Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOLNHF)

• Drug Name: Melphalan Drug Info
• Synonyms: Alkeran; Levofalan; Levofolan; Levopholan; Melfalan; Melfalano; Melphalanum; Alanine Nitrogen Mustard; Phenylalanine mustard; Phenylalanine nitrogen mu stard; Phenylalanine nitrogen mustard; AY3360000; CB 3025; ALKERAN (TN); Alkeran (TN); At-290; CB-3025; L-PAM; L-Phenylalanine mustard; L-Sarcolysin; L-Sarcolysine; L-Sarkolysin; Melfalano [INN-Spanish]; Melphalanum [INN-Latin]; SK-15673; TRANSGENIC MODEL EVALUATION (MELPHALAN); MELPHALAN (SEE ALSO TRANSGENIC MODEL EVALUATION (MELPHALAN)); P-L-Sarcolysin; P-L-sarcolysine; TRANSGENIC LEP (MELPHALAN) (SEE ALSO MELPHALAN); Melphalan (JP15/USP/INN); Melphalan [USAN:INN:BAN:JAN]; P-Bis(beta-chloroethyl)aminophenylalanine; P-N-Di(chloroethyl)aminophenylalanine; P-N-di(chloroethyl)aminophenylala nine; P-Di-(2-chloroethyl)amino-L-phenylalanine; P-N-Bis(2-chloroethyl)amino-L-phenylalanine; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine; P-N,N-bis(2-chloroethyl)amino-L-phenylalanine; (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid; (2s)-2-amino-3-(4-[bis(2-chloroethyl)amino]phenyl)propanoic acid; 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine; 3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine; 4-(Bis(2-chloroethyl)amino)-L-phenylalanine; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine; 4-[Bis-(2-chloroethyl)amino]-L-phenylalanine

Indication

Disease Entry	ICD 11	Status	REF
Hematologic disease	3C0Z	Approved	[1]
Leukemia		Approved	[1]
Multiple myeloma	2A83	Approved	[2]
Myeloproliferative neoplasm	2A20	Approved	[1]
Ovarian cancer	2C73	Approved	[3]
Plasma cell myeloma	2A83.1	Approved	[1]
Refractory plasma cell neoplasm		Approved	[1]
Intrahepatic cholangiocarcinoma	2C12.10	Phase 3	[4]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[5]
Classic Hodgkin lymphoma		Investigative	[1]
Neuroblastoma	2D11.2	Investigative	[1]
Retinoblastoma	2D02.2	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 460612
  ChEBI ID: CHEMBL852
  CAS Number: CAS 148-82-3
  TTD Drug ID: DMOLNHF
  VARIDT Drug ID: DR00379
  INTEDE Drug ID: DR1021
  ACDINA Drug ID: D00394

Molecule-Related Drug Atlas

Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[11]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[12]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[14]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[15]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[16]
Procarbazine	DMIK367	Hodgkin lymphoma	2B30	Approved	[17]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[18]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[19]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[23]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[26]

Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[30]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[31]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[32]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[33]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[34]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[35]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[36]

Drug(s) Affected By BICD family-like cargo adapter 2 (BICDL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By RNA-binding protein MEX3A (MEX3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[44]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Transmembrane protein 131-like (TMEM131L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Rho GTPase-activating protein 42 (ARHGAP42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Aryl hydrocarbon receptor repressor (AHRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[62]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[65]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[66]

Drug(s) Affected By Nucleolar protein 56 (NOP56)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[72]

Drug(s) Affected By Pro-neuregulin-2, membrane-bound isoform (NRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[76]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[58]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[86]

Drug(s) Affected By Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]

Drug(s) Affected By NF-kappa-B-repressing factor (NKRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[101]

Drug(s) Affected By Forkhead box protein P2 (FOXP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]
Crocin	DM5F24X	N. A.	N. A.	Phase 3	[103]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[66]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]

Drug(s) Affected By Unconventional myosin-Ib (MYO1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]

Drug(s) Affected By Ephrin-A2 (EFNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Kalirin (KALRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By NUAK family SNF1-like kinase 1 (NUAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[119]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[119]

Drug(s) Affected By TBC1 domain family member 12 (TBC1D12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[121]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[122]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By DNA polymerase zeta catalytic subunit (REV3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[126]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[127]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[131]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[133]

Drug(s) Affected By Dual specificity protein phosphatase CDC14B (CDC14B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]

Drug(s) Affected By Thiamine transporter 1 (SLC19A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Indomethacin	DMSC4A7	Bursitis		Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[142]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[143]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]

Drug(s) Affected By SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By Suppressor of cytokine signaling 5 (SOCS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Indomethacin	DMSC4A7	Bursitis		Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[146]

Drug(s) Affected By Nebulette (NEBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[58]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[149]

Drug(s) Affected By Thymocyte selection-associated high mobility group box protein TOX (TOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[151]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[58]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[153]

Drug(s) Affected By Fibrinogen silencer-binding protein (RAD54B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[154]

Drug(s) Affected By Transforming acidic coiled-coil-containing protein 2 (TACC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[156]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[160]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[166]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]

Drug(s) Affected By Transcriptional activator GLI3 (GLI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[171]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Fibroblast growth factor 5 (FGF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[172]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[173]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[174]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[175]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[176]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[177]
Suramin	DMTOUY9	African trypanosomiasis	1F51	Phase 1	[178]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Interferon regulatory factor 2 (IRF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Natriuretic peptides B (NPPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[182]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[185]

Drug(s) Affected By Troponin I, cardiac muscle (TNNI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[182]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[186]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Methamphetamine	DMPM4SK	Anxiety		Approved	[188]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase gamma (PTPRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[195]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[196]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]

Drug(s) Affected By Interleukin-12 subunit alpha (IL12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[207]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[209]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[210]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[211]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[214]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By MHC class II transactivator (CIITA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[216]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[219]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[217]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]

Drug(s) Affected By Protein AF-9 (MLLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[223]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[56]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Selenium	DM25CGV	N. A.	N. A.	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[226]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]

Drug(s) Affected By Large ribosomal subunit protein uL15 (RPL27A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[227]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[228]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[229]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[230]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[66]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]

Drug(s) Affected By Homeobox protein MOX-2 (MEOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]

Drug(s) Affected By Ephrin-A5 (EFNA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[237]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[238]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[240]

Drug(s) Affected By Growth arrest-specific protein 1 (GAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[243]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[219]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]

Drug(s) Affected By GTP-binding protein RAD (RRAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[245]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[246]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[247]

Drug(s) Affected By Serine/threonine-protein kinase SIK1 (SIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[119]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[119]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[249]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[250]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[253]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[256]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[257]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[258]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]

Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[259]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[260]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[261]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[58]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 5 (CREB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[154]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By Dystonin (DST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]

Drug(s) Affected By AT-rich interactive domain-containing protein 5A (ARID5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[262]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[263]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[171]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]

Drug(s) Affected By Homeobox protein EMX2 (EMX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[264]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[267]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[268]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[214]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By Protein CBFA2T1 (RUNX1T1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[269]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[58]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[68]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[270]

Drug(s) Affected By Nuclear factor 1 A-type (NFIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[235]

Drug(s) Affected By GRB2-associated-binding protein 1 (GAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[272]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]

Drug(s) Affected By Beta-1-syntrophin (SNTB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]

Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[273]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[274]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[272]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[275]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[276]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[210]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[277]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[279]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[279]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[126]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[280]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[282]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[284]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[284]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[286]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[291]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[292]

Drug(s) Affected By Tigger transposable element-derived protein 2 (TIGD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Fidgetin (FIGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]

Drug(s) Affected By Testis-expressed protein 30 (TEX30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[296]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]

Drug(s) Affected By Cyclin-J (CCNJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[279]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[186]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[279]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]

Drug(s) Affected By Protein furry homolog (FRY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Bortezomib	DMNO38U	Leukemia		Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[151]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[261]

Drug(s) Affected By Janus kinase and microtubule-interacting protein 3 (JAKMIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[195]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[262]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]

Drug(s) Affected By DENN domain-containing protein 4C (DENND4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Bortezomib	DMNO38U	Leukemia		Approved	[99]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[298]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[125]

Drug(s) Affected By BTB/POZ domain-containing protein 8 (BTBD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[299]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[300]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By Autophagy-related protein 16-1 (ATG16L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[287]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[301]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]

Drug(s) Affected By Protein SPT2 homolog (SPTY2D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[66]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[302]

Drug(s) Affected By Ankyrin repeat domain-containing protein 34A (ANKRD34A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By AMMECR1-like protein (AMMECR1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[263]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]

Drug(s) Affected By RPA-related protein RADX (RADX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Repulsive guidance molecule B (RGMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]

Drug(s) Affected By Alpha-(1,3)-fucosyltransferase 10 (FUT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[303]

Drug(s) Affected By Connector enhancer of kinase suppressor of ras 3 (CNKSR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[263]

Drug(s) Affected By Alpha/beta hydrolase domain-containing protein 17C (ABHD17C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[305]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[122]

Drug(s) Affected By Transmembrane protein 88 (TMEM88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[307]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Actin remodeling regulator NHS (NHS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]

Drug(s) Affected By Coiled-coil domain-containing protein 171 (CCDC171)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[309]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By BRCA1-A complex subunit Abraxas 1 (ABRAXAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[66]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[311]

Drug(s) Affected By Leucine-rich repeats and immunoglobulin-like domains protein 3 (LRIG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[125]

Drug(s) Affected By R-spondin-2 (RSPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[58]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[312]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[308]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By Protocadherin Fat 4 (FAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[170]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Thrombospondin type-1 domain-containing protein 4 (THSD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[313]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By RNA-binding protein MEX3B (MEX3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[263]

Drug(s) Affected By Zinc finger protein basonuclin-2 (BNC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]

Drug(s) Affected By Lysophospholipid acyltransferase 1 (MBOAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[315]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[316]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[298]

Drug(s) Affected By Protein MMS22-like (MMS22L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[172]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[317]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[298]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[300]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[318]

Drug(s) Affected By Transmembrane protein 26 (TMEM26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[300]

Drug(s) Affected By FYVE, RhoGEF and PH domain-containing protein 6 (FGD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[127]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[319]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[320]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[298]

Drug(s) Affected By tRNA methyltransferase 10 homolog C (TRMT10C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[321]

Drug(s) Affected By Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (EEPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[262]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF144B (RNF144B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Indomethacin	DMSC4A7	Bursitis		Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]

Drug(s) Affected By Ankyrin and armadillo repeat-containing protein (ANKAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Sprouty-related, EVH1 domain-containing protein 1 (SPRED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By PX domain-containing protein kinase-like protein (PXK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[323]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[58]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[263]

Drug(s) Affected By Pleckstrin homology-like domain family B member 2 (PHLDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By Transmembrane protein 200A (TMEM200A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[90]

Drug(s) Affected By Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Bortezomib	DMNO38U	Leukemia		Approved	[99]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[263]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Protein FAM90A1 (FAM90A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[325]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[326]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[327]

Drug(s) Affected By Copine-8 (CPNE8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[328]

Drug(s) Affected By Rho GTPase-activating protein 12 (ARHGAP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[329]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[122]

Drug(s) Affected By Cilia- and flagella-associated protein 206 (CFAP206)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]

Drug(s) Affected By Rho GTPase-activating protein 24 (ARHGAP24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[330]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[44]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[58]

Drug(s) Affected By Rho GTPase-activating protein 18 (ARHGAP18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]

Drug(s) Affected By Intraflagellar transport protein 70B (IFT70B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[122]

Drug(s) Affected By Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[332]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[324]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]

Drug(s) Affected By Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Activin receptor type-1C (ACVR1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[333]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[334]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[121]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By Methylcytosine dioxygenase TET1 (TET1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[335]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[336]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[336]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Semaphorin-6D (SEMA6D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Exocyst complex component 6 (EXOC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[298]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[121]

Drug(s) Affected By Coiled-coil domain-containing protein 110 (CCDC110)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[337]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By Protein FAM110B (FAM110B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[338]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[113]

Drug(s) Affected By Ecto-NOX disulfide-thiol exchanger 1 (ENOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[339]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[171]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By CDK5 and ABL1 enzyme substrate 1 (CABLES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF128 (RNF128)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[342]

Drug(s) Affected By Sorting nexin-29 (SNX29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[317]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[298]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[121]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[302]

Drug(s) Affected By Protein Shroom3 (SHROOM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[214]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[151]

Drug(s) Affected By Protein prune homolog 2 (PRUNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[343]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[245]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[344]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Mestranol	DMG3F94	Contraception	QA21	Approved	[129]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[129]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[196]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[196]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By PHD finger protein 3 (PHF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[245]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[346]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[263]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[68]

Drug(s) Affected By Ras-like protein family member 10A (RASL10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[347]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[348]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Disks large homolog 3 (DLG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[121]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By PHD finger protein 21A (PHF21A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[346]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]

Drug(s) Affected By AMSH-like protease (STAMBPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Haloperidol	DM96SE0	Delirium		Approved	[349]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[349]

Drug(s) Affected By ELL-associated factor 1 (EAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[90]

Drug(s) Affected By Spermatogenesis-associated protein 17 (SPATA17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[262]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[312]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[312]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[351]

Drug(s) Affected By Leucine rich adaptor protein 1 (LURAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[262]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By Transcriptional-regulating factor 1 (TRERF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[170]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[352]

Drug(s) Affected By Cbp/p300-interacting transactivator 4 (CITED4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[317]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]

Drug(s) Affected By SH3 and cysteine-rich domain-containing protein (STAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[115]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Lysosomal-trafficking regulator (LYST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[353]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[263]

Drug(s) Affected By Ras-like protein family member 11B (RASL11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[148]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[58]

Drug(s) Affected By Metastasis-associated protein MTA3 (MTA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[354]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By RNA-binding protein 24 (RBM24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[154]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[340]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[148]

Drug(s) Affected By Oxysterol-binding protein-related protein 10 (OSBPL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]

Drug(s) Affected By Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[355]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[294]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By Homeobox protein Hox-D1 (HOXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[47]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By CYFIP-related Rac1 interactor A (CYRIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[357]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By Talin rod domain-containing protein 1 (TLNRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[358]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[125]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[311]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[359]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[360]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[361]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[362]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[119]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[214]

Drug(s) Affected By Protein bicaudal C homolog 1 (BICC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[358]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[300]
Nitrobenzanthrone	DMN6L70	N. A.	N. A.	Investigative	[363]

Drug(s) Affected By GRB2-associated and regulator of MAPK protein 1 (GAREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]

Drug(s) Affected By Pleckstrin homology domain-containing family A member 5 (PLEKHA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[91]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]

Drug(s) Affected By Pleckstrin homology domain-containing family A member 2 (PLEKHA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[364]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[195]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]

Drug(s) Affected By E3 ubiquitin-protein ligase Jade-2 (JADE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[365]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[195]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[365]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[309]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[365]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[365]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]

Drug(s) Affected By Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[349]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]

Drug(s) Affected By Ankyrin repeat domain-containing protein 10 (ANKRD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[366]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[367]

Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Bortezomib	DMNO38U	Leukemia		Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By PH and SEC7 domain-containing protein 3 (PSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[353]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]

Drug(s) Affected By Formin-2 (FMN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[120]

Drug(s) Affected By Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[365]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]

Drug(s) Affected By Spermatogenesis-associated protein 7 (SPATA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By Rho GTPase-activating protein 20 (ARHGAP20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[351]

Drug(s) Affected By Coiled-coil and C2 domain-containing protein 2A (CC2D2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[294]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[368]

Drug(s) Affected By Kelch-like protein 42 (KLHL42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[365]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[365]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[365]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[44]

Drug(s) Affected By E3 ubiquitin-protein ligase HECW2 (HECW2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By FERM domain-containing protein 4A (FRMD4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[369]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[370]

Drug(s) Affected By Protein DBF4 homolog A (DBF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By Transcription factor COE1 (EBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[371]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[332]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]

Drug(s) Affected By Cdc42 effector protein 3 (CDC42EP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[253]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[322]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]

Drug(s) Affected By Myocardin-related transcription factor B (MRTFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[199]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[373]

Drug(s) Affected By Protein phosphatase 1H (PPM1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[374]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By Activator of basal transcription 1 (ABT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]

Drug(s) Affected By Trinucleotide repeat-containing gene 6B protein (TNRC6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]

Drug(s) Affected By Inactive phospholipase C-like protein 2 (PLCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[316]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[375]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[375]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]

Drug(s) Affected By Sodium channel protein type 8 subunit alpha (SCN8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[377]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[377]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[378]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[46]

Drug(s) Affected By Dexamethasone-induced Ras-related protein 1 (RASD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[324]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]

Drug(s) Affected By FERM domain-containing protein 4B (FRMD4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[338]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[298]

Drug(s) Affected By Microtubule cross-linking factor 1 (MTCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[334]

Drug(s) Affected By Rho family-interacting cell polarization regulator 2 (RIPOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[379]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[148]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[380]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[381]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[58]

Drug(s) Affected By Krueppel-like factor 12 (KLF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[225]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[264]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]

Drug(s) Affected By Fanconi anemia group G protein (FANCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[382]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[236]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[226]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[279]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[238]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[384]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[387]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[388]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[186]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[390]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[391]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[392]

Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[393]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[394]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[395]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[396]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[397]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[398]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[397]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[382]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[399]

Drug(s) Affected By Fanconi anemia group C protein (FANCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[126]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]

Drug(s) Affected By Elongator complex protein 1 (ELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[279]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[262]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Modulator	[6]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[7]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Glutathione S-transferase alpha-1 (GSTA1) Main DME	DE4ZHS1	GSTA1_HUMAN	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)	OTTK98BH	CP27B_HUMAN	Gene/Protein Processing	[9]
Actin remodeling regulator NHS (NHS)	OTKE8QAT	NHS_HUMAN	Gene/Protein Processing	[9]
Activator of basal transcription 1 (ABT1)	OT9YGIDB	ABT1_HUMAN	Gene/Protein Processing	[9]
Activin receptor type-1C (ACVR1C)	OTOTYERF	ACV1C_HUMAN	Gene/Protein Processing	[9]
Alpha-(1,3)-fucosyltransferase 10 (FUT10)	OT8TI57X	FUT10_HUMAN	Gene/Protein Processing	[9]
Alpha/beta hydrolase domain-containing protein 17C (ABHD17C)	OTB1MTOI	AB17C_HUMAN	Gene/Protein Processing	[9]
AMMECR1-like protein (AMMECR1L)	OTFPJEC1	AMERL_HUMAN	Gene/Protein Processing	[9]
AMSH-like protease (STAMBPL1)	OTI4CYTF	STALP_HUMAN	Gene/Protein Processing	[9]
Ankyrin and armadillo repeat-containing protein (ANKAR)	OTR49F4J	ANKAR_HUMAN	Gene/Protein Processing	[9]
Ankyrin repeat domain-containing protein 10 (ANKRD10)	OTIZ2VK8	ANR10_HUMAN	Gene/Protein Processing	[9]

References

• [1] Melphalan FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7620).
• [3] FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 201379.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] ClinicalTrials.gov (NCT04380376) Low-doses Melphalan Inhalation in Patients With COVID-19 (CoronavIrus Disease 2019) Pneumonia. U.S. National Institutes of Health.
• [6] Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: characterization of mono-alkylated and cross-linked products fr... Chem Biol Interact. 1990;73(2-3):183-94.
• [7] Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. Br J Cancer. 1998;77(2):201-9.
• [8] Metabolism of melphalan by rat liver microsomal glutathione S-transferase. Chem Biol Interact. 2005 Apr 15;152(2-3):101-6.
• [9] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [10] Cisplatin and DNA repair in cancer chemotherapy.Trends Biochem Sci.1995 Oct;20(10):435-9.
• [11] Structures of oxaliplatin-oligonucleotide adducts from DNA.J Mass Spectrom.2012 Oct;47(10):1282-93.
• [12] 31P NMR spectra of ethidium, quinacrine, and daunomycin complexes with poly(adenylic acid).poly(uridylic acid) RNA duplex and calf thymus DNA. Biochemistry. 1989 Apr 4;28(7):2804-12.
• [13] Pharmacokinetics and metabolism of ifosfamide in relation to DNA damage assessed by the COMET assay in children with cancer. Br J Cancer. 2005 May 9;92(9):1626-35.
• [14] O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts. Int J Cancer. 1998 Sep 11;77(6):919-22.
• [15] Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.Clin Cancer Res.2010 Oct 1;16(19):4899-905.
• [16] DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 2004 May;95(5):454-8.
• [17] Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations... DNA Repair (Amst). 2009 Jan 1;8(1):72-86.
• [18] Structural studies of atom-specific anticancer drugs acting on DNA. Pharmacol Ther. 1999 Sep;83(3):181-215.
• [19] Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mono... Melanoma Res. 2011 Dec;21(6):502-8.
• [20] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [21] MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
• [22] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [23] Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
• [24] Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
• [25] Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
• [26] Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
• [27] Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin. Mol Cancer Ther. 2008 Oct;7(10):3247-55.
• [28] Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem. 2001 Aug 31;276(35):33061-5.
• [29] Retinoid X receptor alpha regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Mol Pharmacol. 2005 Dec;68(6):1590-6.
• [30] Comparison of basal glutathione S-transferase activities and of the influence of phenobarbital, butylated hydroxy-anisole or 5,5'-diphenylhydantoin on enzyme activity in male rodents. Comp Biochem Physiol C. 1987;88(1):91-3.
• [31] Characterization and formation of the glutathione conjugate of clofibric acid. Drug Metab Dispos. 1995 Jan;23(1):119-23.
• [32] In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs. 2006 Jan;24(1):3-14.
• [33] Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood. 2004 Sep 1;104(5):1574-7.
• [34] Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5.
• [35] Purification and biochemical properties of glutathione S-transferase from Lactuca sativa. J Biochem Mol Biol. 2005 Mar 31;38(2):232-7.
• [36] Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther. 2000 Apr;67(4):432-7.
• [37] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [38] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [39] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [40] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [41] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [42] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [43] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [44] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [45] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [46] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [47] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [48] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [49] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [50] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [51] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [52] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [53] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [54] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [55] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [56] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [57] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [58] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [59] Genotoxic and epigenotoxic effects of fine particulate matter from rural and urban sites in Lebanon on human bronchial epithelial cells. Environ Res. 2015 Jan;136:352-62. doi: 10.1016/j.envres.2014.10.010. Epub 2014 Nov 25.
• [60] Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Apr;25(3):671-83.
• [61] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [62] 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 2012 Oct;120(10):1425-31. doi: 10.1289/ehp.1205412. Epub 2012 Jul 31.
• [63] Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells. Toxicology. 2011 Jul 29;285(3):97-103.
• [64] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [65] Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
• [66] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [67] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [68] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [69] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [70] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [71] Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):47-55. doi: 10.1016/j.mce.2004.04.010.
• [72] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [73] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [74] Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
• [75] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [76] Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
• [77] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [78] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [79] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [80] Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
• [81] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [82] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [83] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [84] Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
• [85] ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
• [86] Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
• [87] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [88] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [89] Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
• [90] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [91] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [92] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [93] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [94] Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
• [95] A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes. Arthritis Res Ther. 2010;12(1):R18. doi: 10.1186/ar2920. Epub 2010 Jan 29.
• [96] Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. PLoS One. 2012;7(2):e32215. doi: 10.1371/journal.pone.0032215. Epub 2012 Feb 22.
• [97] Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94. doi: 10.1038/sj.onc.1203160.
• [98] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [99] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [100] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [101] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [102] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [103] Crocin suppresses breast cancer cell proliferation by down-regulating tumor promoter miR-122-5p and up-regulating tumor suppressors FOXP2 and SPRY2. Environ Toxicol. 2023 Jul;38(7):1597-1608. doi: 10.1002/tox.23789. Epub 2023 Mar 29.
• [104] Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
• [105] Effects of 25-hydroxyvitamin D(3) on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1alpha-hydroxylase. J Bone Miner Res. 2011 May;26(5):1145-53.
• [106] Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter. Mol Endocrinol. 2004 Oct;18(10):2440-50. doi: 10.1210/me.2002-0441. Epub 2004 Jul 8.
• [107] Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage. J Biol Chem. 2007 Oct 12;282(41):29847-54.
• [108] Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
• [109] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [110] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [111] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [112] Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
• [113] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [114] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [115] Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
• [116] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [117] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [118] Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres. Int J Mol Sci. 2020 Aug 3;21(15):5564. doi: 10.3390/ijms21155564.
• [119] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [120] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [121] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [122] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [123] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [124] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [125] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [126] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [127] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [128] The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression. Biomed Pharmacother. 2016 Aug;82:595-605. doi: 10.1016/j.biopha.2016.05.029. Epub 2016 Jun 9.
• [129] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [130] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [131] Paroxetine modulates immune responses by activating a JAK2/STAT3 signaling pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22464. doi: 10.1002/jbt.22464. Epub 2020 Feb 5.
• [132] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [133] Amlodipine inhibits cell proliferation via PKD1-related pathway. Biochem Biophys Res Commun. 2008 May 2;369(2):376-81. doi: 10.1016/j.bbrc.2008.02.075. Epub 2008 Feb 25.
• [134] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [135] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [136] Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse. Int J Cancer. 2008 Apr 1;122(7):1645-56. doi: 10.1002/ijc.23280.
• [137] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [138] Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
• [139] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [140] The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
• [141] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [142] Melanogenesis and antioxidant defense system in normal human melanocytes cultured in the presence of chlorpromazine. Toxicol In Vitro. 2015 Feb;29(1):221-7.
• [143] PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells. J Cancer. 2015 Oct 29;6(12):1320-30. doi: 10.7150/jca.11126. eCollection 2015.
• [144] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [145] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [146] Glyphosate-based herbicides at low doses affect canonical pathways in estrogen positive and negative breast cancer cell lines. PLoS One. 2019 Jul 11;14(7):e0219610. doi: 10.1371/journal.pone.0219610. eCollection 2019.
• [147] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [148] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [149] Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. J Pharm Pharmacol. 2005 Jan;57(1):83-92.
• [150] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [151] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [152] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [153] Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
• [154] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [155] Identification of novel human CTL epitopes and their agonist epitopes of mesothelin. Clin Cancer Res. 2005 Sep 1;11(17):6342-51. doi: 10.1158/1078-0432.CCR-05-0596.
• [156] Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PLoS One. 2011;6(12):e28862. doi: 10.1371/journal.pone.0028862. Epub 2011 Dec 15.
• [157] Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.
• [158] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [159] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [160] Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
• [161] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [162] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [163] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [164] [Effects of As2O3 on tissue factor, plasminogen activator inhibitor-1 and -2 expression in NB4, HL-60 and THP-1 cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Oct;34(4):645-9.
• [165] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [166] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [167] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [168] Influence of Iron on Cytotoxicity and Gene Expression Profiles Induced by Arsenic in HepG2 Cells. Int J Environ Res Public Health. 2019 Nov 14;16(22):4484. doi: 10.3390/ijerph16224484.
• [169] Profile of estrogen-responsive genes in an estrogen-specific mammary gland outgrowth model. Mol Reprod Dev. 2009 Aug;76(8):733-50. doi: 10.1002/mrd.21041.
• [170] Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
• [171] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [172] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [173] Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
• [174] Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
• [175] Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. Oncogene. 1993 May;8(5):1311-6.
• [176] Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array. Pharmacogenomics. 2017 Jul;18(11):1059-1073. doi: 10.2217/pgs-2017-0046. Epub 2017 Jul 7.
• [177] A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
• [178] Increased expression of fibroblast growth factors (FGFs) and their receptor by protamine and suramin on Kaposi's sarcoma-derived cells. Anticancer Res. 1993 Jul-Aug;13(4):887-90.
• [179] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [180] Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. J Am Coll Cardiol. 2001 Apr;37(5):1228-33. doi: 10.1016/s0735-1097(01)01116-0.
• [181] Efficacy of oral sildenafil in a beraprost-treated patient with severe pulmonary hypertension secondary to type I glycogen storage disease. Circ J. 2009 Oct;73(10):1965-8. doi: 10.1253/circj.cj-08-0181. Epub 2009 Jan 27.
• [182] Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007 Jun;85(5):408-14. doi: 10.1532/IJH97.E0620.
• [183] Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart. Circulation. 2004 Sep 28;110(13):1787-93. doi: 10.1161/01.CIR.0000143072.36782.51. Epub 2004 Sep 13.
• [184] Docetaxel induced cardiotoxicity. Heart. 2001 Aug;86(2):219. doi: 10.1136/heart.86.2.219.
• [185] Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
• [186] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [187] An unexpected increase of troponin I after perphenazine depot injection. Ann Pharmacother. 2004 Feb;38(2):353-4. doi: 10.1345/aph.1D234. Epub 2003 Dec 23.
• [188] Methamphetamine-induced myocardial infarction with elevated troponin I. Am J Emerg Med. 2006 Jan;24(1):132-4. doi: 10.1016/j.ajem.2005.08.005.
• [189] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [190] Utility of troponin I in patients with cocaine-associated chest pain. Acad Emerg Med. 2002 Oct;9(10):1007-13. doi: 10.1111/j.1553-2712.2002.tb02134.x.
• [191] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [192] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [193] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [194] How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
• [195] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [196] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [197] Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
• [198] Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Mol Biol Rep. 2015 Sep;42(9):1419-29. doi: 10.1007/s11033-015-3921-7. Epub 2015 Aug 27.
• [199] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [200] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [201] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [202] Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells. Environ Toxicol. 2021 Sep;36(9):1785-1792. doi: 10.1002/tox.23299. Epub 2021 May 27.
• [203] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [204] A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
• [205] The influence of methotrexate on the gene expression of the pro-inflammatory cytokine IL-12A in the therapy of rheumatoid arthritis. Clin Exp Rheumatol. 2011 Nov-Dec;29(6):963-9. Epub 2011 Dec 22.
• [206] [Effects of vitamin A on the differentiation, maturation and functions of dendritic cells from cord blood]. Zhonghua Er Ke Za Zhi. 2004 May;42(5):340-3.
• [207] Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
• [208] Histamine inhibits the production of interleukin-12 through interaction with H2 receptors. J Clin Invest. 1998 Nov 15;102(10):1866-73. doi: 10.1172/JCI3692.
• [209] Treatment with atorvastatin alters the ratio of interleukin-12/interleukin-10 gene expression [corrected]. Eur J Clin Invest. 2003 Jan;33(1):88-91. doi: 10.1046/j.1365-2362.2003.01105.x.
• [210] Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
• [211] Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023 Feb 9;15(2):140. doi: 10.3390/toxins15020140.
• [212] Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State. Sci Rep. 2016 Mar 15;6:23071. doi: 10.1038/srep23071.
• [213] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [214] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [215] Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
• [216] Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica. 2007 Jan;92(1):115-20.
• [217] Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
• [218] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [219] Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.
• [220] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [221] Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
• [222] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [223] Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
• [224] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [225] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [226] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [227] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [228] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [229] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [230] Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
• [231] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [232] Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders. J Mol Endocrinol. 2015 Jun;54(3):289-303.
• [233] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [234] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [235] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [236] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [237] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [238] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [239] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [240] Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
• [241] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [242] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [243] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [244] Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64.
• [245] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [246] The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicol In Vitro. 2001 Aug-Oct;15(4-5):399-405. doi: 10.1016/s0887-2333(01)00043-1.
• [247] Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers. Ann Surg Oncol. 2007 Apr;14(4):1397-404. doi: 10.1245/s10434-006-9089-6. Epub 2006 Dec 29.
• [248] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [249] Role of DNA Repair Pathways in Response to Zidovudine-induced DNA Damage in Immortalized Human Liver THLE2 Cells. Int J Biomed Sci. 2013 Mar;9(1):18-25.
• [250] Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures. Biol Pharm Bull. 2018 May 1;41(5):722-732. doi: 10.1248/bpb.b17-00913. Epub 2018 Feb 14.
• [251] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [252] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [253] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [254] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [255] Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Blood. 2009 Dec 24;114(27):5512-21. doi: 10.1182/blood-2009-02-204834. Epub 2009 Oct 14.
• [256] Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol. 2012 Apr;168(1):113-24. doi: 10.1111/j.1365-2249.2011.04549.x.
• [257] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [258] Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. J Biochem Mol Toxicol. 2020 Oct;34(10):e22547. doi: 10.1002/jbt.22547. Epub 2020 Jun 26.
• [259] Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
• [260] Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
• [261] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [262] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [263] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [264] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [265] EMX2 is epigenetically silenced and suppresses growth in human lung cancer. Oncogene. 2010 Nov 4;29(44):5969-75. doi: 10.1038/onc.2010.330. Epub 2010 Aug 9.
• [266] 2,3,7,8-tetrachlorodibenzo-p-dioxin augments the modulation of gene expression mediated by the thyroid hormone receptor. Toxicol Appl Pharmacol. 2004 Feb 1;194(3):201-10. doi: 10.1016/j.taap.2003.09.010.
• [267] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [268] Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
• [269] Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
• [270] HDN-1 induces cell differentiation toward apoptosis in promyelocytic leukemia cells depending on its selective effect on client proteins of Hsp90. Toxicol Appl Pharmacol. 2021 Apr 15;417:115459. doi: 10.1016/j.taap.2021.115459. Epub 2021 Feb 17.
• [271] Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion. Mol Cancer. 2015 May 14;14:103. doi: 10.1186/s12943-015-0367-4.
• [272] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [273] Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. J Pharmacol Exp Ther. 2002 Oct;303(1):300-7. doi: 10.1124/jpet.102.036939.
• [274] Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
• [275] The THP-1 cell toolbox: a new concept integrating the key events of skin sensitization. Arch Toxicol. 2019 Apr;93(4):941-951.
• [276] Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
• [277] Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
• [278] Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery. J Interferon Cytokine Res. 2015 Mar;35(3):143-56. doi: 10.1089/jir.2014.0038. Epub 2014 Oct 16.
• [279] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [280] Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res. 2007 Dec 15;67(24):12007-17. doi: 10.1158/0008-5472.CAN-07-2464.
• [281] Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
• [282] Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
• [283] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [284] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [285] Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. Biochem Pharmacol. 2012 May 1;83(9):1172-82. doi: 10.1016/j.bcp.2012.01.017. Epub 2012 Jan 21.
• [286] Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. Apoptosis. 2007 Jan;12(1):195-209. doi: 10.1007/s10495-006-0527-5.
• [287] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [288] Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos. 2006 Feb;34(2):296-304. doi: 10.1124/dmd.105.005280. Epub 2005 Nov 9.
• [289] Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
• [290] Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
• [291] Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis. 2001 Sep;22(9):1393-7. doi: 10.1093/carcin/22.9.1393.
• [292] AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
• [293] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [294] The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
• [295] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [296] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [297] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [298] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [299] Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
• [300] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [301] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [302] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [303] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [304] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [305] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [306] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [307] Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
• [308] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [309] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [310] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [311] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [312] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [313] Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression. Reprod Biomed Online. 2011 Mar;22(3):263-71. doi: 10.1016/j.rbmo.2010.11.002. Epub 2010 Nov 13.
• [314] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [315] Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
• [316] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [317] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [318] Gene expression profile and cytotoxicity of human bronchial epithelial cells exposed to crotonaldehyde. Toxicol Lett. 2010 Aug 16;197(2):113-22.
• [319] Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer Sci. 2013 Aug;104(8):1074-82. doi: 10.1111/cas.12186. Epub 2013 Jun 10.
• [320] BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood. 2012 Oct 4;120(14):2843-52.
• [321] Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
• [322] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [323] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [324] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [325] Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-beta-dependent mechanisms. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.
• [326] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [327] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [328] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [329] Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
• [330] Real-time monitoring of cisplatin-induced cell death. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.
• [331] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [332] In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells. Arch Toxicol. 2016 Mar;90(3):677-89. doi: 10.1007/s00204-015-1483-z. Epub 2015 Feb 26.
• [333] MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance. J Cell Sci. 2011 Feb 1;124(Pt 3):359-68. doi: 10.1242/jcs.072223. Epub 2011 Jan 11.
• [334] Inter- and intra-laboratory study to determine the reproducibility of toxicogenomics datasets. Toxicology. 2011 Nov 28;290(1):50-8.
• [335] Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells. J Toxicol Sci. 2023;48(5):273-283. doi: 10.2131/jts.48.273.
• [336] Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
• [337] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [338] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [339] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [340] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [341] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [342] RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
• [343] Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
• [344] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [345] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [346] Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
• [347] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [348] Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2015 May 1;136(9):2055-64.
• [349] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [350] Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
• [351] Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
• [352] Functional identification of genes causing estrogen independence of human breast cancer cells. Breast Cancer Res Treat. 2009 Mar;114(1):23-30. doi: 10.1007/s10549-008-9969-5. Epub 2008 Mar 21.
• [353] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [354] Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue. J Steroid Biochem Mol Biol. 2005 May;95(1-5):17-23.
• [355] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [356] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [357] Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure. Toxicol Appl Pharmacol. 2016 Nov 1;310:185-194.
• [358] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [359] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [360] Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
• [361] Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. doi: 10.1016/j.bbrc.2009.12.147. Epub 2009 Dec 30.
• [362] p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochem Pharmacol. 2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
• [363] 3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway. Cell Biol Toxicol. 2022 Oct;38(5):865-887. doi: 10.1007/s10565-021-09612-1. Epub 2021 May 25.
• [364] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [365] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [366] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [367] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [368] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [369] Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect. 2015 Jan;123(1):80-7. doi: 10.1289/ehp.1408437. Epub 2014 Aug 19.
• [370] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [371] Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
• [372] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [373] Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells. Br J Nutr. 2013 Dec;110(12):2150-5.
• [374] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [375] Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
• [376] Inhibitory effects of cannabidiol on voltage-dependent sodium currents. J Biol Chem. 2018 Oct 26;293(43):16546-16558. doi: 10.1074/jbc.RA118.004929. Epub 2018 Sep 14.
• [377] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [378] Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
• [379] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [380] Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
• [381] Copper deprivation enhances the chemosensitivity of pancreatic cancer to rapamycin by mTORC1/2 inhibition. Chem Biol Interact. 2023 Sep 1;382:110546. doi: 10.1016/j.cbi.2023.110546. Epub 2023 Jun 7.
• [382] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [383] Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
• [384] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [385] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [386] Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
• [387] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [388] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [389] Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
• [390] Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
• [391] Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
• [392] Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
• [393] Differential expression of dendritic cell markers by all-trans retinoic acid on human acute promyelocytic leukemic cell line. Int Immunopharmacol. 2004 Dec 15;4(13):1587-601. doi: 10.1016/j.intimp.2004.07.010.
• [394] Suppression by (9)-tetrahydrocannabinol of the primary immunoglobulin M response by human peripheral blood B cells is associated with impaired STAT3 activation. Toxicology. 2013 Aug 9;310:84-91. doi: 10.1016/j.tox.2013.05.009. Epub 2013 May 29.
• [395] 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol. 2000 Mar 1;164(5):2405-11. doi: 10.4049/jimmunol.164.5.2405.
• [396] Tacrolimus ointment causes inflammatory dendritic epidermal cell depletion but no Langerhans cell apoptosis in patients with atopic dermatitis. J Allergy Clin Immunol. 2004 Jul;114(1):137-43. doi: 10.1016/j.jaci.2004.03.021.
• [397] 9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development. J Immunol. 2007 May 15;178(10):6130-9. doi: 10.4049/jimmunol.178.10.6130.
• [398] Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients. Exp Hematol. 2009 Jul;37(7):838-48. doi: 10.1016/j.exphem.2009.04.003. Epub 2009 May 14.
• [399] Treatment of chronic lymphocytic leukemia with a hypomethylating agent induces expression of NXF2, an immunogenic cancer testis antigen. Clin Cancer Res. 2009 May 15;15(10):3406-15. doi: 10.1158/1078-0432.CCR-08-2099. Epub 2009 Apr 28.