Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKJ8LB)

• Drug Name: Josamycin Drug Info
• Synonyms: Josacine; Josamicina; Josamycine; Josamycinum; EN 141; Kitasamycin A3; Leucomycin A3; Turimycin A5; Antibiotic yl-704 A3; Iosalide (TN); Josacine (TN); Josalid (TN); Josamicina [INN-Spanish]; Josamina (TN); Josamy (TN); Josamycin (TN); Josamycine [INN-French]; Josamycinum [INN-Latin]; Wilprafen (TN); Yl-704 A3; Josamycin [USAN:INN:JAN]; Josamycin (JP15/USAN/INN); Dro-2H-pyran-3-yl 3-methylbutanoate; Leucomycin V, 3-acetate 4B-(3-methylbutanoate); Leucomycin V, 3-acetate 4(sup B)-(3-methylbutanoate); Leucomycin V,3-acetate 4(sup beta)-(3-methylbutanoate)

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 5282165
  ChEBI ID: CHEBI:31739
  CAS Number: CAS 16846-24-5
  TTD Drug ID: DMKJ8LB

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial 50S ribosomal RNA (Bact 50S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[5]
Telithromycin	DMZ4P3A	Bacterial infection	1A00-1C4Z	Approved	[6]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[7]
Dirithromycin	DM0D9YJ	Bacterial infection	1A00-1C4Z	Approved	[8]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[7]
Zithromax	DMN4H2O	Syphilis infection	1A6Z	Approved	[9]
Troleandomycin	DMUZNIG	Bacterial infection	1A00-1C4Z	Approved	[10]
Retapamulin	DM9JXB7	Impetigo	1B72	Approved	[11]
Dalfopristin	DM4LTKV	Bacterial infection	1A00-1C4Z	Approved	[12]
Tedizolid	DMG2SKR	Skin infection	1F28-1G0Z	Approved	[13]

Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[16]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[3]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[3]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[20]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[21]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[24]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[25]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[24]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By Complement receptor type 1 (CR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[45]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[48]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[49]

Drug(s) Affected By Methionyl-tRNA formyltransferase, mitochondrial (MTFMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[53]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[54]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]

Drug(s) Affected By Ribosome-releasing factor 2, mitochondrial (GFM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[64]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[67]

Drug(s) Affected By ADP-ribosylation factor 1 (ARF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[74]

Drug(s) Affected By Transcriptional regulator ATRX (ATRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[77]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[78]
Bortezomib	DMNO38U	Leukemia		Approved	[79]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]

Drug(s) Affected By Translation initiation factor IF-2, mitochondrial (MTIF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[83]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[3]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[3]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[84]

Drug(s) Affected By ATP synthase subunit d, mitochondrial (ATP5PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[86]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[90]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[25]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[104]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]

Drug(s) Affected By TP53-regulated inhibitor of apoptosis 1 (TRIAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[108]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[108]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[109]

Drug(s) Affected By Glucose-6-phosphate isomerase (GPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[63]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[113]

Drug(s) Affected By ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[114]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[115]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[53]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[116]

Drug(s) Affected By Pericentriolar material 1 protein (PCM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, platelet type (PFKP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By F-box only protein 11 (FBXO11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[81]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[123]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[65]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[130]

Drug(s) Affected By ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[132]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[54]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[116]

Drug(s) Affected By RNA transcription, translation and transport factor protein (RTRAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[134]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[135]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15B (PPP1R15B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]

Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[149]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[147]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[150]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[151]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[152]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[152]

Drug(s) Affected By NAD-dependent malic enzyme, mitochondrial (ME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[153]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[132]

Drug(s) Affected By Transcription initiation factor TFIID subunit 4 (TAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[48]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Translation initiation factor IF-3, mitochondrial (MTIF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[161]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[162]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[163]

Drug(s) Affected By Serine-threonine kinase receptor-associated protein (STRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[63]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[63]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]

Drug(s) Affected By Nucleophosmin (NPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 4 (MAP3K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[170]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Serine/threonine-protein kinase SMG1 (SMG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[173]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[175]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[174]

Drug(s) Affected By ATP synthase subunit O, mitochondrial (ATP5PO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[173]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]

Drug(s) Affected By Transcription initiation factor TFIID subunit 3 (TAF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[59]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[52]

Drug(s) Affected By Monocarboxylate transporter 1 (SLC16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[179]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[178]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[117]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[20]
Telbivudine	DMSWUGE	Hepatitis B virus infection	1E51.0	Approved	[183]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[187]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By DAZ-associated protein 1 (DAZAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[188]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[134]

Drug(s) Affected By Citrate synthase, mitochondrial (CS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[190]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[66]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[191]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]

Drug(s) Affected By Nonsense-mediated mRNA decay factor SMG7 (SMG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[192]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[43]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 50S ribosomal RNA (Bact 50S rRNA)	TTUWYEA	NOUNIPROTAC	Binder	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ADP-ribosylation factor 1 (ARF1)	OT5C4C3L	ARF1_HUMAN	Drug Response	[3]
ATP synthase subunit beta, mitochondrial (ATP5F1B)	OTLFZUQK	ATPB_HUMAN	Drug Response	[3]
ATP synthase subunit d, mitochondrial (ATP5PD)	OTAJDLE2	ATP5H_HUMAN	Drug Response	[3]
ATP synthase subunit O, mitochondrial (ATP5PO)	OTU3MCTN	ATPO_HUMAN	Drug Response	[3]
ATP-citrate synthase (ACLY)	OTRL9ZRP	ACLY_HUMAN	Drug Response	[3]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP)	OTFP7AA8	PFKAP_HUMAN	Drug Response	[3]
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX)	OTIT4JL0	CLPX_HUMAN	Drug Response	[3]
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)	OTEPHG0S	CLPP_HUMAN	Drug Response	[3]
Citrate synthase, mitochondrial (CS)	OTYLYXMO	CISY_HUMAN	Drug Response	[3]
Complement receptor type 1 (CR1)	OTODWRW4	CR1_HUMAN	Gene/Protein Processing	[4]

References

• [1] Drug information of Josamycin, 2008. eduDrugs.
• [2] The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J Mol Biol. 2003 Jul 25;330(5):1005-14.
• [3] A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
• [4] In vitro stimulation of polymorphonuclear cell adhesion by ribomunyl and antibiotic + ribomunyl combinations: effects on CD18, CD35 and CD16 expression. Int J Immunopharmacol. 1993 Feb;15(2):163-73. doi: 10.1016/0192-0561(93)90092-d.
• [5] A synthetic alanyl-initiator tRNA with initiator tRNA properties as determined by fluorescence measurements: comparison to a synthetic alanyl-elongator tRNA. Nucleic Acids Res. 1991 Oct 25;19(20):5749-54.
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