Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3DB8X)

• Drug Name: Icariside II Drug Info
• Synonyms: Baohuoside I; 113558-15-9; Icariside II; CHEBI:82619; Icarlin II; Baohuoside-I; Baohuoside I;; Icarisid II;; AC1NUQWY; 3,5,7-Trihydroxy-4'-methoxyl-8-prenylflavone-3-O-rhamnopyranoside; SCHEMBL4229321; CHEMBL560116; DTXSID40150457; 2h44; MolPort-020-006-007; HY-N0011; ZINC70455423; C27H30O10; CS-3673; 4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-; AK169968; anhydroicaritin-3-O-alpha-L-rhamnopyranoside; N2538; Y0106; FT-0686579; Q-100071

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5488822
  ChEBI ID: CHEBI:82619
  CAS Number: CAS 113558-15-9
  TTD Drug ID: DM3DB8X

Molecule-Related Drug Atlas

Drug(s) Targeting Phosphodiesterase 5A (PDE5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tadalafil	DMJZHT1	Benign prostatic hyperplasia	GA90	Approved	[6]
Udenafil	DM1IQRP	Erectile dysfunction	HA01.1	Approved	[7]
Vardenafil	DMTBGW8	Cystic fibrosis	CA25	Approved	[8]
Dipyridamole	DMXY30O	Atrial fibrillation	BC81.3	Approved	[9]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[10]
Avanafil	DM75CXN	Erectile dysfunction	HA01.1	Approved	[11]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[12]
ICARIIN	DMOJQGT	N. A.	N. A.	Phase 3	[1]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[13]
PF-489791	DM3C8GQ	Chronic obstructive pulmonary disease	CA22	Phase 2	[14]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[18]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[19]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[20]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[19]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[21]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Indomethacin	DMSC4A7	Bursitis		Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[32]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[33]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[35]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[36]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[38]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[39]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[40]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[41]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[46]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[48]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[50]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[52]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[53]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[54]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[56]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[18]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[58]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[59]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[60]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[63]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[68]

Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[72]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[73]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[77]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[78]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[79]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[79]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[80]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[78]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[79]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[81]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[78]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[82]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[78]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[83]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[85]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[86]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[92]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[93]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[96]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[97]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[98]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[56]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[100]

Drug(s) Affected By Serine/threonine-protein kinase B-raf (BRAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[105]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[106]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Aspartate aminotransferase, cytoplasmic (GOT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[110]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[111]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[72]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[112]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[111]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[113]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[116]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[119]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[120]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[116]

Drug(s) Affected By Alanine aminotransferase 1 (GPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[97]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[97]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[97]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[123]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[123]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[125]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[129]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[130]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[133]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[125]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[134]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[135]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[97]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[127]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[137]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[138]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[100]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[143]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[144]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[145]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[147]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[144]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[152]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[158]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[161]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[163]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[171]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[93]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[53]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[98]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[57]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[175]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[20]

Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[114]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[177]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[119]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[178]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[113]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[183]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[185]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[183]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[188]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[189]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[190]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[179]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[194]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]

Drug(s) Affected By Proline-rich AKT1 substrate 1 (AKT1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[72]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[197]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[200]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[201]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[202]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[119]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[202]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[179]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 5A (PDE5A)	TTJ0IQB	PDE5A_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Post-Translational Modifications	[2]
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Protein Interaction/Cellular Processes	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Aspartate aminotransferase, cytoplasmic (GOT1)	OTZLM5UB	AATC_HUMAN	Protein Interaction/Cellular Processes	[3]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[3]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[3]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[3]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[5]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[5]

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