Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQBEYX)

• Drug Name: PHENCYCLIDINE Drug Info
• Synonyms: 1-(1-Phenylcyclohexyl)piperidine; Angel dust; Dust; PCP (Anesthetic); Fenciclidina; Phencyclidinum; Supergrass; Cadillac; Surfer; Crystal; Tranks; Whack; Zombie dust; Magic mist; Busy bee; Piperidine, 1-(1-phenylcyclohexyl)-; Elephant tranquilizer; 1977/10/1; Superweed; Superjoint; Cycline; Sherman; Cyclones; Scuffle; Snorts; Cl-395; Sheets; Selma; Peace; Aurora borealis; Embalming fluid; Pits; Goon; Mist; Crystal joints; Wobble weed; Rocket fuel; Horse tracks; Whacky weed; Monkey dust; Killer weed; Peace weed; Peace pill

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6468
  ChEBI ID: CHEMBL275528
  CAS Number: CAS 77-10-1
  TTD Drug ID: DMQBEYX
  VARIDT Drug ID: DR00661

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2A (NMDAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[6]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[7]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[8]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[9]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[10]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[11]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[12]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[13]
L-698532	DMO9HM7	Neurological disorder	6B60	Terminated	[14]
L-695902	DMT1DNS	N. A.	N. A.	Terminated	[11]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 1 (NMDAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[15]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[16]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[17]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[7]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[8]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[9]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[18]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[11]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[12]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[13]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2B (NMDAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[19]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[17]
CP-101,606	DMIU19E	Parkinson disease	8A00.0	Phase 2	[20]
CERC-301	DMSABRI	Major depressive disorder	6A70.3	Phase 2	[21]
RGH-896	DMCHZAN	Peripheral neuropathy	8C0Z	Phase 2	[22]
MIJ821	DMN45RI	Major depressive disorder	6A70.3	Phase 2	[23]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[7]
Neu-2000	DMNJTLC	Cardiac arrest	MC82	Phase 1	[24]
EVT100	DMAKWQD	Major depressive disorder	6A70.3	Phase 1	[25]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[8]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[29]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[30]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[32]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[33]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[34]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[35]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[46]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[46]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Fructose	DM43AN2	Vomiting	MD90	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[57]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[85]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[55]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[87]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[91]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[92]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[93]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[96]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[97]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[99]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[57]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[103]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[101]

Drug(s) Affected By C-C motif chemokine 24 (CCL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[107]

Drug(s) Affected By Nucleoside diphosphate kinase, mitochondrial (NME4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[116]

Drug(s) Affected By Transcription elongation regulator 1 (TCERG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[124]

Drug(s) Affected By ADAM DEC1 (ADAMDEC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[127]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[129]

Drug(s) Affected By Carbohydrate sulfotransferase 1 (CHST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[133]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[134]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[135]
Ibrolipim	DMOPWSX	Hyperlipidaemia	5C80	Phase 2	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[137]

Drug(s) Affected By Cytohesin-interacting protein (CYTIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Bortezomib	DMNO38U	Leukemia		Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[141]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[142]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Sterol O-acyltransferase 2 (SOAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[149]
BRN-3548355	DM4KXT0	N. A.	N. A.	Investigative	[150]

Drug(s) Affected By Histone acetyltransferase KAT7 (KAT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[152]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[152]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[84]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[154]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[159]

Drug(s) Affected By Muellerian-inhibiting factor (AMH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[163]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[165]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[168]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[170]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[171]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]

Drug(s) Affected By Calpain small subunit 1 (CAPNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[178]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[179]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[180]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[182]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[184]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[43]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]

Drug(s) Affected By Large ribosomal subunit protein P1 (RPLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[191]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[192]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[137]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[193]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[107]

Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]

Drug(s) Affected By Integrin alpha-IIb (ITGA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[200]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[203]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[201]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[204]
Abciximab	DMJO6GV	Acute disease		Approved	[55]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[55]

Drug(s) Affected By Interleukin-3 (IL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[206]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[206]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[207]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[208]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[207]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[55]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[55]

Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]

Drug(s) Affected By CD63 antigen (CD63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]

Drug(s) Affected By CD48 antigen (CD48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[215]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[216]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
Manganese	DMKT129	N. A.	N. A.	Investigative	[217]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[187]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[218]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[224]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[224]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[219]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[227]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[228]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]

Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]

Drug(s) Affected By High affinity immunoglobulin gamma Fc receptor I (FCGR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[134]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[236]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[234]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By Eosinophil cationic protein (RNASE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[238]
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[239]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[238]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[240]
Arformoterol	DMYM974	Chronic obstructive pulmonary disease	CA22	Approved	[241]
Beclomethasone dipropionate	DM5NW1E	Allergic rhinitis	CA08.0	Phase 4	[242]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[224]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]

Drug(s) Affected By Ribonuclease inhibitor (RNH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[243]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[244]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[244]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[219]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[247]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[248]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[251]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[252]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[255]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[256]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[179]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[259]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[259]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[259]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[259]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[263]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[265]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[266]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[268]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[75]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[269]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[184]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[271]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[272]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[273]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[274]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[275]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[277]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[57]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[281]

Drug(s) Affected By T-complex protein 1 subunit alpha (TCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[282]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[244]

Drug(s) Affected By Phosphoglycerate mutase 1 (PGAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[285]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[286]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[287]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[192]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[288]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[293]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[294]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[295]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[281]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[297]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[299]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]

Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[301]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[302]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[294]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[303]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[303]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[304]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[206]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]

Drug(s) Affected By Parathymosin (PTMS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[305]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[307]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[308]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[309]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[308]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[312]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[308]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[315]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[315]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]

Drug(s) Affected By Fibroblast growth factor 7 (FGF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[316]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[318]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[319]

Drug(s) Affected By C-C motif chemokine 1 (CCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[320]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[321]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[322]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[135]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[323]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[324]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[325]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[326]

Drug(s) Affected By Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[329]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[332]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[334]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[335]

Drug(s) Affected By Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Haloperidol	DM96SE0	Delirium		Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[336]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[337]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[337]

Drug(s) Affected By Embryonic growth/differentiation factor 1 (GDF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[339]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[135]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[340]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[339]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[137]

Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[206]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[344]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[345]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[319]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[346]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[347]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[259]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[349]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[228]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[259]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[259]

Drug(s) Affected By RNA-binding protein FUS (FUS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[350]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[350]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]

Drug(s) Affected By Bone morphogenetic protein receptor type-1A (BMPR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[351]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[352]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[353]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[354]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[355]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[356]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[358]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[359]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[360]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[361]

Drug(s) Affected By Cyclin-F (CCNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[364]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[365]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[350]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[350]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[366]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[367]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[359]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[368]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[350]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[370]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[350]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[350]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[330]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[228]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]

Drug(s) Affected By Phosphatidylserine synthase 1 (PTDSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[123]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[152]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[152]

Drug(s) Affected By Proteasome subunit beta type-3 (PSMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[371]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[244]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[192]

Drug(s) Affected By Cysteine-rich protein 1 (CRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[372]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[373]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[374]

Drug(s) Affected By Ras association domain-containing protein 2 (RASSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[228]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]
Indomethacin	DMSC4A7	Bursitis		Approved	[376]

Drug(s) Affected By T-complex protein 1 subunit delta (CCT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[377]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[378]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[379]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Beta-defensin 1 (DEFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[380]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[286]

Drug(s) Affected By CD81 antigen (CD81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[381]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]

Drug(s) Affected By 10 kDa heat shock protein, mitochondrial (HSPE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[277]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[382]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[383]

Drug(s) Affected By Small ribosomal subunit protein uS19 (RPS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[59]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[384]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[193]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[385]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[386]

Drug(s) Affected By T-complex protein 1 subunit beta (CCT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[388]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[85]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[389]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[390]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[391]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[392]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[393]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[365]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]

Drug(s) Affected By Endonuclease III-like protein 1 (NTHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[394]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[192]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[395]

Drug(s) Affected By C-C motif chemokine 7 (CCL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[396]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[135]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[397]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[398]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[179]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[302]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[182]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[101]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[101]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[399]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[401]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[309]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[403]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[404]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[405]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[406]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[405]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]

Drug(s) Affected By Aminoacylase-1 (ACY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[407]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[73]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[408]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[409]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]

Drug(s) Affected By Sialomucin core protein 24 (CD164)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[304]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[410]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[411]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[412]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[413]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[414]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[415]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[416]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[417]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[418]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[419]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[420]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[159]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[421]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[256]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[111]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[422]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[423]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[424]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[425]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[312]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[424]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[427]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[428]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[429]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]

Drug(s) Affected By Cyclin-I (CCNI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[374]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[137]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[398]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[430]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit A (EIF3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[432]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[433]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]

Drug(s) Affected By Eukaryotic initiation factor 4A-II (EIF4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[434]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[432]

Drug(s) Affected By TNFAIP3-interacting protein 1 (TNIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[435]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[436]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[437]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[374]

Drug(s) Affected By Inorganic pyrophosphatase (PPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Haloperidol	DM96SE0	Delirium		Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[65]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[65]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[302]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]

Drug(s) Affected By Reticulocalbin-1 (RCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Haloperidol	DM96SE0	Delirium		Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[438]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[319]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[439]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[440]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[363]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[443]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[445]

Drug(s) Affected By Anti-Muellerian hormone type-2 receptor (AMHR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[434]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[446]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[339]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[339]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[137]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[447]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[449]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[350]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[450]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[308]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[451]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[308]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[73]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[215]

Drug(s) Affected By Type-1 angiotensin II receptor-associated protein (AGTRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Bortezomib	DMNO38U	Leukemia		Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[215]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[452]

Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Bortezomib	DMNO38U	Leukemia		Approved	[140]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[432]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[454]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[455]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[350]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[350]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[456]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[73]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]

Drug(s) Affected By Ribonuclease K6 (RNASE6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[457]

Drug(s) Affected By Fermitin family homolog 2 (FERMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[459]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[302]

Drug(s) Affected By C-C motif chemokine 19 (CCL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[278]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[322]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[460]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[135]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[461]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[127]

Drug(s) Affected By BAG family molecular chaperone regulator 1 (BAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[463]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[465]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[466]

Drug(s) Affected By Cbp/p300-interacting transactivator 1 (CITED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[304]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[467]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[353]

Drug(s) Affected By TNF receptor-associated factor 4 (TRAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[381]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[111]

Drug(s) Affected By Proteasome activator complex subunit 2 (PSME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[407]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[199]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[468]

Drug(s) Affected By Small ribosomal subunit protein bS1m (MRPS28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[440]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[469]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[394]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[470]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[471]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[137]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[472]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[473]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[107]

Drug(s) Affected By Caspase-14 (CASP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[474]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[475]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[107]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[476]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[477]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[478]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[479]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[480]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]

Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[330]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[304]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]

Drug(s) Affected By Tumor protein p73 (TP73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[481]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[358]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[425]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[411]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[482]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[358]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 14 (TNFSF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[483]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[199]

Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]

Drug(s) Affected By Protein sprouty homolog 1 (SPRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[159]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]

Drug(s) Affected By Pituitary homeobox 3 (PITX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[484]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[485]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[486]

Drug(s) Affected By Probable G-protein coupled receptor 32 (GPR32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[487]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[488]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[490]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[491]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[492]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[493]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[494]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[495]
Selenium	DM25CGV	N. A.	N. A.	Approved	[496]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[495]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[497]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[499]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[500]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[501]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[502]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[247]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[503]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[504]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[505]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]

Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[506]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[507]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[413]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[508]
Indomethacin	DMSC4A7	Bursitis		Approved	[376]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[376]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[440]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[407]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[441]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[509]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[510]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[510]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[510]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[510]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]

Drug(s) Affected By Glia-derived nexin (SERPINE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[511]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[512]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[513]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[513]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[514]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]

Drug(s) Affected By Neurofilament heavy polypeptide (NEFH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[515]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[516]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[517]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[518]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[519]
Selenium	DM25CGV	N. A.	N. A.	Approved	[496]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[520]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[521]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]

Drug(s) Affected By 5'-nucleotidase (NT5E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[522]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Alpha-(1,3)-fucosyltransferase 4 (FUT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[523]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[524]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[525]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[526]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[527]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[528]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[529]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[530]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[531]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[532]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[533]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[534]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[534]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[128]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[534]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[535]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[536]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[537]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[538]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[539]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[540]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[541]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[542]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[541]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[537]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[55]

Drug(s) Affected By Merlin (NF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[543]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[544]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[465]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[448]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[545]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[295]

Drug(s) Affected By Collagen alpha-1(XVIII) chain (COL18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[546]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[547]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[548]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[547]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[549]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[550]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[548]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[551]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[552]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[553]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[554]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[555]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[85]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[556]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[557]

Drug(s) Affected By LIM/homeobox protein Lhx1 (LHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Indomethacin	DMSC4A7	Bursitis		Approved	[376]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]

Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[558]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[559]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[560]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[561]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[401]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[562]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[563]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[564]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[370]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[565]

Drug(s) Affected By Eotaxin (CCL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[566]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[567]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[206]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[568]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[569]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[570]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[570]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[457]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[137]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[440]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[381]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]

Drug(s) Affected By Semaphorin-3B (SEMA3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[571]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[552]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[572]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[270]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[572]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[373]

Drug(s) Affected By Growth factor receptor-bound protein 14 (GRB14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[573]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[215]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[574]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[408]

Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[575]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[576]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]

Drug(s) Affected By Sprouty-related, EVH1 domain-containing protein 1 (SPRED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[459]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[414]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[123]

Drug(s) Affected By Homeobox protein ESX1 (ESX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[374]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[577]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]

Drug(s) Affected By Protein phosphatase Slingshot homolog 1 (SSH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[578]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[354]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[579]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[580]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[406]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[434]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Protein kinase C-binding protein NELL1 (NELL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[581]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[582]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[209]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[485]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[583]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[584]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[446]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[286]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]

Drug(s) Affected By GRIP and coiled-coil domain-containing protein 1 (GCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[466]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[572]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[137]

Drug(s) Affected By Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]

Drug(s) Affected By Mucin-4 (MUC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[585]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[586]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[587]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[588]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[586]

Drug(s) Affected By Apolipoprotein L2 (APOL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[572]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[215]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[473]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[589]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[590]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[591]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[446]

Drug(s) Affected By SH2 domain-containing protein 2A (SH2D2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[123]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[475]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[457]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[592]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[593]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[594]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[595]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[146]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[37]

Drug(s) Affected By Appetite-regulating hormone (GHRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor ionotropic NMDA 1 (NMDAR1)	TTLD29N	NMDZ1_HUMAN	Inhibitor	[2]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Inhibitor	[2]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	TTN9D8E	NMDE2_HUMAN	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)	OTPAHDGO	PLCB2_HUMAN	Gene/Protein Processing	[4]
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Gene/Protein Processing	[5]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Gene/Protein Processing	[4]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[5]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)	OTJC60Q7	THIL_HUMAN	Gene/Protein Processing	[5]
ADAM DEC1 (ADAMDEC1)	OTMT7ZMG	ADEC1_HUMAN	Gene/Protein Processing	[5]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Gene/Protein Processing	[5]
Alpha-(1,3)-fucosyltransferase 4 (FUT4)	OTIBXRTL	FUT4_HUMAN	Gene/Protein Processing	[4]
Alpha-1-antitrypsin-related protein (SERPINA2)	OT7UW9HA	A1ATR_HUMAN	Gene/Protein Processing	[4]
Aminoacylase-1 (ACY1)	OT9WU7X3	ACY1_HUMAN	Gene/Protein Processing	[5]

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