Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWUXDZ)

• Drug Name: Hexadecanoic acid Drug Info
• Synonyms: Palmitic acid; palmitic acid; 1957/10/3; Cetylic acid; palmitate; n-Hexadecanoic acid; Hexadecylic acid; Hydrofol; n-Hexadecoic acid; 1-Pentadecanecarboxylic acid; Pentadecanecarboxylic acid; Palmitinic acid; C16 fatty acid; hexaectylic acid; Industrene 4516; Emersol 143; Emersol 140; Hystrene 8016; Hystrene 9016; 1-Hexyldecanoic Acid; hexadecoic acid; Palmitinsaeure; Palmitic acid (natural); Palmitic acid, pure; Palmitic acid 95%; Prifac 2960; FEMA No 2832; Fatty acids, C14-18; Pristerene 4934; Edenor C16; Kortacid 1698; Lunac P; Palmitic Acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 985
  ChEBI ID: CHEMBL82293
  CAS Number: CAS 57-10-3
  TTD Drug ID: DMWUXDZ

Molecule-Related Drug Atlas

Drug(s) Targeting Fatty acid-binding protein 4 (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27109571-Compound-27	DMXRTH4	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-31	DMU690T	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-16	DMZI25U	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-14	DMVY6B9	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-25	DM435GR	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-30	DM24FSP	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-29	DMDMEHQ	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-18	DM4S5ME	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-28	DMTZVY3	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-20	DMQU9XP	N. A.	N. A.	Patented	[9]

Drug(s) Targeting Rhodopsin (RHO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[3]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[3]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[3]
Phosphonothreonine	DMTFHPI	Discovery agent	N.A.	Investigative	[3]
Beta-D-Mannose	DMHIG9K	Discovery agent	N.A.	Investigative	[3]
NSC-88915	DM9WIHJ	Solid tumour/cancer	2A00-2F9Z	Investigative	[10]
Lauryl Dimethylamine-N-Oxide	DM3W2OE	Discovery agent	N.A.	Investigative	[3]
B-2-Octylglucoside	DMEGX8H	Discovery agent	N.A.	Investigative	[3]
(Hydroxyethyloxy)Tri(Ethyloxy)Octane	DMY6FUD	Discovery agent	N.A.	Investigative	[3]
B-Nonylglucoside	DM48VJR	Discovery agent	N.A.	Investigative	[11]

Drug(s) Targeting Fatty acid-binding protein 5 (FABP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27109571-Compound-27	DMXRTH4	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-31	DMU690T	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-16	DMZI25U	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-14	DMVY6B9	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-25	DM435GR	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-30	DM24FSP	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-29	DMDMEHQ	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-18	DM4S5ME	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-28	DMTZVY3	N. A.	N. A.	Patented	[9]
PMID27109571-Compound-20	DMQU9XP	N. A.	N. A.	Patented	[9]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[18]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[19]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[15]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[13]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[15]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[18]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[19]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[22]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[32]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[38]

Drug(s) Affected By Splicing regulator ARVCF (ARVCF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Nucleolar protein 56 (NOP56)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[54]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[56]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[57]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[58]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[57]
Fructose	DM43AN2	Vomiting	MD90	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[57]

Drug(s) Affected By AT-rich interactive domain-containing protein 1A (ARID1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Indomethacin	DMSC4A7	Bursitis		Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[67]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[75]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[76]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[78]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[85]

Drug(s) Affected By Tumor protein D54 (TPD52L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[88]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[90]

Drug(s) Affected By U3 small nucleolar RNA-interacting protein 2 (RRP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[93]

Drug(s) Affected By Peroxisomal ATPase PEX1 (PEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[97]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By TBC1 domain family member 4 (TBC1D4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[100]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[101]

Drug(s) Affected By HMG box-containing protein 1 (HBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By Catenin delta-1 (CTNND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]

Drug(s) Affected By H/ACA ribonucleoprotein complex subunit DKC1 (DKC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]

Drug(s) Affected By Eukaryotic translation initiation factor 5B (EIF5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[111]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]

Drug(s) Affected By Nibrin (NBN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By Auxilin (DNAJC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[120]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[123]

Drug(s) Affected By Nuclear receptor corepressor 1 (NCOR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[128]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]

Drug(s) Affected By Sperm-associated antigen 7 (SPAG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[129]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]

Drug(s) Affected By Vesicle-trafficking protein SEC22b (SEC22B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]

Drug(s) Affected By Pre-mRNA-processing factor 40 homolog A (PRPF40A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[60]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 24 (MED24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[135]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[136]

Drug(s) Affected By Multiple PDZ domain protein (MPDZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[137]

Drug(s) Affected By Serine/threonine-protein kinase D3 (PRKD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[138]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Golgi SNAP receptor complex member 1 (GOSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[140]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[141]

Drug(s) Affected By Histone acetyltransferase KAT7 (KAT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[143]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[143]

Drug(s) Affected By SNARE-associated protein Snapin (SNAPIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[149]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[151]

Drug(s) Affected By Pericentrin (PCNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[152]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[153]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By E3 ubiquitin-protein ligase HERC2 (HERC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[140]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[158]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[159]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[163]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[169]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[172]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[173]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[174]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[175]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[172]

Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[180]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[60]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[181]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[181]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[182]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[184]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[188]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[195]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[13]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[200]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[201]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[202]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By TCF3 fusion partner (TFPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[207]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[208]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[210]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[215]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[213]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[217]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[220]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[221]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[221]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[216]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[222]
Fructose	DM43AN2	Vomiting	MD90	Approved	[59]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[223]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[224]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Haloperidol	DM96SE0	Delirium		Approved	[225]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[227]

Drug(s) Affected By Zinc finger protein 40 (HIVEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[228]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[229]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-7 (ATF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Protein SON (SON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[169]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]

Drug(s) Affected By Negative elongation factor E (NELFE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[231]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Regulator of chromosome condensation (RCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[232]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[233]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[60]

Drug(s) Affected By DNA ligase 1 (LIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[236]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[237]

Drug(s) Affected By Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]

Drug(s) Affected By B-cell lymphoma 3 protein (BCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[169]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]

Drug(s) Affected By Oxysterol-binding protein 1 (OSBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[244]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[245]

Drug(s) Affected By Cadherin-3 (CDH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[248]

Drug(s) Affected By Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[250]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[251]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[253]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[255]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[60]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[202]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[257]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[258]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[261]
Fructose	DM43AN2	Vomiting	MD90	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[266]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[267]
Bortezomib	DMNO38U	Leukemia		Approved	[268]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[269]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[270]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[273]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[275]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[276]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]

Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[140]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[279]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[280]
Haloperidol	DM96SE0	Delirium		Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[281]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[282]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[283]

Drug(s) Affected By Protein ITPRID2 (ITPRID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[284]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[285]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[270]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[286]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[287]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[288]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[269]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[140]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[273]

Drug(s) Affected By CAP-Gly domain-containing linker protein 1 (CLIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[293]

Drug(s) Affected By Alpha-adducin (ADD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[294]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[13]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[295]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[296]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[297]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]

Drug(s) Affected By Protein phosphatase inhibitor 2 (PPP1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[299]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[300]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[111]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[301]

Drug(s) Affected By 5-hydroxytryptamine receptor 2B (HTR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[303]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[266]
Bortezomib	DMNO38U	Leukemia		Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[306]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[307]

Drug(s) Affected By RNA-binding protein 34 (RBM34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[308]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[308]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[308]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[308]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[309]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[313]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[314]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[200]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[315]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[313]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[316]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[320]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[321]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[322]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[317]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[324]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[326]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]

Drug(s) Affected By Sodium- and chloride-dependent betaine transporter (SLC6A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[330]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[332]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Nuclear pore complex protein Nup153 (NUP153)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[333]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[334]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]

Drug(s) Affected By RNA-binding protein FXR2 (FXR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[335]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[336]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Transcription activator BRG1 (SMARCA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[337]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[102]

Drug(s) Affected By Arf-GAP domain and FG repeat-containing protein 1 (AGFG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[338]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[339]

Drug(s) Affected By Cysteine-rich protein 2 (CRIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Bortezomib	DMNO38U	Leukemia		Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Pancreas/duodenum homeobox protein 1 (PDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[341]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[342]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[343]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[344]
Harmine	DMPA5WD	Discovery agent	N.A.	Patented	[345]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[346]

Drug(s) Affected By Microfibrillar-associated protein 1 (MFAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[139]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[252]

Drug(s) Affected By Cadherin-15 (CDH15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[347]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[180]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[348]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[245]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[349]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[350]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[351]

Drug(s) Affected By ATP-binding cassette sub-family E member 1 (ABCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[354]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein K (HNRNPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Haloperidol	DM96SE0	Delirium		Approved	[84]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[357]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[358]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[359]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[356]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[360]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[361]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[362]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[363]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[364]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]

Drug(s) Affected By General transcription factor II-I (GTF2I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[304]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[129]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[175]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]

Drug(s) Affected By Brain acid soluble protein 1 (BASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[370]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[371]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Disabled homolog 2 (DAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[373]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[38]

Drug(s) Affected By AMP deaminase 2 (AMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[251]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[93]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[136]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[375]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[376]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[377]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[378]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[380]

Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[382]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[383]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[384]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[385]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[385]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[385]

Drug(s) Affected By 2-5A-dependent ribonuclease (RNASEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[387]

Drug(s) Affected By Exosome complex component RRP45 (EXOSC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[109]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[139]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[111]

Drug(s) Affected By Sperm-associated antigen 1 (SPAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[303]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[347]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Calmodulin-regulated spectrin-associated protein 2 (CAMSAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[131]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[111]

Drug(s) Affected By Neuroblast differentiation-associated protein AHNAK (AHNAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]

Drug(s) Affected By Nexilin (NEXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[267]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[129]

Drug(s) Affected By General transcription factor 3C polypeptide 1 (GTF3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[348]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[350]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[388]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[390]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[391]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 3 (CHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[392]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[393]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[136]

Drug(s) Affected By TP53-binding protein 1 (TP53BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[394]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[296]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[395]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[396]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[397]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[398]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[260]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[399]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[223]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[113]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[400]

Drug(s) Affected By Chromatin assembly factor 1 subunit A (CHAF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[308]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]

Drug(s) Affected By Serine/threonine-protein kinase PAK 2 (PAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[402]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]

Drug(s) Affected By Chromobox protein homolog 3 (CBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[403]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[403]
Bortezomib	DMNO38U	Leukemia		Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]

Drug(s) Affected By Ras GTPase-activating protein-binding protein 1 (G3BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[404]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]

Drug(s) Affected By Treacle protein (TCOF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[395]

Drug(s) Affected By Splicing factor 3B subunit 2 (SF3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[405]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[406]

Drug(s) Affected By Golgin subfamily A member 4 (GOLGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[85]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[291]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[407]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[409]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[410]

Drug(s) Affected By Apoptosis-stimulating of p53 protein 2 (TP53BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[36]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[411]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[412]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[90]

Drug(s) Affected By Bystin (BYSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[411]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[413]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[113]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[169]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]

Drug(s) Affected By Mediator of DNA damage checkpoint protein 1 (MDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Bortezomib	DMNO38U	Leukemia		Approved	[304]

Drug(s) Affected By Ribosomal RNA processing protein 1 homolog B (RRP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[344]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[414]

Drug(s) Affected By Nucleolar and coiled-body phosphoprotein 1 (NOLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[109]

Drug(s) Affected By Condensin complex subunit 1 (NCAPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[169]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[415]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]

Drug(s) Affected By Plectin (PLEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[416]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[417]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[418]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[169]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[169]

Drug(s) Affected By Prostaglandin E synthase 3 (PTGES3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[419]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[111]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[111]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[420]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[421]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Bortezomib	DMNO38U	Leukemia		Approved	[422]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[423]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[424]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[425]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Nuclear receptor coactivator 2 (NCOA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[427]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[125]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]

Drug(s) Affected By Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[111]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]

Drug(s) Affected By Intersectin-1 (ITSN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[398]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[429]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[430]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[431]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[45]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[432]

Drug(s) Affected By Coiled-coil domain-containing protein 6 (CCDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Bortezomib	DMNO38U	Leukemia		Approved	[304]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[433]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[434]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[436]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[437]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[438]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[316]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[440]

Drug(s) Affected By Drebrin (DBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[441]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[131]

Drug(s) Affected By Nuclear factor interleukin-3-regulated protein (NFIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[442]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[443]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[31]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[169]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[169]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[444]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[445]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[102]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[138]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[446]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[90]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Centrosome and spindle pole-associated protein 1 (CSPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Indomethacin	DMSC4A7	Bursitis		Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[448]

Drug(s) Affected By Ral GTPase-activating protein subunit alpha-2 (RALGAPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]

Drug(s) Affected By Ankyrin repeat domain-containing protein SOWAHC (SOWAHC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[449]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]

Drug(s) Affected By Cordon-bleu protein-like 1 (COBLL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[447]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]

Drug(s) Affected By Protein PRRC2B (PRRC2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[348]

Drug(s) Affected By Cytospin-B (SPECC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By FK506-binding protein 15 (FKBP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Methamphetamine	DMPM4SK	Anxiety		Approved	[450]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Transcription factor Gibbin (AHDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Regulation of nuclear pre-mRNA domain-containing protein 2 (RPRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[90]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Disabled homolog 2-interacting protein (DAB2IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[451]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[452]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By ORC ubiquitin ligase 1 (OBI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[111]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By F-box/WD repeat-containing protein 9 (FBXW9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[358]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL6IP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Ragulator complex protein LAMTOR1 (LAMTOR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[453]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[453]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[267]

Drug(s) Affected By Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[454]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[45]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[136]

Drug(s) Affected By Protein FAM117B (FAM117B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[455]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]

Drug(s) Affected By RNA polymerase-associated protein CTR9 homolog (CTR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]

Drug(s) Affected By Suprabasin (SBSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[457]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[351]

Drug(s) Affected By Activating transcription factor 7-interacting protein 1 (ATF7IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]

Drug(s) Affected By Zinc finger protein AEBP2 (AEBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[458]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Indomethacin	DMSC4A7	Bursitis		Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[459]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[350]

Drug(s) Affected By Nucleolar protein 8 (NOL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[411]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]

Drug(s) Affected By Putative Polycomb group protein ASXL2 (ASXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[460]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[386]

Drug(s) Affected By ATP-dependent RNA helicase DHX29 (DHX29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[461]

Drug(s) Affected By E3 ubiquitin-protein ligase HUWE1 (HUWE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[132]
AMG 176	DM0Q7NO	Acute myeloid leukaemia	2A60	Phase 1	[462]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]
AZD5991	DM7QGHO	Haematological malignancy	2B33.Y	Phase 1	[462]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[348]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Uncharacterized protein C11orf96 (C11ORF96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[463]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[392]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Pleckstrin homology-like domain family B member 2 (PHLDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[54]

Drug(s) Affected By Protein LYRIC (MTDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[169]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By B-cell CLL/lymphoma 9-like protein (BCL9L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[464]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[293]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Glucocorticoid-induced transcript 1 protein (GLCCI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]

Drug(s) Affected By Proline and serine-rich protein 2 (PROSER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[347]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]

Drug(s) Affected By Mitotic interactor and substrate of PLK1 (MISP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]

Drug(s) Affected By Serine/arginine repetitive matrix protein 1 (SRRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[393]

Drug(s) Affected By Oxidation resistance protein 1 (OXR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[284]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[465]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]

Drug(s) Affected By Male-specific lethal 3 homolog (MSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[467]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[143]

Drug(s) Affected By ATP-binding cassette sub-family F member 1 (ABCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[331]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[139]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[252]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[468]

Drug(s) Affected By Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[128]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[339]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Torsin-1A-interacting protein 2 (TOR1AIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[348]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By RB1-inducible coiled-coil protein 1 (RB1CC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[469]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[303]
Bortezomib	DMNO38U	Leukemia		Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[94]

Drug(s) Affected By Histone-lysine N-methyltransferase, H3 lysine-79 specific (DOT1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[396]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[350]

Drug(s) Affected By Protein Shroom3 (SHROOM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[267]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]

Drug(s) Affected By Fibroblast growth factor receptor substrate 2 (FRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[471]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[120]
AZD4547	DM3827C	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[366]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By RNA polymerase-associated protein LEO1 (LEO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Protein POF1B (POF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[472]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[386]

Drug(s) Affected By PEST proteolytic signal-containing nuclear protein (PCNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By LIM domain only protein 7 (LMO7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]

Drug(s) Affected By Piezo-type mechanosensitive ion channel component 1 (PIEZO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[473]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By TBC1 domain family member 5 (TBC1D5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[445]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[139]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[60]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[474]

Drug(s) Affected By A-kinase anchor protein 1, mitochondrial (AKAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[125]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[143]

Drug(s) Affected By Transcription factor AP-2 gamma (TFAP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[475]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[475]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Mestranol	DMG3F94	Contraception	QA21	Approved	[475]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[476]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[475]

Drug(s) Affected By Zinc finger protein ubi-d4 (DPF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[477]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[478]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[169]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[479]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[480]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[481]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[483]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[484]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[485]

Drug(s) Affected By Myocardin-related transcription factor A (MRTFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[486]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Far upstream element-binding protein 1 (FUBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[487]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[488]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]

Drug(s) Affected By Proline-rich AKT1 substrate 1 (AKT1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[489]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]

Drug(s) Affected By EF-hand domain-containing protein D2 (EFHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[490]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[180]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD12 (KCTD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[113]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[447]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[334]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[491]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]

Drug(s) Affected By Mdm2-binding protein (MTBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[266]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[393]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]

Drug(s) Affected By Enhancer of mRNA-decapping protein 3 (EDC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[300]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[492]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By RCC1-like G exchanging factor-like protein (RCC1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[347]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[344]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[350]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[493]

Drug(s) Affected By Dedicator of cytokinesis protein 7 (DOCK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[459]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Serine/threonine-protein kinase SMG1 (SMG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[494]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[495]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[496]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 2 (ASB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[284]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[497]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[180]

Drug(s) Affected By Sodium-coupled neutral amino acid symporter 2 (SLC38A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[498]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[330]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[331]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[499]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[500]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[501]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[502]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[118]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[500]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[501]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[503]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]

Drug(s) Affected By RNA-binding protein 15 (RBM15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[504]
Indomethacin	DMSC4A7	Bursitis		Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[505]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By Bifunctional polynucleotide phosphatase/kinase (PNKP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[506]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[507]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[508]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[509]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[510]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[511]

Drug(s) Affected By Metastasis-associated protein MTA3 (MTA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[512]

Drug(s) Affected By Ashwin (C2ORF49)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Replication initiator 1 (REPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[267]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[347]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[513]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[137]

Drug(s) Affected By Kanadaptin (SLC4A1AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[467]

Drug(s) Affected By Bcl-2-like protein 13 (BCL2L13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[514]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[284]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[231]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Duvelisib	DM7USVA	Follicular lymphoma	2A80	Phase 2 Trial	[515]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Protein BEX2 (BEX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[517]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[414]

Drug(s) Affected By 182 kDa tankyrase-1-binding protein (TNKS1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[518]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]

Drug(s) Affected By ATP-dependent RNA helicase DDX24 (DDX24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[519]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[513]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[415]

Drug(s) Affected By Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[520]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[131]
Bortezomib	DMNO38U	Leukemia		Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[521]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[522]

Drug(s) Affected By Activity-dependent neuroprotector homeobox protein (ADNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Indomethacin	DMSC4A7	Bursitis		Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[152]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]

Drug(s) Affected By Cdc42 effector protein 4 (CDC42EP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[499]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[499]

Drug(s) Affected By ESF1 homolog (ESF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[344]

Drug(s) Affected By Splicing factor, arginine/serine-rich 19 (SCAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[350]

Drug(s) Affected By Tensin-1 (TNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[523]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[36]

Drug(s) Affected By Mitochondrial dynamics protein MIEF1 (MIEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[524]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[415]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]

Drug(s) Affected By E3 ubiquitin-protein ligase RAD18 (RAD18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[525]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[307]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[459]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[200]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[149]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[526]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[527]

Drug(s) Affected By Midasin (MDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[128]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]

Drug(s) Affected By Protein BEX4 (BEX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[528]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[351]

Drug(s) Affected By MICOS complex subunit MIC19 (CHCHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[392]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[459]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[445]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[529]

Drug(s) Affected By BET1-like protein (BET1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[245]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By G2 and S phase-expressed protein 1 (GTSE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[173]

Drug(s) Affected By Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[266]

Drug(s) Affected By Rho guanine nucleotide exchange factor 12 (ARHGEF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[139]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[531]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[350]

Drug(s) Affected By CCR4-NOT transcription complex subunit 2 (CNOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[524]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[532]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[533]

Drug(s) Affected By Very-long-chain (HACD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[534]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]

Drug(s) Affected By Disco-interacting protein 2 homolog B (DIP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[459]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[528]

Drug(s) Affected By Ribosome-binding protein 1 (RRBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[447]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Haloperidol	DM96SE0	Delirium		Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]

Drug(s) Affected By Homologous-pairing protein 2 homolog (PSMC3IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[535]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[308]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[536]
Fructose	DM43AN2	Vomiting	MD90	Approved	[59]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[224]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[537]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[538]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[539]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[539]

Drug(s) Affected By Spastin (SPAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[386]

Drug(s) Affected By LIM domain and actin-binding protein 1 (LIMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[540]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Bortezomib	DMNO38U	Leukemia		Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]

Drug(s) Affected By Septin-9 (SEPTIN9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[541]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[455]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[542]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX20 (DDX20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Drebrin-like protein (DBNL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[543]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[245]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]

Drug(s) Affected By G patch domain-containing protein 8 (GPATCH8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[112]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]

Drug(s) Affected By Apoptotic chromatin condensation inducer in the nucleus (ACIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[544]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[131]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Nuclear pore complex protein Nup50 (NUP50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[109]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 5 (ACSL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[113]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[546]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[547]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[129]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[463]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]

Drug(s) Affected By Synergin gamma (SYNRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[477]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[130]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[533]

Drug(s) Affected By Protein NDRG2 (NDRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[523]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[129]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[451]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]

Drug(s) Affected By LIM and calponin homology domains-containing protein 1 (LIMCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[113]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[445]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]

Drug(s) Affected By Coronin-2B (CORO2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Serine/arginine repetitive matrix protein 2 (SRRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Phospholipid-transporting ATPase IF (ATP11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[472]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[454]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[339]

Drug(s) Affected By Protein SGT1 homolog (SUGT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By Coiled-coil domain-containing protein 9 (CCDC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[347]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]

Drug(s) Affected By DmX-like protein 1 (DMXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[291]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]

Drug(s) Affected By Centrosomal protein of 170 kDa protein B (CEP170B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Rap guanine nucleotide exchange factor 2 (RAPGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[96]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[339]

Drug(s) Affected By Beta/gamma crystallin domain-containing protein 1 (CRYBG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[550]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[463]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By NADPH oxidase 1 (NOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[551]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[181]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[181]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[552]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[181]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[553]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[554]

Drug(s) Affected By DnaJ homolog subfamily C member 15 (DNAJC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[120]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[555]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[556]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[48]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[557]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[558]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[559]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[560]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[561]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[128]

Drug(s) Affected By Glutaminase kidney isoform, mitochondrial (GLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[453]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[334]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[562]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[140]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[563]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[564]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[565]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[566]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[567]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[568]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[569]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[570]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fatty acid-binding protein 4 (FABP4)	TTHWMFZ	FABP4_HUMAN	Inhibitor	[2]
Fatty acid-binding protein 5 (FABP5)	TTNT2S6	FABP5_HUMAN	Inhibitor	[2]
Rhodopsin (RHO)	TTH0KSX	OPSD_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
182 kDa tankyrase-1-binding protein (TNKS1BP1)	OTBIZECQ	TB182_HUMAN	Post-Translational Modifications	[4]
2-5A-dependent ribonuclease (RNASEL)	OTP6UQUP	RN5A_HUMAN	Gene/Protein Processing	[5]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Biotransformations	[6]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Gene/Protein Processing	[7]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Gene/Protein Processing	[7]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Post-Translational Modifications	[4]
A-kinase anchor protein 1, mitochondrial (AKAP1)	OTIIB2JB	AKAP1_HUMAN	Post-Translational Modifications	[4]
A-kinase anchor protein 13 (AKAP13)	OTOZAR14	AKP13_HUMAN	Post-Translational Modifications	[4]
Abscission/NoCut checkpoint regulator	OT6V9IDI	ANCHR_HUMAN	Post-Translational Modifications	[4]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Post-Translational Modifications	[8]

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