Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ0Q1G)

• Drug Name: Permethrin Drug Info
• Synonyms: Ambush; PerFoam; Transpermethrin; Acticin Cream; Elimite Cream; Nix Cream Rinse; Transpermethrin [ISO];FMC 35171; NRDC 146; NRDC 148; PS758_SUPELCO; Permethrin (isomers); Permethrin (isomers) solution; Permethrine,c&t; Trans-(+-)-Permethrin; [3-(phenyloxy)phenyl]methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate; (+)-CIS-PERMETHRIN; (+)-trans-Permethrin; (+-)-cis-Fmc 33297; (+-)-cis-Permethrin; (+-)-trans-Permethrin; (3-Phenoxyphenyl)methyl (+-)-cis,trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate; (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate; 1RS,cis-Permethrin; 1RS-trans-Permethrin; 3-Phenoxybenzyle (1RS)-cis, trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate; 3-phenoxybenzyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Indication

Disease Entry	ICD 11	Status	REF
Pediculus capitis infestation	1G00.0	Approved	[1]
Pediculus humanus corporis infestation		Approved	[1]
Pthirus pubis infestation		Approved	[1]
Sarcoptes scabiei infection	1G04	Approved	[2]

• Therapeutic Class: Insecticides
• Cross-matching ID:
  PubChem CID: 40326
  ChEBI ID: CHEMBL34911
  CAS Number: CAS 52645-53-1
  TTD Drug ID: DMZ0Q1G
  INTEDE Drug ID: DR1262
  ACDINA Drug ID: D01337

Molecule-Related Drug Atlas

Drug(s) Targeting Sodium channel unspecific (NaC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[7]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[8]
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[9]
Eslicarbazepine	DMZREFQ	Seizure disorder	8A6Z	Approved	[10]
LIDOFLAZINE	DMV23GL	Angina pectoris	BA40	Approved	[11]
LOMERIZINE	DME0TC8	Migraine	8A80	Approved	[12]
Levobupivacaine	DM783CH	Anaesthesia	9A78.6	Approved	[13]
Tetrodotoxin	DMWMPRG	Bacterial infection	1A00-1C4Z	Approved	[14]
Rufinamide	DMWE60C	Epilepsy	8A60-8A68	Approved	[15]
Butacaine	DM584TM	Pain	MG30-MG3Z	Approved	[16]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[18]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[25]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[26]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[27]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[28]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[31]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[33]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[34]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[35]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[36]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[36]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[37]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[38]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[39]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[36]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[36]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[41]

Drug(s) Affected By Adenylate kinase isoenzyme 1 (AK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[42]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[42]
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[42]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[42]
Selenium	DM25CGV	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[46]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[49]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[52]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[53]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[57]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[58]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[42]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[59]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[64]

Drug(s) Affected By Shootin-1 (SHTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[70]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]

Drug(s) Affected By Protein shisa-3 homolog (SHISA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Transmembrane protein 72 (TMEM72)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Colipase-like protein 1 (CLPSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Regulator of G-protein signaling protein-like (RGSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Transmembrane protein 247 (TMEM247)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Oocyte-expressed protein homolog (OOEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Calpain-8 (CAPN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Alpha-2-macroglobulin-like protein 1 (A2ML1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[88]

Drug(s) Affected By Small integral membrane protein 22 (SMIM22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]

Drug(s) Affected By Nck-associated protein 5 (NCKAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[95]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 11 (TNFSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Serine/threonine-protein phosphatase with EF-hands 1 (PPEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[108]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Group 10 secretory phospholipase A2 (PLA2G10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[56]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[111]

Drug(s) Affected By Regulator of G-protein signaling 5 (RGS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[95]

Drug(s) Affected By Maltase-glucoamylase (MGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[120]

Drug(s) Affected By Beta-1,3-galactosyltransferase 2 (B3GALT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[88]
Lead acetate	DML0GZ2	Discovery agent	N.A.	Investigative	[121]

Drug(s) Affected By Carbohydrate sulfotransferase 1 (CHST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Ibrolipim	DMOPWSX	Hyperlipidaemia	5C80	Phase 2	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Kallikrein-8 (KLK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[126]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[123]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[126]
Magnesium Sulfate	DMVEK07	Acute pain	MG31	Approved	[126]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]

Drug(s) Affected By Tudor domain-containing protein 6 (TDRD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[56]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By ATP-binding cassette sub-family C member 9 (ABCC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[42]

Drug(s) Affected By RNA-binding motif protein, X-linked-like-2 (RBMXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Ret finger protein-like 2 (RFPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By Olfactory receptor 2J2 (OR2J2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Phospholipid-transporting ATPase VB (ATP10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[134]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By Neurofascin (NFASC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]

Drug(s) Affected By Angiopoietin-related protein 1 (ANGPTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]

Drug(s) Affected By Tetraspanin-15 (TSPAN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 17 (PPP1R17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[139]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[139]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[140]

Drug(s) Affected By Ceruloplasmin (CP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[113]

Drug(s) Affected By Polymeric immunoglobulin receptor (PIGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Selenium	DM25CGV	N. A.	N. A.	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]

Drug(s) Affected By Interferon alpha-6 (IFNA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[154]

Drug(s) Affected By Myosin light chain 1/3, skeletal muscle isoform (MYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[46]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[155]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[140]

Drug(s) Affected By Carbonic anhydrase 3 (CA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]
BICARBONATE	DMT5E36	Discovery agent	N.A.	Investigative	[158]

Drug(s) Affected By Kappa-casein (CSN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Pulmonary surfactant-associated protein B (SFTPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[160]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Terbutaline	DMD4381	Asthma	CA23	Approved	[161]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[161]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[162]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[162]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]

Drug(s) Affected By Homeobox protein Hox-B5 (HOXB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[165]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[166]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[167]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[173]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[174]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[176]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase F (PTPRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]

Drug(s) Affected By Desmoplakin (DSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[56]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Gastricsin (PGC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By B-cell differentiation antigen CD72 (CD72)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[193]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Vitamin K-dependent protein Z (PROZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Endothelin receptor type B (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[196]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[198]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[199]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[200]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[207]
Fructose	DM43AN2	Vomiting	MD90	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[209]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[210]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[211]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[213]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[214]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[215]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[216]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[217]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]

Drug(s) Affected By Embryonic growth/differentiation factor 1 (GDF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[221]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[221]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[223]

Drug(s) Affected By Collagen alpha-1(VIII) chain (COL8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[225]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[211]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[226]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[227]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[228]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[210]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[229]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[213]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[214]

Drug(s) Affected By Leiomodin-1 (LMOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[230]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[231]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[232]

Drug(s) Affected By Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (PDHA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Mitogen-activated protein kinase 4 (MAPK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[233]
IRX4204	DM9SCME	Breast cancer	2C60-2C65	Phase 1	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[235]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[236]

Drug(s) Affected By Cadherin-5 (CDH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[238]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[242]

Drug(s) Affected By Cornifin-A (SPRR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[244]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[245]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Thrombospondin-2 (THBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[143]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[230]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]

Drug(s) Affected By Transcription factor SOX-18 (SOX18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Indomethacin	DMSC4A7	Bursitis		Approved	[249]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[250]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[56]

Drug(s) Affected By Transcription factor ETV6 (ETV6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[251]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[253]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[254]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[257]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[260]

Drug(s) Affected By Transcription factor GATA-4 (GATA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[256]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[266]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[267]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[266]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[268]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[267]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[271]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]

Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[274]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[275]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[274]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[276]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[277]

Drug(s) Affected By Chromaffin granule amine transporter (SLC18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[278]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[279]

Drug(s) Affected By Period circadian protein homolog 3 (PER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[280]
Selenium	DM25CGV	N. A.	N. A.	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[116]

Drug(s) Affected By Junctional adhesion molecule B (JAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[284]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[285]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[278]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Gap junction alpha-9 protein (GJA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[201]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]

Drug(s) Affected By Taste receptor type 2 member 20 (TAS2R20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]

Drug(s) Affected By Major intrinsically disordered NOTCH2-binding receptor 1-like (MINAR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[129]

Drug(s) Affected By Myelin proteolipid protein (PLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[287]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[288]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[285]

Drug(s) Affected By Fibulin-2 (FBLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[290]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]

Drug(s) Affected By Myelin transcription factor 1 (MYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[293]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[294]

Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[295]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[296]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[297]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[298]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[299]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[300]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[301]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[301]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[302]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[301]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[301]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[301]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[304]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[305]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[306]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Binder of sperm protein homolog 1 (BSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Uncharacterized protein C17orf67 (C17ORF67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Fatty acid-binding protein 9 (FABP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[88]

Drug(s) Affected By Forkhead box protein I1 (FOXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[308]

Drug(s) Affected By Interleukin-15 receptor subunit alpha (IL15RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[309]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By GRB2-associated-binding protein 1 (GAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[310]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[311]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[312]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[199]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[133]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[314]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[315]

Drug(s) Affected By Protein FAM110C (FAM110C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[316]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[317]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]

Drug(s) Affected By Keratin-associated protein 27-1 (KRTAP27-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Solute carrier family 9 member C1 (SLC9C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[88]

Drug(s) Affected By IQ domain-containing protein C (IQCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[116]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]

Drug(s) Affected By Sodium/hydrogen exchanger 9B1 (SLC9B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Cation channel sperm-associated targeting subunit tau (C2CD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Kita-kyushu lung cancer antigen 1 (CT83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Uncharacterized protein C1orf141 (C1ORF141)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Ephrin type-A receptor 10 (EPHA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[318]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By Cyclin-dependent kinase-like 4 (CDKL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Histone H2B type 2-F (H2BC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[320]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[321]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1B (IFIT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Acyl-CoA-binding domain-containing protein 5 (ACBD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Fibronectin type III domain-containing protein 7 (FNDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Arylacetamide deacetylase-like 4 (AADACL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Mesenteric estrogen-dependent adipogenesis protein (MEDAG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Phospholipid phosphatase 4 (PLPP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]

Drug(s) Affected By Triple QxxK/R motif-containing protein (TRIQK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[322]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By FERM and PDZ domain-containing protein 2 (FRMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[325]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[326]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[325]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[327]

Drug(s) Affected By Keratin, type I cytoskeletal 40 (KRT40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Proline-rich protein 27 (PRR27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]

Drug(s) Affected By Choriogonadotropin subunit beta variant 2 (CGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[328]
norfluoxetine	DMKNUP3	Discovery agent	N.A.	Investigative	[328]

Drug(s) Affected By Proactivator polypeptide-like 1 (PSAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[88]

Drug(s) Affected By Fanconi anemia core complex-associated protein 20 (FAAP20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[329]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[330]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[331]

Drug(s) Affected By Keratin-associated protein 26-1 (KRTAP26-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Opsin-5 (OPN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Transmembrane protein 270 (TMEM270)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[332]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By Surfactant-associated protein 2 (SFTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[317]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Serine protease 55 (PRSS55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Arylsulfatase K (ARSK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[333]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[334]

Drug(s) Affected By ALK and LTK ligand 2 (ALKAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[56]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[335]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By CMRF35-like molecule 9 (CD300LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Protocadherin-23 (DCHS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (TPTE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[336]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[337]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Thrombospondin type-1 domain-containing protein 4 (THSD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[273]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[312]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[338]

Drug(s) Affected By Death domain-containing protein 1 (DTHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Protein LEKR1 (LEKR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Cilia- and flagella-associated protein 77 (CFAP77)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Proline-rich protein 23B (PRR23B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By UPF0606 protein KIAA1549L (KIAA1549L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[339]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[70]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[340]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[95]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[340]

Drug(s) Affected By Phospholipid phosphatase-related protein type 4 (PLPPR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[122]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By G protein-regulated inducer of neurite outgrowth 1 (GPRIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[341]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[330]

Drug(s) Affected By Transient receptor potential cation channel subfamily M member 8 (TRPM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[343]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[342]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[186]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]

Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[344]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[344]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[344]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[344]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[344]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[344]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[344]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[344]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[344]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]

Drug(s) Affected By Protein RD3 (RD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Putative ATP synthase subunit g 2, mitochondrial (ATP5MGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[345]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Chemokine-like protein TAFA-3 (TAFA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]

Drug(s) Affected By FYVE, RhoGEF and PH domain-containing protein 2 (FGD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[329]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Arpin (ARPIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Regulator of DNA class I crossover intermediates 1 (REDIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[325]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Ras-related protein Rab-43 (RAB43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[346]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[134]

Drug(s) Affected By Kelch domain-containing protein 8A (KLHDC8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[129]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By Stabilizer of axonemal microtubules 1 (SAXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[108]

Drug(s) Affected By Heparan-sulfate 6-O-sulfotransferase 3 (HS6ST3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[348]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Ligand-dependent nuclear receptor corepressor-like protein (LCORL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 16 (GALNT16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[143]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]

Drug(s) Affected By Inactive carboxypeptidase-like protein X2 (CPXM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[309]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By Translocating chain-associated membrane protein 1-like 1 (TRAM1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By IQ domain-containing protein F1 (IQCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By UPF0728 protein C10orf53 (C10ORF53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By POU domain, class 5, transcription factor 2 (POU5F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[154]

Drug(s) Affected By Ankyrin repeat domain-containing protein 31 (ANKRD31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[134]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[88]

Drug(s) Affected By Choline transporter-like protein 5 (SLC44A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[350]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]

Drug(s) Affected By Hemicentin-2 (HMCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Indomethacin	DMSC4A7	Bursitis		Approved	[249]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[351]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[352]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]

Drug(s) Affected By Transient receptor potential cation channel subfamily V member 3 (TRPV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Camphor	DMWIO46	Acute or chronic pain	MG30-MG31	Approved	[353]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
Manganese	DMKT129	N. A.	N. A.	Investigative	[354]
1,4-Naphthoquinone	DMTCMH7	Discovery agent	N.A.	Investigative	[355]
1,2-NAPHTHOQUINONE	DMYXELH	Discovery agent	N.A.	Investigative	[355]

Drug(s) Affected By Protein DBF4 homolog B (DBF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]

Drug(s) Affected By Olfactory receptor 5D18 (OR5D18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[356]

Drug(s) Affected By Olfactory receptor 1L8 (OR1L8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]

Drug(s) Affected By Olfactory receptor 10A6 (OR10A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[88]

Drug(s) Affected By Fibronectin type 3 and ankyrin repeat domains protein 1 (FANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By Serine/threonine-protein kinase BRSK1 (BRSK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[186]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[167]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[357]

Drug(s) Affected By Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]

Drug(s) Affected By Probable glutathione peroxidase 8 (GPX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[358]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[359]

Drug(s) Affected By Uncharacterized protein C10orf105 (C10ORF105)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Partitioning defective 3 homolog (PARD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[196]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[196]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]

Drug(s) Affected By Protein prune homolog 2 (PRUNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[360]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[137]

Drug(s) Affected By Connector enhancer of kinase suppressor of ras 2 (CNKSR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[95]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]

Drug(s) Affected By Cationic amino acid transporter 3 (SLC7A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[362]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[129]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[284]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Rap guanine nucleotide exchange factor 5 (RAPGEF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[363]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[290]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]

Drug(s) Affected By Delta-sarcoglycan (SGCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]

Drug(s) Affected By Synapsin-2 (SYN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[364]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[278]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By Gap junction alpha-10 protein (GJA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Polyadenylate-binding protein 5 (PABPC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By Cysteine and tyrosine-rich protein 1 (CYYR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Beta-galactoside alpha-2,6-sialyltransferase 2 (ST6GAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By Spermatogenesis-associated protein 17 (SPATA17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[181]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[312]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[309]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[335]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[236]

Drug(s) Affected By Coiled-coil domain-containing protein 17 (CCDC17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[181]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[365]

Drug(s) Affected By Testis-specific expressed protein 55 (TEX55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Chloride intracellular channel protein 6 (CLIC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[366]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[366]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]

Drug(s) Affected By Sperm acrosome-associated protein 5 (SPACA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Protocadherin-15 (PCDH15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[367]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[330]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Pannexin-2 (PANX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Bortezomib	DMNO38U	Leukemia		Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[236]

Drug(s) Affected By T-box transcription factor TBX15 (TBX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[343]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[321]

Drug(s) Affected By Protein FAM83C (FAM83C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Leucine-rich repeat-containing protein 1 (LRRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[317]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By FUN14 domain-containing protein 2 (FUNDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[368]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[369]

Drug(s) Affected By Receptor for retinol uptake STRA6 (STRA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[95]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[371]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]

Drug(s) Affected By Complement C1q tumor necrosis factor-related protein 1 (C1QTNF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[236]

Drug(s) Affected By Periaxin (PRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Selenium	DM25CGV	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Iroquois-class homeodomain protein IRX-2 (IRX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[253]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[346]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[95]

Drug(s) Affected By Glutamate receptor-interacting protein 2 (GRIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Very long chain fatty acid elongase 4 (ELOVL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[364]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Radial spoke head protein 6 homolog A (RSPH6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[373]

Drug(s) Affected By Pseudouridylate synthase PUS7L (PUS7L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[374]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[330]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG10 (ATG10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[252]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
AT7519	DMCE08M	Solid tumour/cancer	2A00-2F9Z	Phase 1	[375]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[259]

Drug(s) Affected By Cytosolic beta-glucosidase (GBA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[56]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Thiamin pyrophosphokinase 1 (TPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[374]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[70]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[374]

Drug(s) Affected By Protein ABHD16B (ABHD16B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Gremlin-2 (GREM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[129]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[230]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]

Drug(s) Affected By L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[368]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[316]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[316]

Drug(s) Affected By Protocadherin-9 (PCDH9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[231]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]

Drug(s) Affected By Sodium- and chloride-dependent transporter XTRP3 (SLC6A20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[377]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[374]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[378]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[87]

Drug(s) Affected By Matrix-remodeling-associated protein 5 (MXRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[176]

Drug(s) Affected By Disrupted in schizophrenia 1 protein (DISC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[95]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[380]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[381]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Uncharacterized protein C14orf119 (C14ORF119)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[276]

Drug(s) Affected By Rhomboid-related protein 2 (RHBDL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[382]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[70]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[117]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[325]

Drug(s) Affected By Taste receptor type 2 member 4 (TAS2R4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[88]

Drug(s) Affected By Semaphorin-5B (SEMA5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[383]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Methyl-CpG-binding domain protein 2 (MBD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[384]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[386]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[387]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[388]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[389]

Drug(s) Affected By LIM/homeobox protein Lhx3 (LHX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[201]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[322]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]

Drug(s) Affected By Adherens junction-associated protein 1 (AJAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[390]
Methamphetamine	DMPM4SK	Anxiety		Approved	[391]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[95]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[390]

Drug(s) Affected By F-box/LRR-repeat protein 2 (FBXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[392]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 30 (ADAM30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Peroxisomal carnitine O-octanoyltransferase (CROT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[280]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[393]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[129]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[393]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[165]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[245]

Drug(s) Affected By Gap junction delta-2 protein (GJD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[290]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[394]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Glutamate receptor ionotropic, delta-1 (GRID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Ras-related protein Rab-26 (RAB26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[379]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[143]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 3 (MAPRE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[186]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[395]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]

Drug(s) Affected By Afadin- and alpha-actinin-binding protein (SSX2IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[322]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[396]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[397]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]

Drug(s) Affected By Ankyrin repeat domain-containing protein 6 (ANKRD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[128]

Drug(s) Affected By RNA-binding motif protein, X-linked 2 (RBMX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[330]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[334]

Drug(s) Affected By Sorting and assembly machinery component 50 homolog (SAMM50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[345]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Actin-like protein 7B (ACTL7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[398]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[399]

Drug(s) Affected By Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[322]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[400]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]

Drug(s) Affected By Krueppel-like factor 10 (KLF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[186]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[181]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[402]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[403]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[404]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[405]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[406]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[407]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[197]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[408]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[409]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[410]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[411]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[412]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[413]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[414]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[415]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[414]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[410]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[42]

Drug(s) Affected By Calcium-binding protein 5 (CABP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[416]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[233]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sodium channel unspecific (NaC)	TTRK8B9	NOUNIPROTAC	Blocker	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1)	OT6Z1L2E	PLCH1_HUMAN	Gene/Protein Processing	[5]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1)	OTTHX4NB	F261_HUMAN	Gene/Protein Processing	[5]
Actin-like protein 7B (ACTL7B)	OTCG3IGE	ACL7B_HUMAN	Gene/Protein Processing	[5]
Acyl-CoA-binding domain-containing protein 5 (ACBD5)	OT7L16DY	ACBD5_HUMAN	Gene/Protein Processing	[5]
Adenylate kinase isoenzyme 1 (AK1)	OT614AR3	KAD1_HUMAN	Gene/Protein Processing	[6]
Adherens junction-associated protein 1 (AJAP1)	OTAAW121	AJAP1_HUMAN	Gene/Protein Processing	[5]
Afadin- and alpha-actinin-binding protein (SSX2IP)	OTEIZ7N1	ADIP_HUMAN	Gene/Protein Processing	[5]
ALK and LTK ligand 2 (ALKAL2)	OTTLHL64	ALKL2_HUMAN	Gene/Protein Processing	[5]
Alpha-2-macroglobulin-like protein 1 (A2ML1)	OTWNUXIS	A2ML1_HUMAN	Gene/Protein Processing	[5]
Angiopoietin-related protein 1 (ANGPTL1)	OTXIN6V5	ANGL1_HUMAN	Gene/Protein Processing	[5]

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