Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNQL17)

• Drug Name: 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE Drug Info
• Synonyms: PhIP; 105650-23-5; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine; 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; UNII-909C6UN66T; CHEBI:76290; 909C6UN66T; 1-Methyl-6-phenyl-1H-imidazo(4,5-b)pyridin-2-amine; PIQ; 2-AMINO-1-METHYL-6-PHENYL-IMIDAZO [4,5-b] PYRIDINE; 1H-Imidazo(4,5-b)pyridin-2-amine, 1-methyl-6-phenyl- (9CI); CCRIS 2954; HSDB 7768; BRN 5951264; ACMC-1BRGI; AC1Q4WMI; (3H)PhIP; AC1L1BO3; SCHEMBL151718; CHEMBL1213271; DTXSID3037628; CTK0I0185

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1530
  ChEBI ID: CHEBI:76290
  CAS Number: CAS 105650-23-5
  TTD Drug ID: DMNQL17
  VARIDT Drug ID: DR01342
  INTEDE Drug ID: DR2710

Molecule-Related Drug Atlas

Drug(s) Targeting Estrogen receptor (ESR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[9]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[10]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[10]
Estradiol Valerate	DM8MC6O	Hormone replacement therapy	8E01	Approved	[11]
Estradiol Acetate	DM07U2A	Hormone replacement therapy	8E01	Approved	[11]
Estradiol Cypionate	DM27Z5T	Hormone replacement therapy	8E01	Approved	[11]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[12]
Raloxifene	DMDKF3M	Osteoporosis	FB83.0	Approved	[13]
Ospemifene	DMC4GEI	Dyspareunia	GA12	Approved	[14]
Toremifene	DMQYUWG	Breast cancer	2C60-2C65	Approved	[15]

Drug(s) Affected By Aromatic-L-amino-acid decarboxylase (DDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[28]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[33]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[38]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[39]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[40]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[45]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[53]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[54]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[55]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[56]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[63]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[65]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[66]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[69]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[70]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[52]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[74]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[71]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[28]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[67]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[83]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[85]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[86]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[87]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[88]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[95]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[98]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[101]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[102]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[103]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[104]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[105]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[106]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[107]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[28]

Drug(s) Affected By Speedy protein E3 (SPDYE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]

Drug(s) Affected By Leucine-rich repeat and IQ domain-containing protein 3 (LRRIQ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[114]

Drug(s) Affected By Golgin subfamily A member 8A (GOLGA8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[117]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[119]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]

Drug(s) Affected By Centrosomal protein of 290 kDa (CEP290)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]

Drug(s) Affected By 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[136]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[137]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]

Drug(s) Affected By Synaptogyrin-3 (SYNGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[144]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[145]

Drug(s) Affected By NEDD4-binding protein 1 (N4BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[133]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[145]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[148]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[149]

Drug(s) Affected By Claudin-14 (CLDN14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[152]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]

Drug(s) Affected By Cytochrome b (CYTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[157]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Fialuridine	DMCIGRB	Hepatitis B virus infection	1E51.0	Phase 2	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[161]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[110]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[163]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[164]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[164]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[174]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By High affinity nerve growth factor receptor (NTRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[178]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[119]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[180]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[190]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[191]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[192]
Fructose	DM43AN2	Vomiting	MD90	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[196]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[197]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]

Drug(s) Affected By Guanine nucleotide-binding protein G(t) subunit alpha-1 (GNAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[207]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]

Drug(s) Affected By Oncostatin-M (OSM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[210]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]

Drug(s) Affected By Transcription initiation factor TFIID subunit 1 (TAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[221]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[223]

Drug(s) Affected By Protein S100-A1 (S100A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[225]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]

Drug(s) Affected By Proteinase-activated receptor 1 (F2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[228]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[229]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By CD27 antigen (CD27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[233]
Bortezomib	DMNO38U	Leukemia		Approved	[234]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[235]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Choline O-acetyltransferase (CHAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[237]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[237]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[238]
Methamphetamine	DMPM4SK	Anxiety		Approved	[239]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[241]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[242]
Elaidoylamide	DMP8VDT	Discovery agent	N.A.	Investigative	[243]

Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[157]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[250]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[249]

Drug(s) Affected By cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[117]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]

Drug(s) Affected By Hepatocyte nuclear factor 1-beta (HNF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[257]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[258]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[259]

Drug(s) Affected By C-X-C chemokine receptor type 3 (CXCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[260]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[261]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[262]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[263]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[265]

Drug(s) Affected By Cyclin-dependent kinase 9 (CDK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[268]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[269]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]

Drug(s) Affected By Holocytochrome c-type synthase (HCCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]

Drug(s) Affected By UV excision repair protein RAD23 homolog B (RAD23B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[270]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[271]
Indomethacin	DMSC4A7	Bursitis		Approved	[272]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[184]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[273]

Drug(s) Affected By Serine/threonine-protein kinase SIK1 (SIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[274]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[275]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[274]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[274]

Drug(s) Affected By A-kinase anchor protein 12 (AKAP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[265]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]

Drug(s) Affected By GRB2-associated-binding protein 1 (GAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[282]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[117]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[283]

Drug(s) Affected By Rap guanine nucleotide exchange factor 1 (RAPGEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[284]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Cyclin-dependent kinase 13 (CDK13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[270]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[285]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[286]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]

Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-13 (GNA13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[133]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[283]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD2 (KCTD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[22]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[287]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[288]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[290]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[293]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[294]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]

Drug(s) Affected By Metabotropic glutamate receptor 3 (GRM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[277]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[147]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[116]

Drug(s) Affected By Metabotropic glutamate receptor 4 (GRM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[295]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID20638279C11	DMFHS4V	Discovery agent	N.A.	Investigative	[296]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[297]
4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol	DMTMLXU	Discovery agent	N.A.	Investigative	[295]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[298]

Drug(s) Affected By Programmed cell death protein 1 (PDCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Protein NKG7 (NKG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[299]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[284]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[301]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[302]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[94]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Outer dense fiber protein 4 (ODF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Formin-binding protein 1-like (FNBP1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]

Drug(s) Affected By Tudor domain-containing protein 10 (TDRD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Superkiller complex protein 3 (SKIC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[303]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[148]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[304]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[280]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[251]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[147]

Drug(s) Affected By Lipocalin-15 (LCN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[268]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[305]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By Activating transcription factor 7-interacting protein 1 (ATF7IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[258]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[307]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]

Drug(s) Affected By Zinc finger protein basonuclin-2 (BNC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[251]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[138]

Drug(s) Affected By Membrane progestin receptor alpha (PAQR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[309]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[148]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]

Drug(s) Affected By Thioredoxin domain-containing protein 6 (NME9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By POTE ankyrin domain family member D (POTED)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[301]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PIRINIXIC ACID	DM82Y75	Pulmonary fibrosis	CB03.4	Preclinical	[310]

Drug(s) Affected By Transmembrane channel-like protein 8 (TMC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[311]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[301]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Neuron navigator 2 (NAV2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[312]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Cadherin-like protein 26 (CDH26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[144]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]

Drug(s) Affected By G-protein coupled receptor 135 (GPR135)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[307]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[119]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[314]

Drug(s) Affected By Torsin-1A-interacting protein 2 (TOR1AIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[223]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[149]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[149]

Drug(s) Affected By Tubulin--tyrosine ligase (TTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[258]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[285]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[207]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By DnaJ homolog subfamily B member 8 (DNAJB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Stonin-2 (STON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[315]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[316]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Atlastin-1 (ATL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[317]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Histone acetyltransferase KAT6B (KAT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[274]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[274]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[283]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[274]

Drug(s) Affected By Complement factor H-related protein 4 (CFHR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[207]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[318]

Drug(s) Affected By X-linked retinitis pigmentosa GTPase regulator (RPGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[276]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[285]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[320]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[148]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[149]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF34 (RNF34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[268]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[321]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]

Drug(s) Affected By X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By RNA-binding protein 14 (RBM14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[322]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[117]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]

Drug(s) Affected By Death-inducer obliterator 1 (DIDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[265]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Indomethacin	DMSC4A7	Bursitis		Approved	[272]

Drug(s) Affected By Complement C1q tumor necrosis factor-related protein 3 (C1QTNF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[301]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[307]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[119]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[207]

Drug(s) Affected By Regulating synaptic membrane exocytosis protein 4 (RIMS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[307]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[305]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[305]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[207]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[297]

Drug(s) Affected By PDZ domain-containing protein 7 (PDZD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[301]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]

Drug(s) Affected By Calcium-binding protein 39-like (CAB39L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[324]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[240]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[325]

Drug(s) Affected By Protein diaphanous homolog 3 (DIAPH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[326]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF186 (RNF186)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[327]

Drug(s) Affected By SLAIN motif-containing protein 2 (SLAIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[275]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[119]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[328]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[149]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[329]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[280]

Drug(s) Affected By Heat shock transcription factor, X-linked (HSFX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[318]

Drug(s) Affected By TBC1 domain family member 2B (TBC1D2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[258]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[330]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[251]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[331]

Drug(s) Affected By Serine/arginine repetitive matrix protein 2 (SRRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[332]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[333]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[284]

Drug(s) Affected By DDB1- and CUL4-associated factor 1 (DCAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[335]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[327]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[149]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]

Drug(s) Affected By MTRF1L release factor glutamine methyltransferase (HEMK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[336]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[338]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[340]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[341]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[342]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[343]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[344]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[345]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[346]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[347]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[350]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[351]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[352]

Drug(s) Affected By Bis(5'-adenosyl)-triphosphatase (FHIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[333]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[335]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[353]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[354]
Methamphetamine	DMPM4SK	Anxiety		Approved	[355]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[356]

Drug(s) Affected By Glycine N-methyltransferase (GNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[277]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[152]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[277]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[328]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]

Drug(s) Affected By Trafficking protein particle complex subunit 9 (TRAPPC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[284]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[268]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[357]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By BCAS3 microtubule associated cell migration factor (BCAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[335]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[284]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[357]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[359]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[148]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[149]

Drug(s) Affected By Histone-lysine N-methyltransferase SMYD3 (SMYD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[361]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[362]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[363]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[364]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[365]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[366]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[367]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[368]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[369]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]

Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[370]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[371]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[372]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[373]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[375]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[376]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[377]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[378]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[379]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[378]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[380]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[382]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[384]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[385]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[241]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[386]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[387]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[389]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[390]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[392]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[393]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[394]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[395]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[163]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[396]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[397]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[398]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[399]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[400]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[401]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[99]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[402]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[403]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[404]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[405]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[406]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[407]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[408]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[408]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[408]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[409]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[410]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[411]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[412]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[413]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[414]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[241]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[415]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[416]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[417]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[419]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[420]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[421]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[422]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[423]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[424]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[424]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[425]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[424]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[424]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[426]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[424]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[427]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[424]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[428]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[423]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[429]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[430]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[431]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[431]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[432]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[432]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[433]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[434]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[435]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[437]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[438]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[436]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[440]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[441]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[442]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[241]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[443]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[444]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[241]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[446]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[241]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[346]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[447]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[448]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[449]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[450]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[451]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[452]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[453]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[454]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[455]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[456]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[457]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[457]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[196]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[458]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[459]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[460]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[461]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[463]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[465]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[466]

Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[467]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[468]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[468]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[431]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[469]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[431]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[424]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[470]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[471]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]

Drug(s) Affected By Sulfotransferase 1B1 (SULT1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[379]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[376]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[472]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[473]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[443]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[474]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[475]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[476]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[477]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[265]

Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[478]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[478]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[478]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[471]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[328]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[309]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[479]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[480]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[481]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[482]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[483]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[484]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Fructose	DM43AN2	Vomiting	MD90	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[485]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[486]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[488]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[489]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[490]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]

Drug(s) Affected By GTPase HRas (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[491]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[492]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[493]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[494]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[495]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[496]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[497]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[498]
Fructose	DM43AN2	Vomiting	MD90	Approved	[241]
Ketoprofen	DMRKXPT	Bursitis		Approved	[241]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[499]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[500]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[501]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[502]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[258]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[241]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[503]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[504]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[505]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[506]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[507]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[508]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[509]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[510]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[511]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[512]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[513]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[514]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[515]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[516]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[517]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[518]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[514]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[519]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[520]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[521]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[522]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[523]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[524]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[525]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[526]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[527]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[528]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[529]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[484]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[530]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[531]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[532]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[533]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[534]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[39]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[535]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[536]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[537]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[538]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[539]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[540]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[541]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[542]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[397]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[489]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[543]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[461]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[544]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[545]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[546]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[548]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[549]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[550]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[551]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[552]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[553]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[554]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[555]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[556]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[557]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[558]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[554]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[559]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[560]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[561]
Selenium	DM25CGV	N. A.	N. A.	Approved	[562]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[563]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[565]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[566]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[568]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[569]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[570]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[572]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[573]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[516]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[574]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[575]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[147]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[399]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[576]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[577]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[501]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[562]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[578]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[579]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[581]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[582]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[583]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[584]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[585]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[586]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[587]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[588]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[589]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[590]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[591]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[492]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[592]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[593]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[147]

Drug(s) Affected By Arylamine N-acetyltransferase 1 (NAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[594]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[374]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[595]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[594]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[594]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[233]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[520]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[596]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[543]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[597]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[598]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[599]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[600]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[601]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[602]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[603]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[604]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[605]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[606]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[607]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[599]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[608]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[609]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[610]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[598]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[241]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[601]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[611]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[612]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[613]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[614]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[615]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[616]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[617]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[618]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[133]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[619]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[620]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[621]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[621]

Drug(s) Affected By Dual specificity protein kinase TTK (TTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]

Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[597]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[622]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[623]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[624]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[625]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[626]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[277]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[623]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[625]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[627]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[277]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[277]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[628]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[520]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[629]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[523]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[630]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[299]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[631]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]

Drug(s) Affected By Ubiquitin-conjugating enzyme E2 R1 (CDC34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[120]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[6]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[632]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[633]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]

Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[400]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[265]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[634]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[634]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[635]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[636]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[533]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[611]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[637]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[520]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[638]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[639]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[526]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[382]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[386]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[570]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[640]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[397]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[641]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[399]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[642]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[643]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[644]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[645]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[646]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[647]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[648]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[649]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[650]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[308]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[611]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[651]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[652]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[653]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[611]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[654]

Drug(s) Affected By DNA replication licensing factor MCM6 (MCM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[655]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[656]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[657]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[658]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[659]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[659]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[660]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[661]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[662]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[663]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[664]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[665]

Drug(s) Affected By Histone H3.1t (H3-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[555]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[666]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[667]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[668]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[669]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[670]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[307]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[671]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[672]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[673]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[673]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[274]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[674]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[675]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[676]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[677]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[678]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[616]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[679]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[680]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[619]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[681]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[258]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[682]
Fructose	DM43AN2	Vomiting	MD90	Approved	[683]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[684]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[685]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[686]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[687]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[687]

Drug(s) Affected By DNA polymerase kappa (POLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[129]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[688]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Guanine	DMIWLJE	N. A.	N. A.	Phase 3	[689]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[222]
MK-886	DMT0O7H	Asthma	CA23	Discontinued in Phase 2	[690]

Drug(s) Affected By DNA helicase MCM8 (MCM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[326]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[284]

Drug(s) Affected By DNA polymerase eta (POLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[332]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[335]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[265]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[691]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[691]

Drug(s) Affected By NADPH oxidase 1 (NOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[233]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[692]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[693]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[693]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[264]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[693]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[694]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[4]

Drug(s) Affected By Hemoglobin subunit beta (HBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[437]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[695]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[696]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Voxelotor	DMCS6M5	Sickle-cell disorder	3A51	Approved	[697]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[698]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[699]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[700]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[701]

Drug(s) Affected By Sulfotransferase 1A2 (SULT1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]

Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[702]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[17]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[149]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[17]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[454]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[446]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[456]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[703]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[409]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[457]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[411]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[457]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[446]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[241]

Drug(s) Affected By DNA mismatch repair protein Mlh1 (MLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[390]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[704]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[705]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[706]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[268]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[707]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[708]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[335]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[709]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[710]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[147]

Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[711]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[712]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[270]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[713]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[379]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[378]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[378]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[714]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[715]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[715]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[716]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[717]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[718]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[719]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[720]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[283]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[721]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[714]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[723]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[224]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[724]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]

Drug(s) Affected By Aryl hydrocarbon receptor repressor (AHRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[725]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[726]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[727]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[138]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[728]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[22]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[729]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[730]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[730]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[731]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[241]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[732]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[733]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[734]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[735]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[736]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[737]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[738]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[739]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[740]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[741]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[742]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[743]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[409]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[457]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[744]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[745]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Glycerol/diol dehydratase (dhaB)	DEIN8FB	H6V877_LACRE	Substrate	[2]
Glycerol/diol dehydratase (dhaB)	DE1P7EZ	A0A174P2C4_9FIRM	Substrate	[2]
Glycerol/diol dehydratase (dhaB)	DE4ZRTV	A0A174IA87_FLAPL	Substrate	[2]
Glycerol/diol dehydratase (dhaB)	DEW0ADP	A0A174DDZ6_9FIRM	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)	OTTK98BH	CP27B_HUMAN	Gene/Protein Processing	[3]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[4]
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Gene/Protein Processing	[3]
Activating transcription factor 7-interacting protein 1 (ATF7IP)	OTU6ZA7F	MCAF1_HUMAN	Gene/Protein Processing	[3]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[5]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)	OTAYZZE6	AL3A1_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[6]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[7]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[3]
Aromatic-L-amino-acid decarboxylase (DDC)	OT0TSW09	DDC_HUMAN	Gene/Protein Processing	[8]

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