Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTYOPD)

• Drug Name: Dinoprostone Drug Info
• Synonyms: Cervidil; Dinoproston; Dinoprostona; Dinoprostonum; Prepidil; Propess; Prostenon; Prostin; Prepidil Gel; Prostarmon E;Prostin E; Dinoprostone Prostaglandin E2; Minprositin E2; Minprostin E2; PGE2; PGE2 alpha; PGE2alpha; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostarmon E2; Prostin E2; U 12062; [3H]PGE2; Alpha, PGE2; Alpha, Prostaglandin E2; BML1-F07; Cervidil (TN); Dinoprostona [INN-Spanish]; Dinoprostone beta-Cyclodextrin Clathrate; Dinoprostonum [INN-Latin]; E2 alpha, Prostaglandin; E2, Prostaglandin; E2alpha, Prostaglandin; Gel, Prepidil; L-PGE2; L-Prostaglandin E2; Prepidil (TN); Propess (TN); Prostin E2 (TN); U-12062; BMS-279654 & PGE2; Dinoprostone (JAN/USP/INN); Dinoprostone [USAN:INN:BAN:JAN]; L-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid; (15S)-Prostaglandin E2; (5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; (5Z,11.alpha.,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic; (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid; (5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate; (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate; (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid; (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid; 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-(8CI); 7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid

Indication

Disease Entry	ICD 11	Status	REF
Medical abortion	JA00.1Z	Approved	[1]

• Therapeutic Class: Prostaglandins
• Cross-matching ID:
  PubChem CID: 5280360
  ChEBI ID: CHEBI:15551
  CAS Number: CAS 363-24-6
  TTD Drug ID: DMTYOPD
  VARIDT Drug ID: DR00102
  INTEDE Drug ID: DR0511
  ACDINA Drug ID: D01006

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin E2 receptor EP2 (PTGER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[26]
Alprostadil	DMWH7NQ	Aorta coarctation		Approved	[27]
Iloprost	DMVPZBE	Pulmonary arterial hypertension	BB01.0	Approved	[28]
Omidenepag isopropyl	DMUX7Z8	Glaucoma/ocular hypertension	9C61	Approved	[29]
LAROPIPRANT	DM5FABJ	Coronary heart disease	BA80.Z	Phase 4	[30]
16,16-dimethyl-PGE2	DMNF38S	Stem cell engraftment	QB63.8	Phase 2	[31]
CP-533536	DMZEJLB	Osteoporosis	FB83.0	Phase 2	[32]
Taprenepag	DM1TSHL	Glaucoma/ocular hypertension	9C61	Phase 2	[33]
TPST-1495	DM3GSB2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[34]
PF-4418948	DMMETU8	Endometriosis	GA10	Phase 1	[2]

Drug(s) Targeting Prostaglandin F2-alpha receptor (PTGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Latanoprost	DMI5OXG	Ocular hypertension	9C61.01	Approved	[35]
BOL-303259-X	DM2EXC5	Open-angle glaucoma	9C61	Approved	[36]
Tafluprost	DMFC41K	Glaucoma/ocular hypertension	9C61	Approved	[37]
Carboprost Tromethamine	DMS3508	Abortion	JA00	Approved	[38]
Travoprost	DM20K91	Ocular hypertension	9C61.01	Approved	[39]
LAROPIPRANT	DM5FABJ	Coronary heart disease	BA80.Z	Phase 4	[30]
PGF2ALPHA-IE	DM5DAP3	Glaucoma/ocular hypertension	9C61	Phase 3	[40]
ONO-9054	DM5O6GC	Glaucoma/ocular hypertension	9C61	Phase 2	[41]
PDC-41	DM74YO8	Dysmenorrhea	GA34.3	Phase 1	[42]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[43]

Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[46]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[49]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[50]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[51]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[52]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[53]

Drug(s) Transported By Organic anion transporter 2 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[55]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[56]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[57]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[58]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[59]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[60]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[61]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[57]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[62]

Drug(s) Transported By Organic cation transporter 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[63]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[64]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[65]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[66]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[67]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[68]
Metformin	DM89QE1	Colorectal carcinoma		Approved	[69]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[67]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[60]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[70]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[73]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[72]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[74]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[75]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[76]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[77]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[74]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[78]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[82]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[83]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[84]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[85]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[86]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[67]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[82]

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[88]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[89]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[82]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[90]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[91]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[93]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[82]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[94]

Drug(s) Transported By Organic anion transporter 1 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[56]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[56]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[56]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[97]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[98]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[99]
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[100]
Tenofovir	DM1IS6U	Chronic hepatitis B virus infection		Approved	[101]

Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[56]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[103]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[104]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[105]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[106]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[107]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[108]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[109]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[110]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[172]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[60]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[60]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[173]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[173]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[174]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]

Drug(s) Transported By Organic anion transporter 4 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[112]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[56]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[113]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[62]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[114]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[115]
Levocetirizine	DMQYLGP	Allergic rhinitis	CA08.0	Approved	[116]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[8]
uric acid	DMA1MKT	Discovery agent	N.A.	Investigative	[117]

Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[120]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[107]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[121]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[122]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[123]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[124]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[125]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[126]

Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[127]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[128]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[73]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[129]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[130]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[131]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[132]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[133]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[78]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[134]

Drug(s) Transported By Organic solute transporter subunit alpha (SLC51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[5]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[5]
Taurocholic Acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[5]

Drug(s) Transported By Organic solute transporter subunit beta (SLC51B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[5]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[5]
Taurocholic Acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[5]
Sodium taurocholate	DM3GO0J	Type-2 diabetes	5A11	Phase 1/2	[135]

Drug(s) Transported By Organic anion transporting polypeptide 1C1 (SLCO1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[136]
Levothyroxine	DMHN027	Congenital hypothyroidism		Approved	[6]
[3H]estradiol-17beta-glucuronide	DM3KJ45	Discovery agent	N.A.	Investigative	[137]

Drug(s) Transported By Organic anion transporting polypeptide 2A1 (SLCO2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alprostadil	DMWH7NQ	Aorta coarctation		Approved	[138]
Iloprost	DMVPZBE	Pulmonary arterial hypertension	BB01.0	Approved	[138]
Latanoprost	DMI5OXG	Ocular hypertension	9C61.01	Approved	[139]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[138]

Drug(s) Transported By Organic anion transporting polypeptide 3A1 (SLCO3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alprostadil	DMWH7NQ	Aorta coarctation		Approved	[7]
Iloprost	DMVPZBE	Pulmonary arterial hypertension	BB01.0	Approved	[7]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[4]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[4]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[7]

Drug(s) Transported By Organic anion transporting polypeptide 4A1 (SLCO4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[140]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[141]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[4]
Taurocholic Acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[125]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[142]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[147]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[148]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[149]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[150]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[151]

Drug(s) Metabolized By Cytochrome P450 4F2 (CYP4F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fingolimod	DM5JVAN	Multiple sclerosis	8A40	Approved	[152]
Ebastine	DMH21D9	N. A.	N. A.	Phase 4	[153]
Pafuramidine	DMFKOR9	Malaria	1F40-1F45	Phase 3	[154]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[155]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[156]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Solute carrier organic anion transporter family member 2A1 (SLCO2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[161]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[162]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[163]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[164]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[165]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[167]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[160]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[55]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[55]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[55]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[55]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[55]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[60]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[168]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[182]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[183]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[184]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[185]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[193]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-1 (ATF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[195]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[198]
Pelitinib	DMIW453	Lymphoma	2A80-2A86	Phase 2	[199]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[200]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[201]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[202]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[203]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[205]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[206]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[207]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[208]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[213]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[209]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[215]
Selenium	DM25CGV	N. A.	N. A.	Approved	[216]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[217]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[218]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[219]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[221]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[208]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[222]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[221]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[225]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[227]
Selenium	DM25CGV	N. A.	N. A.	Approved	[228]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[233]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[208]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[235]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Selenium	DM25CGV	N. A.	N. A.	Approved	[228]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[237]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[240]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[241]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[242]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[244]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[245]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[162]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[249]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[222]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[253]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[254]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[254]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[255]

Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[257]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[259]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[260]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[261]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[262]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[263]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[250]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[254]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[254]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[259]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[264]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[250]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[265]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[266]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[259]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[267]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[268]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[271]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[270]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[275]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[278]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[279]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[280]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[281]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[282]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[283]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[284]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[285]

Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[286]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[287]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Bortezomib	DMNO38U	Leukemia		Approved	[289]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[290]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[290]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[291]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[292]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[298]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[299]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[300]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[303]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[304]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[307]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[308]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[309]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[312]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[313]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[314]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[315]

Drug(s) Affected By C-C motif chemokine 22 (CCL22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[317]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[319]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[320]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[321]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[322]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[324]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[325]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[326]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[209]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[209]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[330]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[331]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[332]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[271]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[334]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Selenium	DM25CGV	N. A.	N. A.	Approved	[228]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[337]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[339]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[340]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[335]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[340]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[341]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[343]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[345]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[346]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[335]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[341]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[348]
Selenium	DM25CGV	N. A.	N. A.	Approved	[349]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[350]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[351]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[353]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[354]
Fructose	DM43AN2	Vomiting	MD90	Approved	[225]
Ketoprofen	DMRKXPT	Bursitis		Approved	[225]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[356]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[357]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[235]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[358]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[359]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[360]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[361]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[362]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[364]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[365]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[366]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[367]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[363]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[368]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[369]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[371]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[372]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[373]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[375]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[225]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[377]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[378]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[379]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[380]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[381]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[382]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[383]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[387]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[388]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[389]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[390]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[392]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[393]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[394]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[395]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[396]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[397]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[398]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[362]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[363]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[399]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[360]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[395]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[396]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[400]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[401]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[403]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[404]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[405]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[406]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[242]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[407]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[285]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[409]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[215]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[410]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[411]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[412]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[413]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[285]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[414]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[415]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[209]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[409]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[416]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[418]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[419]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[420]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[420]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[409]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[421]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[422]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[423]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[424]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[225]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[425]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[426]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[356]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[427]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[378]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[428]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[429]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[430]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[432]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[433]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[434]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[416]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[419]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[435]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[420]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[436]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[420]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[437]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[409]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[208]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[438]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[394]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[439]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[440]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[360]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[445]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[419]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[446]

Drug(s) Affected By Phospholipase A2, membrane associated (PLA2G2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[447]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[388]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[448]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[434]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[388]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[449]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[450]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[451]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[452]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[454]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[454]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[314]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[455]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[337]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[457]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[458]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[299]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[459]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[225]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[461]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[463]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[464]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[465]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[466]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[360]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[396]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[467]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[468]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[470]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[365]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[471]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[472]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[473]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[474]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[356]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[475]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[476]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[477]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[478]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[308]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[479]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[474]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[480]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[481]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[473]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[225]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[356]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[475]

Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[360]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[365]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[472]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[483]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[484]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[485]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[486]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[487]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[488]
RGI-2001	DM4AC2F	Graft-versus-host disease	4B24	Phase 2	[489]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[490]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[491]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[492]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[427]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[493]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[494]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[495]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[496]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[350]

Drug(s) Affected By Cytokine receptor common subunit gamma (IL2RG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[497]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[498]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[499]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[500]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[501]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]

Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[435]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[502]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[503]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[504]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[503]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[196]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[505]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[506]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[507]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[508]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[509]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[510]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[511]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[512]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[513]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[514]

Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[515]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[516]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[367]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[517]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[518]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[402]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[367]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[339]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[519]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[520]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[502]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[436]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[521]

Drug(s) Affected By Prostaglandin E2 receptor EP4 subtype (PTGER4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[434]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[314]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[455]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[449]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[437]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[522]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[163]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[523]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[524]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[525]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[527]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[528]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[529]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[530]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[531]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[532]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[533]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[534]

Drug(s) Affected By Interleukin-12 receptor subunit beta-1 (IL12RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[535]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[523]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[536]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[500]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[537]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[538]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[539]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[342]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[437]
Dimethylallyl Diphosphate	DMP5I47	Discovery agent	N.A.	Investigative	[540]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[259]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[541]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[542]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[543]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[544]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[545]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[546]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[547]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[548]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[549]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[550]

Drug(s) Affected By Nuclear receptor ROR-gamma (RORC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[363]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[388]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[551]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[375]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[552]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[247]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[501]

Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[553]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[554]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[555]
I3C	DMIGFOR	Breast cancer	2C60-2C65	Phase 3	[556]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[557]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[322]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[555]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[553]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[437]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[225]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[394]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[396]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[558]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[559]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[560]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[404]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[561]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[378]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[326]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[508]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[562]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[563]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[432]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[565]

Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[325]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[452]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[566]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[434]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[568]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[534]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[452]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[569]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[432]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[570]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[571]

Drug(s) Affected By C-C motif chemokine 17 (CCL17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[316]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[572]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[573]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[321]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[322]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]

Drug(s) Affected By Interleukin-12 receptor subunit beta-2 (IL12RB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[574]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[575]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[576]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[577]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[578]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[535]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[537]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]

Drug(s) Affected By Interleukin-22 (IL22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[579]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[580]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[452]
SGC-CBP30	DMTLRGZ	Discovery agent	N.A.	Investigative	[581]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[363]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[242]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[582]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[289]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[242]
Bortezomib	DMNO38U	Leukemia		Approved	[583]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[196]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[242]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[242]

Drug(s) Affected By Interleukin-26 (IL26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[500]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]

Drug(s) Affected By T-box transcription factor TBX21 (TBX21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[585]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[586]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[587]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[588]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[589]
SGC-CBP30	DMTLRGZ	Discovery agent	N.A.	Investigative	[581]

Drug(s) Affected By Glycoprotein hormones alpha chain (CGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[455]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[590]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[449]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[591]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[359]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[592]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[593]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[594]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[595]

Drug(s) Affected By Short transient receptor potential channel 7 (TRPC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[596]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[597]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[598]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[599]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[434]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[600]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[601]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[314]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]

Drug(s) Affected By Prostaglandin E synthase (PTGES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[457]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[602]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[599]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[603]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[604]
Mestranol	DMG3F94	Contraception	QA21	Approved	[457]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[265]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[605]

Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[326]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[606]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[599]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[434]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[607]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[502]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[378]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[578]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[605]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[608]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[609]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[610]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[536]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[611]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[612]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[416]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[613]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[244]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[434]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[614]
Haloperidol	DM96SE0	Delirium		Approved	[225]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[615]
Selenium	DM25CGV	N. A.	N. A.	Approved	[616]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[617]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[618]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[619]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]

Drug(s) Affected By Fibroblast growth factor 20 (FGF20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[620]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[328]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[621]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[622]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[623]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[624]

Drug(s) Affected By Vasopressin V1a receptor (AVPR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[625]
Vasopressin	DMQ2FPC	Diabetes insipidus	5A61.5	Approved	[626]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[627]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[628]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[291]
Insulin	DMB7CE0	Diabetic complication	5A2Y	Approved	[225]
Alprostadil	DMWH7NQ	Aorta coarctation		Approved	[225]
Dinoprost Tromethamine	DMXQKSL	Abortion	JA00	Approved	[225]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[629]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[416]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[449]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[578]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[605]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[630]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[631]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[632]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[633]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[634]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[458]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[635]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[636]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[637]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[638]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[209]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[209]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[416]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[639]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[640]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[640]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[244]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[640]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[640]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[640]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[388]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[641]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[449]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[641]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin E2 receptor EP2 (PTGER2)	TT1ZAVI	PE2R2_HUMAN	Antagonist	[2]
Prostaglandin F2-alpha receptor (PTGFR)	TTT2ZAR	PF2R_HUMAN	Antagonist	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 5A1 (SLCO5A1)	DTYVQ5M	SO5A1_HUMAN	Substrate	[3]
Organic anion transporting polypeptide 2A1 (SLCO2A1)	DT021JD	SO2A1_HUMAN	Substrate	[4]
Organic solute transporter subunit alpha (SLC51A)	DTMEQ32	OSTA_HUMAN	Substrate	[5]
Organic anion transporting polypeptide 1C1 (SLCO1C1)	DTPYCQ4	SO1C1_HUMAN	Substrate	[6]
Organic anion transporting polypeptide 3A1 (SLCO3A1)	DTVNRXW	SO3A1_HUMAN	Substrate	[7]
Organic solute transporter subunit beta (SLC51B)	DT1V9AJ	OSTB_HUMAN	Substrate	[5]
Organic anion transporting polypeptide 4A1 (SLCO4A1)	DT8H2IC	SO4A1_HUMAN	Substrate	[4]
Organic anion transporter 2 (SLC22A7)	DT0OC1Q	S22A7_HUMAN	Substrate	[8]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[9]
Organic anion transporter 4 (SLC22A11)	DT06JWZ	S22AB_HUMAN	Substrate	[8]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[10]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[11]
Organic anion transporting polypeptide 2B1 (SLCO2B1)	DTPFTEQ	SO2B1_HUMAN	Substrate	[4]
Organic anion transporting polypeptide 1A2 (SLCO1A2)	DTE2B1D	SO1A2_HUMAN	Substrate	[12]
Organic anion transporter 1 (SLC22A6)	DTQ23VB	S22A6_HUMAN	Substrate	[8]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[13]
Organic cation transporter 2 (SLC22A2)	DT9IDPW	S22A2_HUMAN	Substrate	[11]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[8]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[14]
Cytochrome P450 4F2 (CYP4F2)	DE3GT9C	CP4F2_HUMAN	Substrate	[15]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[16]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[17]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Regulation of Drug Effects	[18]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Gene/Protein Processing	[19]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[20]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[21]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Regulation of Drug Effects	[22]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[23]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[24]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[25]

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