General Information of Drug (ID: DM93VBZ)

Drug Name
LY2835219 Drug Info
Synonyms Abemaciclib; 1231929-97-7; Verzenio; LY-2835219; UNII-60UAB198HK; LY2835219 (free base);
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Solid tumour/cancer 2A00-2F9Z Phase 3 [2]
Cross-matching ID
PubChem CID
46220502
CAS Number
CAS 1231929-97-7
TTD Drug ID
DM93VBZ
VARIDT Drug ID
DR00097
INTEDE Drug ID
DR0028
ACDINA Drug ID
D00003

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Apremilast DMTWS9E Psoriasis vulgaris EA90 Approved [10]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [11]
Ribociclib Succinate DM9CIUW Breast cancer 2C60-2C65 Approved [12]
Trilaciclib DMP5A4T Small-cell lung cancer 2C25.Y Approved [13]
LEE011 DMMX75K Breast cancer 2C60-2C65 Phase 3 [14]
Ro 31-7453 DM83QCL Solid tumour/cancer 2A00-2F9Z Phase 2 [15]
P276-00 DM9DJL2 Mantle cell lymphoma 2A85.5 Phase 2 [16]
P-276 DMMJUHD Breast cancer 2C60-2C65 Phase 2 [17]
G1T38 DMQO2IT Breast cancer 2C60-2C65 Phase 2 [18]
GLR2007 DM7DWLY Glioblastoma of brain 2A00.00 Phase 1/2 [19]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Apremilast DMTWS9E Psoriasis vulgaris EA90 Approved [10]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [11]
Ribociclib Succinate DM9CIUW Breast cancer 2C60-2C65 Approved [12]
Trilaciclib DMP5A4T Small-cell lung cancer 2C25.Y Approved [13]
LEE011 DMMX75K Breast cancer 2C60-2C65 Phase 3 [14]
G1T38 DMQO2IT Breast cancer 2C60-2C65 Phase 2 [18]
GLR2007 DM7DWLY Glioblastoma of brain 2A00.00 Phase 1/2 [19]
FCN-437 DMQ8VUW Breast cancer 2C60-2C65 Phase 1/2 [20]
NUV-422 DMQJQNT Malignant glioma 2A00.0 Phase 1/2 [21]
FN-1501 DM7BMD6 Solid tumour/cancer 2A00-2F9Z Phase 1 [22]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [25]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [26]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [27]
Propranolol DM79NTF Angina pectoris BA40 Approved [28]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [29]
Metformin DM89QE1 Colorectal carcinoma Approved [30]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [28]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [31]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [32]
Metformin DM89QE1 Colorectal carcinoma Approved [33]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [32]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [32]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [34]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [32]
Topotecan DMP6G8T Central nervous system neoplasm Approved [32]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [35]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [36]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [37]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [32]
Metformin DM89QE1 Colorectal carcinoma Approved [32]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [32]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [32]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [32]
Topotecan DMP6G8T Central nervous system neoplasm Approved [32]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [36]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [32]
N-methylpyridinium DMVUKEW N. A. N. A. Preclinical [32]
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [32]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [38]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [39]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [40]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [41]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [42]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [43]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [39]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
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Drug(s) Affected By Tripeptidyl-peptidase 1 (TPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Selenium DM25CGV N. A. N. A. Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [53]
Gentamicin DMKINJO Bacteremia 1A73 Approved [54]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [55]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [59]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [60]
Panobinostat DM58WKG Chronic graft versus host disease Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
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Drug(s) Affected By Securin (PTTG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Leflunomide DMR8ONJ Arthritis FA20 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [78]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [80]
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Drug(s) Affected By Apolipoprotein E (APOE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [83]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
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Drug(s) Affected By Fibrinogen beta chain (FGB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [88]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [89]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [90]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [91]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [92]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [93]
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Drug(s) Affected By Fibrinogen gamma chain (FGG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [96]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [97]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [88]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [98]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [94]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [102]
Panobinostat DM58WKG Chronic graft versus host disease Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [104]
Menthol DMG2KW7 Back pain ME84.Z Approved [105]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [106]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [107]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [108]
Gefitinib DM15F0X Colon adenocarcinoma Approved [109]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [111]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [112]
Methotrexate DM2TEOL Anterior urethra cancer Approved [113]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [115]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [116]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [117]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [118]
Cepharanthine DM9Y5JB N. A. N. A. Approved [119]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [120]
Clozapine DMFC71L Schizophrenia 6A20 Approved [121]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [122]
Trifluoperazine DMKBYWI Anxiety Approved [123]
Olanzapine DMPFN6Y Bipolar depression Approved [121]
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Drug(s) Affected By Gamma-enolase (ENO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [124]
Estrone DM5T6US Acne vulgaris ED80 Approved [125]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [126]
Leflunomide DMR8ONJ Arthritis FA20 Approved [73]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [80]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [80]
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Drug(s) Affected By SPARC (SPARC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [129]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [6]
Ethanol DMDRQZU Chronic pain MG30 Approved [130]
Folic Acid DMEMBJC Colorectal carcinoma Approved [131]
Paclitaxel DMLB81S Breast carcinoma Approved [132]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [133]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [134]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [136]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [137]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [138]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [139]
Verapamil DMA7PEW Angina pectoris BA40 Approved [140]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [141]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [142]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [143]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [144]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [145]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [146]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [147]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [112]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [148]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [150]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [151]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [143]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [152]
Gefitinib DM15F0X Colon adenocarcinoma Approved [153]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Selenium DM25CGV N. A. N. A. Approved [48]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [155]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [156]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [78]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [157]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
Gefitinib DM15F0X Colon adenocarcinoma Approved [159]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Etretinate DM2CZFA Keratosis ED56 Approved [160]
Prednisone DM2HG4X Acute asthma CA23 Approved [161]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [162]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [75]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [163]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [164]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [165]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [166]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [167]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [168]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [169]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [171]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [172]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [6]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [53]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [88]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [174]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [175]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [176]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [177]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [178]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [179]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [180]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [181]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [134]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [172]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [139]
Verapamil DMA7PEW Angina pectoris BA40 Approved [140]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [182]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [183]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Meloxicam DM2AR7L Arthritis FA20 Approved [184]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [162]
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Drug(s) Affected By Ephrin-B3 (EFNB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [106]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [185]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [55]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [186]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [187]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [188]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [189]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [190]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [181]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [191]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [89]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [192]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [193]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [194]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [195]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [48]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [196]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [197]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [185]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [198]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [6]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [185]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [88]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [91]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [188]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [199]
Gefitinib DM15F0X Colon adenocarcinoma Approved [200]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [138]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [201]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [202]
Methotrexate DM2TEOL Anterior urethra cancer Approved [203]
Quercetin DM3NC4M Obesity 5B81 Approved [204]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [205]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [207]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Leflunomide DMR8ONJ Arthritis FA20 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [6]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [53]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [208]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclin-dependent kinase 4 (CDK4) TT0PG8F CDK4_HUMAN Modulator [3]
Cyclin-dependent kinase 6 (CDK6) TTO0FDJ CDK6_HUMAN Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug and toxin extrusion protein 2 (SLC47A2) DT3TX4H S47A2_HUMAN Substrate [4]
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [4]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Gene/Protein Processing [6]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [7]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [7]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [8]
BRCA1-associated RING domain protein 1 (BARD1) OTTC0Z9Y BARD1_HUMAN Gene/Protein Processing [6]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [8]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [7]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [6]
Ephrin-B3 (EFNB3) OT12WTXQ EFNB3_HUMAN Gene/Protein Processing [6]

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127 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
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