Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFORDT)

Drug Name
Afimoxifene Drug Info
Synonyms
4-Hydroxytamoxifen; Afimoxifene; (Z)-4-Hydroxytamoxifen; Hydroxytamoxifen; 4-Monohydroxytamoxifen; Tamogel; 68047-06-3; trans-4-Hydroxytamoxifen; Ici 79280; 68392-35-8; 65213-48-1; 4-OH-TAM; (Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol; Z-4-hydroxytamoxifen; UNII-95K54647BZ; CHEMBL489; ICI 79,280; TAMOXIFEN, 4-HYDROXY-, (Z)-; BRN 4910749; (E/Z)-4-Hydroxy Tamoxifen; MLS000069742; C26H29NO2; CHEBI:44616; 95K54647BZ; SMR000058939; 4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Ductal carcinoma 2E65.2 Phase 2 [2]
Cross-matching ID
PubChem CID
449459
ChEBI ID
CHEMBL489
CAS Number
CAS 68047-06-3
TTD Drug ID
DMFORDT
VARIDT Drug ID
DR01487
INTEDE Drug ID
DR1944

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [10]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [11]
Estrone DM5T6US Acne vulgaris ED80 Approved [11]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [12]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [12]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [12]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [13]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [3]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [14]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [16]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Folic Acid DMEMBJC Colorectal carcinoma Approved [19]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [18]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [4]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [28]
Metronidazole DMTIVEN Abscess Approved [29]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [30]
Ethanol DMDRQZU Chronic pain MG30 Approved [31]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By UDP-glucuronosyltransferase 1A8 (UGT1A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [32]
Empagliflozin DMRF9YK Type-1 diabetes 5A10 Approved [33]
Darolutamide DMV7YFT Prostate cancer 2C82.0 Approved [34]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [35]
EUGENOL DM7US1H Discovery agent N.A. Patented [35]
Chrysin DM7V2LG Discovery agent N.A. Investigative [35]
phloretin DMYA50U Discovery agent N.A. Investigative [35]
Anthraflavic acid DMN1YFU N. A. N. A. Investigative [35]
Cis-4-hydroxytamoxifen DMRFTB5 N. A. N. A. Investigative [5]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [36]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [37]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [38]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [39]
Cepharanthine DM9Y5JB N. A. N. A. Approved [40]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [41]
Clozapine DMFC71L Schizophrenia 6A20 Approved [42]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [43]
Trifluoperazine DMKBYWI Anxiety Approved [44]
Olanzapine DMPFN6Y Bipolar depression Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [53]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Gefitinib DM15F0X Colon adenocarcinoma Approved [58]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Etretinate DM2CZFA Keratosis ED56 Approved [61]
Prednisone DM2HG4X Acute asthma CA23 Approved [62]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [63]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCHC-type zinc finger nucleic acid binding protein (CNBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [71]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynein light chain 1, cytoplasmic (DYNLL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-A1 (CCNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Folic Acid DMEMBJC Colorectal carcinoma Approved [85]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SH2 domain-containing adapter protein B (SHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [96]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [97]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Prednisone DM2HG4X Acute asthma CA23 Approved [101]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [105]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [106]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [108]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [110]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming acidic coiled-coil-containing protein 1 (TACC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystatin-A (CSTA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [114]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [116]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [117]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [116]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [121]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [117]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Gefitinib DM15F0X Colon adenocarcinoma Approved [122]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Selenium DM25CGV N. A. N. A. Approved [123]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [124]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [125]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [128]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [129]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [130]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Gefitinib DM15F0X Colon adenocarcinoma Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ephrin-A1 (EFNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Estrone DM5T6US Acne vulgaris ED80 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [143]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [144]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 3 (CCN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [146]
Arsenic DMTL2Y1 N. A. N. A. Approved [147]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [148]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [114]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [150]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [151]
Ampicillin DMHWE7P Acute epiglottitis Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 14 (PSMD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Clozapine DMFC71L Schizophrenia 6A20 Approved [153]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Arsenic DMTL2Y1 N. A. N. A. Approved [154]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent RNA helicase DDX3Y (DDX3Y)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [156]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [158]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Asparagine--tRNA ligase, cytoplasmic (NARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [159]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [160]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [160]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trafficking kinesin-binding protein 2 (TRAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [164]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calsyntenin-1 (CLSTN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [166]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein D (APOD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [171]
Paclitaxel DMLB81S Breast carcinoma Approved [172]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [173]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [174]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [117]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [176]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [178]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [179]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [180]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [87]
Etretinate DM2CZFA Keratosis ED56 Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix Gla protein (MGP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [189]
Phytonadione DM8HDOL Bleeding disorder GA20-GA21 Approved [190]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [191]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Etretinate DM2CZFA Keratosis ED56 Approved [183]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [192]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [180]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [117]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Etretinate DM2CZFA Keratosis ED56 Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [192]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [195]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [196]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein SON (SON)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [197]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [160]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [160]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [160]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [200]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [201]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Ethanol DMDRQZU Chronic pain MG30 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [204]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [205]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [201]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Clozapine DMFC71L Schizophrenia 6A20 Approved [153]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribonucleoside-diphosphate reductase large subunit (RRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [207]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer CD24 (CD24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [210]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Threonine--tRNA ligase 1, cytoplasmic (TARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [153]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [160]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-directed RNA polymerase II subunit RPB2 (POLR2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [212]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [213]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [193]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [215]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [195]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Paclitaxel DMLB81S Breast carcinoma Approved [218]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombospondin-2 (THBS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [222]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [160]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [191]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coatomer subunit beta' (COPB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [197]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [189]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrin-3 (MATR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [224]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [89]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [226]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [201]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Folic Acid DMEMBJC Colorectal carcinoma Approved [85]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H3-like centromeric protein A (CENPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [227]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfate transporter (SLC26A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [228]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [229]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [230]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Importin subunit alpha-1 (KPNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [232]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [233]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [209]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [197]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [235]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [236]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [237]
Minodronate DM50PMY Osteoporosis FB83.0 Approved [238]
Risedronate DM5FLTY Bone Paget disease Approved [239]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Pamidronate DMB4AVP Bone Paget disease Approved [239]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chromobox protein homolog 1 (CBX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [241]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [242]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [166]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [243]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein U (HNRNPU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Ethanol DMDRQZU Chronic pain MG30 Approved [245]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [246]
Arsenic DMTL2Y1 N. A. N. A. Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein eL6 (RPL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [248]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [249]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [250]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Folic Acid DMEMBJC Colorectal carcinoma Approved [85]
Bortezomib DMNO38U Leukemia Approved [252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent RNA helicase A (DHX9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [249]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [146]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [253]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [100]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [254]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuroblast differentiation-associated protein AHNAK (AHNAK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [197]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc transporter ZIP6 (SLC39A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [255]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [256]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Filamin-C (FLNC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [257]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [257]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [257]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Importin subunit beta-1 (KPNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [231]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Folic Acid DMEMBJC Colorectal carcinoma Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteasome activator complex subunit 4 (PSME4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Condensin complex subunit 2 (NCAPH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Haloperidol DM96SE0 Delirium Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PCNA-associated factor (PCLAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [260]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [209]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 6 (PSMD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [262]
MG-132 DMKA2YS N. A. N. A. Preclinical [263]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Elongin-B (ELOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [266]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [214]
Okadaic acid DM47CO1 Discovery agent N.A. Investigative [267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-binding protein RBBP7 (RBBP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [268]
Promegestone DMK4S8I Gynecological disease GA6Z Approved [269]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription initiation factor TFIID subunit 9 (TAF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [271]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [243]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [197]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [272]
GW7604 DMCA4RM Discovery agent N.A. Investigative [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Golgin subfamily A member 5 (GOLGA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [273]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [274]
Milchsaure DM462BT Pruritus EC90 Investigative [275]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Transportin-1 (TNPO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dehydrodolichyl diphosphate synthase complex subunit NUS1 (NUS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [273]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [272]
Milchsaure DM462BT Pruritus EC90 Investigative [275]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By UAP56-interacting factor (FYTTD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [230]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [243]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [273]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [276]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [150]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein ILRUN (ILRUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [151]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [277]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [214]
Lithium chloride DMHYLQ2 Discovery agent N.A. Investigative [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Isoproterenol DMK7MEY Atrioventricular block Approved [279]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [280]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolar RNA helicase 2 (DDX21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Very long chain fatty acid elongase 5 (ELOVL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [281]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [216]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [282]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase 26 (STK26)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Membrane-associated progesterone receptor component 1 (PGRMC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [197]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Gefitinib DM15F0X Colon adenocarcinoma Approved [283]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [284]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [285]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Delta(14)-sterol reductase TM7SF2 (TM7SF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Capsaicin DMGMF6V Back pain ME84.Z Approved [286]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chloride intracellular channel protein 3 (CLIC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ampicillin DMHWE7P Acute epiglottitis Approved [74]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [287]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [93]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 13 (KRT13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [276]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [288]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [290]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [291]
Paclitaxel DMLB81S Breast carcinoma Approved [292]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [271]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD44 antigen (CD44)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [293]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [294]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [295]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [296]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [297]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-type tyrosine-protein phosphatase gamma (PTPRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [299]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [301]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [114]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-9 (SOX9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Selenium DM25CGV N. A. N. A. Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [302]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of G-protein signaling 3 (RGS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [303]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Folic Acid DMEMBJC Colorectal carcinoma Approved [85]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [304]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [303]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ephrin-B2 (EFNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [305]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tricarboxylate transport protein, mitochondrial (SLC25A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [153]
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [178]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribose-phosphate pyrophosphokinase 1 (PRPS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [308]
Arsenic DMTL2Y1 N. A. N. A. Approved [309]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cAMP-dependent protein kinase inhibitor alpha (PKIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Bortezomib DMNO38U Leukemia Approved [252]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ETS-related transcription factor Elf-3 (ELF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [227]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 4-aminobutyrate aminotransferase, mitochondrial (ABAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [188]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [282]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disabled homolog 2 (DAB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [312]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Ethanol DMDRQZU Chronic pain MG30 Approved [313]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 1,4-alpha-glucan-branching enzyme (GBE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [314]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [160]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [160]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kinesin light chain 1 (KLC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [87]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [243]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [244]
Milchsaure DM462BT Pruritus EC90 Investigative [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Latent-transforming growth factor beta-binding protein 1 (LTBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [316]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rab-30 (RAB30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [156]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [317]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [262]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death protein 4 (PDCD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [318]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [319]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [318]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [320]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [318]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [252]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [87]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [189]
Milchsaure DM462BT Pruritus EC90 Investigative [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [89]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [264]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [321]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cohesin subunit SA-1 (STAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [322]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [234]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase MYLIP (MYLIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha/beta-tubulin-N-acetyltransferase 9 (NAT9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [272]
Drug(s) Affected By Protein Niban 1 (NIBAN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [323]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Ethanol DMDRQZU Chronic pain MG30 Approved [245]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Multiple epidermal growth factor-like domains protein 9 (MEGF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Methotrexate DM2TEOL Anterior urethra cancer Approved [166]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [264]
bilirubin DMI0V4O Discovery agent N.A. Investigative [324]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [325]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ethanolamine kinase 1 (ETNK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [261]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [89]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [89]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Bortezomib DMNO38U Leukemia Approved [252]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [327]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prenylcysteine oxidase 1 (PCYOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [252]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor-binding protein GGA2 (GGA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Arsenic DMTL2Y1 N. A. N. A. Approved [329]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [216]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [330]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [266]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [197]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [264]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [316]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [230]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein TASOR (TASOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [331]
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [332]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily C member 12 (DNAJC12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [333]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ornithine decarboxylase antizyme 3 (OAZ3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [299]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
Drug(s) Affected By SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [87]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [334]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [334]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [327]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FERM, ARHGEF and pleckstrin domain-containing protein 1 (FARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [335]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [336]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [337]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [276]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [215]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [338]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [339]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [204]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1F (MT1F)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [340]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [341]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [342]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [343]
Fructose DM43AN2 Vomiting MD90 Approved [128]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [344]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [345]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [117]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [331]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [346]
Methotrexate DM2TEOL Anterior urethra cancer Approved [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1G (MT1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [338]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [348]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [340]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [341]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [318]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Methotrexate DM2TEOL Anterior urethra cancer Approved [349]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [318]
Ethacrynic acid DM60QMR Edema MG29 Approved [350]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [150]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [351]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [337]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [298]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [338]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [352]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [117]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [353]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [354]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [355]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [356]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [357]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [358]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [189]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [204]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [359]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [261]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [360]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [189]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FosB (FOSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [338]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [204]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [361]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [306]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1X (MT1X)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [338]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [363]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [348]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [339]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [364]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [160]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [151]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [91]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related GTP-binding protein Rho6 (RND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [365]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Immediate early response gene 2 protein (IER2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [366]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [216]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [338]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [367]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [368]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ERBB receptor feedback inhibitor 1 (ERRFI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dexamethasone-induced Ras-related protein 1 (RASD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [188]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [370]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [371]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [372]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [373]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [374]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [375]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [376]
Gefitinib DM15F0X Colon adenocarcinoma Approved [377]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [378]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [379]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [380]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [371]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [381]
Paclitaxel DMLB81S Breast carcinoma Approved [382]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [383]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [370]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [128]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [293]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [373]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [384]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [385]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [386]
Selenium DM25CGV N. A. N. A. Approved [87]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [387]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [388]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [389]
Quercetin DM3NC4M Obesity 5B81 Approved [390]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Symplekin (SYMPK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [391]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [392]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [186]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable ATP-dependent RNA helicase DDX27 (DDX27)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [392]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [393]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [213]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase RNF114 (RNF114)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [252]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [392]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor repressor (AHRR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [394]
Quercetin DM3NC4M Obesity 5B81 Approved [395]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Cotinine DMCEZ1B Insecticide N.A. Approved [396]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [327]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [397]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [216]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [398]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Charybdotoxin DMKN345 Scorpion envenoming syndrome 8D43 Approved [399]
Clotrimazole DMMFCIH Cutaneous candidiasis 1F23.14 Approved [398]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [400]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [401]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [402]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related BTB domain-containing protein 1 (RHOBTB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [299]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [91]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protocadherin-8 (PCDH8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [403]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [404]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [405]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [93]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [89]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAS guanyl-releasing protein 1 (RASGRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [406]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Indomethacin DMSC4A7 Bursitis Approved [407]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [408]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Supervillin (SVIL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [197]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Estrone DM5T6US Acne vulgaris ED80 Approved [137]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Mestranol DMG3F94 Contraception QA21 Approved [137]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [409]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [410]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [288]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [410]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [160]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myb-related protein A (MYBL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [411]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Panobinostat DM58WKG Chronic graft versus host disease Approved [369]
Estrone DM5T6US Acne vulgaris ED80 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [348]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [411]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By D(1A) dopamine receptor (DRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [128]
Haloperidol DM96SE0 Delirium Approved [412]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [413]
Pergolide mesylate DM5GKOV N. A. N. A. Approved [414]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [412]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [415]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [416]
Methamphetamine DMPM4SK Anxiety Approved [417]
Clozapine DMFC71L Schizophrenia 6A20 Approved [418]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase FRK (FRK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [278]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [419]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Achaete-scute homolog 1 (ASCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [420]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [291]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [89]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [421]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [274]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [230]
Propanoic Acid DM9TN2W Discovery agent N.A. Investigative [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [177]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [215]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-11 (CDH11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [222]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [409]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Paclitaxel DMLB81S Breast carcinoma Approved [172]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Spectrin beta chain, non-erythrocytic 1 (SPTBN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [423]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Menthol DMG2KW7 Back pain ME84.Z Approved [424]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [282]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [403]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [178]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [228]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [425]
Estrone DM5T6US Acne vulgaris ED80 Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAL-like protein (MALL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Folic Acid DMEMBJC Colorectal carcinoma Approved [426]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [191]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [427]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [405]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [428]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [429]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [271]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-6(IV) chain (COL4A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [409]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [430]
Arecoline DMFJZK3 Parkinson disease 8A00.0 Phase 1 [431]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Estrone DM5T6US Acne vulgaris ED80 Approved [432]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [261]
Mestranol DMG3F94 Contraception QA21 Approved [137]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [433]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [433]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [433]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynein axonemal assembly factor 9 (DNAAF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [312]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [312]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [90]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Semaphorin-3C (SEMA3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [314]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [434]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [435]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Suppressor of cytokine signaling 2 (SOCS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [435]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [278]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [188]
Menthol DMG2KW7 Back pain ME84.Z Approved [424]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [409]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [436]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [437]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [430]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [438]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [439]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-7 (PAX7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [260]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [224]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [156]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [439]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [89]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [216]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-3(IV) chain (COL4A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [440]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [222]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [441]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [291]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [442]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-interacting killer (BIK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [443]
Methotrexate DM2TEOL Anterior urethra cancer Approved [444]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [358]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [446]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Clozapine DMFC71L Schizophrenia 6A20 Approved [447]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein lifeguard 2 (FAIM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [361]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Arsenic DMTL2Y1 N. A. N. A. Approved [449]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [439]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [271]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
Milchsaure DM462BT Pruritus EC90 Investigative [275]
4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol DMTMLXU Discovery agent N.A. Investigative [439]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 6 (CARD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Menthol DMG2KW7 Back pain ME84.Z Approved [424]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein 63 (TP63)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [450]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [288]
Panobinostat DM58WKG Chronic graft versus host disease Approved [451]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [306]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [327]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Topotecan DMP6G8T Central nervous system neoplasm Approved [452]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [453]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [453]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [454]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [455]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [456]
Etidronic acid DM1XHYJ Bone Paget disease Approved [453]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [453]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [453]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [457]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [458]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [459]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Fructose DM43AN2 Vomiting MD90 Approved [460]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [461]
Estrone DM5T6US Acne vulgaris ED80 Approved [462]
Testosterone DM7HUNW Hot flushes GA30 Approved [463]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [462]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [462]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [462]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein beta-1 (HSPB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [367]
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [464]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [465]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [261]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [466]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [467]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Testosterone DM7HUNW Hot flushes GA30 Approved [468]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [469]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [470]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [471]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [472]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [473]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [474]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [475]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [476]
Bortezomib DMNO38U Leukemia Approved [477]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [478]
Gefitinib DM15F0X Colon adenocarcinoma Approved [479]
Prednisone DM2HG4X Acute asthma CA23 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [480]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [481]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [482]
Quercetin DM3NC4M Obesity 5B81 Approved [483]
Fluoxetine DM3PD2C Bipolar depression Approved [484]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [485]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [486]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serpin B9 (SERPINB9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [260]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [487]
Quercetin DM3NC4M Obesity 5B81 Approved [488]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [489]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [490]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [216]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [491]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [492]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [493]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [494]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [495]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [278]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Bortezomib DMNO38U Leukemia Approved [252]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [253]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [496]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear respiratory factor 1 (NRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [487]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [497]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [498]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [490]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [151]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Arsenic DMTL2Y1 N. A. N. A. Approved [499]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [500]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein NANOG (NANOG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [501]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [502]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [503]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [504]
Testosterone DM7HUNW Hot flushes GA30 Approved [505]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [506]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 11 (MAPK11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [507]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [508]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [423]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase 3 (NME3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Menthol DMG2KW7 Back pain ME84.Z Approved [424]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [439]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [509]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [216]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 13 (MAPK13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [510]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [423]
Paclitaxel DMLB81S Breast carcinoma Approved [511]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [91]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [332]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Menthol DMG2KW7 Back pain ME84.Z Approved [424]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Bortezomib DMNO38U Leukemia Approved [252]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [512]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [513]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
PMID25656651-Compound-5 DMAI95U Chronic myeloid leukaemia 2A20 Patented [514]
SB-431542 DM0YOXQ Pulmonary fibrosis CB03.4 Preclinical [515]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Menthol DMG2KW7 Back pain ME84.Z Approved [424]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [87]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [197]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase, mitochondrial (NME4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Folic Acid DMEMBJC Colorectal carcinoma Approved [516]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Paclitaxel DMLB81S Breast carcinoma Approved [511]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [517]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [518]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [400]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [519]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [520]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [521]
GDC0941 DM1YAK6 Breast cancer 2C60-2C65 Phase 2 [522]
GDC-0980/RG7422 DMF3MV1 Non-hodgkin lymphoma 2B33.5 Phase 2 [523]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine kinase-like domain-containing protein STKLD1 (STKLD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [524]
Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [129]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [525]
Quercetin DM3NC4M Obesity 5B81 Approved [526]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [527]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [528]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [529]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [530]
Testosterone DM7HUNW Hot flushes GA30 Approved [531]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [532]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [533]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Methotrexate DM2TEOL Anterior urethra cancer Approved [464]
Quercetin DM3NC4M Obesity 5B81 Approved [535]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [285]
Ethacrynic acid DM60QMR Edema MG29 Approved [536]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [537]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [538]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Hesperidin DMI5DW1 Vascular purpura 3B60 Approved [539]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [332]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [254]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [291]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAP/microtubule affinity-regulating kinase 4 (MARK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [330]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynein axonemal heavy chain 2 (DNAH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [407]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [540]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [93]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
Drug(s) Affected By G-protein coupled receptor family C group 5 member D (GPRC5D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [348]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [331]
Quercetin DM3NC4M Obesity 5B81 Approved [541]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [542]
Testosterone DM7HUNW Hot flushes GA30 Approved [463]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [543]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Capsaicin DMGMF6V Back pain ME84.Z Approved [544]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [545]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein R-Ras2 (RRAS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [303]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [546]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcriptional-regulating factor 1 (TRERF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Folic Acid DMEMBJC Colorectal carcinoma Approved [85]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [327]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [291]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [547]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PAK 6 (PAK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [404]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [89]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [273]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By EKC/KEOPS complex subunit TP53RK (TP53RK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [156]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [316]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [197]
Milchsaure DM462BT Pruritus EC90 Investigative [275]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosomal protein S6 kinase-like 1 (RPS6KL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [524]
Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [548]
Etretinate DM2CZFA Keratosis ED56 Approved [183]
Methotrexate DM2TEOL Anterior urethra cancer Approved [549]
Quercetin DM3NC4M Obesity 5B81 Approved [550]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [551]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Methotrexate DM2TEOL Anterior urethra cancer Approved [549]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [552]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [146]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [553]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurofibromin (NF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [197]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [187]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [187]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [344]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [346]
Methotrexate DM2TEOL Anterior urethra cancer Approved [480]
Quercetin DM3NC4M Obesity 5B81 Approved [554]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [346]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [555]
Sorbitol DMAN0DE Constipation DD91.1 Approved [556]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Creatine kinase U-type, mitochondrial (CKMT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Folic Acid DMEMBJC Colorectal carcinoma Approved [85]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [166]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [166]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [166]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [166]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
dibutyl phthalate DMEDGKO Discovery agent N.A. Investigative [557]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribokinase (RBKS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [558]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [403]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [559]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [560]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [561]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [326]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [274]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [562]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [563]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [344]
Gefitinib DM15F0X Colon adenocarcinoma Approved [564]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [346]
Quercetin DM3NC4M Obesity 5B81 Approved [390]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [180]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [565]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [346]
Ethacrynic acid DM60QMR Edema MG29 Approved [536]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nipped-B-like protein (NIPBL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [197]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [435]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [566]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth factor receptor-bound protein 7 (GRB7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [170]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [365]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [170]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [90]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [512]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [567]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [568]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [569]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [570]
Capsaicin DMGMF6V Back pain ME84.Z Approved [571]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [572]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [573]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [572]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [568]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [510]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [574]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysosomal Pro-X carboxypeptidase (PRCP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [575]
Gentamicin DMKINJO Bacteremia 1A73 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [464]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [189]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [532]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [574]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer anti-estrogen resistance protein 1 (BCAR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Benzatropine DMF7EXL Parkinsonian disorder Approved [153]
Clozapine DMFC71L Schizophrenia 6A20 Approved [153]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [91]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelial differentiation-related factor 1 (EDF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [87]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [282]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15B (PPP1R15B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [72]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [561]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [576]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-lysine N-methyltransferase, H3 lysine-36 specific (NSD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [243]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [197]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [577]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [51]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [562]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By NEDD8-activating enzyme E1 regulatory subunit (NAE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [578]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [262]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [264]
Milchsaure DM462BT Pruritus EC90 Investigative [275]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Tropomyosin alpha-4 chain (TPM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [578]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Ampicillin DMHWE7P Acute epiglottitis Approved [74]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [579]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inositol-tetrakisphosphate 1-kinase (ITPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [566]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [580]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [580]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [326]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 1 (TRIB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [300]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer anti-estrogen resistance protein 3 (BCAR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [160]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [52]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [160]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [304]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Estrone DM5T6US Acne vulgaris ED80 Approved [137]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Mestranol DMG3F94 Contraception QA21 Approved [137]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase JAK3 (JAK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [581]
Ceritinib DMB920Z Non-small-cell lung cancer 2C25.Y Approved [582]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [252]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [299]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [583]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [581]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [584]
Arsenic DMTL2Y1 N. A. N. A. Approved [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Double-strand-break repair protein rad21 homolog (RAD21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [390]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [498]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [585]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [166]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [164]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [586]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [587]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Topotecan DMP6G8T Central nervous system neoplasm Approved [166]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [186]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [588]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inhibitor of growth protein 5 (ING5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [266]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [273]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [307]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [589]
Sorbitol DMAN0DE Constipation DD91.1 Approved [590]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [591]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [592]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [89]
Amsacrine DMZKYIV Acute lymphoblastic leukaemia 2A85 Approved [591]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenylate kinase isoenzyme 5 (AK5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [191]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [254]
Methamphetamine DMPM4SK Anxiety Approved [593]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [586]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Creatine kinase B-type (CKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [323]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [241]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Testosterone enanthate DMB6871 N. A. N. A. Approved [155]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Bortezomib DMNO38U Leukemia Approved [252]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [594]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [308]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [595]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [595]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [262]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [524]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase homolog 7 (NME7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [596]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [576]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolar complex protein 3 homolog (NOC3L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Selenium DM25CGV N. A. N. A. Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Leflunomide DMR8ONJ Arthritis FA20 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [291]
Topotecan DMP6G8T Central nervous system neoplasm Approved [166]
Urethane DM7NSI0 N. A. N. A. Phase 4 [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenylate kinase 2, mitochondrial (AK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [111]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [308]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [270]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [597]
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Menthol DMG2KW7 Back pain ME84.Z Approved [424]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [598]
Indomethacin DMSC4A7 Bursitis Approved [599]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [600]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [5]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DE2GB8N UD18_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Gene/Protein Processing [6]
14-3-3 protein zeta/delta OT2TKG9P 1433Z_HUMAN Gene/Protein Processing [6]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) OTJWHMZ5 PSDE_HUMAN Gene/Protein Processing [7]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6) OTX59EGK PSMD6_HUMAN Gene/Protein Processing [7]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Gene/Protein Processing [6]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Drug Response [8]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [7]
Achaete-scute homolog 1 (ASCL1) OTI4X44G ASCL1_HUMAN Gene/Protein Processing [9]
Adenylate kinase 2, mitochondrial (AK2) OTZG3X2H KAD2_HUMAN Drug Response [8]
Adenylate kinase isoenzyme 5 (AK5) OTTGXLOT KAD5_HUMAN Drug Response [8]

References

1 ClinicalTrials.gov (NCT00272714) Study of Afimoxifene Gel to Treat Cyclic Mastalgia in Premenopausal Women. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620).
4 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
5 Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14.
6 Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res. 2006 Jul 15;66(14):7334-40.
7 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
8 High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
9 Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
10 Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86.
11 Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201.
12 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
13 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8.
14 Clinical pipeline report, company report or official report of Shionogi (2011).
15 Effect of selective estrogen receptor modulators on cell proliferation and estrogen receptor activities in normal human prostate stromal and epithe... Prostate Cancer Prostatic Dis. 2009;12(4):375-81.
16 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
17 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
18 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
19 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
20 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
21 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
22 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
23 Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8.
24 Effect of UDP-glucuronosyltransferase (UGT) 1A polymorphism (rs8330 and rs10929303) on glucuronidation status of acetaminophen. Dose Response. 2017 Sep 11;15(3):1559325817723731.
25 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
26 Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. J Clin Pharmacol. 2009 Sep;49(9):1079-90.
27 Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36.
28 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
29 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
30 Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes. Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):211-4.
31 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
32 Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncol. 2010 Apr;6(4):563-85.
33 Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes. P T. 2015 Jun;40(6):364-8.
34 Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759.
35 Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.
36 Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
37 Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
38 Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
39 Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
40 Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
41 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
42 Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
43 Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
44 Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
45 Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
46 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
47 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
48 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
49 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
50 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
51 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
52 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
53 Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
54 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
55 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
56 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
57 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
58 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
59 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
60 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
61 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
62 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
63 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
64 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
65 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
66 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
67 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
68 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
69 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
70 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
71 Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. Cancer Chemother Pharmacol. 2008 Apr;61(5):791-802.
72 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
73 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
74 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
75 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
76 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
77 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
78 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
79 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
80 The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009 Feb;41(2):178-186.
81 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
82 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
83 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
84 Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting. Biol Pharm Bull. 2010;33(5):743-51. doi: 10.1248/bpb.33.743.
85 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
86 Gene expression signature of parathion-transformed human breast epithelial cells. Int J Mol Med. 2007 May;19(5):741-50.
87 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
88 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
89 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
90 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
91 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
92 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
93 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
94 Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
95 Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol. 2009 Apr 15;77(8):1410-7.
96 Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. World J Gastroenterol. 2005 May 14;11(18):2748-53. doi: 10.3748/wjg.v11.i18.2748.
97 Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
98 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
99 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
100 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
101 Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
102 Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
103 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
104 Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
105 The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol Cancer Ther. 2005 May;4(5):855-63.
106 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
107 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
108 ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antivir Ther. 2004 Aug;9(4):519-28.
109 Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells. Biochem Pharmacol. 2009 Mar 1;77(5):897-909.
110 Prolonged use of aspirin alters human and rat intestinal cells and thereby limits the absorption of clopidogrel. Clin Pharmacol Ther. 2011 Oct;90(4):612-9. doi: 10.1038/clpt.2011.163. Epub 2011 Sep 7.
111 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
112 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
113 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
114 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
115 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
116 Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
117 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
118 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
119 Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
120 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
121 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
122 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
123 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
124 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
125 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
126 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
127 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
128 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
129 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
130 Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
131 Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
132 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
133 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
134 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
135 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
136 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
137 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
138 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
139 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
140 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
141 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
142 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
143 Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
144 Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro. PLoS One. 2011;6(9):e24831. doi: 10.1371/journal.pone.0024831. Epub 2011 Sep 14.
145 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
146 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
147 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
148 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
149 Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
150 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
151 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
152 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
153 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
154 Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
155 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
156 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
157 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
158 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
159 Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017 Feb 17;292(7):2815-2829. doi: 10.1074/jbc.M116.745398. Epub 2017 Jan 4.
160 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
161 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
162 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
163 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
164 Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR. Int J Cancer. 2006 Oct 1;119(7):1599-606.
165 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
166 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
167 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
168 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
169 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
170 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
171 Comparative ligand-binding analysis of ten human lipocalins. Biochim Biophys Acta. 2006 Feb;1764(2):161-73. doi: 10.1016/j.bbapap.2005.12.006. Epub 2006 Jan 6.
172 Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
173 Protecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress. PLoS Genet. 2017 Feb 9;13(2):e1006603. doi: 10.1371/journal.pgen.1006603. eCollection 2017 Feb.
174 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
175 Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution. J Biol Chem. 2014 Aug 1;289(31):21386-400. doi: 10.1074/jbc.M113.528463. Epub 2014 Jun 18.
176 Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
177 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
178 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
179 Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
180 Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
181 Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res. 2009 Sep;50(9):1814-23. doi: 10.1194/jlr.M800343-JLR200. Epub 2009 Apr 21.
182 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
183 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
184 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
185 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
186 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
187 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
188 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
189 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
190 Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney. Kidney Blood Press Res. 2019;44(6):1392-1403. doi: 10.1159/000503300. Epub 2019 Oct 22.
191 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
192 Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
193 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
194 Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
195 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
196 Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells. Biochem Biophys Res Commun. 2004 Jan 23;313(4):863-70. doi: 10.1016/j.bbrc.2003.12.018.
197 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
198 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
199 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
200 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
201 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
202 Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
203 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
204 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
205 Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicol Sci. 2022 Sep 24;189(2):216-224. doi: 10.1093/toxsci/kfac073.
206 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
207 14-3-3 regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression. Oncotarget. 2016 Apr 5;7(14):17726-36. doi: 10.18632/oncotarget.7394.
208 E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
209 Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
210 In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
211 Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells. Int J Cancer. 2018 Jul 1;143(1):113-126.
212 RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome. J Biol Chem. 2018 Oct 26;293(43):16596-16607. doi: 10.1074/jbc.RA118.004973. Epub 2018 Aug 30.
213 Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
214 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
215 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
216 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
217 Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization. Exp Cell Res. 2007 Jan 15;313(2):357-68. doi: 10.1016/j.yexcr.2006.10.016. Epub 2006 Oct 25.
218 Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
219 Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2001 Jun;222(1-2):49-59.
220 Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
221 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
222 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
223 Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. Cancer Genet Cytogenet. 2006 Apr 15;166(2):130-8. doi: 10.1016/j.cancergencyto.2005.09.012.
224 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
225 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
226 Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function. J Biol Chem. 2020 Dec 25;295(52):18105-18121. doi: 10.1074/jbc.RA120.015891. Epub 2020 Oct 21.
227 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
228 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
229 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
230 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
231 Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. Biomed Res. 2008 Jun;29(3):141-5. doi: 10.2220/biomedres.29.141.
232 DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res. 2006 Jun;27(3):99-109. doi: 10.2220/biomedres.27.99.
233 Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients. Viruses. 2021 Oct 15;13(10):2084. doi: 10.3390/v13102084.
234 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
235 Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells. Breast Cancer Res. 2008;10(1):R4. doi: 10.1186/bcr1845. Epub 2008 Jan 11.
236 Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors. Cancer Res Commun. 2023 Dec 8;3(12):2497-2509. doi: 10.1158/2767-9764.CRC-23-0350.
237 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
238 Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells. Cancer Chemother Pharmacol. 2008 Jun;62(1):111-6. doi: 10.1007/s00280-007-0580-y. Epub 2007 Sep 15.
239 Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone. 2001 Oct;29(4):336-43. doi: 10.1016/s8756-3282(01)00589-0.
240 Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
241 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
242 Expression profiling of the estrogen responsive genes in response to phytoestrogens using a customized DNA microarray. FEBS Lett. 2005 Mar 14;579(7):1732-40.
243 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
244 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
245 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
246 The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U. J Biol Chem. 1997 Nov 7;272(45):28471-8. doi: 10.1074/jbc.272.45.28471.
247 Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome. Chem Res Toxicol. 2022 Sep 19;35(9):1589-1597. doi: 10.1021/acs.chemrestox.2c00197. Epub 2022 Aug 22.
248 Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
249 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
250 Factors determining sensitivity or resistance of tumor cell lines towards artesunate. Chem Biol Interact. 2010 Apr 15;185(1):42-52.
251 Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells. Cancer Biol Ther. 2005 Feb;4(2):242-7. doi: 10.4161/cbt.4.2.1477. Epub 2005 Feb 20.
252 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
253 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
254 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
255 Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3. J Leukoc Biol. 2010 May;87(5):833-44. doi: 10.1189/jlb.0409241. Epub 2010 Jan 20.
256 Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
257 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
258 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
259 Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
260 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
261 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
262 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
263 Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity. J Biol Chem. 2020 Jan 31;295(5):1271-1287. doi: 10.1074/jbc.RA119.011174. Epub 2019 Dec 5.
264 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
265 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
266 New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
267 Whole genome mRNA transcriptomics analysis reveals different modes of action of the diarrheic shellfish poisons okadaic acid and dinophysis toxin-1 versus azaspiracid-1 in Caco-2 cells. Toxicol In Vitro. 2018 Feb;46:102-112.
268 Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
269 Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7199-204.
270 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
271 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
272 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
273 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
274 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
275 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
276 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
277 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
278 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
279 Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
280 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
281 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
282 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
283 Identification of protein expression alterations in gefitinib-resistant human lung adenocarcinoma: PCNT and mPR play key roles in the development of gefitinib-associated resistance. Toxicol Appl Pharmacol. 2015 Nov 1;288(3):359-73. doi: 10.1016/j.taap.2015.08.008. Epub 2015 Aug 20.
284 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
285 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
286 Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
287 Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells. Respir Res. 2018 Aug 30;19(1):160. doi: 10.1186/s12931-018-0861-5.
288 Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
289 Retinoic acid-induced glandular differentiation of the oesophagus. Gut. 2007 Jul;56(7):906-17. doi: 10.1136/gut.2006.097915. Epub 2006 Dec 21.
290 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
291 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
292 cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance. Breast Cancer Res Treat. 2006 Mar;96(1):17-39. doi: 10.1007/s10549-005-9026-6. Epub 2005 Dec 2.
293 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
294 Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. J Zhejiang Univ Sci B. 2008 Jan;9(1):22-33. doi: 10.1631/jzus.B071322.
295 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
296 Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. J Biol Chem. 2011 Apr 1;286(13):11314-27. doi: 10.1074/jbc.M110.193714. Epub 2011 Jan 3.
297 Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
298 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
299 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
300 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
301 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
302 The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. Biochimie. 2006 Mar-Apr;88(3-4):387-97. doi: 10.1016/j.biochi.2005.11.007. Epub 2005 Dec 7.
303 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
304 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
305 Role of all-trans retinoic acid in neurite outgrowth and axonal elongation. J Neurobiol. 2006 Jun;66(7):739-56. doi: 10.1002/neu.20241.
306 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
307 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
308 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
309 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
310 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
311 Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
312 Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
313 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
314 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
315 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
316 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
317 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
318 Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
319 Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res. 2007 Jan;5(1):95-108. doi: 10.1158/1541-7786.MCR-06-0125.
320 Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
321 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
322 Chromatin modifiers: A new class of pollutants with potential epigenetic effects revealed by in vitro assays and transcriptomic analyses. Toxicology. 2023 Jan 15;484:153413. doi: 10.1016/j.tox.2022.153413. Epub 2022 Dec 26.
323 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
324 Global changes in gene regulation demonstrate that unconjugated bilirubin is able to upregulate and activate select components of the endoplasmic reticulum stress response pathway. J Biochem Mol Toxicol. 2010 Mar-Apr;24(2):73-88.
325 Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
326 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
327 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
328 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
329 Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
330 ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
331 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
332 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
333 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
334 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
335 Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
336 Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
337 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
338 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
339 Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
340 High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res. 2009 Oct 1;15(19):6070-8.
341 Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res. 2005 May 1;65(9):3837-45.
342 High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
343 Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
344 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
345 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
346 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
347 [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
348 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
349 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
350 Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
351 The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
352 Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
353 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
354 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
355 High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
356 Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
357 Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009 Oct;46(16):3345-57. doi: 10.1016/j.molimm.2009.07.019. Epub 2009 Sep 3.
358 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
359 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
360 Identification of cornifelin and early growth response-1 gene as novel biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model MCTT HCE?. Arch Toxicol. 2015 Sep;89(9):1589-98. doi: 10.1007/s00204-014-1390-8. Epub 2014 Nov 7.
361 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
362 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
363 The effect of zinc and D-penicillamine in a stable human hepatoma ATP7B knockout cell line. PLoS One. 2014 Jun 3;9(6):e98809. doi: 10.1371/journal.pone.0098809. eCollection 2014.
364 Different pathways are involved in arsenic-trioxide-induced cell proliferation and growth inhibition in human keratinocytes. Skin Pharmacol Physiol. 2010;23(2):68-78. doi: 10.1159/000265677. Epub 2009 Dec 14.
365 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
366 Patterns of gene expressions induced by arsenic trioxide in cultured human fibroblasts. Toxicol Lett. 2003 Jul 20;143(2):155-62. doi: 10.1016/s0378-4274(03)00171-1.
367 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
368 Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
369 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
370 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
371 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
372 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
373 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
374 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
375 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
376 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
377 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
378 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
379 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
380 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
381 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
382 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
383 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
384 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
385 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
386 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
387 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
388 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
389 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
390 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
391 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
392 Identification of novel ER-alpha target genes in breast cancer cells: gene- and cell-selective co-regulator recruitment at target promoters determines the response to 17beta-estradiol and tamoxifen. Mol Cell Endocrinol. 2010 Jan 15;314(1):90-100.
393 Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
394 Genotoxic and epigenotoxic effects of fine particulate matter from rural and urban sites in Lebanon on human bronchial epithelial cells. Environ Res. 2015 Jan;136:352-62. doi: 10.1016/j.envres.2014.10.010. Epub 2014 Nov 25.
395 Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Apr;25(3):671-83.
396 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 2012 Oct;120(10):1425-31. doi: 10.1289/ehp.1205412. Epub 2012 Jul 31.
397 Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells. Toxicology. 2011 Jul 29;285(3):97-103.
398 Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression. Am J Physiol Cell Physiol. 2004 Jul;287(1):C125-34. doi: 10.1152/ajpcell.00488.2003. Epub 2004 Feb 25.
399 4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and DeltaF508 CFTR. Eur J Pharmacol. 2005 Jun 1;516(2):118-24. doi: 10.1016/j.ejphar.2005.04.037.
400 Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells. Clin Cancer Res. 2007 Sep 1;13(17):5219-25. doi: 10.1158/1078-0432.CCR-07-0816.
401 Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
402 A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Toxicol Appl Pharmacol. 2015 Jun 1;285(2):79-88.
403 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
404 Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
405 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
406 The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
407 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
408 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
409 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
410 Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation. Toxicol Lett. 2017 Nov 5;281:20-25. doi: 10.1016/j.toxlet.2017.08.012. Epub 2017 Aug 24.
411 A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
412 Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. Chem Res Toxicol. 2013 Jun 17;26(6):878-95.
413 Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry. 1992 Jul;49(7):538-44. doi: 10.1001/archpsyc.1992.01820070032005.
414 Pergolide is an inhibitor of voltage-gated potassium channels, including Kv1.5, and causes pulmonary vasoconstriction. Circulation. 2005 Sep 6;112(10):1494-9. doi: 10.1161/CIRCULATIONAHA.105.556704. Epub 2005 Aug 29.
415 Dopamine-mediated inhibition of renal Na+/K+-ATPase in HK-2 cells is reduced by ouabain. Clin Exp Pharmacol Physiol. 2010 May;37(5-6):613-8. doi: 10.1111/j.1440-1681.2010.05364.x. Epub 2010 Feb 4.
416 Characterizing fucoxanthin as a selective dopamine D(3)/D(4) receptor agonist: Relevance to Parkinson's disease. Chem Biol Interact. 2019 Sep 1;310:108757. doi: 10.1016/j.cbi.2019.108757. Epub 2019 Jul 16.
417 Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users. Mol Psychiatry. 2000 Nov;5(6):664-72. doi: 10.1038/sj.mp.4000760.
418 Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response. J Psychopharmacol. 2007 Sep;21(7):718-27. doi: 10.1177/0269881106072341. Epub 2006 Nov 8.
419 The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
420 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
421 Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann Surg Oncol. 2011 May;18(5):1506-11. doi: 10.1245/s10434-010-1488-z. Epub 2010 Dec 24.
422 Propionic acid induces mitochondrial dysfunction and affects gene expression for mitochondria biogenesis and neuronal differentiation in SH-SY5Y cell line. Neurotoxicology. 2019 Dec;75:116-122. doi: 10.1016/j.neuro.2019.09.009. Epub 2019 Sep 14.
423 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
424 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
425 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
426 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
427 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
428 The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
429 Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
430 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
431 Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway. Environ Toxicol. 2020 Sep;35(9):1007-1014. doi: 10.1002/tox.22937. Epub 2020 May 22.
432 Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
433 Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol Endocrinol. 2004 Feb;18(2):402-11. doi: 10.1210/me.2003-0202. Epub 2003 Nov 6.
434 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
435 Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
436 Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem. 2011 Sep 22;54(18):6342-63. doi: 10.1021/jm2007613. Epub 2011 Aug 18.
437 Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood. 2004 Aug 15;104(4):1094-9. doi: 10.1182/blood-2003-12-4266. Epub 2004 Apr 20.
438 Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia. 2011 May;25(5):838-47. doi: 10.1038/leu.2011.2. Epub 2011 Feb 4.
439 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
440 Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
441 ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model. Int J Cancer. 2006 Jan 15;118(2):483-9. doi: 10.1002/ijc.21340.
442 Pretreatment of 3-MA prevents doxorubicin-induced cardiotoxicity through inhibition of autophagy initiation. Toxicology. 2023 May 15;490:153512. doi: 10.1016/j.tox.2023.153512. Epub 2023 Apr 14.
443 Protective effects of hepatocyte growth factor gene overexpression against hydrogen peroxide-induced apoptosis in mesenchymal stem cells. Environ Toxicol. 2019 Nov;34(11):1236-1245. doi: 10.1002/tox.22824. Epub 2019 Jul 16.
444 A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
445 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
446 Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
447 Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. J Clin Psychopharmacol. 2005 Oct;25(5):419-26. doi: 10.1097/01.jcp.0000177668.42640.fe.
448 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
449 Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
450 Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
451 Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. doi: 10.1016/j.bbrc.2009.12.147. Epub 2009 Dec 30.
452 p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochem Pharmacol. 2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
453 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
454 Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
455 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
456 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
457 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
458 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
459 Serum distribution of the major metabolites of norgestimate in relation to its pharmacological properties. Contraception. 2003 Feb;67(2):93-9. doi: 10.1016/s0010-7824(02)00473-0.
460 Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest. 2007 Dec;117(12):3979-87. doi: 10.1172/JCI32249.
461 Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology. 2001 Jan 9;56(1):31-6. doi: 10.1212/wnl.56.1.31.
462 Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and -fetoprotein. Toxicol Sci. 2015 Feb;143(2):333-48. doi: 10.1093/toxsci/kfu231. Epub 2014 Oct 27.
463 Testosterone or 17{beta}-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. J Endocrinol. 2011 Aug;210(2):219-29. doi: 10.1530/JOE-10-0497. Epub 2011 Jun 1.
464 Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
465 Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
466 Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
467 All-trans retinoic acid induced hypercalcemia in a patient with acute promyelocytic leukemia: its relation to increased PTH-rP. Int J Hematol. 1994 Feb;59(2):143-4.
468 Parathyroid hormone-related protein varies with sex and androgen status in nonsmall cell lung cancer. Cancer. 2007 Sep 15;110(6):1313-20. doi: 10.1002/cncr.22922.
469 Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
470 Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
471 Induced differentiation in HT29, a human colon adenocarcinoma cell line. J Cell Sci. 1999 Aug;112 ( Pt 16):2657-66. doi: 10.1242/jcs.112.16.2657.
472 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
473 Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
474 Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
475 [As2O3 induces demethylation and up-regulates transcription of SHP-1 gene in human lymphoma cell line T2 cells]. Zhonghua Zhong Liu Za Zhi. 2009 Jun;31(6):423-7.
476 Neoplastic-like transformation effect of single-walled and multi-walled carbon nanotubes compared to asbestos on human lung small airway epithelial cells. Nanotoxicology. 2014 Aug;8(5):485-507.
477 Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leuk Res. 2008 Feb;32(2):275-85. doi: 10.1016/j.leukres.2007.05.024. Epub 2007 Jul 19.
478 Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
479 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
480 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
481 Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
482 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
483 Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
484 Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
485 Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
486 Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
487 Trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. J Nat Prod. 2013 Jul 26;76(7):1242-7.
488 Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. Invest Ophthalmol Vis Sci. 2011 Feb 22;52(2):1055-63. doi: 10.1167/iovs.10-5777.
489 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
490 Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):325-34.
491 The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts. Toxicol Appl Pharmacol. 2012 May 15;261(1):42-9. doi: 10.1016/j.taap.2012.03.009.
492 Deficiency of the human mitochondrial transcription factor h-mtTFA in infantile mitochondrial myopathy is associated with mtDNA depletion. Hum Mol Genet. 1994 Oct;3(10):1763-9. doi: 10.1093/hmg/3.10.1763.
493 PPARgama activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol. 2014 Mar;253:16-27.
494 ATPR induces acute promyelocytic leukemia cells differentiation and growth arrest by blockade of SHP2/Rho/ROCK1 pathway. Toxicol Appl Pharmacol. 2020 Jul 15;399:115053. doi: 10.1016/j.taap.2020.115053. Epub 2020 May 15.
495 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
496 Regulation of the vascular endothelial growth factor and growth by estrogen and antiestrogens through Efp in Ishikawa endometrial carcinoma cells. Oncol Rep. 2009 Feb;21(2):395-401.
497 AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
498 Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
499 Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers. Am J Pathol. 2011 May;178(5):2066-76.
500 Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription. Mol Cell Endocrinol. 2010 Jul 29;323(2):268-76. doi: 10.1016/j.mce.2010.03.013. Epub 2010 Mar 17.
501 Methylparaben stimulates tumor initiating cells in ER+ breast cancer models. J Appl Toxicol. 2017 Apr;37(4):417-425. doi: 10.1002/jat.3374. Epub 2016 Sep 1.
502 Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
503 Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
504 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
505 Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone. J Toxicol Sci. 2021;46(11):515-523. doi: 10.2131/jts.46.515.
506 Ivermectin as an inhibitor of cancer stem?like cells. Mol Med Rep. 2018 Feb;17(2):3397-3403. doi: 10.3892/mmr.2017.8231. Epub 2017 Dec 8.
507 Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells. BMC Complement Altern Med. 2016 Aug 11;16(1):281. doi: 10.1186/s12906-016-1267-x.
508 Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide. J Biol Chem. 2002 Nov 22;277(47):44988-95. doi: 10.1074/jbc.M207176200. Epub 2002 Sep 17.
509 Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
510 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
511 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
512 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
513 Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310. doi: 10.1038/srep07310.
514 AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028.
515 Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts. J Biol Chem. 2015 Apr 3;290(14):8834-48.
516 Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
517 Quercetin blocks airway epithelial cell chemokine expression. Am J Respir Cell Mol Biol. 2006 Nov;35(5):602-10. doi: 10.1165/rcmb.2006-0149OC. Epub 2006 Jun 22.
518 Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells. Environ Toxicol. 2021 Sep;36(9):1785-1792. doi: 10.1002/tox.23299. Epub 2021 May 27.
519 A sensitized RNA interference screen identifies a novel role for the PI3K p110 isoform in medulloblastoma cell proliferation and chemoresistance. Mol Cancer Res. 2011 Jul;9(7):925-35. doi: 10.1158/1541-7786.MCR-10-0200. Epub 2011 Jun 7.
520 Promyelocytic leukemia retinoid signaling targets regulate apoptosis,tissue factor and thrombomodulin expression. Haematologica. 2004 Mar;89(3):286-95.
521 Resveratrol is a class IA phosphoinositide 3-kinase inhibitor. Biochem J. 2007 Sep 15;406(3):511-8. doi: 10.1042/BJ20070236.
522 The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem. 2008 Sep 25;51(18):5522-32. doi: 10.1021/jm800295d.
523 GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther. 2011 Dec;10(12):2426-36.
524 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
525 Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009 May;21(5):1317-22. doi: 10.3892/or_00000357.
526 Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol. 2003 Mar;148(3):544-52. doi: 10.1046/j.1365-2133.2003.05174.x.
527 Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation. Biochem Pharmacol. 2009 Feb 1;77(3):384-96. doi: 10.1016/j.bcp.2008.10.035. Epub 2008 Nov 6.
528 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
529 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
530 Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal. 2003 Sep;15(9):851-9. doi: 10.1016/s0898-6568(03)00036-6.
531 Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle. 2010 Apr 15;9(8):1629-38. doi: 10.4161/cc.9.8.11487. Epub 2010 Apr 15.
532 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
533 Madecassoside ameliorates cisplatin-induced nephrotoxicity by inhibiting activation of the mitogen activated protein kinase pathway. Environ Toxicol. 2023 Jul;38(7):1473-1483. doi: 10.1002/tox.23777. Epub 2023 Apr 23.
534 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
535 Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem Biol Interact. 2012 Jan 25;195(2):154-64.
536 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
537 Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIM(EL) to attenuate apoptosis in BEAS-2B cells. Chem Biol Interact. 2023 Jan 5;369:110304. doi: 10.1016/j.cbi.2022.110304. Epub 2022 Dec 10.
538 Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. Mol Pharmacol. 2004 Feb;65(2):470-8.
539 Hesperidin delays cell cycle progression into the G0/G1 phase via suspension of MAPK signaling pathway in intrahepatic cholangiocarcinoma. J Biochem Mol Toxicol. 2022 Apr;36(4):e22981. doi: 10.1002/jbt.22981. Epub 2022 Jan 4.
540 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
541 Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathway. Cancer Lett. 2010 Jun 28;292(2):228-36. doi: 10.1016/j.canlet.2009.12.005. Epub 2010 Jan 18.
542 Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
543 Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N-methyltransferase level in endothelial cells. J Appl Toxicol. 2021 Jul;41(7):1076-1088. doi: 10.1002/jat.4094. Epub 2020 Oct 19.
544 Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
545 Activation of autophagy rescues amiodarone-induced apoptosis of lung epithelial cells and pulmonary toxicity in rats. Toxicol Sci. 2013 Nov;136(1):193-204. doi: 10.1093/toxsci/kft168. Epub 2013 Aug 2.
546 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
547 Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
548 Oxidative modifications of proteins by sodium arsenite in human umbilical vein endothelial cells. Environ Toxicol. 2011 Oct;26(5):459-71. doi: 10.1002/tox.20572. Epub 2010 Mar 1.
549 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
550 Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
551 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
552 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
553 Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction. Neuropharmacology. 2009 Jul;57(1):41-8. doi: 10.1016/j.neuropharm.2009.04.005. Epub 2009 Apr 22.
554 Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4540-50. doi: 10.1111/j.1582-4934.2008.00575.x.
555 Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: possible involvement of p38 MAP kinase. J Biochem Mol Biol. 2002 Jul 31;35(4):377-83. doi: 10.5483/bmbrep.2002.35.4.377.
556 Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. Biochim Biophys Acta. 2014 Feb;1843(2):253-64. doi: 10.1016/j.bbamcr.2013.10.017. Epub 2013 Nov 1.
557 In Vitro Exposure of Human Luteinized Mural Granulosa Cells to Dibutyl Phthalate Affects Global Gene Expression. Toxicol Sci. 2017 Nov 1;160(1):180-188. doi: 10.1093/toxsci/kfx170.
558 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
559 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
560 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
561 A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
562 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
563 Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
564 Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
565 Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
566 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
567 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
568 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
569 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
570 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
571 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
572 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
573 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
574 Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.
575 E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients. Chin Med J (Engl). 2009 Oct 20;122(20):2461-5.
576 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
577 Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells. Environ Pollut. 2019 Dec;255(Pt 2):113318. doi: 10.1016/j.envpol.2019.113318. Epub 2019 Oct 2.
578 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
579 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
580 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
581 [Effect of arsenic trioxide and 5-aza-2'-deoxycytidine on SHP-1, JAK3, TYK2 gene expression in K562 cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Apr;22(2):323-8. doi: 10.7534/j.issn.1009-2137.2014.02.011.
582 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells. Toxicol Appl Pharmacol. 2022 Sep 1;450:116156. doi: 10.1016/j.taap.2022.116156. Epub 2022 Jul 6.
583 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
584 Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs. Nucleic Acids Res. 2014 Jan;42(2):1196-208. doi: 10.1093/nar/gkt903. Epub 2013 Oct 7.
585 Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways. Chem Biol Interact. 2023 Feb 1;371:110342. doi: 10.1016/j.cbi.2023.110342. Epub 2023 Jan 10.
586 A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
587 Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
588 Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1. Br J Pharmacol. 2010 Jul;160(5):1195-211. doi: 10.1111/j.1476-5381.2010.00762.x.
589 Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
590 A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 2004 Dec 1;384(Pt 2):391-400. doi: 10.1042/BJ20041498.
591 Phosphorylation and stabilization of topoisomerase II protein by p38 mitogen-activated protein kinase sensitize breast cancer cells to its poisons. J Biol Chem. 2011 Oct 14;286(41):35883-35890. doi: 10.1074/jbc.M111.229260. Epub 2011 Aug 30.
592 Real-time monitoring of cisplatin-induced cell death. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.
593 Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry. 2008 Mar;65(3):345-55. doi: 10.1001/archpsyc.65.3.345.
594 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
595 Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
596 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
597 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
598 Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression. Environ Toxicol. 2018 Dec;33(12):1237-1244. doi: 10.1002/tox.22630. Epub 2018 Sep 6.
599 [Indomethacin-induced HL-60 leukemic cell apoptosis and the activation of C-jun NH2- terminal kinase signal transduction pathway]. Hunan Yi Ke Da Xue Xue Bao. 2003 Dec;28(6):557-62.
600 Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells. J Signal Transduct. 2012;2012:204236. doi: 10.1155/2012/204236. Epub 2012 Oct 9.