Details of Disease

General Information of Disease (ID: DISLD42D)

Disease Name Oral cancer
Synonyms oral carcinoma; lip and oral cavity cancer; oral cancer; lip and oral cavity carcinoma
Disease Class 2B6E: Lip/oral cavity/pharynx neoplasm
Definition
A carcinoma arising in the lip or oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma. Lip carcinomas are usually basal cell or squamous cell carcinomas.
Disease Hierarchy
DISOU1DS: Head and neck carcinoma
DISLD42D: Oral cancer
ICD Code
ICD-11
ICD-11: 2B6E
ICD-10
ICD-10: C00-C14
Expand ICD-11
'2B6Z
Expand ICD-10
'C00-C14
Disease Identifiers
MONDO ID
MONDO_0023644
UMLS CUI
C0220641
MedGen ID
67387

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
OraTest DMUAGFH Approved NA [1]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Contusugene ladenovec DMN9ETB Phase 3 NA [2]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
INGN-234 DMJM38Q Discontinued in Phase 2 NA [3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 67 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADORA2B TTNE7KG Limited Biomarker [4]
ATG2B TTG6KCU Limited Genetic Variation [5]
ATP2A2 TTE6THL Limited Genetic Variation [6]
CA9 TT2LVK8 Limited Altered Expression [7]
CSNK1E TTA8PLI Limited Genetic Variation [8]
HDGF TTKGV26 Limited Biomarker [9]
MMP1 TTMX39J Limited Genetic Variation [10]
RABL3 TTYGK57 Limited Altered Expression [11]
SEMA4D TT5UT28 Limited Biomarker [12]
SIRPA TTBRJS9 Limited Biomarker [13]
AICDA TTKRTP6 moderate Biomarker [14]
CXCL12 TT4UGTF moderate Biomarker [15]
CYP2E1 TTWVHQ5 moderate Genetic Variation [16]
EGF TTED8JB moderate Biomarker [17]
GALR1 TTX3HNZ moderate Biomarker [18]
KLK4 TT4319X moderate Biomarker [19]
LTB TTHQ6US moderate Biomarker [20]
RGMA TTURJV4 moderate Biomarker [21]
ADAM9 TTTYQNS Strong Altered Expression [22]
ANGPTL3 TT59GO7 Strong Biomarker [23]
ANXA10 TT0NL6U Strong Biomarker [24]
BCL2L2 TTQ79W8 Strong Genetic Variation [25]
CARM1 TTIZQFJ Strong Biomarker [26]
CASP4 TT6KIOT Strong Biomarker [27]
CD83 TTT9MRQ Strong Biomarker [28]
CDC20 TTBKFDV Strong Altered Expression [29]
CPB2 TTP18AY Strong Genetic Variation [30]
CTSB TTF2LRI Strong Biomarker [31]
CYP2A6 TTAQ6ZW Strong Genetic Variation [32]
DAGLA TTRQ6UD Strong Biomarker [33]
DEFB4A TTIVY12 Strong Altered Expression [34]
DSG3 TTEO4P8 Strong Biomarker [35]
FABP5 TTNT2S6 Strong Biomarker [36]
FAT1 TTGUJYV Strong Biomarker [37]
GMNN TT390KA Strong Biomarker [38]
GP1BA TTVB0Q9 Strong Genetic Variation [39]
GRHL2 TTUGH4C Strong Biomarker [40]
GRM5 TTHS256 Strong Altered Expression [41]
GSTA1 TT4P8DE Strong Genetic Variation [42]
HAX1 TT21BYA Strong Altered Expression [43]
HMGCS2 TTS0EZJ Strong Biomarker [44]
IGF2R TTPNE41 Strong Genetic Variation [45]
KDM1A TTNR0UQ Strong Biomarker [46]
KDM5B TTCLI75 Strong Altered Expression [47]
KIF11 TTBGTCW Strong Biomarker [48]
KLF4 TTTI53X Strong Biomarker [49]
KRT17 TTKV0EC Strong Biomarker [50]
LASP1 TTZJA87 Strong Altered Expression [51]
MALT1 TTCI81G Strong Altered Expression [52]
MMP11 TTZW4MV Strong Biomarker [53]
MMP7 TTMTWOS Strong Genetic Variation [54]
MTNR1A TT0WAIE Strong Genetic Variation [55]
NFKBIA TTSHAEB Strong Genetic Variation [56]
NOP2 TTBLG3H Strong Biomarker [57]
NUF2 TTIXBFP Strong Biomarker [58]
OGG1 TTRU01G Strong Biomarker [37]
PPP2R5A TTLONKX Strong Biomarker [59]
PTPRZ1 TT4SEA8 Strong Altered Expression [60]
RECK TTRZBW7 Strong Biomarker [61]
RXRB TTKLV96 Strong Biomarker [62]
SERPINB5 TT1KW50 Strong Genetic Variation [63]
SLC7A11 TTBZMIO Strong Altered Expression [64]
SSRP1 TTETDKQ Strong Biomarker [65]
STOML2 TTOI329 Strong Biomarker [66]
TERF2 TT5XSLT Strong Biomarker [67]
FHIT TTMS54D Definitive Genetic Variation [68]
HPGDS TTCYE56 Definitive Genetic Variation [69]
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⏷ Show the Full List of 67 DTT(s)
This Disease Is Related to 7 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ALDH1A1 DE2JP1Y Limited Biomarker [70]
ADH1C DEM1HNL Strong Genetic Variation [71]
CYP4F3 DEFCMPI Strong Genetic Variation [72]
FADS1 DE05S8C Strong Genetic Variation [73]
GGCT DEKW6PB Strong Genetic Variation [74]
NNMT DECVGJ3 Strong Biomarker [75]
THOP1 DE95LJC Strong Genetic Variation [76]
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⏷ Show the Full List of 7 DME(s)
This Disease Is Related to 146 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ATG10 OTVRPC5X Limited Genetic Variation [5]
CIP2A OTVS2GXA Limited Altered Expression [77]
DNAJB7 OT4BOECZ Limited Biomarker [78]
GIMAP7 OTBZO19Y Limited Altered Expression [11]
MCC OTQVI1EM Limited Genetic Variation [79]
N4BP2L1 OTEGV3GO Limited Biomarker [80]
OAS2 OT64CCTM Limited Altered Expression [81]
POLG2 OTDBMZJB Limited Genetic Variation [82]
POLRMT OT5Q8ZUJ Limited Genetic Variation [82]
BUB3 OTU91HAU moderate Altered Expression [83]
CD82 OTH8MC64 moderate Biomarker [84]
SMIM10L2B OT04IG2N moderate Biomarker [85]
ST3GAL2 OT8WM21E moderate Altered Expression [86]
ST3GAL3 OTOORKUE moderate Altered Expression [86]
ABCE1 OTH19LOA Strong Biomarker [87]
ACTR2 OT3C8U5T Strong Biomarker [14]
ADAMTS14 OTFJ1PDB Strong Genetic Variation [88]
AHRR OTSJ12W6 Strong Genetic Variation [89]
ANAPC10 OTM03SME Strong Biomarker [90]
ANOS1 OTZJT4KN Strong Biomarker [91]
ANP32A OTRHPFO2 Strong Biomarker [92]
APOBEC3A OTYO6F5P Strong Biomarker [93]
ATP6V1C1 OT2LI8ZG Strong Biomarker [94]
BAG2 OTI6LD27 Strong Altered Expression [95]
BCAR1 OTKT2C2N Strong Biomarker [96]
BEX4 OT3LXD15 Strong Biomarker [97]
BID OTOSHSHU Strong Genetic Variation [25]
BRD8 OTIKS3PC Strong Biomarker [57]
BTG3 OT9ANHVT Strong Biomarker [98]
C6orf141 OTUS3SIQ Strong Altered Expression [99]
CAVIN2 OTFHHDRU Strong Biomarker [100]
CCNG2 OTII38K2 Strong Biomarker [101]
CCNH OTKDU3SR Strong Genetic Variation [102]
CDCA3 OTUI8QK3 Strong Altered Expression [103]
CDK2AP1 OTNFOHDJ Strong Biomarker [90]
CELF1 OT6JQ5RS Strong Altered Expression [104]
CEMIP OTK80FYN Strong Biomarker [105]
CENPN OTRO7XPD Strong Biomarker [106]
CLPTM1L OTDJWQXI Strong Genetic Variation [107]
COL10A1 OTC4G2YC Strong Biomarker [108]
COL4A3 OT6SB8X5 Strong Biomarker [109]
CTTN OTJRG4ES Strong Biomarker [14]
DACH1 OTMKNAGG Strong Posttranslational Modification [110]
DCTN3 OTQOSUES Strong Altered Expression [66]
DDX60 OTVPHA0C Strong Biomarker [111]
DEPDC1B OTMVFOT1 Strong Biomarker [112]
DPAGT1 OTYEJAGZ Strong Biomarker [113]
DSC1 OTNII6GZ Strong Biomarker [114]
DSP OTB2MOP8 Strong Biomarker [115]
DSPP OT1TYNDN Strong Biomarker [116]
DST OTHZBM4X Strong Biomarker [117]
ECT2 OTQDUCT6 Strong Altered Expression [118]
ESM1 OT331Y8V Strong Biomarker [119]
ETV4 OT8C98UZ Strong Biomarker [120]
EXO1 OTI87RS5 Strong Genetic Variation [121]
EYA4 OTINGR3Z Strong Biomarker [122]
FBLIM1 OTFHXMON Strong Biomarker [123]
FGF3 OT9PK2SI Strong Biomarker [124]
FILIP1L OTPY8IMS Strong Biomarker [90]
FOXI2 OTFQ0E2X Strong Posttranslational Modification [125]
FOXN3 OTOJYJZP Strong Altered Expression [126]
FUT1 OTODG57A Strong Biomarker [127]
FUT2 OTLXM6WI Strong Genetic Variation [128]
FUT8 OTJJCVG1 Strong Altered Expression [129]
GDF10 OTEVXGJ7 Strong Biomarker [130]
GEMIN2 OT4L6TLL Strong Altered Expression [131]
GOPC OTRBGH71 Strong Biomarker [132]
GPN1 OTM03SFL Strong Genetic Variation [107]
GSTM2 OTG4WT05 Strong Genetic Variation [133]
GSTM3 OTLA2WJT Strong Genetic Variation [134]
HAS2 OTTD3PAL Strong Altered Expression [135]
HAS3 OTPM8IL8 Strong Altered Expression [136]
HBP1 OTDPGGDV Strong Altered Expression [65]
HLA-DQA2 OT1DH0N9 Strong Genetic Variation [137]
HNRNPU OTLQN1E2 Strong Biomarker [57]
HOXA10 OTB6GQ09 Strong Biomarker [138]
HOXB5 OTU74TB8 Strong Biomarker [139]
HOXB7 OTC7WYU8 Strong Biomarker [140]
HTRA3 OTXJ0H4X Strong Biomarker [141]
IFITM1 OTECO1G8 Strong Biomarker [142]
IGSF1 OT3XD6U2 Strong Biomarker [57]
ING5 OTRNNSFM Strong Biomarker [143]
INTS2 OT2N5TCK Strong Biomarker [124]
KIF4A OT3UWL7D Strong Biomarker [144]
KLK13 OT8LOD2U Strong Altered Expression [145]
KRT13 OTTYSKGX Strong Altered Expression [146]
LAMC3 OTKNAYJO Strong Genetic Variation [107]
LCP1 OTK61F2A Strong Biomarker [147]
LPCAT1 OTCV7AGV Strong Biomarker [148]
LRG1 OTLD0KWA Strong Biomarker [129]
LTO1 OTQ17ZDT Strong Biomarker [149]
MAD2L1 OTXNGZCG Strong Altered Expression [150]
MAU2 OTALDF8Q Strong Altered Expression [151]
MED15 OT0D0JVD Strong Biomarker [152]
MIEN1 OTCQ8DAD Strong Biomarker [153]
MMP20 OT16S5S3 Strong Biomarker [116]
MMP25 OT3BG37V Strong Biomarker [154]
MSN OTZJ4J6G Strong Biomarker [155]
MTA2 OTCCYIQJ Strong Biomarker [156]
MTMR3 OTBIT23O Strong Altered Expression [157]
MYCL OT1MFQ5U Strong Genetic Variation [158]
MYO1B OTGZUJ0I Strong Altered Expression [159]
NAA25 OTS3QVF1 Strong Biomarker [57]
NME4 OT2JTT42 Strong Biomarker [160]
NRBP1 OTRWEJ65 Strong Biomarker [161]
NSUN5 OTBN7RS8 Strong Biomarker [57]
OAZ1 OTPT0PKZ Strong Biomarker [162]
PABPN1 OT3MC5SE Strong Biomarker [163]
PAX1 OT0Y3MIM Strong Biomarker [164]
PCBP2 OTXCN9CG Strong Altered Expression [165]
PDCD7 OTK5YO7J Strong Altered Expression [166]
PDPN OTBUV19I Strong Biomarker [167]
PHLDA1 OTFTWMIQ Strong Biomarker [168]
PIWIL2 OT1PXQIF Strong Biomarker [169]
PPIG OTZ8BTTM Strong Genetic Variation [170]
PSME3 OTSTC4YY Strong Biomarker [171]
PTPRR OT790UA2 Strong Biomarker [172]
PTRH2 OTBU39Q1 Strong Biomarker [173]
RAB25 OTW0W6NP Strong Biomarker [174]
RAB2A OT6SK83U Strong Altered Expression [175]
RAD17 OT1I93DT Strong Biomarker [176]
RASSF5 OT6Q41I2 Strong Altered Expression [177]
RBMX OTFZN66E Strong Altered Expression [178]
RIN1 OTPBROUD Strong Biomarker [179]
RNF139 OT0PR1X5 Strong Biomarker [180]
RRAS2 OT83NCEB Strong Biomarker [181]
S100A14 OTVFJJ91 Strong Genetic Variation [182]
S100A7 OTJFVJRF Strong Altered Expression [175]
SCAF11 OTX59D0X Strong Altered Expression [131]
SEMA3C OTEGUY7F Strong Altered Expression [183]
SEPTIN1 OT4GVSU3 Strong Altered Expression [184]
SIAH2 OTKED2XN Strong Biomarker [185]
SLC12A9 OTR7VRAK Strong Genetic Variation [186]
SLPI OTUNFUU8 Strong Altered Expression [187]
SMR3B OTL5HNM8 Strong Biomarker [188]
SSR1 OTQ6GDL2 Strong Biomarker [189]
STATH OTQHBHM9 Strong Biomarker [190]
SYT12 OT86PAFL Strong Biomarker [191]
TMEFF2 OT1WZ2QO Strong Biomarker [192]
TMOD1 OTTRYF9Y Strong Altered Expression [193]
TRAM2 OTSFG0ST Strong Altered Expression [194]
TRIT1 OTCU9FS5 Strong Altered Expression [195]
ANKRD17 OTQ3DYEP Definitive Biomarker [68]
CNTN4 OTULXVE0 Definitive Genetic Variation [196]
SNTB1 OTSRBECI Definitive Genetic Variation [196]
STAG2 OTR6X1Q7 Definitive Altered Expression [197]
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⏷ Show the Full List of 146 DOT(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 ClinicalTrials.gov (NCT00041613) Study to Compare the Overall Survival of Patients Receiving INGN 201 (Study Drug) With Patients Receiving Methotrexate. U.S. National Institutes of Health.
3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028790)
4 Adenosine A2b receptor promotes progression of human oral cancer.BMC Cancer. 2015 Jul 31;15:563. doi: 10.1186/s12885-015-1577-2.
5 Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma.Sci Rep. 2017 Jul 31;7(1):6887. doi: 10.1038/s41598-017-07270-0.
6 Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines.Mol Carcinog. 2016 Oct;55(10):1477-85. doi: 10.1002/mc.22402. Epub 2015 Sep 1.
7 Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells.Oncotarget. 2017 Aug 12;8(47):83088-83099. doi: 10.18632/oncotarget.20236. eCollection 2017 Oct 10.
8 Impact of Polymorphisms in Casein Kinase 1 Epsilon and Environmental Factors in Oral Cancer Susceptibility.J Cancer. 2019 Aug 28;10(21):5065-5069. doi: 10.7150/jca.34592. eCollection 2019.
9 Novel HDGF/HIF-1/VEGF axis in oral cancer impacts disease prognosis.BMC Cancer. 2019 Nov 11;19(1):1083. doi: 10.1186/s12885-019-6229-5.
10 Association Between Matrix Metalloproteinase-1, 2, 3 Polymorphisms and Oral Cancer Risk: A Meta-Analysis.Genet Test Mol Biomarkers. 2018 Aug;22(8):456-464. doi: 10.1089/gtmb.2018.0089.
11 Identification of GIMAP7 and Rabl3 as Putative Biomarkers for Oral Squamous Cell Carcinoma Through Comparative Proteomic Approach.Pathol Oncol Res. 2020 Jul;26(3):1817-1822. doi: 10.1007/s12253-019-00775-1. Epub 2019 Nov 20.
12 Semaphorin4D Inhibition Improves Response to Immune-Checkpoint Blockade via Attenuation of MDSC Recruitment and Function.Cancer Immunol Res. 2019 Feb;7(2):282-291. doi: 10.1158/2326-6066.CIR-18-0156. Epub 2018 Dec 4.
13 Signal regulatory protein associated with the progression of oral leukoplakia and oral squamous cell carcinoma regulates phenotype switch of macrophages.Oncotarget. 2016 Dec 6;7(49):81305-81321. doi: 10.18632/oncotarget.12874.
14 An update of knowledge on cortactin as a metastatic driver and potential therapeutic target in oral squamous cell carcinoma.Oral Dis. 2019 May;25(4):949-971. doi: 10.1111/odi.12913. Epub 2018 Jul 6.
15 SDF-1-loaded PLGA nanoparticles for the targeted photoacoustic imaging and photothermal therapy of metastatic lymph nodes in tongue squamous cell carcinoma.Int J Pharm. 2019 Jan 10;554:93-104. doi: 10.1016/j.ijpharm.2018.10.064. Epub 2018 Oct 29.
16 CYP2E1 RsaI/PstI polymorphisms contributed to oral cancer susceptibility: a meta-analysis.Int J Clin Exp Pathol. 2015 Nov 1;8(11):14685-92. eCollection 2015.
17 p73 induction by Abrus agglutinin facilitates Snail ubiquitination to inhibit epithelial to mesenchymal transition in oral cancer.Phytomedicine. 2019 Mar 1;55:179-190. doi: 10.1016/j.phymed.2018.08.003. Epub 2018 Aug 6.
18 Galanin is an epigenetically silenced tumor suppressor gene in gastric cancer cells.PLoS One. 2018 Feb 20;13(2):e0193275. doi: 10.1371/journal.pone.0193275. eCollection 2018.
19 Clinical significance of kallikrein-related peptidase-4 in oral cancer.Anticancer Res. 2015 Apr;35(4):1861-6.
20 Oral cancer-associated tertiary lymphoid structures: gene expression profile and prognostic value.Clin Exp Immunol. 2020 Feb;199(2):172-181. doi: 10.1111/cei.13389. Epub 2019 Nov 8.
21 Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma.Biomed Pharmacother. 2019 Apr;112:108608. doi: 10.1016/j.biopha.2019.108608. Epub 2019 Feb 21.
22 Overexpression of ADAM9 in oral squamous cell carcinoma.Oncol Lett. 2018 Jan;15(1):495-502. doi: 10.3892/ol.2017.7284. Epub 2017 Oct 30.
23 ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer.Cancer Med. 2015 May;4(5):759-69. doi: 10.1002/cam4.418. Epub 2015 Jan 30.
24 Annexin A10 in human oral cancer: biomarker for tumoral growth via G1/S transition by targeting MAPK signaling pathways.PLoS One. 2012;7(9):e45510. doi: 10.1371/journal.pone.0045510. Epub 2012 Sep 17.
25 Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.Mitochondrion. 2015 Nov;25:28-33. doi: 10.1016/j.mito.2015.09.001. Epub 2015 Sep 21.
26 Functional interplay between YY1 and CARM1 promotes oral carcinogenesis.Oncotarget. 2019 Jun 4;10(38):3709-3724. doi: 10.18632/oncotarget.26984. eCollection 2019 Jun 4.
27 LOH at PDCD4, CTNNB1, and CASP4 loci contributes to stage progression of oral cancer.Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2 Suppl):89-93. doi: 10.1177/03946320110240S216.
28 Variation and significance of secretory immunoglobulin A, interleukin 6 and dendritic cells in oral cancer.Oncol Lett. 2017 Apr;13(4):2297-2303. doi: 10.3892/ol.2017.5703. Epub 2017 Feb 8.
29 Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer.Carcinogenesis. 2007 Jan;28(1):81-92. doi: 10.1093/carcin/bgl100. Epub 2006 Jun 15.
30 The 1040C/T polymorphism influencing thermal stability and activity of thrombin activatable fibrinolysis inhibitor is associated with risk for oral cancer.Am J Hematol. 2007 Nov;82(11):1010-2. doi: 10.1002/ajh.20985.
31 Cathepsin B Expression and the Correlation with Clinical Aspects of Oral Squamous Cell Carcinoma.PLoS One. 2016 Mar 31;11(3):e0152165. doi: 10.1371/journal.pone.0152165. eCollection 2016.
32 CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka.Carcinogenesis. 2002 Apr;23(4):595-8. doi: 10.1093/carcin/23.4.595.
33 Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.Exp Cell Res. 2018 Jun 1;367(1):112-118. doi: 10.1016/j.yexcr.2018.03.041. Epub 2018 Mar 31.
34 HBD-2 is downregulated in oral carcinoma cells by DNA hypermethylation, and increased expression of hBD-2 by DNA demethylation and gene transfection inhibits cell proliferation and invasion.Oncol Rep. 2014 Aug;32(2):462-8. doi: 10.3892/or.2014.3260. Epub 2014 Jun 12.
35 Desmoglein 3 - Influence on oral carcinoma cell migration and invasion.Exp Cell Res. 2018 Sep 15;370(2):353-364. doi: 10.1016/j.yexcr.2018.06.037. Epub 2018 Jun 30.
36 Fatty-acid-binding protein 5 promotes cell proliferation and invasion in oral squamous cell carcinoma.J Oral Pathol Med. 2010 Apr;39(4):342-8. doi: 10.1111/j.1600-0714.2009.00836.x. Epub 2009 Dec 15.
37 Signature of genetic associations in oral cancer.Tumour Biol. 2017 Oct;39(10):1010428317725923. doi: 10.1177/1010428317725923.
38 DNA ploidy and cell cycle protein expression in oral squamous cell carcinomas with and without lymph node metastases.J Oral Pathol Med. 2017 Oct;46(9):738-743. doi: 10.1111/jop.12554. Epub 2017 Feb 23.
39 The platelet glycoprotein Ibalpha VNTR polymorphism is associated with risk for oral cancer.Anticancer Res. 2007 Nov-Dec;27(6B):4121-5.
40 Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF- signaling pathways.Oncogenesis. 2018 May 8;7(5):38. doi: 10.1038/s41389-018-0047-5.
41 Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract.World J Gastroenterol. 2017 Jul 7;23(25):4500-4507. doi: 10.3748/wjg.v23.i25.4500.
42 Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer.Head Neck. 2010 Aug;32(8):1079-87. doi: 10.1002/hed.21297.
43 HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.Cancer Res. 2007 Jun 1;67(11):5275-84. doi: 10.1158/0008-5472.CAN-07-0318.
44 HMGCS2 enhances invasion and metastasis via direct interaction with PPAR to activate Src signaling in colorectal cancer and oral cancer.Oncotarget. 2017 Apr 4;8(14):22460-22476. doi: 10.18632/oncotarget.13006.
45 Association between Gly1619ARG polymorphism of IGF2R domain 11 (rs629849) and advanced stage of oral cancer.Med Oncol. 2012 Jun;29(2):682-5. doi: 10.1007/s12032-011-9863-6. Epub 2011 Feb 24.
46 Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models.Oncotarget. 2017 May 16;8(20):33756-33769. doi: 10.18632/oncotarget.16808.
47 Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer.Oncotarget. 2017 Dec 15;9(10):8985-8998. doi: 10.18632/oncotarget.23739. eCollection 2018 Feb 6.
48 Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.Int J Oncol. 2018 Jan;52(1):155-165. doi: 10.3892/ijo.2017.4181. Epub 2017 Oct 31.
49 Induced Pluripotent Stem Cell-related Genes Correlate With Poor Prognoses of Oral Squamous Cell Carcinoma.Anticancer Res. 2019 Mar;39(3):1205-1216. doi: 10.21873/anticanres.13231.
50 Keratin 17 Promotes Lung Adenocarcinoma Progression by Enhancing Cell Proliferation and Invasion.Med Sci Monit. 2018 Jul 11;24:4782-4790. doi: 10.12659/MSM.909350.
51 Overexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancer.PLoS One. 2013 Dec 26;8(12):e83187. doi: 10.1371/journal.pone.0083187. eCollection 2013.
52 Single nucleotide polymorphisms of mucosa-associated lymphoid tissue 1 in oral carcinoma cells and gingival fibroblasts.Odontology. 2013 Jul;101(2):150-5. doi: 10.1007/s10266-012-0079-9. Epub 2012 Jul 3.
53 MMP-11 promoted the oral cancer migration and Fak/Src activation.Oncotarget. 2017 May 16;8(20):32783-32793. doi: 10.18632/oncotarget.15824.
54 Association of Matrix Metalloproteinase-7 Genotypes to the Risk of Oral Cancer in Taiwan.Anticancer Res. 2018 Apr;38(4):2087-2092. doi: 10.21873/anticanres.12448.
55 Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development.PLoS One. 2015 Mar 25;10(3):e0121677. doi: 10.1371/journal.pone.0121677. eCollection 2015.
56 A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population-based and in vitro study.Cancer Med. 2018 May;7(5):2211-2218. doi: 10.1002/cam4.1453. Epub 2018 Apr 10.
57 Nucleolar protein p120 expression in oral carcinoma.Anticancer Res. 1999 Mar-Apr;19(2B):1423-6.
58 Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer.Int J Oncol. 2016 Oct;49(4):1385-93. doi: 10.3892/ijo.2016.3649. Epub 2016 Aug 5.
59 MicroRNA-218 promotes cisplatin resistance in oral cancer via the PPP2R5A/Wnt signaling pathway.Oncol Rep. 2017 Oct;38(4):2051-2061. doi: 10.3892/or.2017.5899. Epub 2017 Aug 11.
60 Protein tyrosine phosphatase receptor R and Z1 expression as independent prognostic indicators in oral squamous cell carcinoma.Head Neck. 2015 Dec;37(12):1816-22. doi: 10.1002/hed.23835. Epub 2015 Jan 27.
61 Prognostic role of RECK in pathological outcome-dependent buccal mucosa squamous cell carcinoma.Oral Dis. 2020 Jan;26(1):62-71. doi: 10.1111/odi.13214. Epub 2019 Nov 15.
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