Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0AFY7)

• Drug Name: Glyphosate Drug Info
• Synonyms: glyphosate; 1071-83-6; N-(Phosphonomethyl)glycine; Glyphosphate; Roundup; Glycine, N-(phosphonomethyl)-; N-Phosphonomethyl-glycine; 2-(phosphonomethylamino)acetic acid; Silglif; Pondmaster; Roundup Max; N-Phosphonomethylglycine; N-Phosphomethylglycine; Caswell No. 661A; MON 2139; C3H8NO5P; N-(Phosphonomethyl) Glycine; NSC151063; Glialka; Phosphonomethyliminoacetic acid; Mon 6000; Glyphosate [ANSI:BSI:ISO]; UNII-4632WW1X5A; CCRIS 1587; CP 67573; HSDB 3432; XDDAORKBJWWYJS-UHFFFAOYSA-N; EINECS 213-997-4; 2-((Phosphonomethyl)amino)acetic

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3496
  ChEBI ID: CHEBI:27744
  CAS Number: CAS 1071-83-6
  TTD Drug ID: DM0AFY7

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[5]
Shikimate-3-Phosphate	DMBE0CT	Discovery agent	N.A.	Investigative	[5]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[6]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[8]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[11]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[8]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[15]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[16]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[17]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[18]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[19]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[16]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[20]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[17]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[16]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Haloperidol	DM96SE0	Delirium		Approved	[22]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[26]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Protein S100-A6 (S100A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Haloperidol	DM96SE0	Delirium		Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[59]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]

Drug(s) Affected By Cartilage-associated protein (CRTAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]

Drug(s) Affected By Decapping and exoribonuclease protein (DXO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[76]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[80]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[81]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[82]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[87]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[88]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[90]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[91]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Monoacylglycerol lipase ABHD2 (ABHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Mestranol	DMG3F94	Contraception	QA21	Approved	[93]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[93]
Bortezomib	DMNO38U	Leukemia		Approved	[95]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[100]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[105]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[108]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[109]

Drug(s) Affected By Ephrin-A1 (EFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]

Drug(s) Affected By Tenascin-X (TNXB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[119]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[22]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[122]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[122]

Drug(s) Affected By Stanniocalcin-1 (STC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[127]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase S (PTPRS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[115]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[42]

Drug(s) Affected By Semaphorin-5A (SEMA5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[131]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]

Drug(s) Affected By Calicin (CCIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[134]

Drug(s) Affected By AP2-associated protein kinase 1 (AAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Baricitinib	DM4ONW5	Rheumatoid arthritis	FA20	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[141]
Mestranol	DMG3F94	Contraception	QA21	Approved	[139]

Drug(s) Affected By Cysteine-rich hydrophobic domain-containing protein 1 (CHIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[143]

Drug(s) Affected By Lipase member H (LIPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[145]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By Alpha-1,2-mannosyltransferase ALG9 (ALG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[115]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[150]

Drug(s) Affected By Immunity-related GTPase family M protein (IRGM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
Ginsenoside Re	DM46FVD	N. A.	N. A.	Investigative	[151]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[152]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[139]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]

Drug(s) Affected By Bone morphogenetic protein receptor type-1B (BMPR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[158]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[160]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[161]

Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[164]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[171]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]

Drug(s) Affected By Claudin-5 (CLDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[175]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[176]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[177]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[178]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
CS-600G	DM1PV4Y	N. A.	N. A.	Phase 3	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[181]
JWH-133	DM1DEYU	Discovery agent	N.A.	Investigative	[182]

Drug(s) Affected By Delta-like protein 1 (DLL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]

Drug(s) Affected By Transcription factor E2F3 (E2F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[185]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Suppressor of cytokine signaling 2 (SOCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[142]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-2 (DVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[190]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]
Calphostin C	DM9X2D0	N. A.	N. A.	Terminated	[193]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[205]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[154]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[206]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[209]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[154]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[210]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[214]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[215]

Drug(s) Affected By Mitogen-activated protein kinase 13 (MAPK13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[217]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[218]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]

Drug(s) Affected By Histone deacetylase 3 (HDAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[222]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[223]

Drug(s) Affected By MutS protein homolog 4 (MSH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[224]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[227]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[230]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[233]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[234]

Drug(s) Affected By N-glycosylase/DNA lyase (OGG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[237]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[238]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[218]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[224]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[239]

Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[242]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[173]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[244]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[246]

Drug(s) Affected By Ras GTPase-activating protein 4 (RASA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[248]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[249]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[250]

Drug(s) Affected By Band 4.1-like protein 2 (EPB41L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[257]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Neuronal migration protein doublecortin (DCX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[260]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[261]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[150]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[263]

Drug(s) Affected By Speckle-type POZ protein (SPOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[115]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[42]

Drug(s) Affected By Frizzled-6 (FZD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[265]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[173]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By Eukaryotic translation initiation factor 5B (EIF5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[67]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[267]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[268]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]

Drug(s) Affected By Nucleolar protein 3 (NOL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]

Drug(s) Affected By Probable phospholipid-transporting ATPase IIA (ATP9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[271]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[38]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[273]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[274]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[150]

Drug(s) Affected By Suppressor of cytokine signaling 5 (SOCS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Indomethacin	DMSC4A7	Bursitis		Approved	[276]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]

Drug(s) Affected By RNA/RNP complex-1-interacting phosphatase (DUSP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[280]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[250]

Drug(s) Affected By Filamin-B (FLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[282]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[283]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[286]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[290]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[291]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[288]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 6 (LRP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[292]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[293]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[294]

Drug(s) Affected By E3 SUMO-protein ligase PIAS2 (PIAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[295]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[296]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[299]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[300]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[301]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[302]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[305]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Methyl-CpG-binding domain protein 4 (MBD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[307]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[308]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[309]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[310]

Drug(s) Affected By RAS guanyl-releasing protein 1 (RASGRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[312]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Indomethacin	DMSC4A7	Bursitis		Approved	[313]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[317]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[318]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[319]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[320]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[122]

Drug(s) Affected By Tyrosine-protein kinase ABL1 (ABL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[22]
Anagrelide	DMSQ8MD	Thrombocythemia	3B63	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[323]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[324]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[325]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[326]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[327]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[328]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[330]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[331]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[332]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[335]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[338]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[338]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[340]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[343]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[344]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[345]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[346]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[347]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[348]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]

Drug(s) Affected By GTPase NRas (NRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[350]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[351]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[354]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[355]
Fructose	DM43AN2	Vomiting	MD90	Approved	[356]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[358]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[359]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[360]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[361]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[362]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[363]
Fructose	DM43AN2	Vomiting	MD90	Approved	[22]
Ketoprofen	DMRKXPT	Bursitis		Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[365]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[366]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[367]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[368]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]

Drug(s) Affected By Interferon alpha-21 (IFNA21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[370]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[371]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[372]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[375]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[376]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[377]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[378]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[379]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[382]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[384]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[22]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[385]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[386]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[387]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[388]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[389]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[390]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[393]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[394]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[395]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[328]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[398]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[396]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[400]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[401]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[36]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[402]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[404]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[405]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[406]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[407]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[408]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[409]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[410]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[412]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]

Drug(s) Affected By Interferon alpha-4 (IFNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[413]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[415]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[416]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[417]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[418]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[419]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[420]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[421]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[422]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[424]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[425]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[426]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[427]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[428]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[422]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[429]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
Fructose	DM43AN2	Vomiting	MD90	Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[431]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[432]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[433]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[434]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[435]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Fructose	DM43AN2	Vomiting	MD90	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[437]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[439]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[440]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[441]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[442]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[22]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[443]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[440]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[444]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[445]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[444]

Drug(s) Affected By Complement C2 (C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[446]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[447]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[448]

Drug(s) Affected By Integrin alpha-V (ITGAV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[450]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[451]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[450]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[450]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[450]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[452]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[453]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[454]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[455]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[456]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[334]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[458]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[459]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[460]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[461]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[462]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[463]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[464]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[462]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[467]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[468]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[469]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[470]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[471]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[472]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[473]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[474]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[422]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[476]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[477]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[478]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[380]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[480]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[477]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[481]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[482]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[483]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[265]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[484]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[485]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[486]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[487]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[488]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[489]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Integrin alpha-5 (ITGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[490]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[476]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[491]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[492]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[493]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[494]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[495]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[496]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]

Drug(s) Affected By CD63 antigen (CD63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[497]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[498]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[499]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[500]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[501]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[502]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[503]

Drug(s) Affected By Inhibin beta B chain (INHBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[484]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[504]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[505]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[424]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[506]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[426]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[507]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[508]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[509]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[510]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[511]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[512]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[512]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[514]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[515]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[516]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[517]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[505]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[333]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[518]

Drug(s) Affected By Calmodulin-1 (CALM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[519]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[519]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[520]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[520]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[520]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[521]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[522]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[523]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[524]
Selenium	DM25CGV	N. A.	N. A.	Approved	[525]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[526]

Drug(s) Affected By Ras-related protein R-Ras (RRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[527]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[528]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[529]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[530]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[531]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[532]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[533]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[365]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[534]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[535]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[536]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[497]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[537]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[538]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[539]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[501]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[541]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[474]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[543]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[545]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[546]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[547]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[547]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[548]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]

Drug(s) Affected By Ras-related protein Ral-A (RALA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[550]

Drug(s) Affected By Ras-related protein Ral-B (RALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[519]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[551]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[426]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[552]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[553]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[554]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[345]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[555]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[556]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[557]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[345]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[388]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[558]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[559]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[560]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[561]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[562]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[563]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[564]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[437]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]

Drug(s) Affected By Glycogen synthase, muscle (GYS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[565]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[566]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[22]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[22]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[567]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[568]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[569]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Haloperidol	DM96SE0	Delirium		Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[570]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[571]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[572]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[572]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[573]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[574]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[575]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[576]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[577]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[345]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[578]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[579]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[519]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[581]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[582]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]

Drug(s) Affected By Protein C-ets-2 (ETS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[583]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[584]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[585]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[499]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[586]

Drug(s) Affected By Replication protein A 32 kDa subunit (RPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[587]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[588]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[589]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[590]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[435]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[591]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[591]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[592]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[593]

Drug(s) Affected By Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[594]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[595]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[596]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[597]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[598]

Drug(s) Affected By Prolactin receptor (PRLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[89]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[129]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[505]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[599]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[600]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[474]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]

Drug(s) Affected By Interferon alpha/beta receptor 1 (IFNAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[601]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[602]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[603]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[604]

Drug(s) Affected By Integrin alpha-2 (ITGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[519]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[491]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[432]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[519]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[605]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[606]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[598]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[607]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[608]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]

Drug(s) Affected By Potassium voltage-gated channel subfamily A member 6 (KCNA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Neuromodulin (GAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[610]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[610]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[611]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[610]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[612]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[497]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[610]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[613]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[613]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[613]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[613]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By ADP-ribosylation factor 4 (ARF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[614]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[158]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[615]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[616]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[617]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[505]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[518]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[599]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[282]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[527]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[474]

Drug(s) Affected By Integrin beta-6 (ITGB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[618]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[619]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[615]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[519]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[290]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[291]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[549]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[620]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[621]

Drug(s) Affected By Histidine decarboxylase (HDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[622]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[623]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[540]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[624]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[624]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[625]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[625]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[626]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[627]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[628]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[629]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[504]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[606]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[307]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[630]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[631]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[632]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[633]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[577]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[558]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[634]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[635]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[631]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[636]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]

Drug(s) Affected By Aromatic-L-amino-acid decarboxylase (DDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[637]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[625]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[638]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[518]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[599]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[639]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]

Drug(s) Affected By Filamin-A (FLNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[640]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[641]

Drug(s) Affected By Bone morphogenetic protein 5 (BMP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[642]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[643]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[644]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[644]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[42]

Drug(s) Affected By Lactoperoxidase (LPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[539]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[539]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[539]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[539]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[539]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[539]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[645]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[646]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[647]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[648]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[649]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[650]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[651]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[652]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[653]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[534]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[394]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[326]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[654]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[552]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[346]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[655]

Drug(s) Affected By Interleukin-4 receptor subunit alpha (IL4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[656]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[505]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[307]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[657]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[519]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[658]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[527]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[659]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[660]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[661]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[558]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[662]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[623]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[663]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[664]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[577]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[661]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[665]
Selenium	DM25CGV	N. A.	N. A.	Approved	[345]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[666]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[556]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]

Drug(s) Affected By DNA replication licensing factor MCM3 (MCM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[553]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[614]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[667]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[668]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[669]
Fructose	DM43AN2	Vomiting	MD90	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[670]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[671]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[334]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[672]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[670]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[673]

Drug(s) Affected By Integrin alpha-3 (ITGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[583]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[318]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[674]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[675]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[676]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[677]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[678]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[100]

Drug(s) Affected By Paired box protein Pax-6 (PAX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[679]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[679]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[680]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[679]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[679]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[681]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[679]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[682]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[683]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[590]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[365]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[684]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[685]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[686]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[687]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[688]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[689]

Drug(s) Affected By Replication protein A 70 kDa DNA-binding subunit (RPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[307]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[690]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[67]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[691]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[692]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[693]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[694]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By ETS domain-containing protein Elk-4 (ELK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[695]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[122]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[122]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[122]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[136]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[696]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[683]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[697]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[698]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[699]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[682]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[365]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[684]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[507]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[700]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[701]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[581]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[553]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[702]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]

Drug(s) Affected By DNA excision repair protein ERCC-5 (ERCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[519]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[519]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[703]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[704]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[705]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[706]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[707]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[708]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[709]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[427]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[710]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[540]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[712]

Drug(s) Affected By CD40 ligand (CD40LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[671]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[713]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[714]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[498]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[715]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[716]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[717]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[715]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[718]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[719]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[720]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[721]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[267]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[557]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[722]

Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[723]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[724]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[570]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[725]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[726]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[727]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[539]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[728]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[729]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[539]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[730]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[731]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[534]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[732]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[648]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[733]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[388]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[346]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[734]

Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[581]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[553]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[634]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[581]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Profilin-2 (PFN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[272]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[735]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[42]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[431]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[736]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[737]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[738]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[739]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[740]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[741]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[742]

Drug(s) Affected By Replication factor C subunit 4 (RFC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Replication factor C subunit 2 (RFC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[581]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[171]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[743]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[331]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[744]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[745]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By G protein-coupled receptor kinase 3 (GRK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[746]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[505]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[747]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[207]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[288]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[748]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[749]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]

Drug(s) Affected By Protein phosphatase 1A (PPM1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[750]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[751]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[752]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[753]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[754]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[755]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[756]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[757]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[758]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[759]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[760]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[761]
Haloperidol	DM96SE0	Delirium		Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[67]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[762]

Drug(s) Affected By Bone morphogenetic protein receptor type-1A (BMPR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[763]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[764]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[765]

Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[490]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[766]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[767]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[768]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[768]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By TGF-beta receptor type-2 (TGFBR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[490]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[497]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Bortezomib	DMNO38U	Leukemia		Approved	[769]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[770]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[394]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[771]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[772]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]

Drug(s) Affected By Integrin alpha-E (ITGAE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[584]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[551]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[551]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[584]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[773]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[319]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[774]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[654]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[578]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[775]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[154]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[776]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[777]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[778]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[779]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[780]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[781]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[782]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[783]

Drug(s) Affected By Interleukin-15 (IL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[784]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[785]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[619]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[776]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[67]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[171]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[218]

Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[171]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[786]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[370]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[787]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[670]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[787]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[787]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[788]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[646]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[647]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[691]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[346]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[539]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[789]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[300]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[790]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[791]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[792]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[408]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[793]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[794]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[795]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[796]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[797]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[798]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[533]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[799]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[800]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[801]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[317]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[802]

Drug(s) Affected By Leukemia inhibitory factor receptor (LIFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[803]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[804]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[775]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[557]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[805]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[406]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[806]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[807]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[808]

Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[809]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[810]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[171]

Drug(s) Affected By Tyrosine-protein kinase SYK (SYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[811]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[446]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[812]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]

Drug(s) Affected By Transcription factor GATA-4 (GATA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[813]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[814]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[815]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[816]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[261]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[817]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[818]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[431]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[367]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[507]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[819]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[820]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[433]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[821]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[631]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[822]
Indomethacin	DMSC4A7	Bursitis		Approved	[823]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[824]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[825]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[326]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[775]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[826]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[827]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[328]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[828]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[662]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[829]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[830]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[831]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[832]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[833]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[834]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[835]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[836]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[837]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Glutamine--tRNA ligase (QARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[838]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[839]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[617]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[840]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[841]

Drug(s) Affected By Leptin receptor (LEPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[842]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[843]
Ketamine	DMT5HA4	Anaesthesia	9A78.6	Approved	[844]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[274]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]

Drug(s) Affected By Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]

Drug(s) Affected By Interferon alpha/beta receptor 2 (IFNAR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[497]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[845]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[846]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[446]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[746]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]

Drug(s) Affected By Nestin (NES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[847]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By MAP kinase-activated protein kinase 2 (MAPKAPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[848]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[701]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[849]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[848]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[850]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]

Drug(s) Affected By Beta-arrestin-1 (ARRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[851]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]

Drug(s) Affected By Inositol polyphosphate 1-phosphatase (INPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[595]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[581]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[852]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Thrombospondin-3 (THBS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[584]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[484]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[853]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]

Drug(s) Affected By Presenilin-2 (PSEN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[834]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[854]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[855]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By DNA ligase 3 (LIG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[856]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[857]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[129]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[858]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[207]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[859]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[860]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[518]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[861]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[862]

Drug(s) Affected By Cyclin-dependent kinase 7 (CDK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[863]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[718]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[864]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]

Drug(s) Affected By Ras-related protein Rab-5C (RAB5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[865]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[107]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[866]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[866]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[701]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[837]

Drug(s) Affected By Serine/threonine-protein phosphatase 5 (PPP5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[507]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[867]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[765]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]

Drug(s) Affected By Dipeptidyl peptidase 1 (CTSC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[122]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[122]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[497]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[868]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[869]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[870]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[644]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[871]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[872]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[873]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[874]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[874]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[631]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[875]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[876]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[802]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[877]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[533]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[878]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[879]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[880]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[881]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[882]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[658]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[883]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[884]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[471]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[384]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Selenium	DM25CGV	N. A.	N. A.	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[885]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[886]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[592]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By C-terminal-binding protein 2 (CTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[887]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[816]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[888]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]

Drug(s) Affected By Ras-related protein Rab-25 (RAB25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[889]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[150]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[890]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Ras-related protein Rab-5B (RAB5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[891]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[838]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[892]

Drug(s) Affected By ADP-ribosylation factor 6 (ARF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[893]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[894]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]

Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[895]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[896]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[351]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[897]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]

Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[401]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[898]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[898]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[67]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[67]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[899]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[501]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[900]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[901]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[834]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[902]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[903]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[703]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]

Drug(s) Affected By 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[124]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[484]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[252]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[904]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[766]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[905]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[816]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[127]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[906]

Drug(s) Affected By Solute carrier family 25 member 3 (SLC25A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[246]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[907]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[908]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[115]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[909]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[217]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[910]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[910]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[911]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[912]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[406]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[913]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[914]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[661]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[915]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[154]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[916]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[917]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[918]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[613]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[919]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[613]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[633]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[920]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[921]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[821]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[922]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 5 (CREB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[923]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[309]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[252]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[275]

Drug(s) Affected By Histone-lysine N-methyltransferase MECOM (MECOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]

Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-12 (GNA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[534]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[772]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[632]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[883]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[924]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[925]

Drug(s) Affected By Activin receptor type-1 (ACVR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[283]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[926]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[927]

Drug(s) Affected By Glutamate decarboxylase 2 (GAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[625]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[625]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[625]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[625]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[625]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[928]

Drug(s) Affected By Glutamate receptor ionotropic, NMDA 1 (GRIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[539]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[539]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[929]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[539]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[539]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[930]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[931]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[539]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[932]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[816]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[933]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[856]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[275]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[934]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[935]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[936]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[937]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]

Drug(s) Affected By Recombining binding protein suppressor of hairless (RBPJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[834]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[938]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[888]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[939]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[528]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[798]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[532]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[878]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[654]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[559]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[940]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[941]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[910]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[518]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[365]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[23]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[942]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[943]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[599]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[944]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[234]

Drug(s) Affected By DNA polymerase epsilon catalytic subunit A (POLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[570]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[631]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[351]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[861]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[945]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[67]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[888]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]

Drug(s) Affected By Histone acetyltransferase p300 (EP300)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[766]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[946]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[816]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[834]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[719]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Forkhead box protein I1 (FOXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[309]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[817]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[947]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[948]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[384]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[122]

Drug(s) Affected By Rho guanine nucleotide exchange factor TIAM1 (TIAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[949]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[916]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[129]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[950]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]

Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[950]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]

Drug(s) Affected By Serine/threonine-protein kinase PAK 1 (PAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[571]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[951]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[824]

Drug(s) Affected By Dual specificity protein phosphatase 8 (DUSP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[702]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[310]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By DNA excision repair protein ERCC-8 (ERCC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[107]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[952]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[953]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[954]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Phospholipase D1 (PLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[918]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[581]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[265]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[955]

Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[553]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[734]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[292]

Drug(s) Affected By Splicing factor 3B subunit 2 (SF3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[192]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[735]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[956]

Drug(s) Affected By Mothers against decapentaplegic homolog 4 (SMAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[766]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[957]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[798]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[861]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[958]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[959]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[960]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[961]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[962]

Drug(s) Affected By Oligodendrocyte transcription factor 2 (OLIG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[539]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[539]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[539]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[963]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[549]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[964]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[861]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[965]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[966]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[217]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[967]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[968]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[969]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[970]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]

Drug(s) Affected By SNW domain-containing protein 1 (SNW1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[834]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[971]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[927]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[971]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[616]

Drug(s) Affected By Cullin-1 (CUL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Bortezomib	DMNO38U	Leukemia		Approved	[769]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[107]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[972]

Drug(s) Affected By Cullin-4A (CUL4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[888]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]

Drug(s) Affected By Activin receptor type-2B (ACVR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[973]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[974]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[505]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[975]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[976]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[977]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[599]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]

Drug(s) Affected By General transcription factor IIH subunit 3 (GTF2H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[605]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[274]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[735]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[978]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[712]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[122]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[979]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[553]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]

Drug(s) Affected By Transcription factor HES-1 (HES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[980]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By DNA replication licensing factor MCM6 (MCM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[614]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[497]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[585]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[265]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[856]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[981]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[982]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[983]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[984]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]

Drug(s) Affected By Ras GTPase-activating protein 3 (RASA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[951]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[854]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[158]

Drug(s) Affected By Separin (ESPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[318]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[136]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[985]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[985]
Bortezomib	DMNO38U	Leukemia		Approved	[95]

Drug(s) Affected By Latent-transforming growth factor beta-binding protein 1 (LTBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[274]

Drug(s) Affected By DNA polymerase delta subunit 3 (POLD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]

Drug(s) Affected By Angiopoietin-1 (ANGPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[986]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[987]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[988]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[476]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[989]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]

Drug(s) Affected By Mothers against decapentaplegic homolog 1 (SMAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[973]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[22]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[990]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[506]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[991]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[992]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[993]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[994]

Drug(s) Affected By Transcription factor E2F4 (E2F4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[995]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[996]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[604]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[997]

Drug(s) Affected By Serine/threonine-protein kinase N2 (PKN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[136]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[649]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[998]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[422]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[897]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[673]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[716]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[422]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[999]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1000]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1001]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[1002]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1003]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1004]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]

Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[282]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1005]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By CREB-regulated transcription coactivator 2 (CRTC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[927]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[866]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[866]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[1006]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 8 (ENTPD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[115]

Drug(s) Affected By Acyl-coenzyme A thioesterase THEM4 (THEM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[888]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]

Drug(s) Affected By Transcription factor HES-5 (HES5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1007]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[969]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[643]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[42]

Drug(s) Affected By Interleukin-23 receptor (IL23R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1008]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
SGC-CBP30	DMTLRGZ	Discovery agent	N.A.	Investigative	[1009]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[1010]

Drug(s) Affected By General transcription factor IIH subunit 2-like protein (GTF2H2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]

Drug(s) Affected By SHC-transforming protein 4 (SHC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1011]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[1012]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[294]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[273]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Kielin/chordin-like protein (KCP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[115]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[158]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Centrosomal protein of 68 kDa (CEP68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[979]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1013]

Drug(s) Affected By C-myc promoter-binding protein (DENND4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[596]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[551]

Drug(s) Affected By Peroxisome assembly protein 26 (PEX26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[250]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[152]

Drug(s) Affected By BRCA1-associated protein (BRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[192]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[250]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 5 (GALNT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1014]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]

Drug(s) Affected By Protein S100-A7A (S100A7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[35]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Corepressor interacting with RBPJ 1 (CIR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[192]

Drug(s) Affected By E3 ubiquitin-protein ligase SIAH1 (SIAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[1015]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[1016]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[519]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[888]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[854]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[143]

Drug(s) Affected By Regulatory-associated protein of mTOR (RPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[816]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[95]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1017]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1018]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[124]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1019]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[617]

Drug(s) Affected By Macoilin (MACO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[1020]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase DTX3 (DTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[834]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]

Drug(s) Affected By Structural maintenance of chromosomes protein 1B (SMC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1021]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[693]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[1022]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[1023]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[644]

Drug(s) Affected By Endonuclease 8-like 3 (NEIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]

Drug(s) Affected By Minor histocompatibility antigen H13 (HM13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1024]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[952]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[158]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[952]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Hepatitis A virus cellular receptor 2 (HAVCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[246]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[1025]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[448]

Drug(s) Affected By Suppressor of cytokine signaling 4 (SOCS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[65]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[150]

Drug(s) Affected By Nicastrin (NCSTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[834]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Isoflurane	DMY6T31	Anaesthesia	9A78.6	Approved	[1026]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Mestranol	DMG3F94	Contraception	QA21	Approved	[93]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[93]

Drug(s) Affected By Hamartin (TSC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[173]

Drug(s) Affected By Mastermind-like protein 1 (MAML1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[834]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[1027]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1028]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1029]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1030]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[1031]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1032]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[1033]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1034]
Mestranol	DMG3F94	Contraception	QA21	Approved	[1035]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[1036]

Drug(s) Affected By Fibroblast growth factor 13 (FGF13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[916]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[1037]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1038]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[604]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1039]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[798]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1040]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1041]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1042]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-3 (DVL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[719]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]

Drug(s) Affected By Interleukin-22 receptor subunit alpha-2 (IL22RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[250]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[1043]

Drug(s) Affected By Protein FAM162A (FAM162A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[122]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Mestranol	DMG3F94	Contraception	QA21	Approved	[93]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[93]

Drug(s) Affected By HSPB1-associated protein 1 (HSPBAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[927]

Drug(s) Affected By Ras/Rap GTPase-activating protein SynGAP (SYNGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[115]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[677]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[625]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1044]

Drug(s) Affected By Oncostatin-M-specific receptor subunit beta (OSMR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[596]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[916]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1045]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[551]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[154]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1046]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[1047]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1048]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[824]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By 5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[979]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[979]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[765]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[1049]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[274]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[250]

Drug(s) Affected By Anaphase-promoting complex subunit 13 (ANAPC13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[3]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1019]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[1050]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[65]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[152]

Drug(s) Affected By Glucose-6-phosphatase 3 (G6PC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[519]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1051]

Drug(s) Affected By TNF receptor-associated factor 4 (TRAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[384]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[283]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[583]

Drug(s) Affected By Synaptonemal complex protein 2 (SYCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1052]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1053]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[1020]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Dual specificity protein phosphatase 16 (DUSP16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[159]

Drug(s) Affected By GTP-binding protein 4 (GTPBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[67]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[894]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]

Drug(s) Affected By F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[157]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[95]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[275]

Drug(s) Affected By Homeobox protein TGIF2 (TGIF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[854]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]

Drug(s) Affected By Anaphase-promoting complex subunit 1 (ANAPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1054]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[937]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[854]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[147]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[647]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1055]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[299]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1056]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[1057]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1058]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[528]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]

Drug(s) Affected By Guanine nucleotide-binding protein subunit beta-4 (GNB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[854]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[280]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]

Drug(s) Affected By MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[484]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]

Drug(s) Affected By Sentrin-specific protease 2 (SENP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[250]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[65]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[152]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 8 (CHD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1059]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[192]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[250]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[1060]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[1060]

Drug(s) Affected By Charged multivesicular body protein 1a (CHMP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[606]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[889]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[765]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[838]

Drug(s) Affected By Frizzled-3 (FZD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[763]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Methamphetamine	DMPM4SK	Anxiety		Approved	[1061]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1062]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]

Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[497]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[1063]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[549]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1055]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[1064]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[299]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[1065]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[1064]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[302]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[505]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[918]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1066]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1067]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[320]

Drug(s) Affected By Non-structural maintenance of chromosomes element 4 homolog A (NSMCE4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]

Drug(s) Affected By Kv channel-interacting protein 1 (KCNIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[252]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[1020]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[1068]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Lysophosphatidic acid receptor 3 (LPAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[178]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[129]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[158]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By DNA-(apurinic or apyrimidinic site) endonuclease 2 (APEX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1069]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[1070]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1071]

Drug(s) Affected By Poly polymerase 2 (PARP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[1072]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]

Drug(s) Affected By DNA polymerase lambda (POLL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1073]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[274]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1074]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[1075]

Drug(s) Affected By Ragulator complex protein LAMTOR3 (LAMTOR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[927]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[75]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[250]

Drug(s) Affected By DNA mismatch repair protein Mlh3 (MLH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[224]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Serine/threonine-protein kinase TBK1 (TBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[1076]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1077]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1078]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[446]
Flavonoid derivative 1	DMCQP0B	N. A.	N. A.	Patented	[1078]

Drug(s) Affected By Ras GTPase-activating protein nGAP (RASAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[927]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]

Drug(s) Affected By Anaphase-promoting complex subunit 5 (ANAPC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Bortezomib	DMNO38U	Leukemia		Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[927]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]

Drug(s) Affected By Serine/threonine-protein kinase TAO2 (TAOK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1079]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[294]

Drug(s) Affected By Frizzled-4 (FZD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[265]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[484]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]

Drug(s) Affected By Synaptopodin-2 (SYNPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[171]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[484]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[485]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[274]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[644]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[644]

Drug(s) Affected By U3 small nucleolar RNA-associated protein NOL7 (NOL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[264]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1080]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[65]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[1081]

Drug(s) Affected By Cytosolic phospholipase A2 gamma (PLA2G4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[192]

Drug(s) Affected By Exonuclease 1 (EXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[734]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[776]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[171]

Drug(s) Affected By GRB2-associated-binding protein 2 (GAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[173]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1073]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[1020]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1082]

Drug(s) Affected By RuvB-like 1 (RUVBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[1083]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[811]

Drug(s) Affected By Inversin (INVS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]

Drug(s) Affected By V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[539]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[158]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[107]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]

Drug(s) Affected By Disheveled-associated activator of morphogenesis 1 (DAAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[497]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[274]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[107]

Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[519]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[909]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[583]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1084]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1085]

Drug(s) Affected By DNA (DNMT3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[675]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1086]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[100]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1087]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1088]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1089]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[701]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[702]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[1090]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[1091]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[1092]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[1093]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1094]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[518]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1095]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[474]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[1096]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[1097]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA)	TTB30PF	AROA_ECOLI	Inhibitor	[2]
Plasmodium Enopyruvyl shikimate phosphate synthase (Malaria ESPS)	TTVL895	A0A1C3KAW3_PLAMA	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Gene/Protein Processing	[3]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[3]
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Gene/Protein Processing	[3]
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Gene/Protein Processing	[3]
4-aminobutyrate aminotransferase, mitochondrial (ABAT)	OTXAGR7J	GABT_HUMAN	Post-Translational Modifications	[4]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Gene/Protein Processing	[3]
5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7)	OTSLAEUP	COQ7_HUMAN	Post-Translational Modifications	[4]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[3]
Activin receptor type-1 (ACVR1)	OT4JATFE	ACVR1_HUMAN	Gene/Protein Processing	[3]
Activin receptor type-2B (ACVR2B)	OT209XLA	AVR2B_HUMAN	Gene/Protein Processing	[3]

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