Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGJSVD)

• Drug Name: P-Coumaric Acid Drug Info
• Synonyms: p-coumaric acid; 4-Hydroxycinnamic acid; p-Hydroxycinnamic acid; 501-98-4; 4-Coumaric acid; trans-4-Hydroxycinnamic acid; 7400-08-0; trans-p-Coumaric acid; p-Cumaric acid; 3-(4-hydroxyphenyl)acrylic acid; Para-Coumaric acid; Hydroxycinnamic acid; p-Hydroxy-cinnamic acid; Naringeninic acid; p-Hydroxyphenylacrylic acid; (E)-p-Coumaric acid; trans-p-Coumarinic acid; 4'-hydroxycinnamic acid; (E)-3-(4-Hydroxyphenyl)acrylic acid; Cinnamic acid, p-hydroxy-; (E)-p-Hydroxycinnamic acid; trans-p-Hydroxycinnamic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 637542
  ChEBI ID: CHEBI:32374
  CAS Number: CAS 501-98-4
  TTD Drug ID: DMGJSVD

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase VI (CA-VI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[8]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
SAR566658	DM6Q295	Solid tumour/cancer	2A00-2F9Z	Phase 2	[11]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[12]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[2]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[14]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[14]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[15]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[14]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[16]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]

Drug(s) Targeting Carbonic anhydrase XII (CA-XII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[17]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[2]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[13]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[17]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[18]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[19]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[20]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[20]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[21]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[22]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[23]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]

Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[24]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[12]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[12]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[2]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[25]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[8]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[26]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[27]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[28]

Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[29]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[14]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[30]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[27]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]

Drug(s) Targeting Carbonic anhydrase IX (CA-IX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[10]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[31]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[32]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[33]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[34]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[35]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Fructose	DM43AN2	Vomiting	MD90	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[46]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[47]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[48]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[54]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[55]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[56]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[56]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[56]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[57]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[58]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[59]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[60]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[61]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[62]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[38]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[63]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[64]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[67]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[68]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[69]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[70]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[73]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[74]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[75]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[86]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[87]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[88]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[92]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[98]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[99]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[100]

Drug(s) Affected By Glycogen phosphorylase, liver form (PYGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[110]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[113]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[115]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[116]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[118]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[122]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[123]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[124]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[125]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[127]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[128]
Fructose	DM43AN2	Vomiting	MD90	Approved	[129]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[130]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[132]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Haloperidol	DM96SE0	Delirium		Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[136]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[92]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[139]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[140]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[98]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[141]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[142]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[146]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[147]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[153]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[92]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[137]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[159]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[86]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[160]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[162]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[163]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[165]

Drug(s) Affected By Biotin--protein ligase (HLCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[5]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[166]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[168]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[145]

Drug(s) Affected By Glycogen synthase, liver (GYS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[151]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[170]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[171]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[172]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[116]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[175]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[176]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[177]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[178]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[110]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[115]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[179]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[173]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[181]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[182]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[175]
Selenium	DM25CGV	N. A.	N. A.	Approved	[139]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[186]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[189]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[191]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[92]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[98]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[141]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[143]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Fructose	DM43AN2	Vomiting	MD90	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[204]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[205]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[2]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[2]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[2]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[2]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[2]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[2]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[2]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[3]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[4]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[3]
Biotin--protein ligase (HLCS)	OTPDUX30	BPL1_HUMAN	Gene/Protein Processing	[5]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[3]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Protein Interaction/Cellular Processes	[3]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[4]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[6]

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