Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5H2W9)

• Drug Name: dioscin Drug Info
• Synonyms: Dioscin; 19057-60-4; Collettiside III; Dioscine; CHEBI:74023; CCRIS 4123; UNII-3B95U4OLWV; 3-O-(Rhaalpha1-4(Rhaalpha1-2)Glcbeta)-(25R)-spirost-5-en-3beta-ol; 3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]-diosgenin; 3-O-[alpha-L-Rhap-(1->4)-[alpha-L-Rhap-(1->2)]-beta-D-Glcp]-diosgenin; (25R)-spirost-5-en-3beta-yl alpha-L-rhamnopyranosyl-(1->2)-[alpha-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside; 3B95U4OLWV; AC1L3OGN; Dioscin(Collettiside III); Dioscin (Collettiside III); GTPL840

Indication

Disease Entry	ICD 11	Status	REF
Hepatic fibrosis	DB93.0	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 119245
  ChEBI ID: CHEBI:74023
  CAS Number: CAS 19057-60-4
  TTD Drug ID: DM5H2W9
  VARIDT Drug ID: DR00897

Molecule-Related Drug Atlas

Drug(s) Targeting C-X-C chemokine receptor type 3 (CXCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
T487	DMZTL7H	Psoriatic disorder	EA90	Discontinued in Phase 2	[7]
JT07	DMHBWOP	Solid tumour/cancer	2A00-2F9Z	Preclinical	[8]
kallstroemin D	DM7YAE0	Discovery agent	N.A.	Investigative	[2]
NBI-74330	DMURC6X	Discovery agent	N.A.	Investigative	[7]
Sch-900875	DM346KA	Inflammation	1A00-CA43.1	Investigative	[9]
hypoglaucin A	DMJKIUX	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Selenium	DM25CGV	N. A.	N. A.	Approved	[15]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[10]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[16]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[34]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[36]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[37]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[44]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[46]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[50]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[51]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[52]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[53]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[55]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[56]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[57]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[58]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[56]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[60]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[57]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[56]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[37]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[22]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[62]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[65]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[66]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[75]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[53]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[81]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[82]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[61]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[19]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[22]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[87]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[62]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[10]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[48]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[72]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[66]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[82]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[100]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[101]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[107]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[108]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[105]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[109]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[120]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[121]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[122]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[123]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[124]

Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[127]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[130]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[131]

Drug(s) Affected By Caspase-10 (CASP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[137]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[130]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[36]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[42]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[141]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[144]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[153]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[155]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[10]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[92]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[162]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[166]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[167]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[168]
Fructose	DM43AN2	Vomiting	MD90	Approved	[48]
Ketoprofen	DMRKXPT	Bursitis		Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[52]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[170]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[103]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[173]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[177]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[176]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[181]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[186]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[187]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[188]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[189]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[190]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[191]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[192]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[193]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[194]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[195]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[196]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[197]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[198]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[199]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[197]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[202]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[62]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[202]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[203]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[206]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[209]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[37]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[218]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[42]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[221]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[53]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[82]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[225]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[218]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[227]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[37]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[232]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[233]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[235]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[237]
Fructose	DM43AN2	Vomiting	MD90	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[234]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[239]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[48]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[242]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[243]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[249]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[250]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[251]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[252]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[255]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[186]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[256]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[257]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[258]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[259]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[260]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[240]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[87]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[263]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[264]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[265]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[266]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[267]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[227]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Fructose	DM43AN2	Vomiting	MD90	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[273]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[274]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[275]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[276]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[277]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[51]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[280]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[281]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[282]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[149]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[285]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[286]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[200]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[288]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[289]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[190]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[290]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[292]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[44]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[50]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[234]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[278]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[293]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[62]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[294]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[296]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[301]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[301]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[304]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[130]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[159]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[307]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[308]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[309]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[313]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[315]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[316]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[317]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[318]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[321]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[322]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[323]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[324]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[325]
Mestranol	DMG3F94	Contraception	QA21	Approved	[326]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[327]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[328]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[329]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-X-C chemokine receptor type 3 (CXCR3)	TT1UCIJ	CXCR3_HUMAN	Antagonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)	OT1OG4QZ	AAKB1_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[3]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[4]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[5]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[3]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[6]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[3]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[6]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[4]

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