Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKYXJW)

Drug Name
Dorsomorphin Drug Info
Synonyms
dorsomorphin; 866405-64-3; 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; BML-275; Compound C; AMPK Inhibitor, Compound C; 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine; CHEMBL478629; CHEBI:78510; 4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine; 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine; AMPK Inhibitor
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11524144
ChEBI ID
CHEBI:78510
CAS Number
CAS 866405-64-3
TTD Drug ID
DMKYXJW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting AMP-activated protein kinase (AMPK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acadesine DM1RMF5 Diabetic complication 5A2Y Phase 3 [8]
MB-11055 DM3RBJW Fatty liver disease DB92.Z Phase 2 [9]
Imeglimin DMMQFG2 Diabetic complication 5A2Y Phase 2 [10]
PXL-770 DMNSRY7 Non-alcoholic fatty liver disease DB92 Phase 2 [11]
ENERGI-F701 DMMIHSO Alopecia ED70 Phase 2 [12]
O-304 DMXM34I Type 2 diabetes 5A11 Phase 2 [13]
IM156 DM4MY9C Solid tumour/cancer 2A00-2F9Z Phase 1 [14]
Phenformin DMQ52JG Diabetic complication 5A2Y Withdrawn from market [15]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [16]
PMID23639540C13a DMLXOAQ Discovery agent N.A. Investigative [17]
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Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [18]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Selenium DM25CGV N. A. N. A. Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [24]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [25]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [26]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [27]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [28]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [30]
Gefitinib DM15F0X Colon adenocarcinoma Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [33]
Selenium DM25CGV N. A. N. A. Approved [21]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [34]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [35]
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Drug(s) Affected By Forkhead box protein O1 (FOXO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Panobinostat DM58WKG Chronic graft versus host disease Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [41]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
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Drug(s) Affected By Bone morphogenetic protein receptor type-1B (BMPR1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
Testosterone DM7HUNW Hot flushes GA30 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [48]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Arsenic DMTL2Y1 N. A. N. A. Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [52]
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Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [58]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [60]
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Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Capsaicin DMGMF6V Back pain ME84.Z Approved [67]
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Drug(s) Affected By Transferrin receptor protein 1 (TFRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [74]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [77]
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Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [82]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [84]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [85]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [86]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [91]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [91]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [93]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [96]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [97]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [99]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [100]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Verapamil DMA7PEW Angina pectoris BA40 Approved [101]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [102]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [103]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [30]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [104]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Selenium DM25CGV N. A. N. A. Approved [106]
Etretinate DM2CZFA Keratosis ED56 Approved [107]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [108]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Selenium DM25CGV N. A. N. A. Approved [21]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [113]
Etretinate DM2CZFA Keratosis ED56 Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [116]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [117]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [121]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [103]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [122]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [123]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [124]
Gefitinib DM15F0X Colon adenocarcinoma Approved [125]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [128]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [121]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [129]
Paclitaxel DMLB81S Breast carcinoma Approved [130]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [131]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [100]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [103]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [122]
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Drug(s) Affected By Bone morphogenetic protein receptor type-1A (BMPR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [133]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [135]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [136]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [137]
Arsenic DMTL2Y1 N. A. N. A. Approved [138]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [7]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [48]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [139]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [140]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [141]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Gefitinib DM15F0X Colon adenocarcinoma Approved [142]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Etretinate DM2CZFA Keratosis ED56 Approved [107]
Prednisone DM2HG4X Acute asthma CA23 Approved [145]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [146]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [147]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [149]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [35]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [156]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [157]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [158]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [159]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [160]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [161]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [162]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [163]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [164]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [165]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [166]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [102]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [167]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [168]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
Meloxicam DM2AR7L Arthritis FA20 Approved [169]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [170]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [171]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [172]
Methotrexate DM2TEOL Anterior urethra cancer Approved [173]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [174]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [176]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [177]
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [179]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
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Drug(s) Affected By Hepcidin (HAMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [180]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [181]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [182]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [183]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [7]
Papaverine DMCA9QP Brain ischaemia 8B1Z Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Ethanol DMDRQZU Chronic pain MG30 Approved [184]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [96]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [164]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Verapamil DMA7PEW Angina pectoris BA40 Approved [101]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [185]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [167]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [186]
Meloxicam DM2AR7L Arthritis FA20 Approved [187]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
Selenium DM25CGV N. A. N. A. Approved [21]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [189]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [191]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [192]
Quercetin DM3NC4M Obesity 5B81 Approved [193]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [194]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [103]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [185]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [195]
Methotrexate DM2TEOL Anterior urethra cancer Approved [196]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [197]
Quercetin DM3NC4M Obesity 5B81 Approved [198]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [199]
Ethacrynic acid DM60QMR Edema MG29 Approved [200]
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Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [149]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [198]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [203]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [204]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [205]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [206]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [74]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [207]
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Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [209]
Testosterone DM7HUNW Hot flushes GA30 Approved [210]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [211]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [212]
Capsaicin DMGMF6V Back pain ME84.Z Approved [213]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [214]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [137]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [215]
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Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [216]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [217]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Etretinate DM2CZFA Keratosis ED56 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [204]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [219]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [75]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [220]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [221]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [149]
Gefitinib DM15F0X Colon adenocarcinoma Approved [222]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [223]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [224]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [225]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
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Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [227]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Fluoxetine DM3PD2C Bipolar depression Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [229]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [230]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [231]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [179]
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Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [186]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [232]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [233]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [234]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [235]
Arsenic DMTL2Y1 N. A. N. A. Approved [236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [237]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [238]
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Drug(s) Affected By Methylcytosine dioxygenase TET2 (TET2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [239]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Arsenic DMTL2Y1 N. A. N. A. Approved [138]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [240]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [242]
Urethane DM7NSI0 N. A. N. A. Phase 4 [243]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [242]
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Drug(s) Affected By Hemojuvelin (HJV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [244]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [237]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [245]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [246]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [247]
SU9516 DMQHG0R Discovery agent N.A. Investigative [7]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Selenium DM25CGV N. A. N. A. Approved [21]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [248]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [249]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [221]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [250]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [251]
Testosterone DM7HUNW Hot flushes GA30 Approved [252]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [253]
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Drug(s) Affected By Forkhead box protein P3 (FOXP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [254]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [255]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [256]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [257]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [258]
GSK618334 DMJPXZ4 Drug abuse 6C4G.1Z Phase 1 [259]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [246]
Mepacrine DMU8L7C Discovery agent N.A. Investigative [260]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [149]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [261]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [56]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [262]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [263]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-17 (SOX17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [264]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [264]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [264]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [264]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [264]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [264]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [265]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [135]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [264]
Ziprasidone DMM58JY Bipolar disorder 6A60 Approved [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transferrin receptor protein 2 (TFR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [133]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
PEITC DMOMN31 Prostate cancer 2C82.0 Phase 2 [267]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [268]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [246]
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [7]
SU9516 DMQHG0R Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Krueppel-like factor 2 (KLF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [269]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [270]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [271]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [272]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [273]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [274]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [137]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [275]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [276]
Methotrexate DM2TEOL Anterior urethra cancer Approved [269]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [277]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [278]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [158]
Paclitaxel DMLB81S Breast carcinoma Approved [279]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [280]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [281]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [282]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
AMP-activated protein kinase (AMPK) TTLAFZV AAPK1_HUMAN; AAKB1_HUMAN; AAKG1_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Gene/Protein Processing [3]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [4]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [5]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Gene/Protein Processing [6]
Bone morphogenetic protein receptor type-1A (BMPR1A) OTQOA4ZH BMR1A_HUMAN Gene/Protein Processing [7]
Bone morphogenetic protein receptor type-1B (BMPR1B) OTGFN0OD BMR1B_HUMAN Gene/Protein Processing [7]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [5]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [3]

References

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