Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKA2YS)

• Drug Name: MG-132 Drug Info
• Synonyms: MG-132; Z-Leu-leu-leu-al; MG132; Zlllal; MG 132; Z-LLL-CHO; Zlll-cho; Z-Leu-leu-leucinal; Z-Leu-Leu-Leu-H; Z-Leu-Leu-Leu-CHO; Carbobenzoxy-leucyl-leucyl-leucinal; UNII-RF1P63GW3K; Benzyloxycarbonyl-leu-leu-leu-aldehyde; Benzyloxycarbonyl-leucyl-leucyl-leucinal; Lll cpd; Carbobenzoxyl-leucinyl-leucinyl-leucinal-H; Cbz-Leu-Leu-Leu-H; Benzyloxycarbonylleucyl-leucyl-leucine aldehyde; benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate; RF1P63GW3K
• Cross-matching ID:
  PubChem CID: 462382
  ChEBI ID: CHEBI:75142
  CAS Number: CAS 133407-82-6
  TTD Drug ID: DMKA2YS
  VARIDT Drug ID: DR01613

Molecule-Related Drug Atlas

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[3]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[5]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[6]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[5]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[5]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[7]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[5]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[9]

Drug(s) Affected By Carbonyl reductase 3 (CBR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Bortezomib	DMNO38U	Leukemia		Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[10]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Glutathione S-transferase A2 (GSTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[19]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[25]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[26]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[27]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase A (PPIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[42]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[42]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[30]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[45]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[53]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[54]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[55]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[56]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[57]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[60]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[61]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Fructose	DM43AN2	Vomiting	MD90	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[78]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[80]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[82]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[86]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[82]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[88]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[89]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[90]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[90]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[94]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[88]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[96]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[97]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[95]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[88]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[104]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[105]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[106]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[112]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[113]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]

Drug(s) Affected By Transcription factor Sp3 (SP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[119]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[121]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By HCLS1-associated protein X-1 (HAX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[125]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[126]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[127]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[128]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[131]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[134]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 11 (PSMD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[139]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[141]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 12 (PSMD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Bortezomib	DMNO38U	Leukemia		Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 14 (PSMD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[149]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[150]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[153]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[151]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[156]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[155]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[161]

Drug(s) Affected By Proteasome subunit alpha type-7 (PSMA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[165]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[166]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[167]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[183]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[184]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[185]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[188]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[196]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[197]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[198]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[202]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[198]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[203]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[140]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 3 (PSMD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[167]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[205]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[206]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[207]

Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[212]
Bortezomib	DMNO38U	Leukemia		Approved	[213]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[214]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[216]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[217]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[218]
Methamphetamine	DMPM4SK	Anxiety		Approved	[219]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[222]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[223]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[224]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[29]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[222]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[226]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[227]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[228]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[226]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[227]

Drug(s) Affected By Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[230]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[230]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[230]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[230]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[231]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[234]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[104]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[241]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[239]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[80]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]

Drug(s) Affected By Pre-mRNA-splicing factor SPF27 (BCAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[149]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[205]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Ketoprofen	DMRKXPT	Bursitis		Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[253]
Haloperidol	DM96SE0	Delirium		Approved	[68]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[189]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[256]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[257]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[258]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[260]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[261]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[262]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[263]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[264]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Selenium	DM25CGV	N. A.	N. A.	Approved	[268]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[269]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[271]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Selenium	DM25CGV	N. A.	N. A.	Approved	[274]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[275]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[276]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[280]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[283]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[284]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[286]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[289]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[291]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[292]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[296]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[297]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[298]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[299]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[300]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[301]
Fructose	DM43AN2	Vomiting	MD90	Approved	[68]
Ketoprofen	DMRKXPT	Bursitis		Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[303]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[304]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[305]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[307]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[309]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[64]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[310]
Selenium	DM25CGV	N. A.	N. A.	Approved	[311]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[312]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[313]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[315]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[317]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[319]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[320]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[321]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[322]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[323]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[264]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[324]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[325]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[326]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[323]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[327]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[329]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[330]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[331]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[332]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[271]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[333]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[334]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[335]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[336]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[338]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[339]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[340]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[341]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[342]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[343]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[344]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[346]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[347]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[307]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[310]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[348]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[349]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[351]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[352]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[353]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[354]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[355]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[356]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[357]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[358]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[359]
Selenium	DM25CGV	N. A.	N. A.	Approved	[360]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[364]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[365]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[368]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[370]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Annexin A2 (ANXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[371]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[374]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[375]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[344]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[376]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[377]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[378]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[376]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[344]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[379]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[346]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[380]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[381]
Selenium	DM25CGV	N. A.	N. A.	Approved	[382]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[383]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[385]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[386]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[387]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[390]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[391]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[390]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[392]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[393]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[394]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[395]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[396]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[397]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[346]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[398]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[399]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[64]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[189]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[400]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[401]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[401]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[401]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[401]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[403]

Drug(s) Affected By Retinol-binding protein 3 (RBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[404]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[405]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[407]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[409]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[30]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[410]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[411]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[412]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[413]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[414]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[415]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[416]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[417]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[418]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[418]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[419]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]

Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[420]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[421]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[422]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Bortezomib	DMNO38U	Leukemia		Approved	[15]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[423]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[424]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[424]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[425]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[401]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[426]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[427]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[428]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[429]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[430]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[431]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[151]

Drug(s) Affected By 26S proteasome regulatory subunit 6A (PSMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[147]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[433]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[434]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[184]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[104]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[241]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[112]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[435]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[436]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[437]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[104]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[106]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[112]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[239]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[439]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[440]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[441]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[442]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[443]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[445]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[401]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[446]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[448]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[449]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[450]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[451]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[452]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[453]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[454]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[456]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[458]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[459]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[460]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[461]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[462]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[321]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[262]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[463]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[464]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[275]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[465]

Drug(s) Affected By Proteasome subunit alpha type-1 (PSMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[147]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[466]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[467]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[468]

Drug(s) Affected By Proteasome subunit alpha type-2 (PSMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[469]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[470]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[471]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]

Drug(s) Affected By Proteasome subunit alpha type-3 (PSMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[472]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[473]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[466]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[224]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[474]

Drug(s) Affected By Proteasome subunit alpha type-4 (PSMA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[466]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[475]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[165]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[407]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[167]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[206]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[68]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[476]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[381]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[477]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[478]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[174]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[479]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[480]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[481]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[482]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[483]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[484]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[265]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[485]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[144]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[486]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[487]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[170]

Drug(s) Affected By Proteasome subunit beta type-9 (PSMB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[488]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[448]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[489]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[490]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[491]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[492]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[488]

Drug(s) Affected By Proteasome subunit alpha type-5 (PSMA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[493]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[472]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[466]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[224]

Drug(s) Affected By Proteasome subunit beta type-4 (PSMB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[495]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[496]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[497]

Drug(s) Affected By Proteasome subunit beta type-6 (PSMB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[499]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[500]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[475]

Drug(s) Affected By Proteasome subunit beta type-5 (PSMB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[501]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[500]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[503]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[29]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[503]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]

Drug(s) Affected By Cystatin-D (CST5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[505]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[425]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[407]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[506]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[507]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[508]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[509]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[510]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[472]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[511]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[511]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[512]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[513]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[341]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[462]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[514]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[515]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[516]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[275]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[517]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[518]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[519]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[520]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[521]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[522]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[523]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[524]

Drug(s) Affected By Polycomb complex protein BMI-1 (BMI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[525]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[526]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[527]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[528]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[529]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[158]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[410]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[530]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]

Drug(s) Affected By Copper-transporting ATPase 2 (ATP7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[531]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[532]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[533]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[534]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[535]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[536]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[537]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[538]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[482]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[113]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[539]

Drug(s) Affected By 26S proteasome regulatory subunit 7 (PSMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[540]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[541]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[542]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[543]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[544]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[546]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[547]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[548]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[284]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[550]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Bortezomib	DMNO38U	Leukemia		Approved	[551]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[552]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By Proteasome subunit beta type-10 (PSMB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[488]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[289]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[490]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[553]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[554]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[555]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[553]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[556]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[453]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[454]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[557]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[275]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[558]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[559]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[439]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[560]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[561]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[562]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[338]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[563]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[564]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[565]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[566]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[567]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[476]

Drug(s) Affected By 26S proteasome regulatory subunit 6B (PSMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Bortezomib	DMNO38U	Leukemia		Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[568]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[569]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[262]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[570]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[571]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[572]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[573]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[574]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[575]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[576]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[577]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[578]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[579]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[580]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[581]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[582]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[381]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[348]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[583]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[584]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[585]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[587]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[588]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[170]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[589]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[590]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[591]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 8 (PSMD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[470]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[592]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[593]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[594]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[595]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[595]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]

Drug(s) Affected By Proteasome subunit beta type-3 (PSMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[165]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[29]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[166]

Drug(s) Affected By Proteasome subunit beta type-2 (PSMB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[596]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[466]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[497]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[597]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[598]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[599]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[600]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[601]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[241]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[239]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[239]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[602]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[239]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[239]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[602]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[603]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[604]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[605]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[606]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[607]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[608]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[608]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[609]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[610]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[611]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[341]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[612]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[613]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[614]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[615]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[616]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[292]

Drug(s) Affected By Proteasome subunit alpha type-6 (PSMA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[568]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[466]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[617]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[136]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[618]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[167]

Drug(s) Affected By 26S proteasome regulatory subunit 4 (PSMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[619]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[29]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[166]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[127]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[612]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[620]

Drug(s) Affected By 26S proteasome regulatory subunit 8 (PSMC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[147]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[127]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[167]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[205]

Drug(s) Affected By 26S proteasome regulatory subunit 10B (PSMC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[184]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[621]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[622]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Glutathione S-transferase omega-1 (GSTO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[623]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[472]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[624]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[625]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[472]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[580]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[626]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[627]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[628]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[404]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[629]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[630]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[630]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[631]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[632]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[630]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[630]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[630]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[630]

Drug(s) Affected By Protein SET (SET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[633]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[285]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[495]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[634]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[635]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[636]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[637]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[638]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[639]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[178]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[640]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[462]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[641]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[642]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[643]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[634]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[590]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[644]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]

Drug(s) Affected By Heat shock factor protein 2 (HSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Bortezomib	DMNO38U	Leukemia		Approved	[645]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[166]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[138]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[462]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[510]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[646]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[479]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[647]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[648]

Drug(s) Affected By Sex-determining region Y protein (SRY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[649]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[425]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[650]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[407]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[205]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[170]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[651]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[652]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[653]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[654]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[655]

Drug(s) Affected By Proteasome activator complex subunit 1 (PSME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[656]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Recombining binding protein suppressor of hairless (RBPJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[612]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[580]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[657]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[223]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[622]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[341]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[658]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[659]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[660]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[363]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[303]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[189]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[232]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[661]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[415]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[662]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[197]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[663]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[470]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[524]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[170]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[664]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[665]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[319]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[292]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[401]

Drug(s) Affected By TAR DNA-binding protein 43 (TARDBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[666]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[667]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[668]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[387]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[669]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 2 (PSMD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[29]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[407]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[136]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[205]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[670]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[476]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[612]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[671]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[673]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[674]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[675]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[676]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[170]

Drug(s) Affected By Transcription factor E2F2 (E2F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[334]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[677]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]

Drug(s) Affected By Reticulocalbin-2 (RCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[292]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[678]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[679]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[149]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[680]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[681]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[540]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[682]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[683]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[684]

Drug(s) Affected By Phosphatidate phosphatase LPIN1 (LPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[685]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[250]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[686]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[15]

Drug(s) Affected By Proteasome activator complex subunit 4 (PSME4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[284]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[377]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 6 (PSMD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[224]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[141]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[99]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[167]

Drug(s) Affected By Prostaglandin E synthase 3 (PTGES3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[497]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[475]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[475]

Drug(s) Affected By ELAV-like protein 1 (ELAVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[687]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[688]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[688]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[689]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[473]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[690]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[380]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[169]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[429]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[430]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[691]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[692]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[693]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[694]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[695]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[696]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[697]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[698]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[699]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[700]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[701]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[701]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[702]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[703]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[704]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[415]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[685]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[457]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[705]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[706]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[649]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[707]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[708]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[709]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[710]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[711]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[346]

Drug(s) Affected By Rab-like protein 6 (RABL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[224]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[125]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[136]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[712]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[136]

Drug(s) Affected By Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[147]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[683]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF144B (RNF144B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[86]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[713]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Indomethacin	DMSC4A7	Bursitis		Approved	[714]

Drug(s) Affected By FUN14 domain-containing protein 1 (FUNDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[715]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[407]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[205]

Drug(s) Affected By Regulatory-associated protein of mTOR (RPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[612]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[15]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[716]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[717]

Drug(s) Affected By COMM domain-containing protein 1 (COMMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[718]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[127]
CLIOQUINOL	DM746BZ	N. A.	N. A.	Withdrawn from market	[719]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[612]
BRN-3548355	DM4KXT0	N. A.	N. A.	Investigative	[720]

Drug(s) Affected By Programmed cell death 6-interacting protein (PDCD6IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[721]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[722]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[723]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[718]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[724]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[725]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[726]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[727]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[728]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[729]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[730]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[731]
Mestranol	DMG3F94	Contraception	QA21	Approved	[732]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[733]

Drug(s) Affected By Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[734]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[585]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[735]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[736]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[737]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[621]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[738]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[25]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[739]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[740]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[741]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[621]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[742]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]

Drug(s) Affected By Histone acetyltransferase KAT5 (KAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[743]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[744]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[738]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[745]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[743]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[52]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[746]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[289]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[671]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[170]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[589]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[671]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[80]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]

Drug(s) Affected By Proteasome subunit beta type-7 (PSMB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[147]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[747]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[500]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 1 (PSMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[470]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[748]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[166]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[749]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[155]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]

Drug(s) Affected By Equilibrative nucleoside transporter 1 (SLC29A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[750]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[751]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[752]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[419]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[753]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[754]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[755]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[755]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[756]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[757]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[757]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[757]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[757]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[757]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[757]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[757]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[757]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[757]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[453]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[557]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[758]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[112]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[759]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[760]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[761]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[439]

Drug(s) Affected By Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[761]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[401]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[401]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[762]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[86]

Drug(s) Affected By Glutathione S-transferase omega-2 (GSTO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[763]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[125]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[764]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[650]

Drug(s) Affected By Thiol S-methyltransferase TMT1A (TMT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[587]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[765]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[766]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[767]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[768]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[239]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[104]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[241]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[435]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[421]
Fructose	DM43AN2	Vomiting	MD90	Approved	[769]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[770]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[771]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[602]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[772]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[772]

Drug(s) Affected By Proteasome activator complex subunit 2 (PSME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[404]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[52]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[773]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 13 (PSMD13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Bortezomib	DMNO38U	Leukemia		Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[774]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By E3 ubiquitin-protein ligase ARIH1 (ARIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[775]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[432]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[776]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[777]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[778]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[779]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[780]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[781]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[782]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[783]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[783]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[784]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[785]

Drug(s) Affected By Parkinson disease protein 7 (PARK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[786]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[787]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[472]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[568]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[679]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[788]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[789]

Drug(s) Affected By Polyamine-transporting ATPase 13A2 (ATP13A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[683]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[790]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[791]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[127]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[205]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[792]
Manganese	DMKT129	N. A.	N. A.	Investigative	[790]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 1 (PSMD1)	OTW258OV	PSMD1_HUMAN	Gene/Protein Processing	[2]
26S proteasome non-ATPase regulatory subunit 11 (PSMD11)	OT8KO67V	PSD11_HUMAN	Gene/Protein Processing	[2]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Gene/Protein Processing	[2]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13)	OTNQ351N	PSD13_HUMAN	Gene/Protein Processing	[2]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14)	OTJWHMZ5	PSDE_HUMAN	Gene/Protein Processing	[2]
26S proteasome non-ATPase regulatory subunit 2 (PSMD2)	OT6HZHN7	PSMD2_HUMAN	Gene/Protein Processing	[2]
26S proteasome non-ATPase regulatory subunit 3 (PSMD3)	OT585WY8	PSMD3_HUMAN	Gene/Protein Processing	[2]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6)	OTX59EGK	PSMD6_HUMAN	Gene/Protein Processing	[2]
26S proteasome non-ATPase regulatory subunit 8 (PSMD8)	OTY6X27P	PSMD8_HUMAN	Gene/Protein Processing	[2]
26S proteasome regulatory subunit 10B (PSMC6)	OTG8997V	PRS10_HUMAN	Gene/Protein Processing	[2]

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