Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0AFY7)

• Drug Name: Glyphosate Drug Info
• Synonyms: glyphosate; 1071-83-6; N-(Phosphonomethyl)glycine; Glyphosphate; Roundup; Glycine, N-(phosphonomethyl)-; N-Phosphonomethyl-glycine; 2-(phosphonomethylamino)acetic acid; Silglif; Pondmaster; Roundup Max; N-Phosphonomethylglycine; N-Phosphomethylglycine; Caswell No. 661A; MON 2139; C3H8NO5P; N-(Phosphonomethyl) Glycine; NSC151063; Glialka; Phosphonomethyliminoacetic acid; Mon 6000; Glyphosate [ANSI:BSI:ISO]; UNII-4632WW1X5A; CCRIS 1587; CP 67573; HSDB 3432; XDDAORKBJWWYJS-UHFFFAOYSA-N; EINECS 213-997-4; 2-((Phosphonomethyl)amino)acetic

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3496
  ChEBI ID: CHEMBL95764
  CAS Number: CAS 1071-83-6
  TTD Drug ID: DM0AFY7

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[6]
Shikimate-3-Phosphate	DMBE0CT	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[12]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[13]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By Protein S100-A6 (S100A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]

Drug(s) Affected By Cartilage-associated protein (CRTAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]

Drug(s) Affected By Decapping and exoribonuclease protein (DXO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[36]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[44]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[45]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[46]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]

Drug(s) Affected By Monoacylglycerol lipase ABHD2 (ABHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Mestranol	DMG3F94	Contraception	QA21	Approved	[48]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[48]
Bortezomib	DMNO38U	Leukemia		Approved	[50]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[48]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[59]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[60]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[64]

Drug(s) Affected By Ephrin-A1 (EFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]

Drug(s) Affected By Tenascin-X (TNXB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[75]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[40]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase S (PTPRS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[19]

Drug(s) Affected By Semaphorin-5A (SEMA5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[19]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[19]

Drug(s) Affected By Calicin (CCIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[86]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[88]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[91]
Mestranol	DMG3F94	Contraception	QA21	Approved	[88]

Drug(s) Affected By Cysteine-rich hydrophobic domain-containing protein 1 (CHIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By Lipase member H (LIPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[95]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[95]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Alpha-1,2-mannosyltransferase ALG9 (ALG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]

Drug(s) Affected By Immunity-related GTPase family M protein (IRGM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
Ginsenoside Re	DM46FVD	N. A.	N. A.	Investigative	[101]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[102]

Drug(s) Affected By Bone morphogenetic protein receptor type-1B (BMPR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[107]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[117]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]

Drug(s) Affected By Claudin-5 (CLDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[120]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[121]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[122]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[123]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
CS-600G	DM1PV4Y	N. A.	N. A.	Phase 3	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[126]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[127]
JWH-133	DM1DEYU	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Transcription factor E2F3 (E2F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[129]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]

Drug(s) Affected By Suppressor of cytokine signaling 2 (SOCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[92]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-2 (DVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[135]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]
Calphostin C	DM9X2D0	N. A.	N. A.	Terminated	[138]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[139]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[143]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[152]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[157]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[158]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[161]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[163]

Drug(s) Affected By Mitogen-activated protein kinase 13 (MAPK13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[166]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]

Drug(s) Affected By MutS protein homolog 4 (MSH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[167]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[168]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[169]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[170]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[171]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[174]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[177]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[178]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[181]

Drug(s) Affected By Ras GTPase-activating protein 4 (RASA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]

Drug(s) Affected By Band 4.1-like protein 2 (EPB41L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[117]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[97]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[188]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[193]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By Neuronal migration protein doublecortin (DCX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[196]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[197]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[198]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[199]

Drug(s) Affected By Speckle-type POZ protein (SPOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[19]

Drug(s) Affected By Frizzled-6 (FZD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[201]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[81]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[118]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]

Drug(s) Affected By Eukaryotic translation initiation factor 5B (EIF5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[29]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[204]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]

Drug(s) Affected By Nucleolar protein 3 (NOL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[205]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]

Drug(s) Affected By Probable phospholipid-transporting ATPase IIA (ATP9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[207]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[15]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[209]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[210]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]

Drug(s) Affected By Suppressor of cytokine signaling 5 (SOCS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Bortezomib	DMNO38U	Leukemia		Approved	[50]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Indomethacin	DMSC4A7	Bursitis		Approved	[212]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]

Drug(s) Affected By RNA/RNP complex-1-interacting phosphatase (DUSP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[217]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]

Drug(s) Affected By Filamin-B (FLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[226]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[227]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[228]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[225]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 6 (LRP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[229]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[81]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[230]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[231]

Drug(s) Affected By E3 SUMO-protein ligase PIAS2 (PIAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[232]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[233]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[236]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[237]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[238]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]

Drug(s) Affected By Methyl-CpG-binding domain protein 4 (MBD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[244]

Drug(s) Affected By RAS guanyl-releasing protein 1 (RASGRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[246]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Indomethacin	DMSC4A7	Bursitis		Approved	[247]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[205]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[252]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[255]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[257]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[258]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[258]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[263]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Selenium	DM25CGV	N. A.	N. A.	Approved	[265]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[266]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[267]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]

Drug(s) Affected By Interferon alpha-21 (IFNA21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[205]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[40]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[269]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[270]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[271]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[272]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[273]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[276]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[98]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[13]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[278]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By Interferon alpha-4 (IFNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[279]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[281]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[283]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[284]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[285]
Fructose	DM43AN2	Vomiting	MD90	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[286]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[287]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[288]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[290]

Drug(s) Affected By Complement C2 (C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[291]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[292]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[298]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[300]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[304]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[306]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[307]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[117]

Drug(s) Affected By CD63 antigen (CD63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[308]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[309]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[310]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]

Drug(s) Affected By Inhibin beta B chain (INHBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[312]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[313]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[248]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[315]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[316]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[315]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[317]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[318]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]

Drug(s) Affected By Ras-related protein R-Ras (RRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[321]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[257]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[308]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[323]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[324]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[325]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[331]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[333]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[334]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[336]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]

Drug(s) Affected By Ras-related protein Ral-A (RALA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[337]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[338]

Drug(s) Affected By Ras-related protein Ral-B (RALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[340]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[343]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[344]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[347]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]

Drug(s) Affected By Glycogen synthase, muscle (GYS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[40]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[40]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[350]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[351]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[352]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Haloperidol	DM96SE0	Delirium		Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[353]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[310]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[355]

Drug(s) Affected By Replication protein A 32 kDa subunit (RPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[356]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[357]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[359]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[360]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[362]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[364]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[287]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[337]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[367]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[362]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[368]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[369]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[19]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[370]

Drug(s) Affected By Potassium voltage-gated channel subfamily A member 6 (KCNA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[371]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[371]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[371]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]

Drug(s) Affected By ADP-ribosylation factor 4 (ARF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[372]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[104]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[373]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[181]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[374]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[375]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[339]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[227]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[228]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[337]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[376]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[377]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[378]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[379]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[143]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[380]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[381]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[367]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[382]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[383]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[384]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[384]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[389]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[364]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[390]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]

Drug(s) Affected By Bone morphogenetic protein 5 (BMP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[391]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[19]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[392]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[393]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[393]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[19]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[19]

Drug(s) Affected By Interleukin-4 receptor subunit alpha (IL4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[397]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[398]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[399]

Drug(s) Affected By DNA replication licensing factor MCM3 (MCM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[400]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[372]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[403]
Fructose	DM43AN2	Vomiting	MD90	Approved	[404]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[405]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[407]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[408]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[406]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[409]

Drug(s) Affected By Integrin alpha-3 (ITGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[410]

Drug(s) Affected By Paired box protein Pax-6 (PAX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[411]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[411]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[412]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[411]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[411]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[413]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[411]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[414]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[415]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[416]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[417]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[418]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[419]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[420]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[421]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]

Drug(s) Affected By Replication protein A 70 kDa DNA-binding subunit (RPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[424]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[29]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[337]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[428]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By ETS domain-containing protein Elk-4 (ELK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[429]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[79]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[79]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[430]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[415]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[432]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[433]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[434]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[414]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[417]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[418]

Drug(s) Affected By DNA excision repair protein ERCC-5 (ERCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[339]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[435]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[436]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[437]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[438]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[439]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[440]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]

Drug(s) Affected By CD40 ligand (CD40LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[441]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[407]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[442]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[443]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[309]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[444]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[445]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[446]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[444]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[447]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[448]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[449]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[450]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[203]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[451]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[143]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[452]

Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[454]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[353]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[455]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[457]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[325]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[458]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[459]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[325]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[460]

Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[461]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[400]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By Profilin-2 (PFN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[208]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[462]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[19]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[286]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[463]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[465]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[466]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[467]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[468]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[469]

Drug(s) Affected By Replication factor C subunit 4 (RFC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Replication factor C subunit 2 (RFC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[461]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[471]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[472]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[473]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By G protein-coupled receptor kinase 3 (GRK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[81]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[474]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[475]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[155]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[476]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[477]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]

Drug(s) Affected By Bone morphogenetic protein receptor type-1A (BMPR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[478]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[479]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[480]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[308]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[182]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[481]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[483]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[484]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[485]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[486]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[257]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[288]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[487]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[488]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[489]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[490]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[316]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[491]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[491]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[29]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[166]

Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[490]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[451]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[492]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[493]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[495]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[496]

Drug(s) Affected By Transcription factor GATA-4 (GATA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[497]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[498]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[500]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[197]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[501]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[502]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[286]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[504]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[505]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[506]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[289]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[507]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[384]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[508]
Indomethacin	DMSC4A7	Bursitis		Approved	[509]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[511]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[512]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[490]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[513]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[514]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[515]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[516]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[517]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[518]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[519]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[520]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[521]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[522]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[523]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[524]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[525]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[526]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Glutamine--tRNA ligase (QARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[527]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[528]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[375]

Drug(s) Affected By Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[340]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[214]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[461]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[530]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Thrombospondin-3 (THBS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[531]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[312]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[532]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]

Drug(s) Affected By DNA ligase 3 (LIG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[533]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[534]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[81]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[536]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[155]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[537]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[538]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[539]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[540]

Drug(s) Affected By Ras-related protein Rab-5C (RAB5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[541]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[62]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[542]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[542]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[544]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[526]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[308]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[545]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[546]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[547]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[393]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[549]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[550]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By C-terminal-binding protein 2 (CTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[551]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[500]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[552]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]

Drug(s) Affected By Ras-related protein Rab-25 (RAB25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[553]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[554]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]

Drug(s) Affected By Ras-related protein Rab-5B (RAB5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[555]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[527]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[556]

Drug(s) Affected By ADP-ribosylation factor 6 (ARF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[557]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[558]
Bortezomib	DMNO38U	Leukemia		Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[285]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]

Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[559]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[560]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[544]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]

Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[562]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[562]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[29]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[29]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[563]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[564]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[523]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[565]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[566]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[435]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]

Drug(s) Affected By 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[113]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[312]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[188]

Drug(s) Affected By Solute carrier family 25 member 3 (SLC25A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[181]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[567]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[568]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[569]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[570]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[571]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[572]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[573]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[574]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[575]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 5 (CREB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[576]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[117]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[188]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[211]

Drug(s) Affected By Histone-lysine N-methyltransferase MECOM (MECOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]

Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-12 (GNA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[577]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[485]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[385]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[578]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[579]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[580]

Drug(s) Affected By Activin receptor type-1 (ACVR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[581]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[582]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[583]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[500]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[584]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[533]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[211]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[585]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[587]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Bortezomib	DMNO38U	Leukemia		Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[588]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[589]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[590]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[591]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[592]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[389]

Drug(s) Affected By DNA polymerase epsilon catalytic subunit A (POLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[353]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[384]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[544]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]

Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[539]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[593]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[552]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]

Drug(s) Affected By Forkhead box protein I1 (FOXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[501]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[594]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[596]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]

Drug(s) Affected By Rho guanine nucleotide exchange factor TIAM1 (TIAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[597]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[574]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[81]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[370]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[126]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[598]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]

Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[598]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[98]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]

Drug(s) Affected By Serine/threonine-protein kinase PAK 1 (PAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[599]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[600]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]

Drug(s) Affected By Dual specificity protein phosphatase 8 (DUSP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[601]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[244]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]

Drug(s) Affected By DNA excision repair protein ERCC-8 (ERCC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[62]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[602]

Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[400]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[460]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[229]

Drug(s) Affected By Splicing factor 3B subunit 2 (SF3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[137]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[462]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[603]

Drug(s) Affected By Mothers against decapentaplegic homolog 4 (SMAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[604]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[544]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[605]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[606]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[607]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[539]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[608]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[609]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[610]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[611]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[612]

Drug(s) Affected By Oligodendrocyte transcription factor 2 (OLIG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[325]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[340]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[325]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[81]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[613]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[614]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[615]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]

Drug(s) Affected By SNW domain-containing protein 1 (SNW1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[523]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[616]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[582]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[616]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[374]

Drug(s) Affected By Cullin-1 (CUL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Bortezomib	DMNO38U	Leukemia		Approved	[481]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[62]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[617]

Drug(s) Affected By Cullin-4A (CUL4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[552]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[618]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[619]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[620]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[364]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]

Drug(s) Affected By General transcription factor IIH subunit 3 (GTF2H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[210]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[462]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[621]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[622]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[623]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[400]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[117]

Drug(s) Affected By Transcription factor HES-1 (HES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[624]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[308]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[201]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[533]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[625]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[626]

Drug(s) Affected By Ras GTPase-activating protein 3 (RASA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[600]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[627]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[104]

Drug(s) Affected By Separin (ESPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[628]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[430]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]

Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[629]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[630]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[629]
Bortezomib	DMNO38U	Leukemia		Approved	[50]

Drug(s) Affected By Latent-transforming growth factor beta-binding protein 1 (LTBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[210]

Drug(s) Affected By DNA polymerase delta subunit 3 (POLD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]

Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[631]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[632]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[633]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]

Drug(s) Affected By Mothers against decapentaplegic homolog 1 (SMAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[634]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[40]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[635]

Drug(s) Affected By Transcription factor E2F4 (E2F4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[636]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[637]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[638]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[639]

Drug(s) Affected By Serine/threonine-protein kinase N2 (PKN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[430]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[640]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[641]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[383]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[642]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[643]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[644]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[645]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[646]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]

Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[98]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[647]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 8 (ENTPD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Acyl-coenzyme A thioesterase THEM4 (THEM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[430]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[552]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[81]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]

Drug(s) Affected By Transcription factor HES-5 (HES5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[648]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[614]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[19]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[392]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[19]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[19]

Drug(s) Affected By General transcription factor IIH subunit 2-like protein (GTF2H2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[139]

Drug(s) Affected By SHC-transforming protein 4 (SHC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[649]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[650]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[231]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[126]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[209]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Kielin/chordin-like protein (KCP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[104]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Centrosomal protein of 68 kDa (CEP68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[623]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[651]

Drug(s) Affected By C-myc promoter-binding protein (DENND4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Bortezomib	DMNO38U	Leukemia		Approved	[50]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[360]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]

Drug(s) Affected By Peroxisome assembly protein 26 (PEX26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[370]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[102]

Drug(s) Affected By BRCA1-associated protein (BRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[137]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 5 (GALNT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[652]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]

Drug(s) Affected By Protein S100-A7A (S100A7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[12]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[12]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Corepressor interacting with RBPJ 1 (CIR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[137]

Drug(s) Affected By E3 ubiquitin-protein ligase SIAH1 (SIAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[98]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[653]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[654]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[339]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Bortezomib	DMNO38U	Leukemia		Approved	[50]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[552]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[627]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[126]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By Regulatory-associated protein of mTOR (RPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[500]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[50]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[655]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[656]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[181]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[657]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[375]

Drug(s) Affected By Macoilin (MACO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[658]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase DTX3 (DTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[523]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[370]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]

Drug(s) Affected By Structural maintenance of chromosomes protein 1B (SMC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[659]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[337]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[98]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[660]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[661]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[393]

Drug(s) Affected By Endonuclease 8-like 3 (NEIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]

Drug(s) Affected By Minor histocompatibility antigen H13 (HM13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[662]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[602]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[104]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[602]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Hepatitis A virus cellular receptor 2 (HAVCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[126]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[181]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[663]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Suppressor of cytokine signaling 4 (SOCS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[27]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]

Drug(s) Affected By Nicastrin (NCSTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[523]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Isoflurane	DMY6T31	Anaesthesia	9A78.6	Approved	[664]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Mestranol	DMG3F94	Contraception	QA21	Approved	[48]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[48]

Drug(s) Affected By Hamartin (TSC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[340]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[665]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[118]

Drug(s) Affected By Mastermind-like protein 1 (MAML1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[523]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[666]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]

Drug(s) Affected By Fibroblast growth factor 13 (FGF13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[574]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[667]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[668]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[638]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[669]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[607]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[670]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[671]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[672]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[673]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[143]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-3 (DVL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[448]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]

Drug(s) Affected By Interleukin-22 receptor subunit alpha-2 (IL22RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[674]

Drug(s) Affected By Protein FAM162A (FAM162A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Mestranol	DMG3F94	Contraception	QA21	Approved	[48]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[48]

Drug(s) Affected By HSPB1-associated protein 1 (HSPBAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[340]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[582]

Drug(s) Affected By Ras/Rap GTPase-activating protein SynGAP (SYNGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[675]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[676]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[677]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[678]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[131]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[679]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[680]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[81]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]

Drug(s) Affected By 5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[623]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[623]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[480]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[681]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[210]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]

Drug(s) Affected By Anaphase-promoting complex subunit 13 (ANAPC13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[3]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[657]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[682]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[27]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[102]

Drug(s) Affected By TNF receptor-associated factor 4 (TRAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[596]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[410]

Drug(s) Affected By Synaptonemal complex protein 2 (SYCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[683]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[684]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[658]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Dual specificity protein phosphatase 16 (DUSP16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]

Drug(s) Affected By GTP-binding protein 4 (GTPBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[29]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[558]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]

Drug(s) Affected By F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[50]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[211]

Drug(s) Affected By Homeobox protein TGIF2 (TGIF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[627]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[99]

Drug(s) Affected By Anaphase-promoting complex subunit 1 (ANAPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[685]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[588]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[627]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[97]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[686]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[687]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[236]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[688]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[689]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[690]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[691]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]

Drug(s) Affected By Guanine nucleotide-binding protein subunit beta-4 (GNB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[627]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[217]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]

Drug(s) Affected By MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[312]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[340]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]

Drug(s) Affected By Sentrin-specific protease 2 (SENP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[139]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[27]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[102]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 8 (CHD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[692]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[137]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[693]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[693]

Drug(s) Affected By Charged multivesicular body protein 1a (CHMP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[367]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[553]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[480]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[527]

Drug(s) Affected By Frizzled-3 (FZD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[478]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Methamphetamine	DMPM4SK	Anxiety		Approved	[694]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[695]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[205]

Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[337]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[308]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[696]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[337]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[687]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[697]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[698]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[697]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[239]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[699]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[700]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[701]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[702]

Drug(s) Affected By Non-structural maintenance of chromosomes element 4 homolog A (NSMCE4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]

Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Bortezomib	DMNO38U	Leukemia		Approved	[50]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]

Drug(s) Affected By Kv channel-interacting protein 1 (KCNIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[188]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[658]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[703]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[246]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[171]

Drug(s) Affected By Lysophosphatidic acid receptor 3 (LPAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[123]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[81]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[104]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[19]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By DNA-(apurinic or apyrimidinic site) endonuclease 2 (APEX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[704]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[705]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[706]

Drug(s) Affected By Poly polymerase 2 (PARP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[707]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]

Drug(s) Affected By DNA polymerase lambda (POLL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[708]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[709]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[710]

Drug(s) Affected By Ragulator complex protein LAMTOR3 (LAMTOR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[582]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[38]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[186]

Drug(s) Affected By DNA mismatch repair protein Mlh3 (MLH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[167]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[167]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Ras GTPase-activating protein nGAP (RASAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[582]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[126]

Drug(s) Affected By Anaphase-promoting complex subunit 5 (ANAPC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Bortezomib	DMNO38U	Leukemia		Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[582]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]

Drug(s) Affected By Serine/threonine-protein kinase TAO2 (TAOK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[711]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[231]

Drug(s) Affected By Frizzled-4 (FZD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[201]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[312]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]

Drug(s) Affected By Synaptopodin-2 (SYNPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[312]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[712]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[393]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[393]

Drug(s) Affected By U3 small nucleolar RNA-associated protein NOL7 (NOL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[200]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[713]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[27]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[714]

Drug(s) Affected By Cytosolic phospholipase A2 gamma (PLA2G4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[182]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[535]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[137]

Drug(s) Affected By Exonuclease 1 (EXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[460]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[491]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]

Drug(s) Affected By GRB2-associated-binding protein 2 (GAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[182]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[708]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[658]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[715]

Drug(s) Affected By RuvB-like 1 (RUVBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[716]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[717]

Drug(s) Affected By Inversin (INVS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[126]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[139]

Drug(s) Affected By V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[104]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[62]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[19]

Drug(s) Affected By Disheveled-associated activator of morphogenesis 1 (DAAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[308]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[210]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[124]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[62]

Drug(s) Affected By DNA (DNMT3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[718]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[719]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[720]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[721]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[722]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA)	TTB30PF	AROA_ECOLI	Inhibitor	[2]
Plasmodium Enopyruvyl shikimate phosphate synthase (Malaria ESPS)	TTVL895	A0A1C3KAW3_PLAMA	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Gene/Protein Processing	[3]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[3]
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Gene/Protein Processing	[3]
4-aminobutyrate aminotransferase, mitochondrial (ABAT)	OTXAGR7J	GABT_HUMAN	Post-Translational Modifications	[4]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Gene/Protein Processing	[3]
5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7)	OTSLAEUP	COQ7_HUMAN	Post-Translational Modifications	[4]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[3]
Activin receptor type-1 (ACVR1)	OT4JATFE	ACVR1_HUMAN	Gene/Protein Processing	[3]
Acyl-coenzyme A thioesterase THEM4 (THEM4)	OTSIZU8Y	THEM4_HUMAN	Gene/Protein Processing	[3]
ADP-ribosylation factor 4 (ARF4)	OT3GMDHA	ARF4_HUMAN	Gene/Protein Processing	[5]

References

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