. A. N. A. Approved [93]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [441]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [442]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [205]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Gefitinib DM15F0X Colon adenocarcinoma Approved [415]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [443]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [402]
Methotrexate DM2TEOL Anterior urethra cancer Approved [444]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [445]
Quercetin DM3NC4M Obesity 5B81 Approved [135]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [446]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [447]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 6 (IGFBP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [448]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [403]
Testosterone DM7HUNW Hot flushes GA30 Approved [449]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [450]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [451]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [452]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [433]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [453]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ethanol DMDRQZU Chronic pain MG30 Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Deoxyribonuclease-1 (DNASE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [309]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [203]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [454]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [454]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [455]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenomatous polyposis coli protein (APC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Selenium DM25CGV N. A. N. A. Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [456]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Folic Acid DMEMBJC Colorectal carcinoma Approved [457]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [191]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [451]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [245]
Methotrexate DM2TEOL Anterior urethra cancer Approved [459]
Epinephrine DM3KJBC Acute asthma CA23 Approved [460]
Quercetin DM3NC4M Obesity 5B81 Approved [340]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [461]
Fructose DM43AN2 Vomiting MD90 Approved [462]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [463]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteasome subunit alpha type-3 (PSMA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [464]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
PEITC DMOMN31 Prostate cancer 2C82.0 Phase 2 [465]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [466]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [433]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [295]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [467]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [466]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [468]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Elongation factor 1-gamma (EEF1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [294]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [469]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [470]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [471]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [472]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD27 antigen (CD27)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [473]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
Bortezomib DMNO38U Leukemia Approved [474]
Arsenic DMTL2Y1 N. A. N. A. Approved [241]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [475]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [476]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteasome subunit alpha type-5 (PSMA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [477]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [478]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [464]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [479]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [479]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Quinidine DMLPICK N. A. N. A. Approved [479]
Arsenic DMTL2Y1 N. A. N. A. Approved [181]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [68]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [480]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [481]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-3-methyladenine glycosylase (MPG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [109]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [482]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [482]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [50]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By AT-rich interactive domain-containing protein 4A (ARID4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [456]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [483]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysine-specific demethylase 5A (KDM5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [484]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ethanol DMDRQZU Chronic pain MG30 Approved [485]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [486]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [487]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [488]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [489]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [490]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [491]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [492]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [493]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nitric oxide synthase 1 (NOS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [494]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [281]
Testosterone DM7HUNW Hot flushes GA30 Approved [495]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [281]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [496]
Capsaicin DMGMF6V Back pain ME84.Z Approved [497]
Bortezomib DMNO38U Leukemia Approved [498]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [499]
Interferon gamma-1b DMWUMRL Chronic granulomatous disease 4A00.0Y Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein PML (PML)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [500]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [281]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [281]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [501]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [501]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD40 ligand (CD40LG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [265]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [433]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [502]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [503]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [504]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [505]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Eptifibatide DMQXTJS Acute cardiac ischemic events BA40.Z Approved [506]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [505]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [507]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxiredoxin-5, mitochondrial (PRDX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [508]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [509]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Translocator protein (TSPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [250]
Alprazolam DMC7XDN Anxiety Approved [250]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [510]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [511]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [370]
Gefitinib DM15F0X Colon adenocarcinoma Approved [512]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [513]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [514]
Selenium DM25CGV N. A. N. A. Approved [93]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [307]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [441]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [307]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [402]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [402]
Testosterone DM7HUNW Hot flushes GA30 Approved [515]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [516]
Paclitaxel DMLB81S Breast carcinoma Approved [517]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [431]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-14 (CASP14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [518]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
Milchsaure DM462BT Pruritus EC90 Investigative [185]
PHENCYCLIDINE DMQBEYX Discovery agent N.A. Investigative [519]
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Drug(s) Affected By CD70 antigen (CD70)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [520]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 8 (TNFSF8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [83]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
Arsenic DMTL2Y1 N. A. N. A. Approved [181]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [480]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [475]
PF-3758309 DM36PKZ Solid tumour/cancer 2A00-2F9Z Phase 1 [171]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
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Drug(s) Affected By Cannabinoid receptor 2 (CNR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [521]
NABILONE DMVRYT2 Insomnia 7A00-7A0Z Approved [522]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [523]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [524]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [525]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [424]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [425]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [155]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [319]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [526]
Quercetin DM3NC4M Obesity 5B81 Approved [340]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [527]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [528]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [529]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [530]
Testosterone DM7HUNW Hot flushes GA30 Approved [531]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [532]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [203]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [533]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [533]
Cenestin DMXQS7K Menopause symptom GA30.0 Approved [533]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [534]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [535]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [536]
Haloperidol DM96SE0 Delirium Approved [297]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Clozapine DMFC71L Schizophrenia 6A20 Approved [297]
Orlistat DMRJSP8 Obesity 5B81 Approved [537]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [538]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 3 (LTBR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [281]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [539]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [540]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [540]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [164]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [250]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [541]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [542]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [543]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [544]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear pore glycoprotein p62 (NUP62)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [545]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [546]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [547]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [548]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [251]
Gefitinib DM15F0X Colon adenocarcinoma Approved [549]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [327]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [451]
Etretinate DM2CZFA Keratosis ED56 Approved [134]
Prednisone DM2HG4X Acute asthma CA23 Approved [550]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [551]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [110]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 9 (TNFSF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [445]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [552]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [553]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [554]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [301]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [555]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [556]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [557]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [558]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [559]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [560]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-2 (CASP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [369]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [561]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [562]
Quercetin DM3NC4M Obesity 5B81 Approved [563]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [247]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [564]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [565]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Prednisone DM2HG4X Acute asthma CA23 Approved [550]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [566]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [567]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [299]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [568]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [569]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [570]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Huntingtin (HTT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [571]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [481]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [103]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [435]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Pimecrolimus DMZLGRB Atopic dermatitis EA80 Approved [572]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [475]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [292]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [573]
Indomethacin DMSC4A7 Bursitis Approved [574]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [575]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein uS4 (RPS9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [576]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [296]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [470]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [223]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Gefitinib DM15F0X Colon adenocarcinoma Approved [577]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [578]
Epinephrine DM3KJBC Acute asthma CA23 Approved [460]
Quercetin DM3NC4M Obesity 5B81 Approved [579]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Fructose DM43AN2 Vomiting MD90 Approved [462]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [580]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [581]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-4 (CASP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [251]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [582]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [583]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [49]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Presenilin-1 (PSEN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [332]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [584]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [585]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [203]
Bortezomib DMNO38U Leukemia Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [586]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Type-2 angiotensin II receptor (AGTR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Coprexa DMA0WEK Neurological disorder 6B60 Phase 3 [587]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [72]
paraquat DMR8O3X Discovery agent N.A. Investigative [588]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Serpin B9 (SERPINB9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [309]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [589]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [112]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Selenium DM25CGV N. A. N. A. Approved [93]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [590]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [591]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [592]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [593]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death-associated protein 1 (DAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [174]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [160]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Capsaicin DMGMF6V Back pain ME84.Z Approved [594]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [539]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [109]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [595]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein mS29 (DAP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [596]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [597]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [539]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Bortezomib DMNO38U Leukemia Approved [598]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [599]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [586]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Bortezomib DMNO38U Leukemia Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [472]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [600]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [102]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID25656651-Compound-5 DMAI95U Chronic myeloid leukaemia 2A20 Patented [601]
SB-431542 DM0YOXQ Pulmonary fibrosis CB03.4 Preclinical [602]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-5 (CASP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [492]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [492]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Paclitaxel DMLB81S Breast carcinoma Approved [213]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [77]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
9-hydroxyoctadecadienoic acid DM0FWNJ Discovery agent N.A. Investigative [603]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [77]
CHLORANIL DMCHGF1 Discovery agent N.A. Investigative [604]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-G1 (CCNG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [453]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [605]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [158]
Arsenic DMTL2Y1 N. A. N. A. Approved [606]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [607]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Methotrexate DM2TEOL Anterior urethra cancer Approved [608]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [609]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [277]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [610]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [611]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Sorbitol DMAN0DE Constipation DD91.1 Approved [612]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [613]
Ethanol DMDRQZU Chronic pain MG30 Approved [614]
Dicumarol DMFQCB1 Bleeding disorder GA20-GA21 Approved [612]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [615]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [612]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [349]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By UV excision repair protein RAD23 homolog B (RAD23B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [616]
Indomethacin DMSC4A7 Bursitis Approved [617]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [158]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [618]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epithelial membrane protein 3 (EMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [445]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [619]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Allograft inflammatory factor 1 (AIF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [170]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [620]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [169]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [72]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [621]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Exportin-2 (CSE1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [592]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [622]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [597]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [623]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [624]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [625]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [626]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [627]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [627]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [292]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [628]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [382]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [564]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [629]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [369]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [630]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [631]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [245]
Meloxicam DM2AR7L Arthritis FA20 Approved [632]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [633]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [634]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-6 (CASP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Methotrexate DM2TEOL Anterior urethra cancer Approved [444]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [266]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [635]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [582]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor D (CDKN2D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Etretinate DM2CZFA Keratosis ED56 Approved [636]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [637]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [341]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [545]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [636]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [245]
Selenium DM25CGV N. A. N. A. Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [638]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [639]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [640]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase homolog 5 (NME5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [375]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 18 (CARD18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
Milchsaure DM462BT Pruritus EC90 Investigative [185]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Triosephosphate isomerase (TPI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Etretinate DM2CZFA Keratosis ED56 Approved [294]
Methotrexate DM2TEOL Anterior urethra cancer Approved [641]
Quercetin DM3NC4M Obesity 5B81 Approved [267]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [642]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [643]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [296]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [250]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [644]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [645]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [646]
Methotrexate DM2TEOL Anterior urethra cancer Approved [647]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [648]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [649]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [650]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [651]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [652]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Selenium DM25CGV N. A. N. A. Approved [93]
Etretinate DM2CZFA Keratosis ED56 Approved [294]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [653]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein uS10 (RPS20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [223]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [654]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [655]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [656]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [657]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [68]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [658]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein eS1 (RPS3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [659]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [660]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [661]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 10 kDa heat shock protein, mitochondrial (HSPE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [662]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [355]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Ethanol DMDRQZU Chronic pain MG30 Approved [663]
Folic Acid DMEMBJC Colorectal carcinoma Approved [388]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [191]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [664]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein eL31 (RPL31)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [665]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [471]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [68]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [666]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Quercetin DM3NC4M Obesity 5B81 Approved [667]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [668]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [277]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [669]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Elongation factor 1-alpha 1 (EEF1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [294]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [405]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [269]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [296]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [670]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [670]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [670]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [191]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [671]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [158]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-complex protein 1 subunit beta (CCT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [478]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [158]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [672]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase omega-1 (GSTO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [405]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [599]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [673]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [674]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [585]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [675]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [665]
Arsenic DMTL2Y1 N. A. N. A. Approved [606]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [676]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [406]
Selenium DM25CGV N. A. N. A. Approved [120]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [677]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [170]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [677]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [677]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [677]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [677]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [678]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [100]
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Drug(s) Affected By Protein BEX3 (BEX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [223]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [109]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [679]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Spectrin beta chain, non-erythrocytic 1 (SPTBN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [613]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [222]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [203]
Bortezomib DMNO38U Leukemia Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolysin TIAR (TIAL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [680]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [681]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [546]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E2F1 (E2F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [682]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [683]
Gefitinib DM15F0X Colon adenocarcinoma Approved [684]
Selenium DM25CGV N. A. N. A. Approved [93]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [110]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [329]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [448]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein K2 (FOXK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [685]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [223]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [686]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [687]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [688]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [163]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [78]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [689]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [107]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [232]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [690]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [270]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [691]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [692]
Ethacrynic acid DM60QMR Edema MG29 Approved [693]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [99]
Testosterone DM7HUNW Hot flushes GA30 Approved [276]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Capsaicin DMGMF6V Back pain ME84.Z Approved [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [384]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [694]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [158]
Arsenic DMTL2Y1 N. A. N. A. Approved [695]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caveolin-1 (CAV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [370]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [696]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [697]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [698]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [699]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [700]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [277]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [152]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [152]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [701]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lactoylglutathione lyase (GLO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [662]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [702]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [411]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Focal adhesion kinase 1 (PTK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [703]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [704]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [448]
Quercetin DM3NC4M Obesity 5B81 Approved [705]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [403]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [706]
Testosterone DM7HUNW Hot flushes GA30 Approved [707]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [708]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxiredoxin-1 (PRDX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [709]
Etretinate DM2CZFA Keratosis ED56 Approved [294]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [160]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [296]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [710]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [711]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [712]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [364]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [560]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Verapamil DMA7PEW Angina pectoris BA40 Approved [368]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [630]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [327]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Meloxicam DM2AR7L Arthritis FA20 Approved [713]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [551]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [261]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [714]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [715]
Quercetin DM3NC4M Obesity 5B81 Approved [340]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [716]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [717]
Ethacrynic acid DM60QMR Edema MG29 Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [456]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [718]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lactadherin (MFGE8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Methyl aminolevulinate DMIUX3D Acne vulgaris ED80 Approved [719]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [176]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [126]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [158]
Arsenic DMTL2Y1 N. A. N. A. Approved [163]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [720]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [721]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [722]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [723]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone acetyltransferase p300 (EP300)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [724]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [725]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [585]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [726]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [250]
Selenium DM25CGV N. A. N. A. Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [727]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [728]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [729]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [730]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 13 (PTPN13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [731]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [292]
Paclitaxel DMLB81S Breast carcinoma Approved [732]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [732]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [733]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 2 (TRAF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [734]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Ceritinib DMB920Z Non-small-cell lung cancer 2C25.Y Approved [735]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Capsaicin DMGMF6V Back pain ME84.Z Approved [153]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [149]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [736]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [737]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [483]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [448]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Quinolones DM5GVHU Bacterial infection 1A00-1C4Z Approved [738]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [173]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [160]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [677]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [739]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [677]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [677]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [740]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [677]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 1 (NAIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Bortezomib DMNO38U Leukemia Approved [741]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [742]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [743]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [744]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [745]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [213]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [712]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Folic Acid DMEMBJC Colorectal carcinoma Approved [746]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 3 (TRAF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Capsaicin DMGMF6V Back pain ME84.Z Approved [153]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [747]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FAS-associated death domain protein (FADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Selenium DM25CGV N. A. N. A. Approved [748]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [292]
Quercetin DM3NC4M Obesity 5B81 Approved [631]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [749]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [160]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PAK 2 (PAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [431]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase CBL-B (CBLB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [188]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase 3 (NME3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [750]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [375]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [102]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [475]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Paclitaxel DMLB81S Breast carcinoma Approved [751]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [752]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [753]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [754]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [755]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [756]
Etretinate DM2CZFA Keratosis ED56 Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [340]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [757]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [589]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 5 activator 2 (CDK5R2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Folic Acid DMEMBJC Colorectal carcinoma Approved [175]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Bcl-2-interacting killer (BIK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [758]
Methotrexate DM2TEOL Anterior urethra cancer Approved [444]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [759]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [491]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [492]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Clozapine DMFC71L Schizophrenia 6A20 Approved [760]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [239]
Arsenic DMTL2Y1 N. A. N. A. Approved [761]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [188]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [762]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GRB2-associated-binding protein 1 (GAB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [763]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Folic Acid DMEMBJC Colorectal carcinoma Approved [175]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [764]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [431]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [765]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [560]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [245]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [463]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [428]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [766]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [404]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [767]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [404]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Ethanol DMDRQZU Chronic pain MG30 Approved [768]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Bortezomib DMNO38U Leukemia Approved [769]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Deoxyribonuclease gamma (DNASE1L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Testosterone undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [770]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [771]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [72]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis-stimulating of p53 protein 2 (TP53BP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [50]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [109]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [660]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [198]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [772]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [773]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [774]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [232]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 13 (CDK13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [234]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [775]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-interleukin-16 (IL16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [776]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ethanol DMDRQZU Chronic pain MG30 Approved [351]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [777]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [764]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [507]
Arsenic DMTL2Y1 N. A. N. A. Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dedicator of cytokinesis protein 1 (DOCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [778]
Arsenic DMTL2Y1 N. A. N. A. Approved [779]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [236]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Dp-1 (TFDP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [565]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [233]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [780]
Bortezomib DMNO38U Leukemia Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Dp-2 (TFDP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [701]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [191]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [781]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [155]
Arsenic DMTL2Y1 N. A. N. A. Approved [606]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fas-activated serine/threonine kinase (FASTK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [309]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Folic Acid DMEMBJC Colorectal carcinoma Approved [175]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [309]
Bortezomib DMNO38U Leukemia Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [664]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [782]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [783]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [784]
Fluoxetine DM3PD2C Bipolar depression Approved [785]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [786]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [787]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [788]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [789]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [790]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [791]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [792]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [577]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [793]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [245]
Selenium DM25CGV N. A. N. A. Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [633]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate receptor ionotropic, NMDA 2C (GRIN2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [451]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [764]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [451]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [190]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear mitotic apparatus protein 1 (NUMA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [622]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [794]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [795]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein disulfide-isomerase A6 (PDIA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [26]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [796]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [797]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoblastoma-binding protein 5 (RBBP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Ethanol DMDRQZU Chronic pain MG30 Approved [485]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [458]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [129]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [155]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E2F5 (E2F5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Paclitaxel DMLB81S Breast carcinoma Approved [75]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [780]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [431]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [734]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [160]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Hesperidin DMI5DW1 Vascular purpura 3B60 Approved [798]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [799]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
AMG 386 DMQJXL4 Breast cancer 2C60-2C65 Phase 3 [800]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [165]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Programmed cell death protein 2 (PDCD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [164]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [483]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [546]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [801]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [802]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [803]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [374]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [582]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [804]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [805]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [245]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [806]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [680]
Amifostine DM5FL14 Mucositis CA00 Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [622]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [202]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase LMTK1 (AATK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [750]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [165]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase RBBP6 (RBBP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [548]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Selenium DM25CGV N. A. N. A. Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [597]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase SIAH1 (SIAH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [807]
Selenium DM25CGV N. A. N. A. Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [808]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Hexachlorophene DMLKSE0 Bacterial infection 1A00-1C4Z Approved [809]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Secreted frizzled-related protein 1 (SFRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [810]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ethanol DMDRQZU Chronic pain MG30 Approved [74]
Folic Acid DMEMBJC Colorectal carcinoma Approved [811]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [149]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TRAF3-interacting protein 1 (TRAF3IP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [812]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
crotylaldehyde DMTWRQI Discovery agent N.A. Investigative [813]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By MAP kinase-activating death domain protein (MADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [174]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Paclitaxel DMLB81S Breast carcinoma Approved [75]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [753]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [750]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [814]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Unconventional myosin-XVIIIa (MYO18A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [794]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [223]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [815]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAN (NSMAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Panobinostat DM58WKG Chronic graft versus host disease Approved [816]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [817]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [231]
Topotecan DMP6G8T Central nervous system neoplasm Approved [231]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein ubi-d4 (DPF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [818]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [103]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [819]
Hexadecanoic acid DMWUXDZ Discovery agent N.A. Investigative [820]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [821]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [433]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [822]
Bortezomib DMNO38U Leukemia Approved [823]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [434]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Bortezomib DMNO38U Leukemia Approved [59]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [431]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [824]
Arsenic DMTL2Y1 N. A. N. A. Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-10 (CASP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [245]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [825]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [826]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [827]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [560]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [828]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [829]
Quercetin DM3NC4M Obesity 5B81 Approved [308]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [830]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [233]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [831]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Folic Acid DMEMBJC Colorectal carcinoma Approved [746]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [99]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Capsaicin DMGMF6V Back pain ME84.Z Approved [153]
Hesperidin DMI5DW1 Vascular purpura 3B60 Approved [798]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Benzatropine DMF7EXL Parkinsonian disorder Approved [297]
Clozapine DMFC71L Schizophrenia 6A20 Approved [297]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [832]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Modulator of apoptosis 1 (MOAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [833]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [481]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PRKC apoptosis WT1 regulator protein (PAWR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [807]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [834]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [835]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Bendamustine hydrochloride DMFH15Z leukaemia 2A60-2B33 Approved [836]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-modifying factor (BMF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Panobinostat DM58WKG Chronic graft versus host disease Approved [837]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [372]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [838]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [28]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Parkinson disease protein 7 (PARK7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [839]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [840]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [671]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [586]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [108]
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [841]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [842]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [843]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [734]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Mecamylamine DMGQFYB Essential hypertension BA00 Approved [844]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [766]
Quercetin DM3NC4M Obesity 5B81 Approved [705]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [54]
Arsenic DMTL2Y1 N. A. N. A. Approved [845]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [575]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [846]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BAG family molecular chaperone regulator 1 (BAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [847]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [203]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [778]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [848]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By B-cell CLL/lymphoma 7 protein family member B (BCL7B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [548]
Selenium DM25CGV N. A. N. A. Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [174]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [103]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxidoreductase HTATIP2 (HTATIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [202]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [849]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [849]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 4 (TRAF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [160]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ethanol DMDRQZU Chronic pain MG30 Approved [614]
Folic Acid DMEMBJC Colorectal carcinoma Approved [746]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase TRAIP (TRAIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Folic Acid DMEMBJC Colorectal carcinoma Approved [746]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 10 (CARD10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [243]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [540]
Arsenic DMTL2Y1 N. A. N. A. Approved [248]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [540]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 6 (CARD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [50]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 14 (CARD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [162]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
Milchsaure DM462BT Pruritus EC90 Investigative [185]
Drug(s) Affected By Caspase recruitment domain-containing protein 11 (CARD11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [850]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [851]
Drug(s) Affected By Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [492]
Clozapine DMFC71L Schizophrenia 6A20 Approved [297]
Testosterone undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [770]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [72]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [852]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 1 (NLRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [492]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [492]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [853]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [481]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [190]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Autophagy protein 5 (ATG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [854]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [855]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [856]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [857]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [788]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [805]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [858]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [364]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 9 (CARD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [203]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [797]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Bcl-2-like protein 12 (BCL2L12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [859]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [860]
Topotecan DMP6G8T Central nervous system neoplasm Approved [459]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [366]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleotide-binding oligomerization domain-containing protein 2 (NOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Aripiprazole DM3NUMH Bipolar I disorder Approved [861]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [862]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [863]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By p53-regulated apoptosis-inducing protein 1 (TP53AIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Folic Acid DMEMBJC Colorectal carcinoma Approved [175]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
Milchsaure DM462BT Pruritus EC90 Investigative [185]
Drug(s) Affected By Bcl-2-like protein 10 (BCL2L10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [244]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [864]
paraquat DMR8O3X Discovery agent N.A. Investigative [865]
Drug(s) Affected By NLR family CARD domain-containing protein 4 (NLRC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [866]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [193]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [867]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [245]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [868]
Quercetin DM3NC4M Obesity 5B81 Approved [340]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [869]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [639]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [870]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [157]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [157]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [157]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [375]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional apoptosis regulator (BFAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Folic Acid DMEMBJC Colorectal carcinoma Approved [746]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
EMODIN DMAEDQG Coronavirus Disease 2019 (COVID-19) 1D6Y Terminated [871]
paraquat DMR8O3X Discovery agent N.A. Investigative [865]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Hematopoietic cell signal transducer (HCST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [170]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [872]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [475]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [873]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [874]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Clozapine DMFC71L Schizophrenia 6A20 Approved [875]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peflin (PEF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [174]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [545]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [100]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase 17A (STK17A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [876]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death domain-associated protein 6 (DAXX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [877]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [316]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Bendamustine hydrochloride DMFH15Z leukaemia 2A60-2B33 Approved [836]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipid transferase CIDEB (CIDEB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [230]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Folic Acid DMEMBJC Colorectal carcinoma Approved [746]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [28]
Bortezomib DMNO38U Leukemia Approved [598]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [824]
Arsenic DMTL2Y1 N. A. N. A. Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 12 (NDUFA12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [375]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [216]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [797]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [232]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [658]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Death-associated protein kinase 2 (DAPK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [878]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [147]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [203]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [599]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [151]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inhibitor of growth protein 1 (ING1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [191]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [879]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [546]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CASP8-associated protein 2 (CASP8AP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [191]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [880]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [881]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [882]
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Drug(s) Affected By BAG family molecular chaperone regulator 5 (BAG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [876]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [883]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
EMODIN DMAEDQG Coronavirus Disease 2019 (COVID-19) 1D6Y Terminated [871]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [220]
Milchsaure DM462BT Pruritus EC90 Investigative [185]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [884]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [492]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [493]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Ethanol DMDRQZU Chronic pain MG30 Approved [885]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [886]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-11 (CAPN11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [203]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Arsenic DMTL2Y1 N. A. N. A. Approved [761]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [595]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [546]
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Drug(s) Affected By Bcl-2-related ovarian killer protein (BOK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Folic Acid DMEMBJC Colorectal carcinoma Approved [175]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [181]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [375]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 18 (TNFSF18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [165]
PF-3758309 DM36PKZ Solid tumour/cancer 2A00-2F9Z Phase 1 [171]
Drug(s) Affected By FAS-associated factor 1 (FAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [281]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Bortezomib DMNO38U Leukemia Approved [474]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [778]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [158]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleotide-binding oligomerization domain-containing protein 1 (NOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [664]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By RAC-gamma serine/threonine-protein kinase (AKT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [72]
Paclitaxel DMLB81S Breast carcinoma Approved [517]
Topotecan DMP6G8T Central nervous system neoplasm Approved [231]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [517]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 8 (CARD8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [402]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [887]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Folic Acid DMEMBJC Colorectal carcinoma Approved [746]
Arsenic DMTL2Y1 N. A. N. A. Approved [752]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [731]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ethanol DMDRQZU Chronic pain MG30 Approved [768]
Arsenic DMTL2Y1 N. A. N. A. Approved [779]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [888]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [889]
GSK618334 DMJPXZ4 Drug abuse 6C4G.1Z Phase 1 [890]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [80]
OLEIC ACID DM54O1Z Discovery agent N.A. Investigative [891]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B essential modulator (IKBKG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [892]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [233]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [893]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [893]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-6 (CAPN6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [609]
Testosterone enanthate DMB6871 N. A. N. A. Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Indomethacin DMSC4A7 Bursitis Approved [894]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [155]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [654]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [895]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [341]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [163]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [50]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [164]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [896]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Telbivudine DMSWUGE Hepatitis B virus infection 1E51.0 Approved [897]
Arsenic DMTL2Y1 N. A. N. A. Approved [898]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [216]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [899]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [900]
Quercetin DM3NC4M Obesity 5B81 Approved [293]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [901]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [899]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [899]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [902]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [899]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [152]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [903]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [285]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [904]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [739]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [265]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [489]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [905]
Methotrexate DM2TEOL Anterior urethra cancer Approved [152]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [906]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [907]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [908]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [909]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [910]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [910]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [911]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [912]
Capsaicin DMGMF6V Back pain ME84.Z Approved [913]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [914]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [915]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [916]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [917]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [285]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [320]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [739]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [677]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [252]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [918]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [677]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [907]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [919]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [910]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [909]
Capsaicin DMGMF6V Back pain ME84.Z Approved [920]
Zafirlukast DMHNQOG Asthma CA23 Approved [921]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [910]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [922]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [909]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [910]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [469]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [901]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [923]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [924]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [319]
Gefitinib DM15F0X Colon adenocarcinoma Approved [263]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [278]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [321]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [371]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [925]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [321]
Ethacrynic acid DM60QMR Edema MG29 Approved [693]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming protein RhoA (RHOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [270]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [926]
Quercetin DM3NC4M Obesity 5B81 Approved [705]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [309]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [927]
Pamidronate DMB4AVP Bone Paget disease Approved [928]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [929]
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Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [309]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [930]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [453]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [927]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [931]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [932]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [228]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [933]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [404]
Minodronate DM50PMY Osteoporosis FB83.0 Approved [934]
Risedronate DM5FLTY Bone Paget disease Approved [935]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [936]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Pamidronate DMB4AVP Bone Paget disease Approved [935]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [370]
Selenium DM25CGV N. A. N. A. Approved [93]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [500]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [266]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [937]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [938]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transient receptor potential cation channel subfamily V member 1 (TRPV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [939]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [524]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Capsaicin DMGMF6V Back pain ME84.Z Approved [940]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [941]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [942]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Long transient receptor potential channel 8 (TRPM8) TTXDKTO TRPM8_HUMAN Activator [3]
Transformation-sensitive protein p120 (TRPA1) TTELV3W TRPA1_HUMAN Activator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Gene/Protein Processing [4]
14-3-3 protein epsilon OT3WQXNA 1433E_HUMAN Gene/Protein Processing [4]
14-3-3 protein zeta/delta OT2TKG9P 1433Z_HUMAN Gene/Protein Processing [4]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [4]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Gene/Protein Processing [4]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Gene/Protein Processing [4]
ADP/ATP translocase 1 (SLC25A4) OTKYLK2J ADT1_HUMAN Gene/Protein Processing [4]
Allograft inflammatory factor 1 (AIF1) OTGES18F AIF1_HUMAN Gene/Protein Processing [4]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Gene/Protein Processing [4]
Annexin A5 (ANXA5) OTZS877V ANXA5_HUMAN Gene/Protein Processing [4]

References

1 methyl salicylate FDA Label
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128 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
129 Daunorubicin-induced variations in gene transcription: commitment to proliferation arrest, senescence and apoptosis. Biochem J. 2003 Jun 15;372(Pt 3):703-11. doi: 10.1042/BJ20021950.
130 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
131 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
132 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
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179 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
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817 Gene expression profile of colon cancer cell lines treated with SN-38. Chemotherapy. 2010;56(1):17-25. doi: 10.1159/000287353. Epub 2010 Feb 24.
818 Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
819 Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
820 Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448. doi: 10.1002/hep.29033. Epub 2017 Jun 16.
821 Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth. J Cell Biochem. 2005 Nov 1;96(4):760-74. doi: 10.1002/jcb.20474.
822 Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013 Oct;12(10):2200-12. doi: 10.1158/1535-7163.MCT-13-0095. Epub 2013 Jul 26.
823 [Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1016-20.
824 Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
825 Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells. Haematologica. 2012 Jan;97(1):38-46. doi: 10.3324/haematol.2011.046466. Epub 2011 Sep 20.
826 Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. J Biol Chem. 2002 Dec 20;277(51):49504-10. doi: 10.1074/jbc.M207836200. Epub 2002 Oct 17.
827 Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ. 2000 Jun;7(6):574-86. doi: 10.1038/sj.cdd.4400688.
828 Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Cancer Res. 2003 Feb 1;63(3):616-20.
829 Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation. 2002 Oct 27;74(8):1063-9. doi: 10.1097/00007890-200210270-00001.
830 Down regulation of N-acetylglucosaminyltransferase V facilitates all-transretinoic acid to induce apoptosis of human hepatocarcinoma cells. Mol Cell Biochem. 2006 Mar;284(1-2):103-10. doi: 10.1007/s11010-005-9022-5. Epub 2006 Jan 13.
831 Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
832 Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):47-55. doi: 10.1016/j.mce.2004.04.010.
833 Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses. Mutat Res. 2005 Dec 11;591(1-2):198-211.
834 Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter. J Biol Chem. 2003 May 30;278(22):19995-20005. doi: 10.1074/jbc.M205865200. Epub 2003 Mar 17.
835 Down-regulation of wt1 expression in leukemia cell lines as part of apoptotic effect in arsenic treatment using two compounds. Leuk Lymphoma. 2006 Aug;47(8):1629-38. doi: 10.1080/10428190600625398.
836 Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochem Pharmacol. 2003 Sep 1;66(5):711-24. doi: 10.1016/s0006-2952(03)00410-6.
837 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
838 Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
839 DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin. Free Radic Res. 2001 Dec;35(6):885-93. doi: 10.1080/10715760100301381.
840 Inhibition by pesticides of the DJ-1/Park7 protein related to Parkinson disease. Toxicology. 2023 Mar 15;487:153467. doi: 10.1016/j.tox.2023.153467. Epub 2023 Feb 24.
841 Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease. J Biol Chem. 2011 Apr 29;286(17):14941-51. doi: 10.1074/jbc.M110.211029. Epub 2011 Mar 3.
842 Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease. J Neurochem. 2008 Jun 1;105(6):2435-53. doi: 10.1111/j.1471-4159.2008.05333.x.
843 Nuclear proteomics with XRCC3 knockdown to reveal the development of doxorubicin-resistant uterine cancer. Toxicol Sci. 2014 Jun;139(2):396-406. doi: 10.1093/toxsci/kfu051. Epub 2014 Mar 27.
844 Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J Biol Chem. 2003 May 2;278(18):15633-40.
845 Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen. 2014 Apr;55(3):196-208. doi: 10.1002/em.21842. Epub 2013 Dec 10.
846 ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
847 Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther. 2002 Jul;1(9):667-77.
848 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
849 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
850 BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol. 2012 Dec;92(6):1147-54. doi: 10.1189/jlb.0312165. Epub 2012 Jul 16.
851 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
852 4-HPR modulates gene expression in ovarian cells. Int J Cancer. 2006 Sep 1;119(5):1005-13. doi: 10.1002/ijc.21797.
853 Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro. Oncotarget. 2014 Dec 30;5(24):12891-907.
854 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
855 Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
856 Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
857 TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
858 Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231-43. doi: 10.1016/j.chom.2009.08.004.
859 Effect of doxorubicin, oxaliplatin, and methotrexate administration on the transcriptional activity of BCL-2 family gene members in stomach cancer cells. Cancer Biol Ther. 2013 Jul;14(7):587-96. doi: 10.4161/cbt.24591. Epub 2013 May 10.
860 The effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells. In Vitro Cell Dev Biol Anim. 2009 Jan-Feb;45(1-2):69-74. doi: 10.1007/s11626-008-9154-5. Epub 2008 Nov 18.
861 Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium. Chem Res Toxicol. 2019 Oct 21;32(10):1997-2005. doi: 10.1021/acs.chemrestox.9b00149. Epub 2019 Sep 11.
862 Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire. Reprod Toxicol. 2017 Oct;73:184-195. doi: 10.1016/j.reprotox.2017.07.023. Epub 2017 Aug 6.
863 NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease. Am J Gastroenterol. 2008 May;103(5):1197-202. doi: 10.1111/j.1572-0241.2007.01741.x. Epub 2008 Mar 26.
864 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
865 Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways. J Toxicol Environ Health A. 2008;71(22):1457-67. doi: 10.1080/15287390802329364.
866 AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance. Cell Biol Toxicol. 2023 Oct;39(5):2165-2181. doi: 10.1007/s10565-022-09703-7. Epub 2022 Feb 28.
867 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
868 Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
869 Combination of all-trans retinoic acid and taxol regressed glioblastoma T98G xenografts in nude mice. Apoptosis. 2007 Nov;12(11):2077-87. doi: 10.1007/s10495-007-0116-2. Epub 2007 Aug 16.
870 Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes. J Membr Biol. 2001 Nov 1;184(1):35-43. doi: 10.1007/s00232-001-0072-7.
871 Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells. Cell Res. 2005 Jul;15(7):511-22.
872 The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics. 2008 Oct 10;1:49.
873 Effect of benzo[a]pyrene on proliferation and metastasis of oral squamous cell carcinoma cells: A transcriptome analysis based on RNA-seq. Environ Toxicol. 2022 Nov;37(11):2589-2604. doi: 10.1002/tox.23621. Epub 2022 Jul 23.
874 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
875 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
876 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
877 Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta. J Biol Chem. 2009 Oct 16;284(42):28783-94. doi: 10.1074/jbc.M109.041186. Epub 2009 Aug 18.
878 Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL. J Leukoc Biol. 2017 Dec;102(6):1357-1370. doi: 10.1189/jlb.1A0317-132R. Epub 2017 Oct 4.
879 Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-beta-dependent mechanisms. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.
880 Differential gene expression profiles may differentiate responder and nonresponder patients with rheumatoid arthritis for methotrexate (MTX) monotherapy and MTX plus tumor necrosis factor inhibitor combined therapy. J Rheumatol. 2012 Aug;39(8):1524-32. doi: 10.3899/jrheum.120092. Epub 2012 Jul 1.
881 Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein. Neoplasia. 2004 Jul-Aug;6(4):354-63. doi: 10.1593/neo.03478.
882 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
883 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
884 Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
885 Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells. Toxicology. 2015 Aug 6;334:104-10. doi: 10.1016/j.tox.2015.06.006. Epub 2015 Jun 12.
886 Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis. J Appl Toxicol. 2011 Nov;31(8):762-72.
887 MiR-146a affects the alteration in myeloid differentiation induced by hydroquinone in human CD34(+) hematopoietic progenitor cells and HL-60 cells. Toxicol Res (Camb). 2016 Feb 16;5(3):848-858. doi: 10.1039/c5tx00419e. eCollection 2016 May 1.
888 Phenylephrine induces necroptosis and apoptosis in corneal epithelial cells dose- and time-dependently. Toxicology. 2019 Dec 1;428:152305. doi: 10.1016/j.tox.2019.152305. Epub 2019 Oct 9.
889 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
890 FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol Lett. 2015 Jul 2;236(1):43-59. doi: 10.1016/j.toxlet.2015.04.015. Epub 2015 May 1.
891 PGAM5 regulates DRP1-mediated mitochondrial fission/mitophagy flux in lipid overload-induced renal tubular epithelial cell necroptosis. Toxicol Lett. 2023 Jan 1;372:14-24. doi: 10.1016/j.toxlet.2022.10.003. Epub 2022 Oct 20.
892 PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome. Biochem Pharmacol. 2019 Apr;162:98-108. doi: 10.1016/j.bcp.2018.10.005. Epub 2018 Oct 6.
893 Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes. Biochem Biophys Res Commun. 2015 Aug 14;464(1):221-228. doi: 10.1016/j.bbrc.2015.06.120. Epub 2015 Jun 23.
894 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
895 Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
896 9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts. Reprod Toxicol. 2019 Aug;87:21-31. doi: 10.1016/j.reprotox.2019.04.008. Epub 2019 May 1.
897 Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction. Chem Biol Interact. 2023 Sep 25;383:110692. doi: 10.1016/j.cbi.2023.110692. Epub 2023 Sep 1.
898 Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population. Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1367-75. doi: 10.1158/1055-9965.EPI-06-0106.
899 A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
900 Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
901 Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
902 In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells. Antimicrob Agents Chemother. 2006 Nov;50(11):3824-32. doi: 10.1128/AAC.00437-06. Epub 2006 Aug 28.
903 Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
904 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
905 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
906 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
907 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
908 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
909 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
910 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
911 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
912 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
913 Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
914 Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
915 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
916 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
917 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
918 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
919 Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46.
920 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
921 Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica. 2004 May;34(5):429-38.
922 The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. Life Sci. 2006 Nov 25;79(26):2432-40.
923 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
924 Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
925 Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
926 Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol. 2004 May;30(5):662-70. doi: 10.1165/rcmb.2003-0267OC. Epub 2003 Nov 20.
927 Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol. 2005 Sep;130(6):912-25. doi: 10.1111/j.1365-2141.2005.05696.x.
928 Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma. J Hepatol. 2006 Jan;44(1):142-50. doi: 10.1016/j.jhep.2005.09.022. Epub 2005 Nov 9.
929 RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. Cell Death Differ. 2006 Nov;13(11):1845-56. doi: 10.1038/sj.cdd.4401873. Epub 2006 Feb 10.
930 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
931 Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. Int J Cancer. 2008 May 1;122(9):2115-24. doi: 10.1002/ijc.23315.
932 Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells. Breast Cancer Res. 2008;10(1):R4. doi: 10.1186/bcr1845. Epub 2008 Jan 11.
933 Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors. Cancer Res Commun. 2023 Dec 8;3(12):2497-2509. doi: 10.1158/2767-9764.CRC-23-0350.
934 Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells. Cancer Chemother Pharmacol. 2008 Jun;62(1):111-6. doi: 10.1007/s00280-007-0580-y. Epub 2007 Sep 15.
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936 Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
937 Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
938 Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
939 Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001 Oct;134(4):845-52. doi: 10.1038/sj.bjp.0704327.
940 Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol. 2004 Mar;13(3):129-39. doi: 10.1111/j.0906-6705.2004.0178.x.
941 The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest. 2008 Feb;118(2):763-76. doi: 10.1172/JCI32751.
942 Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.