Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFORDT)

Drug Name
Afimoxifene Drug Info
Synonyms
4-Hydroxytamoxifen; Afimoxifene; (Z)-4-Hydroxytamoxifen; Hydroxytamoxifen; 4-Monohydroxytamoxifen; Tamogel; 68047-06-3; trans-4-Hydroxytamoxifen; Ici 79280; 68392-35-8; 65213-48-1; 4-OH-TAM; (Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol; Z-4-hydroxytamoxifen; UNII-95K54647BZ; CHEMBL489; ICI 79,280; TAMOXIFEN, 4-HYDROXY-, (Z)-; BRN 4910749; (E/Z)-4-Hydroxy Tamoxifen; MLS000069742; C26H29NO2; CHEBI:44616; 95K54647BZ; SMR000058939; 4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Ductal carcinoma 2E65.2 Phase 2 [2]
Cross-matching ID
PubChem CID
449459
ChEBI ID
CHEBI:44616
CAS Number
CAS 68047-06-3
TTD Drug ID
DMFORDT
VARIDT Drug ID
DR01487
INTEDE Drug ID
DR1944

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [10]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [11]
Estrone DM5T6US Acne vulgaris ED80 Approved [11]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [12]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [12]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [12]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [13]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [3]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [14]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [15]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [16]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Folic Acid DMEMBJC Colorectal carcinoma Approved [19]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [18]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [4]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [28]
Metronidazole DMTIVEN Abscess Approved [29]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [30]
Ethanol DMDRQZU Chronic pain MG30 Approved [31]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A8 (UGT1A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [32]
Empagliflozin DMRF9YK Type-1 diabetes 5A10 Approved [33]
Darolutamide DMV7YFT Prostate cancer 2C82.0 Approved [34]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [35]
EUGENOL DM7US1H Discovery agent N.A. Patented [35]
Chrysin DM7V2LG Discovery agent N.A. Investigative [35]
phloretin DMYA50U Discovery agent N.A. Investigative [35]
Anthraflavic acid DMN1YFU N. A. N. A. Investigative [35]
Cis-4-hydroxytamoxifen DMRFTB5 N. A. N. A. Investigative [5]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [36]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [37]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [38]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [39]
Cepharanthine DM9Y5JB N. A. N. A. Approved [40]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [41]
Clozapine DMFC71L Schizophrenia 6A20 Approved [42]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [43]
Trifluoperazine DMKBYWI Anxiety Approved [44]
Olanzapine DMPFN6Y Bipolar depression Approved [42]
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Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [49]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
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Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [62]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [63]
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Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [73]
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Drug(s) Affected By Ephrin type-A receptor 1 (EPHA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Bortezomib DMNO38U Leukemia Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [80]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [82]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Gefitinib DM15F0X Colon adenocarcinoma Approved [84]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Etretinate DM2CZFA Keratosis ED56 Approved [87]
Prednisone DM2HG4X Acute asthma CA23 Approved [88]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [89]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
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Drug(s) Affected By Hepatoma-derived growth factor (HDGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [74]
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Drug(s) Affected By CCHC-type zinc finger nucleic acid binding protein (CNBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [74]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [101]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [102]
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Drug(s) Affected By Dynein light chain 1, cytoplasmic (DYNLL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [106]
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Drug(s) Affected By Cyclin-A1 (CCNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [110]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Folic Acid DMEMBJC Colorectal carcinoma Approved [111]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [112]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Ethacrynic acid DM60QMR Edema MG29 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Testosterone DM7HUNW Hot flushes GA30 Approved [119]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
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Drug(s) Affected By SH2 domain-containing adapter protein B (SHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [122]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [74]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [124]
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Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [125]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [126]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [127]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [127]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [128]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [129]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [130]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [131]
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Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [132]
Methotrexate DM2TEOL Anterior urethra cancer Approved [133]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [134]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [135]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [136]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Prednisone DM2HG4X Acute asthma CA23 Approved [139]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [140]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [141]
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Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [142]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [143]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [144]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [146]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [147]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
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Drug(s) Affected By Transforming acidic coiled-coil-containing protein 1 (TACC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [149]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
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Drug(s) Affected By Cystatin-A (CSTA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Verapamil DMA7PEW Angina pectoris BA40 Approved [153]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [153]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [155]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [156]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [158]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Gefitinib DM15F0X Colon adenocarcinoma Approved [159]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Selenium DM25CGV N. A. N. A. Approved [160]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [161]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [162]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [165]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [166]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Gefitinib DM15F0X Colon adenocarcinoma Approved [167]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Quercetin DM3NC4M Obesity 5B81 Approved [169]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
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Drug(s) Affected By Cathepsin D (CTSD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [171]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [173]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [174]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [175]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
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Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Selenium DM25CGV N. A. N. A. Approved [160]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [177]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [178]
Meloxicam DM2AR7L Arthritis FA20 Approved [179]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Epinephrine DM3KJBC Acute asthma CA23 Approved [181]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [182]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [178]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [183]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [185]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ephrin-A1 (EFNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Estrone DM5T6US Acne vulgaris ED80 Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin receptor substrate 1 (IRS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Testosterone DM7HUNW Hot flushes GA30 Approved [194]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 3 (CCN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
Arsenic DMTL2Y1 N. A. N. A. Approved [197]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [198]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [137]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix metalloproteinase-15 (MMP15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Selenium DM25CGV N. A. N. A. Approved [200]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [201]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [202]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [203]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [204]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Ampicillin DMHWE7P Acute epiglottitis Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 14 (PSMD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Clozapine DMFC71L Schizophrenia 6A20 Approved [206]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Arsenic DMTL2Y1 N. A. N. A. Approved [207]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aurora kinase A (AURKA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [208]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [208]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 1D (PPM1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [210]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [212]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent RNA helicase DDX3Y (DDX3Y)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [215]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [217]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Asparagine--tRNA ligase, cytoplasmic (NARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [218]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [213]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [213]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trafficking kinesin-binding protein 2 (TRAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [219]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calsyntenin-1 (CLSTN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [222]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [171]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [225]
Estrone DM5T6US Acne vulgaris ED80 Approved [226]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [227]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [224]
Testosterone DM7HUNW Hot flushes GA30 Approved [228]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein D (APOD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [230]
Paclitaxel DMLB81S Breast carcinoma Approved [231]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [232]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [233]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [234]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [235]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [236]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [237]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [238]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [239]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleophosmin (NPM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Etretinate DM2CZFA Keratosis ED56 Approved [241]
Methotrexate DM2TEOL Anterior urethra cancer Approved [242]
Quercetin DM3NC4M Obesity 5B81 Approved [243]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [244]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [245]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [246]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [91]
Etretinate DM2CZFA Keratosis ED56 Approved [241]
Quercetin DM3NC4M Obesity 5B81 Approved [243]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [249]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [250]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [250]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [208]
Methotrexate DM2TEOL Anterior urethra cancer Approved [251]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [252]
Fluoxetine DM3PD2C Bipolar depression Approved [250]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix Gla protein (MGP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [253]
Phytonadione DM8HDOL Bleeding disorder GA20-GA21 Approved [254]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [255]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High mobility group protein B1 (HMGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Gefitinib DM15F0X Colon adenocarcinoma Approved [256]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [257]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-cathepsin H (CTSH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [260]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [261]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [262]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Etretinate DM2CZFA Keratosis ED56 Approved [241]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [263]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [239]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [246]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Etretinate DM2CZFA Keratosis ED56 Approved [241]
Quercetin DM3NC4M Obesity 5B81 Approved [263]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [266]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [267]
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Drug(s) Affected By DNA topoisomerase 1 (TOP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [165]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmin (HSP90B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [246]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [270]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [271]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [272]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [273]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [274]
Estrone DM5T6US Acne vulgaris ED80 Approved [187]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [50]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stathmin (STMN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Etretinate DM2CZFA Keratosis ED56 Approved [241]
Quercetin DM3NC4M Obesity 5B81 Approved [269]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [276]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein SON (SON)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [213]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [213]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [213]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolin (NCL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [277]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [243]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [241]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [280]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [281]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [245]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Ethanol DMDRQZU Chronic pain MG30 Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [284]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [245]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Clozapine DMFC71L Schizophrenia 6A20 Approved [206]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribonucleoside-diphosphate reductase large subunit (RRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [286]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [287]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer CD24 (CD24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [289]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [290]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Threonine--tRNA ligase 1, cytoplasmic (TARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [206]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [213]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-directed RNA polymerase II subunit RPB2 (POLR2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [291]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [292]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [264]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [201]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [266]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [294]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Paclitaxel DMLB81S Breast carcinoma Approved [295]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [296]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [246]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [297]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombospondin-2 (THBS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [299]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [213]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [255]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coatomer subunit beta' (COPB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [253]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [301]
Methotrexate DM2TEOL Anterior urethra cancer Approved [251]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [302]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [303]
Quercetin DM3NC4M Obesity 5B81 Approved [304]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [305]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [251]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrin-3 (MATR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [306]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [243]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [308]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [245]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Folic Acid DMEMBJC Colorectal carcinoma Approved [111]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H3-like centromeric protein A (CENPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [212]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfate transporter (SLC26A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [309]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [310]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [311]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Importin subunit alpha-1 (KPNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [313]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [314]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [288]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [316]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [317]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [318]
Minodronate DM50PMY Osteoporosis FB83.0 Approved [319]
Risedronate DM5FLTY Bone Paget disease Approved [320]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [321]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Pamidronate DMB4AVP Bone Paget disease Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [322]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [323]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [324]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chromobox protein homolog 1 (CBX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [175]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [325]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [222]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [326]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [327]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein U (HNRNPU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Ethanol DMDRQZU Chronic pain MG30 Approved [328]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [329]
Arsenic DMTL2Y1 N. A. N. A. Approved [330]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein eL6 (RPL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [331]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [332]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [333]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [334]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [335]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [336]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
Arsenic DMTL2Y1 N. A. N. A. Approved [337]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Folic Acid DMEMBJC Colorectal carcinoma Approved [111]
Bortezomib DMNO38U Leukemia Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent RNA helicase A (DHX9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [332]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [338]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [339]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuroblast differentiation-associated protein AHNAK (AHNAK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc transporter ZIP6 (SLC39A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [340]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [341]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Filamin-C (FLNC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [342]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [342]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [342]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Importin subunit beta-1 (KPNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [312]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [312]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Folic Acid DMEMBJC Colorectal carcinoma Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteasome activator complex subunit 4 (PSME4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Condensin complex subunit 2 (NCAPH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Haloperidol DM96SE0 Delirium Approved [206]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [271]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PCNA-associated factor (PCLAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [344]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [288]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 6 (PSMD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [345]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [346]
MG-132 DMKA2YS N. A. N. A. Preclinical [347]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [348]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Elongin-B (ELOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [349]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [64]
Okadaic acid DM47CO1 Discovery agent N.A. Investigative [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-binding protein RBBP7 (RBBP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [351]
Promegestone DMK4S8I Gynecological disease GA6Z Approved [352]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription initiation factor TFIID subunit 9 (TAF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [353]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [326]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [92]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [354]
GW7604 DMCA4RM Discovery agent N.A. Investigative [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Golgin subfamily A member 5 (GOLGA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [356]
Milchsaure DM462BT Pruritus EC90 Investigative [357]
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Drug(s) Affected By Transportin-1 (TNPO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [313]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dehydrodolichyl diphosphate synthase complex subunit NUS1 (NUS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [354]
Milchsaure DM462BT Pruritus EC90 Investigative [357]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By UAP56-interacting factor (FYTTD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [311]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [326]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [204]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein ILRUN (ILRUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [345]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [358]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [64]
Lithium chloride DMHYLQ2 Discovery agent N.A. Investigative [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Isoproterenol DMK7MEY Atrioventricular block Approved [360]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [361]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolar RNA helicase 2 (DDX21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Very long chain fatty acid elongase 5 (ELOVL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [208]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [293]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [362]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase 26 (STK26)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Membrane-associated progesterone receptor component 1 (PGRMC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Gefitinib DM15F0X Colon adenocarcinoma Approved [363]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Suppressor of cytokine signaling 1 (SOCS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [364]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [69]
Lomustine DMMWSUL Brain cancer 2A00 Approved [365]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Delta(14)-sterol reductase TM7SF2 (TM7SF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Capsaicin DMGMF6V Back pain ME84.Z Approved [366]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chloride intracellular channel protein 3 (CLIC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ampicillin DMHWE7P Acute epiglottitis Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [367]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [124]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-1-antitrypsin (SERPINA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [136]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Folic Acid DMEMBJC Colorectal carcinoma Approved [370]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Steryl-sulfatase (STS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [251]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [251]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [371]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Danazol DML8KTN Menorrhagia GA20.50 Approved [372]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [371]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 13 (KRT13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [373]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [374]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [375]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [376]
Paclitaxel DMLB81S Breast carcinoma Approved [377]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [353]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carboxypeptidase M (CPM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [378]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [233]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [124]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [345]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD44 antigen (CD44)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [380]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [381]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [382]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [383]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [384]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [385]
Testosterone DM7HUNW Hot flushes GA30 Approved [386]
Dydrogesterone DMAKIDV Menstrual disorder GA20.3 Approved [387]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [388]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [389]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [387]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Syndecan-1 (SDC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [390]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-type tyrosine-protein phosphatase gamma (PTPRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [202]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [391]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [393]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [394]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-9 (SOX9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [395]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lanosterol synthase (LSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [250]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [396]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [250]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Fluoxetine DM3PD2C Bipolar depression Approved [250]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [252]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of G-protein signaling 3 (RGS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [397]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Folic Acid DMEMBJC Colorectal carcinoma Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [398]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [397]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ephrin-B2 (EFNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [399]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [400]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tricarboxylate transport protein, mitochondrial (SLC25A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [206]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [237]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [309]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribose-phosphate pyrophosphokinase 1 (PRPS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [401]
Arsenic DMTL2Y1 N. A. N. A. Approved [402]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cAMP-dependent protein kinase inhibitor alpha (PKIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [400]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Bortezomib DMNO38U Leukemia Approved [78]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ETS-related transcription factor Elf-3 (ELF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [212]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 4-aminobutyrate aminotransferase, mitochondrial (ABAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [48]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [362]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disabled homolog 2 (DAB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [403]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [404]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Ethanol DMDRQZU Chronic pain MG30 Approved [405]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 1,4-alpha-glucan-branching enzyme (GBE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [406]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [213]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [213]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 18 (CDK18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [376]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [47]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [92]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [407]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Kinesin light chain 1 (KLC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [91]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [326]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [327]
Milchsaure DM462BT Pruritus EC90 Investigative [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Latent-transforming growth factor beta-binding protein 1 (LTBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [408]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By LIM and SH3 domain protein 1 (LASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [409]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [410]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [411]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rab-30 (RAB30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [215]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [412]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [346]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death protein 4 (PDCD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [413]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [414]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [413]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [415]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [413]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [78]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [345]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [91]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [253]
Milchsaure DM462BT Pruritus EC90 Investigative [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [348]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [416]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cohesin subunit SA-1 (STAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [149]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [417]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase MYLIP (MYLIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha/beta-tubulin-N-acetyltransferase 9 (NAT9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [354]
Drug(s) Affected By Cyclin-dependent kinase 19 (CDK19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [208]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [418]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [248]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein Niban 1 (NIBAN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [271]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Ethanol DMDRQZU Chronic pain MG30 Approved [328]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Multiple epidermal growth factor-like domains protein 9 (MEGF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [222]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [348]
bilirubin DMI0V4O Discovery agent N.A. Investigative [420]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ethanolamine kinase 1 (ETNK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [345]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [71]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Bortezomib DMNO38U Leukemia Approved [78]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [423]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [411]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prenylcysteine oxidase 1 (PCYOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [78]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor-binding protein GGA2 (GGA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Arsenic DMTL2Y1 N. A. N. A. Approved [424]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [293]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [425]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [349]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [92]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [348]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [408]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [311]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein TASOR (TASOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [378]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [426]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily C member 12 (DNAJC12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [427]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ornithine decarboxylase antizyme 3 (OAZ3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [202]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
Drug(s) Affected By SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [428]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [428]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [428]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [423]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FERM, ARHGEF and pleckstrin domain-containing protein 1 (FARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [429]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [430]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [251]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [251]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [201]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of G-protein signaling 16 (RGS16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [249]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [90]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [423]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [249]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [431]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [284]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [432]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [433]
Fructose DM43AN2 Vomiting MD90 Approved [165]
Ketoprofen DMRKXPT Bursitis Approved [165]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [434]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [435]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [436]
Gefitinib DM15F0X Colon adenocarcinoma Approved [437]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [438]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [439]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-2 (MT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [440]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [441]
Quercetin DM3NC4M Obesity 5B81 Approved [442]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1A (MT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [440]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [443]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [444]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [266]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [445]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [443]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [443]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [362]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1F (MT1F)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [446]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [447]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [448]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [449]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [450]
Quercetin DM3NC4M Obesity 5B81 Approved [451]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [452]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [453]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [454]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [455]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [456]
Fructose DM43AN2 Vomiting MD90 Approved [165]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [457]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [458]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [378]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [459]
Methotrexate DM2TEOL Anterior urethra cancer Approved [460]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1G (MT1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [249]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [461]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [446]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [447]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Early growth response protein 1 (EGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [249]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [304]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [236]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [342]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [266]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [249]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [208]
Methotrexate DM2TEOL Anterior urethra cancer Approved [463]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [441]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-2 (EDN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [464]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [361]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [338]
Arsenic DMTL2Y1 N. A. N. A. Approved [465]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
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Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [413]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [466]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [413]
Ethacrynic acid DM60QMR Edema MG29 Approved [467]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [204]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [468]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [413]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [165]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [469]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [470]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [471]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [472]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [473]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [141]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [474]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [471]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [475]
Methotrexate DM2TEOL Anterior urethra cancer Approved [476]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [477]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [50]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [284]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [251]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [384]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [249]
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Drug(s) Affected By Prostaglandin E2 receptor EP4 subtype (PTGER4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [478]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [202]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [401]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [249]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [479]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [480]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [481]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [482]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [483]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [484]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [370]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [253]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [284]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [485]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [345]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [486]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [253]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FosB (FOSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [249]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [284]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [487]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [400]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [488]
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Drug(s) Affected By Metallothionein-1X (MT1X)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [249]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [489]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [461]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [431]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [490]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [213]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [122]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related GTP-binding protein Rho6 (RND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [261]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [415]
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [204]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [415]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [48]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [491]
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Drug(s) Affected By Immediate early response gene 2 protein (IER2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [492]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [293]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [249]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [493]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [494]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [212]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ERBB receptor feedback inhibitor 1 (ERRFI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [463]
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Drug(s) Affected By Dexamethasone-induced Ras-related protein 1 (RASD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [362]
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Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [495]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [496]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [497]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [497]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [498]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [499]
Quercetin DM3NC4M Obesity 5B81 Approved [500]
Fluoxetine DM3PD2C Bipolar depression Approved [497]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [501]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [502]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [503]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [435]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [504]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [505]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [506]
Gefitinib DM15F0X Colon adenocarcinoma Approved [507]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [508]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [509]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [510]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [502]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [511]
Paclitaxel DMLB81S Breast carcinoma Approved [512]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [513]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [501]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [165]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [435]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [504]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [514]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [515]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [516]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [517]
Gefitinib DM15F0X Colon adenocarcinoma Approved [518]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [519]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [520]
Selenium DM25CGV N. A. N. A. Approved [91]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [177]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [161]
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Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [391]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [521]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [169]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [237]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [82]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [212]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [213]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [522]
Epinephrine DM3KJBC Acute asthma CA23 Approved [523]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [477]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [260]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [524]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [525]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [526]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [527]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [528]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [529]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [530]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [165]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Verapamil DMA7PEW Angina pectoris BA40 Approved [531]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [532]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [435]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [517]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Filamin-A (FLNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [533]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [245]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [410]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [516]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [210]
Selenium DM25CGV N. A. N. A. Approved [91]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [535]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [536]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [537]
Quercetin DM3NC4M Obesity 5B81 Approved [538]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Symplekin (SYMPK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [539]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [540]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [172]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [326]
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Drug(s) Affected By Probable ATP-dependent RNA helicase DDX27 (DDX27)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [206]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [540]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [541]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [292]
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Drug(s) Affected By E3 ubiquitin-protein ligase RNF114 (RNF114)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [540]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor repressor (AHRR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [542]
Quercetin DM3NC4M Obesity 5B81 Approved [543]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Cotinine DMCEZ1B Insecticide N.A. Approved [544]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [423]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [545]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [293]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [546]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Charybdotoxin DMKN345 Scorpion envenoming syndrome 8D43 Approved [547]
Clotrimazole DMMFCIH Cutaneous candidiasis 1F23.14 Approved [546]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [548]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [549]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [550]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related BTB domain-containing protein 1 (RHOBTB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [202]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [122]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protocadherin-8 (PCDH8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [551]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [552]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [553]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [124]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAS guanyl-releasing protein 1 (RASGRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [554]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Indomethacin DMSC4A7 Bursitis Approved [555]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [556]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Supervillin (SVIL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Estrone DM5T6US Acne vulgaris ED80 Approved [187]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Mestranol DMG3F94 Contraception QA21 Approved [187]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [557]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenosine deaminase (ADA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [558]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [559]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Corticotropin DMP9TWZ Cushing disease 5A70 Approved [560]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [561]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Aripiprazole DM3NUMH Bipolar I disorder Approved [562]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [563]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [564]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Ethacrynic acid DM60QMR Edema MG29 Approved [565]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [566]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [201]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [567]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [568]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [569]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [570]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [571]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
Ethacrynic acid DM60QMR Edema MG29 Approved [572]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [266]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [573]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [574]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [575]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [373]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [403]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [575]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [213]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [391]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [182]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [521]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [160]
Etretinate DM2CZFA Keratosis ED56 Approved [87]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [576]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [180]
Quercetin DM3NC4M Obesity 5B81 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myb-related protein A (MYBL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [577]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Panobinostat DM58WKG Chronic graft versus host disease Approved [463]
Estrone DM5T6US Acne vulgaris ED80 Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [461]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [577]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By L-selectin (SELL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [578]
Meloxicam DM2AR7L Arthritis FA20 Approved [578]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [579]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [578]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [580]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [578]
Phenylbutazone DMAYL0T Chronic pain MG30 Approved [578]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By D(1A) dopamine receptor (DRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [165]
Haloperidol DM96SE0 Delirium Approved [581]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [582]
Pergolide mesylate DM5GKOV N. A. N. A. Approved [583]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [581]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [584]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [585]
Methamphetamine DMPM4SK Anxiety Approved [586]
Clozapine DMFC71L Schizophrenia 6A20 Approved [587]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcitonin receptor (CALCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [553]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [588]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [589]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [64]
Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [590]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [591]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [592]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [593]
Quercetin DM3NC4M Obesity 5B81 Approved [594]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [595]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [596]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [597]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase FRK (FRK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [598]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Excitatory amino acid transporter 3 (SLC1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [309]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [599]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [600]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADP-dependent malic enzyme (ME1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [136]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Selenium DM25CGV N. A. N. A. Approved [91]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [396]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [461]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [213]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [601]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Achaete-scute homolog 1 (ASCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [602]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [376]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [71]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [603]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [356]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [311]
Propanoic Acid DM9TN2W Discovery agent N.A. Investigative [604]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [243]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [236]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [201]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-11 (CDH11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [299]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [557]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [202]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Paclitaxel DMLB81S Breast carcinoma Approved [231]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Spectrin beta chain, non-erythrocytic 1 (SPTBN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [605]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [362]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [551]
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Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [237]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [309]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [606]
Estrone DM5T6US Acne vulgaris ED80 Approved [187]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAL-like protein (MALL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Folic Acid DMEMBJC Colorectal carcinoma Approved [607]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [255]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [608]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [553]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [609]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [610]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [353]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-6(IV) chain (COL4A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [557]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [478]
Arecoline DMFJZK3 Parkinson disease 8A00.0 Phase 1 [611]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [568]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [612]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [613]
Estrone DM5T6US Acne vulgaris ED80 Approved [614]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [615]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [616]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [617]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [618]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [619]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Estrone DM5T6US Acne vulgaris ED80 Approved [620]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [345]
Mestranol DMG3F94 Contraception QA21 Approved [187]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [621]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [621]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [621]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynein axonemal assembly factor 9 (DNAAF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [404]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [404]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [53]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Semaphorin-3C (SEMA3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [406]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [622]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [623]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor 7-like 2 (TCF7L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [624]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [625]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [261]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
Bortezomib DMNO38U Leukemia Approved [626]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Suppressor of cytokine signaling 2 (SOCS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [623]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [48]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [557]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 2 (TLR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [251]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [627]
Quercetin DM3NC4M Obesity 5B81 Approved [628]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [251]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [629]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [630]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [631]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [627]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [632]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [632]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [439]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [632]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [538]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [632]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [633]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [634]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [478]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [635]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [636]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-7 (PAX7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [344]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [306]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [215]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [636]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [71]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [293]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-3(IV) chain (COL4A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [637]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [299]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [638]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [376]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [639]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-interacting killer (BIK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [640]
Methotrexate DM2TEOL Anterior urethra cancer Approved [641]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [370]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [260]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [642]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Clozapine DMFC71L Schizophrenia 6A20 Approved [643]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metabotropic glutamate receptor 4 (GRM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
PMID20638279C11 DMFHS4V Discovery agent N.A. Investigative [644]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [64]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [416]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 Discovery agent N.A. Investigative [645]
4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol DMTMLXU Discovery agent N.A. Investigative [636]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [646]
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Drug(s) Affected By Protein lifeguard 2 (FAIM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [647]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [487]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Arsenic DMTL2Y1 N. A. N. A. Approved [648]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [636]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [353]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
Milchsaure DM462BT Pruritus EC90 Investigative [357]
4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol DMTMLXU Discovery agent N.A. Investigative [636]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 6 (CARD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein 63 (TP63)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [649]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [373]
Panobinostat DM58WKG Chronic graft versus host disease Approved [650]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [400]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [423]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Topotecan DMP6G8T Central nervous system neoplasm Approved [651]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [125]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [126]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [652]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [653]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [654]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [654]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [655]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [127]
Capsaicin DMGMF6V Back pain ME84.Z Approved [656]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [657]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [658]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [659]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [658]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [659]
Sulfinpyrazone DMEV954 Gout FA25 Approved [660]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [658]
Zafirlukast DMHNQOG Asthma CA23 Approved [658]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [658]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [661]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [662]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [663]
Methoxsalen DME8FZ9 Cutaneous T-cell lymphoma 2B01 Approved [664]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [665]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [666]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [667]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [668]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [605]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [669]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [670]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [396]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [671]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [672]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [318]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [673]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [674]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [675]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [676]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [676]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [677]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [678]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [679]
Etidronic acid DM1XHYJ Bone Paget disease Approved [676]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [676]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [676]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [680]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [681]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [682]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [683]
Gefitinib DM15F0X Colon adenocarcinoma Approved [684]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [685]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [686]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [687]
Quercetin DM3NC4M Obesity 5B81 Approved [688]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [689]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [685]
Estrone DM5T6US Acne vulgaris ED80 Approved [491]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [690]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Fructose DM43AN2 Vomiting MD90 Approved [691]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [692]
Estrone DM5T6US Acne vulgaris ED80 Approved [693]
Testosterone DM7HUNW Hot flushes GA30 Approved [694]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [693]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [693]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [693]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein beta-1 (HSPB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [219]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [493]
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [476]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [695]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [193]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [345]
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Drug(s) Affected By Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [696]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [697]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [698]
Estrone DM5T6US Acne vulgaris ED80 Approved [699]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [700]
Testosterone DM7HUNW Hot flushes GA30 Approved [701]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [229]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [702]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [703]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
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Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [704]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [704]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [704]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [705]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [706]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [696]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [707]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [708]
Selenium DM25CGV N. A. N. A. Approved [709]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [710]
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Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [711]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [712]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [713]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [714]
Bortezomib DMNO38U Leukemia Approved [78]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [715]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [716]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [716]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [717]
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Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [718]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [719]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Testosterone DM7HUNW Hot flushes GA30 Approved [720]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [311]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [647]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [721]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [722]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [723]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [687]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [724]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [725]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
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Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [481]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [726]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [727]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [728]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [729]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [730]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [605]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [731]
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Drug(s) Affected By Gap junction alpha-1 protein (GJA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [732]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [695]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Folic Acid DMEMBJC Colorectal carcinoma Approved [607]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [557]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [732]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [733]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [734]
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Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [735]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [736]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [737]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Haloperidol DM96SE0 Delirium Approved [206]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [485]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [738]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [739]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [517]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [683]
Gefitinib DM15F0X Colon adenocarcinoma Approved [740]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [741]
Selenium DM25CGV N. A. N. A. Approved [91]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [161]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [742]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [743]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [178]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [89]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Fluoxetine DM3PD2C Bipolar depression Approved [744]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [235]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [745]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [746]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [747]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [748]
Bortezomib DMNO38U Leukemia Approved [749]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [750]
Gefitinib DM15F0X Colon adenocarcinoma Approved [740]
Prednisone DM2HG4X Acute asthma CA23 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [751]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [752]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [686]
Quercetin DM3NC4M Obesity 5B81 Approved [753]
Fluoxetine DM3PD2C Bipolar depression Approved [744]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [754]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [755]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serpin B9 (SERPINB9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [344]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen-related receptor gamma (ESRRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [737]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [48]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [756]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [757]
Quercetin DM3NC4M Obesity 5B81 Approved [758]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [712]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [713]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [293]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [759]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [760]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [761]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [762]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [763]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Bortezomib DMNO38U Leukemia Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [338]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [764]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear respiratory factor 1 (NRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [757]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [765]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [766]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [713]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Arsenic DMTL2Y1 N. A. N. A. Approved [767]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [768]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Olfactomedin-4 (OLFM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [769]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [770]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [771]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [407]
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Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [772]
Quercetin DM3NC4M Obesity 5B81 Approved [773]
Estrone DM5T6US Acne vulgaris ED80 Approved [774]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [775]
Testosterone DM7HUNW Hot flushes GA30 Approved [776]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [777]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [778]
Mestranol DMG3F94 Contraception QA21 Approved [779]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [780]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein NANOG (NANOG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [781]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [381]
Quercetin DM3NC4M Obesity 5B81 Approved [782]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [783]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [384]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [784]
Testosterone DM7HUNW Hot flushes GA30 Approved [785]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [786]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 11 (MAPK11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Quercetin DM3NC4M Obesity 5B81 Approved [787]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [788]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [605]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
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Drug(s) Affected By Nucleoside diphosphate kinase 3 (NME3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [636]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [789]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [293]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [422]
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Drug(s) Affected By Heat shock protein beta-8 (HSPB8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [253]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [261]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [149]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [790]
Minoxidil DMA2Z4F Alopecia ED70 Approved [791]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [792]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [791]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [793]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Methotrexate DM2TEOL Anterior urethra cancer Approved [794]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 13 (MAPK13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [605]
Paclitaxel DMLB81S Breast carcinoma Approved [795]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [122]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [426]
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Drug(s) Affected By Ketohexokinase (KHK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [796]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [797]
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Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Bortezomib DMNO38U Leukemia Approved [78]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [717]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [798]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
PMID25656651-Compound-5 DMAI95U Chronic myeloid leukaemia 2A20 Patented [799]
SB-431542 DM0YOXQ Pulmonary fibrosis CB03.4 Preclinical [800]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [91]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [92]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [64]
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Drug(s) Affected By Cyclin-dependent kinase 9 (CDK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [801]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [802]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [803]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase, mitochondrial (NME4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Folic Acid DMEMBJC Colorectal carcinoma Approved [804]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Paclitaxel DMLB81S Breast carcinoma Approved [795]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [222]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [805]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [806]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [548]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [807]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [808]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [809]
GDC0941 DM1YAK6 Breast cancer 2C60-2C65 Phase 2 [810]
GDC-0980/RG7422 DMF3MV1 Non-hodgkin lymphoma 2B33.5 Phase 2 [811]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Atrial natriuretic peptide receptor 2 (NPR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [487]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [549]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [293]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine kinase-like domain-containing protein STKLD1 (STKLD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [797]
Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [812]
Quercetin DM3NC4M Obesity 5B81 Approved [813]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [814]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [815]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [816]
Testosterone DM7HUNW Hot flushes GA30 Approved [119]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [817]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [818]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [219]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [471]
Methotrexate DM2TEOL Anterior urethra cancer Approved [476]
Quercetin DM3NC4M Obesity 5B81 Approved [819]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [50]
Ethacrynic acid DM60QMR Edema MG29 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [820]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [821]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Hesperidin DMI5DW1 Vascular purpura 3B60 Approved [822]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [426]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [339]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [376]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAP/microtubule affinity-regulating kinase 4 (MARK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [425]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GTPase KRas (KRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [823]
Quercetin DM3NC4M Obesity 5B81 Approved [304]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [824]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [825]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [418]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [826]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [827]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynein axonemal heavy chain 2 (DNAH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [555]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [828]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [124]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
Drug(s) Affected By G-protein coupled receptor family C group 5 member D (GPRC5D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [461]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [378]
Quercetin DM3NC4M Obesity 5B81 Approved [829]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [830]
Testosterone DM7HUNW Hot flushes GA30 Approved [694]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [831]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Capsaicin DMGMF6V Back pain ME84.Z Approved [832]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [833]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein R-Ras2 (RRAS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [397]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [260]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [445]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor gamma (RARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [834]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [835]
Ethanol DMDRQZU Chronic pain MG30 Approved [328]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [557]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [836]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [215]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [376]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [789]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcriptional-regulating factor 1 (TRERF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Folic Acid DMEMBJC Colorectal carcinoma Approved [111]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [423]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [376]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [345]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [837]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PAK 6 (PAK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [552]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [838]
Gefitinib DM15F0X Colon adenocarcinoma Approved [740]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [839]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [686]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [840]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [841]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Selenium DM25CGV N. A. N. A. Approved [200]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By EKC/KEOPS complex subunit TP53RK (TP53RK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [215]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [408]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [92]
Milchsaure DM462BT Pruritus EC90 Investigative [357]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [212]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosomal protein S6 kinase-like 1 (RPS6KL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [797]
Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [842]
Etretinate DM2CZFA Keratosis ED56 Approved [241]
Methotrexate DM2TEOL Anterior urethra cancer Approved [242]
Quercetin DM3NC4M Obesity 5B81 Approved [843]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [844]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [177]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [208]
Quercetin DM3NC4M Obesity 5B81 Approved [845]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [208]
Testosterone DM7HUNW Hot flushes GA30 Approved [846]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [847]
Paclitaxel DMLB81S Breast carcinoma Approved [848]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [242]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [849]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [850]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurofibromin (NF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [248]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [457]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [459]
Methotrexate DM2TEOL Anterior urethra cancer Approved [751]
Quercetin DM3NC4M Obesity 5B81 Approved [851]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [459]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [852]
Sorbitol DMAN0DE Constipation DD91.1 Approved [853]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Creatine kinase U-type, mitochondrial (CKMT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Folic Acid DMEMBJC Colorectal carcinoma Approved [111]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [222]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [222]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [222]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [222]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
dibutyl phthalate DMEDGKO Discovery agent N.A. Investigative [854]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribokinase (RBKS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [559]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [551]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [855]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [856]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [857]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [422]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [356]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [858]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [859]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [457]
Gefitinib DM15F0X Colon adenocarcinoma Approved [437]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [471]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [459]
Quercetin DM3NC4M Obesity 5B81 Approved [538]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [239]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [860]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [459]
Ethacrynic acid DM60QMR Edema MG29 Approved [116]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nipped-B-like protein (NIPBL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [623]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [345]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [861]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth factor receptor-bound protein 7 (GRB7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [261]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [69]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [717]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [126]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [862]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [653]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [863]
Capsaicin DMGMF6V Back pain ME84.Z Approved [864]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [654]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [865]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [654]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [862]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [126]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [866]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [654]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [653]
Capsaicin DMGMF6V Back pain ME84.Z Approved [864]
Zafirlukast DMHNQOG Asthma CA23 Approved [867]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [654]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [868]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [653]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [654]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [869]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [870]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [871]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [324]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [872]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [873]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [874]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [875]
Gefitinib DM15F0X Colon adenocarcinoma Approved [876]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [877]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [161]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [878]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [879]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [880]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysosomal Pro-X carboxypeptidase (PRCP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [881]
Gentamicin DMKINJO Bacteremia 1A73 Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [476]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [253]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [817]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [880]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer anti-estrogen resistance protein 1 (BCAR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Benzatropine DMF7EXL Parkinsonian disorder Approved [206]
Clozapine DMFC71L Schizophrenia 6A20 Approved [206]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [122]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelial differentiation-related factor 1 (EDF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [91]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [362]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15B (PPP1R15B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [102]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [857]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [882]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [883]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [883]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [883]
Capsaicin DMGMF6V Back pain ME84.Z Approved [864]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [884]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [865]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [885]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [886]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [887]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-lysine N-methyltransferase, H3 lysine-36 specific (NSD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [196]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [326]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [92]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [888]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [60]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [858]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By NEDD8-activating enzyme E1 regulatory subunit (NAE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [305]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [346]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [348]
Milchsaure DM462BT Pruritus EC90 Investigative [357]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Protein kinase C zeta type (PRKCZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [889]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [890]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [891]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [892]
Diazepam DM08E9O Alcohol withdrawal Approved [892]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [892]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [892]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [892]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [892]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [892]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [892]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tropomyosin alpha-4 chain (TPM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [305]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Ampicillin DMHWE7P Acute epiglottitis Approved [47]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [410]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calmodulin-1 (CALM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [208]
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [208]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [863]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [893]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [894]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [895]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [896]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [897]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [898]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [899]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [900]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [901]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inositol-tetrakisphosphate 1-kinase (ITPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [861]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [612]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [612]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [422]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphomevalonate kinase (PMVK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [101]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [902]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 1 (TRIB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer anti-estrogen resistance protein 3 (BCAR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [400]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [213]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [213]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [398]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Estrone DM5T6US Acne vulgaris ED80 Approved [187]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Mestranol DMG3F94 Contraception QA21 Approved [187]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [187]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase JAK3 (JAK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [903]
Ceritinib DMB920Z Non-small-cell lung cancer 2C25.Y Approved [904]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [78]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [202]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [905]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [903]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [906]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bromodomain-containing protein 2 (BRD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [213]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [213]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Double-strand-break repair protein rad21 homolog (RAD21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [538]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [766]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [907]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [222]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [221]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [908]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [909]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Topotecan DMP6G8T Central nervous system neoplasm Approved [222]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [172]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [910]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [216]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inhibitor of growth protein 5 (ING5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [345]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [349]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [911]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [912]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [913]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [91]
APR-246 DMNFADH Ovarian cancer 2C73 Phase 2 [914]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C delta type (PRKCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [248]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [915]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [916]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [917]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [918]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [293]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [919]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [219]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [368]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [871]
Sorbitol DMAN0DE Constipation DD91.1 Approved [920]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [921]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [922]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [71]
Amsacrine DMZKYIV Acute lymphoblastic leukaemia 2A85 Approved [921]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenylate kinase isoenzyme 5 (AK5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [189]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [255]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [339]
Methamphetamine DMPM4SK Anxiety Approved [923]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [908]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Creatine kinase B-type (CKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [175]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [924]
Selenium DM25CGV N. A. N. A. Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [814]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [925]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [637]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [318]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Testosterone enanthate DMB6871 N. A. N. A. Approved [214]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Bortezomib DMNO38U Leukemia Approved [78]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [926]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [401]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sphingosine kinase 1 (SPHK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [817]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Bortezomib DMNO38U Leukemia Approved [927]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [427]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [928]
Gefitinib DM15F0X Colon adenocarcinoma Approved [929]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [177]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [930]
Quercetin DM3NC4M Obesity 5B81 Approved [322]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [385]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [418]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [931]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [278]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [931]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [346]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [797]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase homolog 7 (NME7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [932]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [345]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [882]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolar complex protein 3 homolog (NOC3L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Selenium DM25CGV N. A. N. A. Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [376]
Topotecan DMP6G8T Central nervous system neoplasm Approved [222]
Urethane DM7NSI0 N. A. N. A. Phase 4 [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenylate kinase 2, mitochondrial (AK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [149]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [401]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [933]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [934]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [935]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [936]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [937]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [938]
Capsaicin DMGMF6V Back pain ME84.Z Approved [864]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [654]
Quinidine DMLPICK N. A. N. A. Approved [939]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [940]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [168]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [302]
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Menthol DMG2KW7 Back pain ME84.Z Approved [120]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [941]
Indomethacin DMSC4A7 Bursitis Approved [942]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [943]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [5]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DE2GB8N UD18_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Gene/Protein Processing [6]
14-3-3 protein zeta/delta OT2TKG9P 1433Z_HUMAN Gene/Protein Processing [6]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) OTJWHMZ5 PSDE_HUMAN Gene/Protein Processing [7]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6) OTX59EGK PSMD6_HUMAN Gene/Protein Processing [7]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) OTQRET2B S5A1_HUMAN Gene/Protein Processing [6]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Gene/Protein Processing [6]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Drug Response [8]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [7]
Achaete-scute homolog 1 (ASCL1) OTI4X44G ASCL1_HUMAN Gene/Protein Processing [9]
Adenosine deaminase (ADA) OTOX2872 ADA_HUMAN Gene/Protein Processing [9]

References

1 ClinicalTrials.gov (NCT00272714) Study of Afimoxifene Gel to Treat Cyclic Mastalgia in Premenopausal Women. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620).
4 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
5 Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14.
6 Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res. 2006 Jul 15;66(14):7334-40.
7 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
8 High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
9 Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
10 Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86.
11 Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201.
12 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
13 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8.
14 Clinical pipeline report, company report or official report of Shionogi (2011).
15 Effect of selective estrogen receptor modulators on cell proliferation and estrogen receptor activities in normal human prostate stromal and epithe... Prostate Cancer Prostatic Dis. 2009;12(4):375-81.
16 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
17 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
18 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
19 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
20 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
21 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
22 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
23 Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8.
24 Effect of UDP-glucuronosyltransferase (UGT) 1A polymorphism (rs8330 and rs10929303) on glucuronidation status of acetaminophen. Dose Response. 2017 Sep 11;15(3):1559325817723731.
25 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
26 Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. J Clin Pharmacol. 2009 Sep;49(9):1079-90.
27 Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36.
28 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
29 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
30 Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes. Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):211-4.
31 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
32 Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncol. 2010 Apr;6(4):563-85.
33 Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes. P T. 2015 Jun;40(6):364-8.
34 Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759.
35 Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.
36 Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
37 Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
38 Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
39 Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
40 Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
41 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
42 Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
43 Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
44 Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
45 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
46 Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
47 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
48 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
49 Tissue availability of insulin-like growth factor I is inversely related to insulin resistance in essential hypertension: effects of angiotensin converting enzyme inhibition. J Hypertens. 1998 Jun;16(6):863-70. doi: 10.1097/00004872-199816060-00018.
50 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
51 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
52 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
53 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
54 Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
55 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
56 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
57 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
58 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
59 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
60 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
61 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
62 Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
63 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
64 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
65 Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
66 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
67 Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
68 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
69 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
70 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
71 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
72 Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
73 DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
74 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
75 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
76 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
77 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
78 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
79 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
80 Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. Br J Cancer. 2009 Apr 7;100(7):1095-102. doi: 10.1038/sj.bjc.6604970. Epub 2009 Mar 10.
81 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
82 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
83 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
84 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
85 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
86 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
87 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
88 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
89 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
90 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
91 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
92 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
93 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
94 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
95 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
96 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
97 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
98 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
99 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
100 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
101 Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. Cancer Chemother Pharmacol. 2008 Apr;61(5):791-802.
102 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
103 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
104 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
105 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
106 The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009 Feb;41(2):178-186.
107 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
108 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
109 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
110 Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting. Biol Pharm Bull. 2010;33(5):743-51. doi: 10.1248/bpb.33.743.
111 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
112 Gene expression signature of parathion-transformed human breast epithelial cells. Int J Mol Med. 2007 May;19(5):741-50.
113 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
114 Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res. 2004 Aug 1;298(1):188-96. doi: 10.1016/j.yexcr.2004.04.012.
115 Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice. Cancer. 2008 Feb 1;112(3):596-607. doi: 10.1002/cncr.23223.
116 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
117 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
118 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
119 Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle. 2010 Apr 15;9(8):1629-38. doi: 10.4161/cc.9.8.11487. Epub 2010 Apr 15.
120 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
121 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
122 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
123 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
124 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
125 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
126 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
127 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
128 Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metab Dispos. 2005 Jul;33(7):1074-81. doi: 10.1124/dmd.104.002279. Epub 2005 Apr 8.
129 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
130 Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. J Toxicol Sci. 2017;42(3):343-348.
131 Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines. Drug Metab Dispos. 2013 Feb;41(2):281-90.
132 Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
133 Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol. 2009 Apr 15;77(8):1410-7.
134 Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. World J Gastroenterol. 2005 May 14;11(18):2748-53. doi: 10.3748/wjg.v11.i18.2748.
135 Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
136 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
137 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
138 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
139 Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
140 Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
141 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
142 Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
143 The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol Cancer Ther. 2005 May;4(5):855-63.
144 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
145 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
146 ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antivir Ther. 2004 Aug;9(4):519-28.
147 Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells. Biochem Pharmacol. 2009 Mar 1;77(5):897-909.
148 Prolonged use of aspirin alters human and rat intestinal cells and thereby limits the absorption of clopidogrel. Clin Pharmacol Ther. 2011 Oct;90(4):612-9. doi: 10.1038/clpt.2011.163. Epub 2011 Sep 7.
149 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
150 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
151 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
152 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
153 Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
154 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
155 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
156 Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
157 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
158 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
159 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
160 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
161 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
162 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
163 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
164 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
165 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
166 Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
167 Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
168 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
169 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
170 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
171 Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int J Cancer. 2004 Mar 20;109(2):167-73. doi: 10.1002/ijc.11720.
172 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
173 Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL. Apoptosis. 2006 Oct;11(10):1851-60. doi: 10.1007/s10495-006-9529-6.
174 Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line. Cancer Res Treat. 2013 Jun;45(2):126-33. doi: 10.4143/crt.2013.45.2.126. Epub 2013 Jun 30.
175 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
176 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
177 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
178 Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
179 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
180 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
181 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
182 G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
183 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
184 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
185 CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
186 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
187 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
188 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
189 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
190 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
191 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
192 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
193 Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro. PLoS One. 2011;6(9):e24831. doi: 10.1371/journal.pone.0024831. Epub 2011 Sep 14.
194 Effects of testosterone and metformin on glucose metabolism in endometrium. Fertil Steril. 2010 May 1;93(7):2295-8. doi: 10.1016/j.fertnstert.2009.01.096. Epub 2009 Mar 27.
195 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
196 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
197 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
198 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
199 Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
200 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
201 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
202 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
203 Up-regulated gene expression of angiogenesis factors in post-chemotherapeutic lung cancer tissues determined by cDNA macroarray. Oncol Rep. 2002 Jul-Aug;9(4):723-8.
204 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
205 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
206 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
207 Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
208 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
209 Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Lett. 2006 Sep 8;241(1):93-101. doi: 10.1016/j.canlet.2005.10.014. Epub 2005 Dec 9.
210 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
211 microRNA expression alteration after arsenic trioxide treatment in HepG-2 cells. J Gastroenterol Hepatol. 2011 Jan;26(1):186-93. doi: 10.1111/j.1440-1746.2010.06317.x.
212 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
213 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
214 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
215 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
216 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
217 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
218 Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017 Feb 17;292(7):2815-2829. doi: 10.1074/jbc.M116.745398. Epub 2017 Jan 4.
219 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
220 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
221 Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR. Int J Cancer. 2006 Oct 1;119(7):1599-606.
222 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
223 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
224 Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals. Toxicol In Vitro. 2022 Jun;81:105348. doi: 10.1016/j.tiv.2022.105348. Epub 2022 Mar 18.
225 Estrogenic activities of Ginkgo biloba extracts. Life Sci. 2004 Jan 30;74(11):1325-35. doi: 10.1016/j.lfs.2003.06.045.
226 Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity. Toxicology. 2012 Aug 16;298(1-3):40-51. doi: 10.1016/j.tox.2012.04.014. Epub 2012 May 3.
227 Arsenic induces functional re-expression of estrogen receptor by demethylation of DNA in estrogen receptor-negative human breast cancer. PLoS One. 2012;7(4):e35957. doi: 10.1371/journal.pone.0035957. Epub 2012 Apr 27.
228 Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model. Toxicol Sci. 2005 Feb;83(2):257-63.
229 Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug;116(3):461-70. doi: 10.1007/s10549-008-0151-x. Epub 2008 Aug 3.
230 Comparative ligand-binding analysis of ten human lipocalins. Biochim Biophys Acta. 2006 Feb;1764(2):161-73. doi: 10.1016/j.bbapap.2005.12.006. Epub 2006 Jan 6.
231 Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
232 Protecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress. PLoS Genet. 2017 Feb 9;13(2):e1006603. doi: 10.1371/journal.pgen.1006603. eCollection 2017 Feb.
233 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
234 Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution. J Biol Chem. 2014 Aug 1;289(31):21386-400. doi: 10.1074/jbc.M113.528463. Epub 2014 Jun 18.
235 Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
236 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
237 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
238 Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
239 Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
240 Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res. 2009 Sep;50(9):1814-23. doi: 10.1194/jlr.M800343-JLR200. Epub 2009 Apr 21.
241 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
242 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
243 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
244 Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007 Apr;8(4):394-400. doi: 10.1038/sj.embor.7400909. Epub 2007 Feb 23.
245 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
246 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
247 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
248 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
249 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
250 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
251 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
252 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
253 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
254 Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney. Kidney Blood Press Res. 2019;44(6):1392-1403. doi: 10.1159/000503300. Epub 2019 Oct 22.
255 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
256 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
257 Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicol In Vitro. 2021 Mar;71:105063. doi: 10.1016/j.tiv.2020.105063. Epub 2020 Dec 1.
258 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
259 Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells. Chem Biol Interact. 2021 May 1;340:109434. doi: 10.1016/j.cbi.2021.109434. Epub 2021 Mar 6.
260 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
261 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
262 Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
263 Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
264 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
265 Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
266 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
267 Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells. Biochem Biophys Res Commun. 2004 Jan 23;313(4):863-70. doi: 10.1016/j.bbrc.2003.12.018.
268 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
269 Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
270 Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):571-7. doi: 10.1161/01.ATV.0000154142.61859.94. Epub 2004 Dec 23.
271 Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
272 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
273 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
274 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
275 Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma. Biochem Biophys Res Commun. 2001 Mar 9;281(4):1051-6. doi: 10.1006/bbrc.2001.4466.
276 Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. Cancer Biol Ther. 2010 Sep 15;10(6):632-43. doi: 10.4161/cbt.10.6.12654. Epub 2010 Sep 13.
277 Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
278 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
279 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
280 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
281 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
282 Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
283 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
284 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
285 Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicol Sci. 2022 Sep 24;189(2):216-224. doi: 10.1093/toxsci/kfac073.
286 14-3-3 regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression. Oncotarget. 2016 Apr 5;7(14):17726-36. doi: 10.18632/oncotarget.7394.
287 E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
288 Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
289 In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
290 Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells. Int J Cancer. 2018 Jul 1;143(1):113-126.
291 RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome. J Biol Chem. 2018 Oct 26;293(43):16596-16607. doi: 10.1074/jbc.RA118.004973. Epub 2018 Aug 30.
292 Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
293 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
294 Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization. Exp Cell Res. 2007 Jan 15;313(2):357-68. doi: 10.1016/j.yexcr.2006.10.016. Epub 2006 Oct 25.
295 Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
296 Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2001 Jun;222(1-2):49-59.
297 Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
298 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
299 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
300 Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. Cancer Genet Cytogenet. 2006 Apr 15;166(2):130-8. doi: 10.1016/j.cancergencyto.2005.09.012.
301 Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem. 1999 Jun 18;274(25):17580-6. doi: 10.1074/jbc.274.25.17580.
302 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
303 Molecular mechanisms underlying the inhibition of IFN--induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J Cell Biochem. 2011 Feb;112(2):675-83. doi: 10.1002/jcb.22976.
304 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
305 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
306 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
307 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
308 Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function. J Biol Chem. 2020 Dec 25;295(52):18105-18121. doi: 10.1074/jbc.RA120.015891. Epub 2020 Oct 21.
309 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
310 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
311 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
312 Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. Biomed Res. 2008 Jun;29(3):141-5. doi: 10.2220/biomedres.29.141.
313 DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res. 2006 Jun;27(3):99-109. doi: 10.2220/biomedres.27.99.
314 Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients. Viruses. 2021 Oct 15;13(10):2084. doi: 10.3390/v13102084.
315 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
316 Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells. Breast Cancer Res. 2008;10(1):R4. doi: 10.1186/bcr1845. Epub 2008 Jan 11.
317 Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors. Cancer Res Commun. 2023 Dec 8;3(12):2497-2509. doi: 10.1158/2767-9764.CRC-23-0350.
318 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
319 Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells. Cancer Chemother Pharmacol. 2008 Jun;62(1):111-6. doi: 10.1007/s00280-007-0580-y. Epub 2007 Sep 15.
320 Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone. 2001 Oct;29(4):336-43. doi: 10.1016/s8756-3282(01)00589-0.
321 Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
322 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
323 Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. Chem Biol Interact. 2010 Mar 19;184(1-2):207-11.
324 Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
325 Expression profiling of the estrogen responsive genes in response to phytoestrogens using a customized DNA microarray. FEBS Lett. 2005 Mar 14;579(7):1732-40.
326 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
327 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
328 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
329 The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U. J Biol Chem. 1997 Nov 7;272(45):28471-8. doi: 10.1074/jbc.272.45.28471.
330 Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome. Chem Res Toxicol. 2022 Sep 19;35(9):1589-1597. doi: 10.1021/acs.chemrestox.2c00197. Epub 2022 Aug 22.
331 Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
332 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
333 Factors determining sensitivity or resistance of tumor cell lines towards artesunate. Chem Biol Interact. 2010 Apr 15;185(1):42-52.
334 Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells. Cancer Biol Ther. 2005 Feb;4(2):242-7. doi: 10.4161/cbt.4.2.1477. Epub 2005 Feb 20.
335 HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase II and . Chem Res Toxicol. 2018 Feb 19;31(2):137-144. doi: 10.1021/acs.chemrestox.7b00302. Epub 2018 Jan 8.
336 Chlorpyrifos Induces MLL Translocations Through Caspase 3-Dependent Genomic Instability and Topoisomerase II Inhibition in Human Fetal Liver Hematopoietic Stem Cells. Toxicol Sci. 2015 Oct;147(2):588-606. doi: 10.1093/toxsci/kfv153. Epub 2015 Jul 20.
337 Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. Eur J Cancer Prev. 2011 Mar;20(2):123-31. doi: 10.1097/cej.0b013e328341017a.
338 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
339 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
340 Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3. J Leukoc Biol. 2010 May;87(5):833-44. doi: 10.1189/jlb.0409241. Epub 2010 Jan 20.
341 Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
342 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
343 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
344 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
345 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
346 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
347 Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity. J Biol Chem. 2020 Jan 31;295(5):1271-1287. doi: 10.1074/jbc.RA119.011174. Epub 2019 Dec 5.
348 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
349 New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
350 Whole genome mRNA transcriptomics analysis reveals different modes of action of the diarrheic shellfish poisons okadaic acid and dinophysis toxin-1 versus azaspiracid-1 in Caco-2 cells. Toxicol In Vitro. 2018 Feb;46:102-112.
351 Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
352 Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7199-204.
353 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
354 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
355 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
356 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
357 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
358 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
359 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
360 Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
361 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
362 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
363 Identification of protein expression alterations in gefitinib-resistant human lung adenocarcinoma: PCNT and mPR play key roles in the development of gefitinib-associated resistance. Toxicol Appl Pharmacol. 2015 Nov 1;288(3):359-73. doi: 10.1016/j.taap.2015.08.008. Epub 2015 Aug 20.
364 [Correlation of cell cycle alteration to SOCS-1 gene demethylation induced by arsenic trioxide in myeloma cell lines]. Ai Zheng. 2008 Nov;27(11):1150-4.
365 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
366 Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
367 Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells. Respir Res. 2018 Aug 30;19(1):160. doi: 10.1186/s12931-018-0861-5.
368 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
369 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
370 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
371 Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. J Cell Biochem. 2006 Feb 1;97(2):327-50. doi: 10.1002/jcb.20579.
372 Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. Eur J Med Chem. 2001 Jul-Aug;36(7-8):659-71. doi: 10.1016/s0223-5234(01)01262-4.
373 Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
374 Retinoic acid-induced glandular differentiation of the oesophagus. Gut. 2007 Jul;56(7):906-17. doi: 10.1136/gut.2006.097915. Epub 2006 Dec 21.
375 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
376 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
377 cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance. Breast Cancer Res Treat. 2006 Mar;96(1):17-39. doi: 10.1007/s10549-005-9026-6. Epub 2005 Dec 2.
378 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
379 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
380 Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. J Zhejiang Univ Sci B. 2008 Jan;9(1):22-33. doi: 10.1631/jzus.B071322.
381 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
382 Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. J Biol Chem. 2011 Apr 1;286(13):11314-27. doi: 10.1074/jbc.M110.193714. Epub 2011 Jan 3.
383 Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
384 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
385 Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
386 Effects of low dose treatment of tributyltin on the regulation of estrogen receptor functions in MCF-7 cells. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):176-86.
387 Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
388 Androgen receptor modulation following combination exposure to brominated flame-retardants. Sci Rep. 2018 Mar 19;8(1):4843. doi: 10.1038/s41598-018-23181-0.
389 Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment. J Steroid Biochem Mol Biol. 2006 Aug;100(4-5):129-40.
390 The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells. Br J Haematol. 1998 Mar;100(4):637-46. doi: 10.1046/j.1365-2141.1998.00623.x.
391 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
392 A novel mechanism for pergolide-induced neuroprotection: inhibition of NF-kappaB nuclear translocation. Biochem Pharmacol. 2004 May 1;67(9):1743-50. doi: 10.1016/j.bcp.2004.01.012.
393 Antitumor effects of aminobisphosphonates on renal cell carcinoma cell lines. J Urol. 2006 Nov;176(5):2255-61. doi: 10.1016/j.juro.2006.07.053.
394 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
395 The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. Biochimie. 2006 Mar-Apr;88(3-4):387-97. doi: 10.1016/j.biochi.2005.11.007. Epub 2005 Dec 7.
396 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
397 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
398 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
399 Role of all-trans retinoic acid in neurite outgrowth and axonal elongation. J Neurobiol. 2006 Jun;66(7):739-56. doi: 10.1002/neu.20241.
400 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
401 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
402 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
403 Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
404 Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
405 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
406 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
407 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
408 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
409 Proteomic analysis to identify the cellular responses induced by hydroquinone in human embryonic lung fibroblasts. Toxicol Mech Methods. 2006;16(1):1-6. doi: 10.1080/15376520500191797.
410 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
411 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
412 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
413 Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
414 Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res. 2007 Jan;5(1):95-108. doi: 10.1158/1541-7786.MCR-06-0125.
415 Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
416 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
417 Chromatin modifiers: A new class of pollutants with potential epigenetic effects revealed by in vitro assays and transcriptomic analyses. Toxicology. 2023 Jan 15;484:153413. doi: 10.1016/j.tox.2022.153413. Epub 2022 Dec 26.
418 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
419 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
420 Global changes in gene regulation demonstrate that unconjugated bilirubin is able to upregulate and activate select components of the endoplasmic reticulum stress response pathway. J Biochem Mol Toxicol. 2010 Mar-Apr;24(2):73-88.
421 Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
422 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
423 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
424 Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
425 ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
426 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
427 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
428 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
429 Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
430 Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
431 Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
432 Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
433 A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
434 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
435 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
436 Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
437 Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
438 Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
439 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
440 Expression pattern of cisplatin-induced metallothionein isoforms in squamous cell carcinoma. Anticancer Res. 2003 Jan-Feb;23(1A):299-303.
441 Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
442 Expression of antioxidant proteins in human intestinal Caco-2 cells treated with dietary flavonoids. Cancer Lett. 1999 Nov 15;146(2):161-7.
443 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
444 Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells. Biol Trace Elem Res. 2012 Dec;149(3):331-9.
445 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
446 High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res. 2009 Oct 1;15(19):6070-8.
447 Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res. 2005 May 1;65(9):3837-45.
448 ?-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts. Eur J Pharmacol. 2012 Sep 15;691(1-3):218-24. doi: 10.1016/j.ejphar.2012.07.002. Epub 2012 Jul 13.
449 Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells. Cardiovasc Pathol. 2001 Nov-Dec;10(6):311-5. doi: 10.1016/s1054-8807(01)00095-3.
450 [Effect of simvastatin on endothelin-1 expression in endothelial cell cultured hypoxically]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jan;39(1):72-5.
451 Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008 Feb;67(1):42-7.
452 Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 2013 Aug;134(2):323-34. doi: 10.1093/toxsci/kft105. Epub 2013 May 2.
453 Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007 Jun;85(5):408-14. doi: 10.1532/IJH97.E0620.
454 Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. Mediators Inflamm. 2008;2008:305087. doi: 10.1155/2008/305087. Epub 2008 Dec 1.
455 High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
456 Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
457 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
458 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
459 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
460 [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
461 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
462 The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
463 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
464 Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis. Aliment Pharmacol Ther. 2005 Feb 1;21(3):227-34. doi: 10.1111/j.1365-2036.2005.02307.x.
465 Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
466 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
467 Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
468 The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
469 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
470 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
471 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
472 Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
473 Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J Biol Chem. 2001 Dec 21;276(51):47828-33. doi: 10.1074/jbc.M106103200. Epub 2001 Oct 8.
474 Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
475 Complex genetic response of human cells to sublethal levels of pure nitric oxide. Cancer Res. 1998 Aug 1;58(15):3435-40.
476 Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
477 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
478 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
479 Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
480 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
481 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
482 High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
483 Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
484 Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009 Oct;46(16):3345-57. doi: 10.1016/j.molimm.2009.07.019. Epub 2009 Sep 3.
485 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
486 Identification of cornifelin and early growth response-1 gene as novel biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model MCTT HCE?. Arch Toxicol. 2015 Sep;89(9):1589-98. doi: 10.1007/s00204-014-1390-8. Epub 2014 Nov 7.
487 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
488 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
489 The effect of zinc and D-penicillamine in a stable human hepatoma ATP7B knockout cell line. PLoS One. 2014 Jun 3;9(6):e98809. doi: 10.1371/journal.pone.0098809. eCollection 2014.
490 Different pathways are involved in arsenic-trioxide-induced cell proliferation and growth inhibition in human keratinocytes. Skin Pharmacol Physiol. 2010;23(2):68-78. doi: 10.1159/000265677. Epub 2009 Dec 14.
491 Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
492 Patterns of gene expressions induced by arsenic trioxide in cultured human fibroblasts. Toxicol Lett. 2003 Jul 20;143(2):155-62. doi: 10.1016/s0378-4274(03)00171-1.
493 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
494 Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
495 Aromatase inhibition: translation into a successful therapeutic approach. Clin Cancer Res. 2005 Apr 15;11(8):2809-21. doi: 10.1158/1078-0432.CCR-04-2187.
496 Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling. Reprod Toxicol. 2020 Apr;93:75-82. doi: 10.1016/j.reprotox.2020.01.003. Epub 2020 Jan 14.
497 Effects of selective serotonin reuptake inhibitors on three sex steroids in two versions of the aromatase enzyme inhibition assay and in the H295R cell assay. Toxicol In Vitro. 2015 Oct;29(7):1729-35.
498 Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 10;48(5):1563-75.
499 Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res. 2004 Aug;30(3):387-94.
500 Estrogen synthesis in human colon cancer epithelial cells. J Steroid Biochem Mol Biol. 1999 Dec 31;71(5-6):223-30.
501 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
502 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
503 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
504 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
505 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
506 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
507 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
508 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
509 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
510 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
511 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
512 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
513 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
514 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
515 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
516 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
517 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
518 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
519 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
520 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
521 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
522 Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action. Int J Clin Pharmacol Ther. 2001 Jun;39(6):265-70.
523 Effects of beta-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells. Biochim Biophys Acta. 2003 May 12;1640(2-3):137-42.
524 Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds. J Biomol Screen. 2006 Oct;11(7):782-91.
525 Design, synthesis, and biological evaluation of novel carbohydrate-based sulfamates as carbonic anhydrase inhibitors. J Med Chem. 2011 Mar 10;54(5):1481-9.
526 Inhibition profiles of Voriconazole against acetylcholinesterase, -glycosidase, and human carbonic anhydrase I and II isoenzymes. J Biochem Mol Toxicol. 2019 Oct;33(10):e22385. doi: 10.1002/jbt.22385. Epub 2019 Sep 3.
527 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
528 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
529 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
530 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
531 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
532 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
533 Filamin A phosphorylation by Akt promotes cell migration in response to arsenic. Oncotarget. 2015 May 20;6(14):12009-19. doi: 10.18632/oncotarget.3617.
534 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
535 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
536 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
537 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
538 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
539 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
540 Identification of novel ER-alpha target genes in breast cancer cells: gene- and cell-selective co-regulator recruitment at target promoters determines the response to 17beta-estradiol and tamoxifen. Mol Cell Endocrinol. 2010 Jan 15;314(1):90-100.
541 Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
542 Genotoxic and epigenotoxic effects of fine particulate matter from rural and urban sites in Lebanon on human bronchial epithelial cells. Environ Res. 2015 Jan;136:352-62. doi: 10.1016/j.envres.2014.10.010. Epub 2014 Nov 25.
543 Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Apr;25(3):671-83.
544 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 2012 Oct;120(10):1425-31. doi: 10.1289/ehp.1205412. Epub 2012 Jul 31.
545 Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells. Toxicology. 2011 Jul 29;285(3):97-103.
546 Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression. Am J Physiol Cell Physiol. 2004 Jul;287(1):C125-34. doi: 10.1152/ajpcell.00488.2003. Epub 2004 Feb 25.
547 4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and DeltaF508 CFTR. Eur J Pharmacol. 2005 Jun 1;516(2):118-24. doi: 10.1016/j.ejphar.2005.04.037.
548 Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells. Clin Cancer Res. 2007 Sep 1;13(17):5219-25. doi: 10.1158/1078-0432.CCR-07-0816.
549 Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
550 A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Toxicol Appl Pharmacol. 2015 Jun 1;285(2):79-88.
551 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
552 Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
553 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
554 The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
555 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
556 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
557 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
558 Enhancement of erythrocytic adenosine deaminase following treatment of AIDS-related complex/AIDS patients with zidovudine. AIDS. 1990 Aug;4(8):799-802. doi: 10.1097/00002030-199008000-00012.
559 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
560 Activity of adenosine deaminase in red blood cells of patients suffering from multiple sclerosis treated with adrenocorticotropic hormone. Pol J Pharmacol. 1995 Nov-Dec;47(6):525-30.
561 Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway. Free Radic Biol Med. 2006 May 1;40(9):1664-74. doi: 10.1016/j.freeradbiomed.2006.01.003. Epub 2006 Jan 26.
562 Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium. Chem Res Toxicol. 2019 Oct 21;32(10):1997-2005. doi: 10.1021/acs.chemrestox.9b00149. Epub 2019 Sep 11.
563 Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
564 Retinoic acid remodels extracellular matrix (ECM) of cultured human fetal palate mesenchymal cells (hFPMCs) through down-regulation of TGF-/Smad signaling. Toxicol Lett. 2014 Mar 3;225(2):208-15. doi: 10.1016/j.toxlet.2013.12.013. Epub 2013 Dec 24.
565 Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294.
566 An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
567 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
568 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
569 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
570 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
571 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
572 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
573 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
574 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
575 Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation. Toxicol Lett. 2017 Nov 5;281:20-25. doi: 10.1016/j.toxlet.2017.08.012. Epub 2017 Aug 24.
576 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
577 A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
578 Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. J Biol Chem. 2002 Oct 11;277(41):38212-21. doi: 10.1074/jbc.M205142200. Epub 2002 Jul 29.
579 The in vitro effects of quinupristin/dalfopristin, erythromycin and levofloxacin at low concentrations on the expression of different cell adhesion molecules on the surface of endothelial cells (Eahy926). Toxicology. 2006 Jan 20;218(1):30-8. doi: 10.1016/j.tox.2005.09.014. Epub 2005 Nov 16.
580 Immunological consequences of thalidomide treatment in Sj?gren's syndrome. Ann Rheum Dis. 2006 Jan;65(1):112-4. doi: 10.1136/ard.2005.038406.
581 Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. Chem Res Toxicol. 2013 Jun 17;26(6):878-95.
582 Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry. 1992 Jul;49(7):538-44. doi: 10.1001/archpsyc.1992.01820070032005.
583 Pergolide is an inhibitor of voltage-gated potassium channels, including Kv1.5, and causes pulmonary vasoconstriction. Circulation. 2005 Sep 6;112(10):1494-9. doi: 10.1161/CIRCULATIONAHA.105.556704. Epub 2005 Aug 29.
584 Dopamine-mediated inhibition of renal Na+/K+-ATPase in HK-2 cells is reduced by ouabain. Clin Exp Pharmacol Physiol. 2010 May;37(5-6):613-8. doi: 10.1111/j.1440-1681.2010.05364.x. Epub 2010 Feb 4.
585 Characterizing fucoxanthin as a selective dopamine D(3)/D(4) receptor agonist: Relevance to Parkinson's disease. Chem Biol Interact. 2019 Sep 1;310:108757. doi: 10.1016/j.cbi.2019.108757. Epub 2019 Jul 16.
586 Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users. Mol Psychiatry. 2000 Nov;5(6):664-72. doi: 10.1038/sj.mp.4000760.
587 Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response. J Psychopharmacol. 2007 Sep;21(7):718-27. doi: 10.1177/0269881106072341. Epub 2006 Nov 8.
588 Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. PLoS One. 2011;6(7):e21920. doi: 10.1371/journal.pone.0021920. Epub 2011 Jul 6.
589 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
590 Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
591 Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chem Biol Interact. 2014 Feb 5;208:64-76. doi: 10.1016/j.cbi.2013.11.018. Epub 2013 Dec 6.
592 Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab. 2006 Apr;7(3):301-13. doi: 10.2174/138920006776359310.
593 Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
594 Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells. Phytother Res. 2012 Nov;26(11):1746-52.
595 Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
596 Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
597 Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
598 The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
599 Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64.
600 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
601 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
602 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
603 Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann Surg Oncol. 2011 May;18(5):1506-11. doi: 10.1245/s10434-010-1488-z. Epub 2010 Dec 24.
604 Propionic acid induces mitochondrial dysfunction and affects gene expression for mitochondria biogenesis and neuronal differentiation in SH-SY5Y cell line. Neurotoxicology. 2019 Dec;75:116-122. doi: 10.1016/j.neuro.2019.09.009. Epub 2019 Sep 14.
605 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
606 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
607 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
608 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
609 The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
610 Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
611 Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway. Environ Toxicol. 2020 Sep;35(9):1007-1014. doi: 10.1002/tox.22937. Epub 2020 May 22.
612 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
613 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
614 In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
615 Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
616 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
617 Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
618 Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
619 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
620 Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
621 Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol Endocrinol. 2004 Feb;18(2):402-11. doi: 10.1210/me.2003-0202. Epub 2003 Nov 6.
622 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
623 Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
624 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
625 Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
626 Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
627 Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
628 Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-B signaling pathway. Immunobiology. 2011 Mar;216(3):367-73. doi: 10.1016/j.imbio.2010.07.011. Epub 2010 Aug 19.
629 Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
630 A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women. Thromb Res. 2012 Jul;130(1):45-51. doi: 10.1016/j.thromres.2011.12.009. Epub 2012 Jan 2.
631 Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol. 2012 Apr;168(1):113-24. doi: 10.1111/j.1365-2249.2011.04549.x.
632 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
633 Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem. 2011 Sep 22;54(18):6342-63. doi: 10.1021/jm2007613. Epub 2011 Aug 18.
634 Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood. 2004 Aug 15;104(4):1094-9. doi: 10.1182/blood-2003-12-4266. Epub 2004 Apr 20.
635 Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia. 2011 May;25(5):838-47. doi: 10.1038/leu.2011.2. Epub 2011 Feb 4.
636 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
637 Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
638 ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model. Int J Cancer. 2006 Jan 15;118(2):483-9. doi: 10.1002/ijc.21340.
639 Pretreatment of 3-MA prevents doxorubicin-induced cardiotoxicity through inhibition of autophagy initiation. Toxicology. 2023 May 15;490:153512. doi: 10.1016/j.tox.2023.153512. Epub 2023 Apr 14.
640 Protective effects of hepatocyte growth factor gene overexpression against hydrogen peroxide-induced apoptosis in mesenchymal stem cells. Environ Toxicol. 2019 Nov;34(11):1236-1245. doi: 10.1002/tox.22824. Epub 2019 Jul 16.
641 A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
642 Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
643 Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. J Clin Psychopharmacol. 2005 Oct;25(5):419-26. doi: 10.1097/01.jcp.0000177668.42640.fe.
644 An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4901-5.
645 Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
646 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
647 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
648 Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
649 Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
650 Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. doi: 10.1016/j.bbrc.2009.12.147. Epub 2009 Dec 30.
651 p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochem Pharmacol. 2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
652 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
653 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
654 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
655 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
656 Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
657 Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
658 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
659 Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics. 1997 Jun;7(3):211-21.
660 Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. Arch Biochem Biophys. 2003 Jan 1;409(1):32-44.
661 Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chem Biol Interact. 2021 Apr 1;338:109401. doi: 10.1016/j.cbi.2021.109401. Epub 2021 Feb 5.
662 Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy. Toxicol Appl Pharmacol. 2022 Jan 1;434:115797. doi: 10.1016/j.taap.2021.115797. Epub 2021 Nov 13.
663 Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans. Drug Metab Dispos. 2005 Sep;33(9):1361-6. doi: 10.1124/dmd.105.004796. Epub 2005 Jun 24.
664 Mimicking gene defects to treat drug dependence. Ann N Y Acad Sci. 2000;909:233-46. doi: 10.1111/j.1749-6632.2000.tb06685.x.
665 Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur. Jpn J Cancer Res. 2001 May;92(5):524-8. doi: 10.1111/j.1349-7006.2001.tb01125.x.
666 CYP1A1/1B1 and CYP2A6/2A13 activity is conserved in cultures of differentiated primary human tracheobronchial epithelial cells. Toxicol In Vitro. 2011 Jun;25(4):922-9.
667 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
668 Measurement of 4-hydroxylation of ifosfamide in human liver microsomes using the estimation of free and protein-bound acrolein and codetermination of keto- and carboxyifosfamide. J Cancer Res Clin Oncol. 2002 Jul;128(7):385-92.
669 Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes. Xenobiotica. 2009 Nov;39(11):795-802. doi: 10.3109/00498250903171395.
670 A novel single nucleotide polymorphism altering stability and activity of CYP2a6. Biochem Biophys Res Commun. 2001 Mar 2;281(3):810-4. doi: 10.1006/bbrc.2001.4422.
671 The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Mol Pharmacol. 2005 Aug;68(2):551-8. doi: 10.1124/mol.105.012104. Epub 2005 May 23.
672 Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression. J Biol Chem. 2015 Feb 27;290(9):5673-84. doi: 10.1074/jbc.M114.602540. Epub 2014 Dec 30.
673 Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos. 2006 Oct;34(10):1756-63. doi: 10.1124/dmd.106.010033. Epub 2006 Jul 12.
674 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
675 Regulation of hepatic drug transporter activity and expression by organochlorine pesticides. J Biochem Mol Toxicol. 2014 Mar;28(3):119-28.
676 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
677 Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
678 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
679 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
680 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
681 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
682 Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology. 2003 Jun;144(6):2425-36. doi: 10.1210/en.2002-221054.
683 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
684 Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat. 2006 Mar;96(2):131-46. doi: 10.1007/s10549-005-9070-2. Epub 2005 Oct 27.
685 Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
686 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
687 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
688 Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol. 2001 Sep;60(3):595-602.
689 Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth. Br J Cancer. 2007 Apr 23;96(8):1204-15. doi: 10.1038/sj.bjc.6603705. Epub 2007 Mar 27.
690 Serum distribution of the major metabolites of norgestimate in relation to its pharmacological properties. Contraception. 2003 Feb;67(2):93-9. doi: 10.1016/s0010-7824(02)00473-0.
691 Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest. 2007 Dec;117(12):3979-87. doi: 10.1172/JCI32249.
692 Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology. 2001 Jan 9;56(1):31-6. doi: 10.1212/wnl.56.1.31.
693 Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and -fetoprotein. Toxicol Sci. 2015 Feb;143(2):333-48. doi: 10.1093/toxsci/kfu231. Epub 2014 Oct 27.
694 Testosterone or 17{beta}-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. J Endocrinol. 2011 Aug;210(2):219-29. doi: 10.1530/JOE-10-0497. Epub 2011 Jun 1.
695 Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
696 Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70. doi: 10.1016/s0960-0760(01)00173-x.
697 Conception and pharmacodynamic profile of drospirenone. Steroids. 2003 Nov;68(10-13):891-905. doi: 10.1016/j.steroids.2003.08.008.
698 Biological activity of all-trans-retinoic acid with and without tamoxifen and alpha-interferon 2a in breast cancer patients. Int J Oncol. 2000 Nov;17(5):991-1000. doi: 10.3892/ijo.17.5.991.
699 Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells. Oncogene. 2005 Jun 23;24(27):4388-400. doi: 10.1038/sj.onc.1208623.
700 Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects. Steroids. 2005 Nov;70(12):840-5. doi: 10.1016/j.steroids.2005.04.010.
701 Expression of estrogen-, progesterone-, and androgen-responsive genes in MCF-7 and MDA-MB-231 cells treated with o,p'-DDT, p,p'-DDT, or endosulfan. J Biochem Mol Toxicol. 2021 Jun;35(6):1-8. doi: 10.1002/jbt.22773. Epub 2021 Mar 16.
702 A comparative study of the effect of raloxifene and gosereline on uterine leiomyoma volume changes and estrogen receptor, progesterone receptor, bcl-2 and p53 expression immunohistochemically in premenopausal women. Eur J Obstet Gynecol Reprod Biol. 2007 Nov;135(1):94-103. doi: 10.1016/j.ejogrb.2006.07.042. Epub 2006 Sep 14.
703 Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range. Toxicol In Vitro. 2006 Apr;20(3):382-94. doi: 10.1016/j.tiv.2005.08.016. Epub 2005 Oct 19.
704 TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer. Toxicol Appl Pharmacol. 2016 Sep 15;307:91-101. doi: 10.1016/j.taap.2016.07.018. Epub 2016 Jul 27.
705 Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies. Nucleic Acids Res. 2015 Jul 13;43(12):5880-97. doi: 10.1093/nar/gkv262. Epub 2015 Apr 23.
706 Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells. Prostate. 2005 Nov 1;65(3):268-75. doi: 10.1002/pros.20282.
707 Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform. Toxicology. 2017 Jun 15;385:48-58. doi: 10.1016/j.tox.2017.05.001. Epub 2017 May 4.
708 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
709 Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res. 2004 Jan 1;64(1):19-22. doi: 10.1158/0008-5472.can-03-2789.
710 Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals. Toxicology. 2004 Feb 15;195(2-3):177-86. doi: 10.1016/j.tox.2003.09.012.
711 Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
712 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
713 Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):325-34.
714 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
715 Estrogen receptor-related receptor alpha mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells. Mol Endocrinol. 2010 Jun;24(6):1175-86.
716 [Regulation of orphan receptor ERR alpha by estrogen and progesterone in endometrial carcinoma cell line]. Beijing Da Xue Xue Bao Yi Xue Ban. 2005 Jun 18;37(3):281-3.
717 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
718 Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
719 All-trans retinoic acid induced hypercalcemia in a patient with acute promyelocytic leukemia: its relation to increased PTH-rP. Int J Hematol. 1994 Feb;59(2):143-4.
720 Parathyroid hormone-related protein varies with sex and androgen status in nonsmall cell lung cancer. Cancer. 2007 Sep 15;110(6):1313-20. doi: 10.1002/cncr.22922.
721 Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
722 Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
723 Induced differentiation in HT29, a human colon adenocarcinoma cell line. J Cell Sci. 1999 Aug;112 ( Pt 16):2657-66. doi: 10.1242/jcs.112.16.2657.
724 Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
725 Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
726 Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis. Toxicol Sci. 2017 Sep 1;159(1):159-169. doi: 10.1093/toxsci/kfx121.
727 Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
728 Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicol Sci. 2018 Aug 1;164(2):477-488.
729 Regulation of CD36 expression in human melanoma cells. Adv Exp Med Biol. 2002;507:337-42. doi: 10.1007/978-1-4615-0193-0_52.
730 Comparative study of the effects of ziram and disulfiram on human monocyte-derived macrophage functions and polarization: involvement of zinc. Cell Biol Toxicol. 2021 Jun;37(3):379-400. doi: 10.1007/s10565-020-09540-6. Epub 2020 Jul 25.
731 Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
732 Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers. Toxicol Appl Pharmacol. 2018 Jan 1;338:182-190. doi: 10.1016/j.taap.2017.11.020. Epub 2017 Nov 24.
733 Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment. Am J Hypertens. 2006 Feb;19(2):129-35. doi: 10.1016/j.amjhyper.2005.08.020.
734 Role of connexin 43 in cadmium-induced proliferation of human prostate epithelial cells. J Appl Toxicol. 2017 Aug;37(8):933-942. doi: 10.1002/jat.3441. Epub 2017 Feb 8.
735 Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
736 Effect of arsenic trioxide on vascular endothelial cell proliferation and expression of vascular endothelial growth factor receptors Flt-1 and KDR in gastric cancer in nude mice. World J Gastroenterol. 2007 Dec 28;13(48):6498-505. doi: 10.3748/wjg.v13.i48.6498.
737 9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts. Reprod Toxicol. 2019 Aug;87:21-31. doi: 10.1016/j.reprotox.2019.04.008. Epub 2019 May 1.
738 The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
739 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
740 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
741 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
742 Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
743 Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
744 Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
745 Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells. Exp Cell Res. 2004 Jul 1;297(1):68-81. doi: 10.1016/j.yexcr.2004.02.017.
746 [P27(Kip1), cyclin E and endogenous TGF-beta1 changes in apoptosis of NB4 cells induced by As(2)O(3) and/or TGF-beta1 and their significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Feb;17(1):74-9.
747 [As2O3 induces demethylation and up-regulates transcription of SHP-1 gene in human lymphoma cell line T2 cells]. Zhonghua Zhong Liu Za Zhi. 2009 Jun;31(6):423-7.
748 Neoplastic-like transformation effect of single-walled and multi-walled carbon nanotubes compared to asbestos on human lung small airway epithelial cells. Nanotoxicology. 2014 Aug;8(5):485-507.
749 Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leuk Res. 2008 Feb;32(2):275-85. doi: 10.1016/j.leukres.2007.05.024. Epub 2007 Jul 19.
750 Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
751 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
752 Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
753 Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
754 Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
755 Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
756 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8880-4. doi: 10.1073/pnas.151244398. Epub 2001 Jul 10.
757 Trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. J Nat Prod. 2013 Jul 26;76(7):1242-7.
758 Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. Invest Ophthalmol Vis Sci. 2011 Feb 22;52(2):1055-63. doi: 10.1167/iovs.10-5777.
759 The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts. Toxicol Appl Pharmacol. 2012 May 15;261(1):42-9. doi: 10.1016/j.taap.2012.03.009.
760 Deficiency of the human mitochondrial transcription factor h-mtTFA in infantile mitochondrial myopathy is associated with mtDNA depletion. Hum Mol Genet. 1994 Oct;3(10):1763-9. doi: 10.1093/hmg/3.10.1763.
761 PPARgama activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol. 2014 Mar;253:16-27.
762 ATPR induces acute promyelocytic leukemia cells differentiation and growth arrest by blockade of SHP2/Rho/ROCK1 pathway. Toxicol Appl Pharmacol. 2020 Jul 15;399:115053. doi: 10.1016/j.taap.2020.115053. Epub 2020 May 15.
763 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
764 Regulation of the vascular endothelial growth factor and growth by estrogen and antiestrogens through Efp in Ishikawa endometrial carcinoma cells. Oncol Rep. 2009 Feb;21(2):395-401.
765 AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
766 Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
767 Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers. Am J Pathol. 2011 May;178(5):2066-76.
768 Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription. Mol Cell Endocrinol. 2010 Jul 29;323(2):268-76. doi: 10.1016/j.mce.2010.03.013. Epub 2010 Mar 17.
769 SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
770 Olfactomedin-4 regulation by estrogen in the human endometrium requires epidermal growth factor signaling. Am J Pathol. 2010 Nov;177(5):2495-508. doi: 10.2353/ajpath.2010.100026.
771 Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
772 Combined tamoxifen and gefitinib in non-small cell lung cancer shows antiproliferative effects. Biomed Pharmacother. 2010 Feb;64(2):88-92. doi: 10.1016/j.biopha.2009.06.010. Epub 2009 Oct 23.
773 Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor-positive breast cancer therapy: An in vitro study. Environ Toxicol. 2020 Nov;35(11):1179-1193. doi: 10.1002/tox.22983. Epub 2020 Jun 12.
774 Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology. 2001 Sep 14;166(1-2):79-89. doi: 10.1016/s0300-483x(01)00437-1.
775 Estrogenic effects of natural and synthetic compounds including tibolone assessed in Saccharomyces cerevisiae expressing the human estrogen alpha and beta receptors. FASEB J. 2006 Jul;20(9):1552-4. doi: 10.1096/fj.05-5413fje. Epub 2006 May 23.
776 Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications. Toxicol Lett. 2010 Feb 15;192(3):298-315. doi: 10.1016/j.toxlet.2009.11.004. Epub 2009 Nov 12.
777 Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect. 2004 Apr;112(5):524-31. doi: 10.1289/ehp.6649.
778 Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner. Reprod Toxicol. 2013 Dec;42:49-57. doi: 10.1016/j.reprotox.2013.07.019. Epub 2013 Jul 26.
779 Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci Biotechnol Biochem. 2002 Jul;66(7):1479-87. doi: 10.1271/bbb.66.1479.
780 Arylpiperazines for management of benign prostatic hyperplasia: design, synthesis, quantitative structure-activity relationships, and pharmacokinetic studies. J Med Chem. 2011 Jan 13;54(1):302-11. doi: 10.1021/jm101163m. Epub 2010 Dec 3.
781 Methylparaben stimulates tumor initiating cells in ER+ breast cancer models. J Appl Toxicol. 2017 Apr;37(4):417-425. doi: 10.1002/jat.3374. Epub 2016 Sep 1.
782 Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
783 Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
784 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
785 Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone. J Toxicol Sci. 2021;46(11):515-523. doi: 10.2131/jts.46.515.
786 Ivermectin as an inhibitor of cancer stem?like cells. Mol Med Rep. 2018 Feb;17(2):3397-3403. doi: 10.3892/mmr.2017.8231. Epub 2017 Dec 8.
787 Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells. BMC Complement Altern Med. 2016 Aug 11;16(1):281. doi: 10.1186/s12906-016-1267-x.
788 Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide. J Biol Chem. 2002 Nov 22;277(47):44988-95. doi: 10.1074/jbc.M207176200. Epub 2002 Sep 17.
789 Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
790 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
791 Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. Drug Metab Dispos. 2001 Mar;29(3):274-81.
792 Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
793 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
794 Methotrexate induction of human sulfotransferases in Hep G2 and Caco-2 cells. J Appl Toxicol. 2005 Sep-Oct;25(5):354-60.
795 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
796 Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
797 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
798 Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310. doi: 10.1038/srep07310.
799 AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028.
800 Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts. J Biol Chem. 2015 Apr 3;290(14):8834-48.
801 Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors. Cancer Biol Ther. 2005 Mar;4(3):277-81. doi: 10.4161/cbt.4.3.1497. Epub 2005 Mar 20.
802 Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
803 Elucidating progesterone effects in breast cancer: cross talk with PDGF signaling pathway in smooth muscle cell. J Cell Biochem. 2007 Jan 1;100(1):174-83. doi: 10.1002/jcb.21045.
804 Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
805 Quercetin blocks airway epithelial cell chemokine expression. Am J Respir Cell Mol Biol. 2006 Nov;35(5):602-10. doi: 10.1165/rcmb.2006-0149OC. Epub 2006 Jun 22.
806 Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells. Environ Toxicol. 2021 Sep;36(9):1785-1792. doi: 10.1002/tox.23299. Epub 2021 May 27.
807 A sensitized RNA interference screen identifies a novel role for the PI3K p110 isoform in medulloblastoma cell proliferation and chemoresistance. Mol Cancer Res. 2011 Jul;9(7):925-35. doi: 10.1158/1541-7786.MCR-10-0200. Epub 2011 Jun 7.
808 Promyelocytic leukemia retinoid signaling targets regulate apoptosis,tissue factor and thrombomodulin expression. Haematologica. 2004 Mar;89(3):286-95.
809 Resveratrol is a class IA phosphoinositide 3-kinase inhibitor. Biochem J. 2007 Sep 15;406(3):511-8. doi: 10.1042/BJ20070236.
810 The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem. 2008 Sep 25;51(18):5522-32. doi: 10.1021/jm800295d.
811 GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther. 2011 Dec;10(12):2426-36.
812 Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009 May;21(5):1317-22. doi: 10.3892/or_00000357.
813 Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol. 2003 Mar;148(3):544-52. doi: 10.1046/j.1365-2133.2003.05174.x.
814 Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation. Biochem Pharmacol. 2009 Feb 1;77(3):384-96. doi: 10.1016/j.bcp.2008.10.035. Epub 2008 Nov 6.
815 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
816 Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal. 2003 Sep;15(9):851-9. doi: 10.1016/s0898-6568(03)00036-6.
817 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
818 Madecassoside ameliorates cisplatin-induced nephrotoxicity by inhibiting activation of the mitogen activated protein kinase pathway. Environ Toxicol. 2023 Jul;38(7):1473-1483. doi: 10.1002/tox.23777. Epub 2023 Apr 23.
819 Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem Biol Interact. 2012 Jan 25;195(2):154-64.
820 Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIM(EL) to attenuate apoptosis in BEAS-2B cells. Chem Biol Interact. 2023 Jan 5;369:110304. doi: 10.1016/j.cbi.2022.110304. Epub 2022 Dec 10.
821 Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. Mol Pharmacol. 2004 Feb;65(2):470-8.
822 Hesperidin delays cell cycle progression into the G0/G1 phase via suspension of MAPK signaling pathway in intrahepatic cholangiocarcinoma. J Biochem Mol Toxicol. 2022 Apr;36(4):e22981. doi: 10.1002/jbt.22981. Epub 2022 Jan 4.
823 Cytotoxicity of simvastatin to pancreatic adenocarcinoma cells containing mutant ras gene. Jpn J Cancer Res. 1994 Jun;85(6):633-8. doi: 10.1111/j.1349-7006.1994.tb02406.x.
824 Regulation of the signal transduction program by drugs. Adv Enzyme Regul. 1997;37:35-55. doi: 10.1016/s0065-2571(96)00025-8.
825 Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS. Toxicol Lett. 2016 Sep 30;259:133-142. doi: 10.1016/j.toxlet.2016.08.006. Epub 2016 Aug 8.
826 Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol. 2005 Sep;130(6):912-25. doi: 10.1111/j.1365-2141.2005.05696.x.
827 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
828 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
829 Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathway. Cancer Lett. 2010 Jun 28;292(2):228-36. doi: 10.1016/j.canlet.2009.12.005. Epub 2010 Jan 18.
830 Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
831 Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N-methyltransferase level in endothelial cells. J Appl Toxicol. 2021 Jul;41(7):1076-1088. doi: 10.1002/jat.4094. Epub 2020 Oct 19.
832 Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
833 Activation of autophagy rescues amiodarone-induced apoptosis of lung epithelial cells and pulmonary toxicity in rats. Toxicol Sci. 2013 Nov;136(1):193-204. doi: 10.1093/toxsci/kft168. Epub 2013 Aug 2.
834 A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer. Nat Genet. 2015 Sep;47(9):1079-84. doi: 10.1038/ng.3374. Epub 2015 Aug 3.
835 Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
836 Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. Chin Med J (Engl). 2007 Sep 20;120(18):1626-31.
837 Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
838 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
839 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
840 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
841 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
842 Oxidative modifications of proteins by sodium arsenite in human umbilical vein endothelial cells. Environ Toxicol. 2011 Oct;26(5):459-71. doi: 10.1002/tox.20572. Epub 2010 Mar 1.
843 Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
844 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
845 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
846 A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):291-4.
847 Glucocorticoid programming mechanism for hypercholesterolemia in prenatal ethanol-exposed adult offspring rats. Toxicol Appl Pharmacol. 2019 Jul 15;375:46-56.
848 Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis. 2008 Feb;13(2):259-71. doi: 10.1007/s10495-007-0165-6.
849 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
850 Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction. Neuropharmacology. 2009 Jul;57(1):41-8. doi: 10.1016/j.neuropharm.2009.04.005. Epub 2009 Apr 22.
851 Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4540-50. doi: 10.1111/j.1582-4934.2008.00575.x.
852 Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: possible involvement of p38 MAP kinase. J Biochem Mol Biol. 2002 Jul 31;35(4):377-83. doi: 10.5483/bmbrep.2002.35.4.377.
853 Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. Biochim Biophys Acta. 2014 Feb;1843(2):253-64. doi: 10.1016/j.bbamcr.2013.10.017. Epub 2013 Nov 1.
854 In Vitro Exposure of Human Luteinized Mural Granulosa Cells to Dibutyl Phthalate Affects Global Gene Expression. Toxicol Sci. 2017 Nov 1;160(1):180-188. doi: 10.1093/toxsci/kfx170.
855 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
856 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
857 A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
858 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
859 Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
860 Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
861 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
862 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
863 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
864 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
865 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
866 Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46.
867 Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica. 2004 May;34(5):429-38.
868 The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. Life Sci. 2006 Nov 25;79(26):2432-40.
869 Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
870 Targeting of EGFR increase?anti-cancer effects of arsenic trioxide: Promising treatment for glioblastoma multiform. Eur J Pharmacol. 2018 Feb 5;820:274-285. doi: 10.1016/j.ejphar.2017.12.041. Epub 2017 Dec 20.
871 Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
872 An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem. 2008 Feb 1;283(5):2564-74. doi: 10.1074/jbc.M702454200. Epub 2007 Oct 31.
873 eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
874 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
875 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
876 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
877 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
878 Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
879 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
880 Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.
881 E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients. Chin Med J (Engl). 2009 Oct 20;122(20):2461-5.
882 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
883 In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
884 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
885 Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
886 Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60.
887 Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
888 Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells. Environ Pollut. 2019 Dec;255(Pt 2):113318. doi: 10.1016/j.envpol.2019.113318. Epub 2019 Oct 2.
889 Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner in human gastric adenocarcinoma cells. Cancer Lett. 2000 Oct 1;158(2):125-32. doi: 10.1016/s0304-3835(00)00489-4.
890 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
891 Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation. J Biol Chem. 2007 Jul 20;282(29):21268-77. doi: 10.1074/jbc.M701613200. Epub 2007 May 24.
892 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
893 Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
894 Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
895 Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chem Res Toxicol. 2014 Feb 17;27(2):304-308.
896 Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28.
897 Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16.
898 Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol. 2005 Jun;67(6):1954-65.
899 Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
900 Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Arch Biochem Biophys. 2005 Feb 1;434(1):75-85.
901 Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36.
902 Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. J Lipid Res. 1997 Nov;38(11):2216-23.
903 [Effect of arsenic trioxide and 5-aza-2'-deoxycytidine on SHP-1, JAK3, TYK2 gene expression in K562 cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Apr;22(2):323-8. doi: 10.7534/j.issn.1009-2137.2014.02.011.
904 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells. Toxicol Appl Pharmacol. 2022 Sep 1;450:116156. doi: 10.1016/j.taap.2022.116156. Epub 2022 Jul 6.
905 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
906 Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs. Nucleic Acids Res. 2014 Jan;42(2):1196-208. doi: 10.1093/nar/gkt903. Epub 2013 Oct 7.
907 Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways. Chem Biol Interact. 2023 Feb 1;371:110342. doi: 10.1016/j.cbi.2023.110342. Epub 2023 Jan 10.
908 A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
909 Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
910 Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1. Br J Pharmacol. 2010 Jul;160(5):1195-211. doi: 10.1111/j.1476-5381.2010.00762.x.
911 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
912 BAP1 loss defines a new class of renal cell carcinoma. Nat Genet. 2012 Jun 10;44(7):751-9. doi: 10.1038/ng.2323.
913 Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets. Int J Cancer. 2003 Mar 20;104(2):204-12.
914 Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
915 Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice. Cell Rep. 2018 Apr 17;23(3):866-877. doi: 10.1016/j.celrep.2018.03.087.
916 Protein kinase Cdelta-dependent induction of manganese superoxide dismutase gene expression by microtubule-active anticancer drugs. J Biol Chem. 1998 Dec 18;273(51):34639-45. doi: 10.1074/jbc.273.51.34639.
917 Aspirin induces apoptosis through release of cytochrome c from mitochondria. Neoplasia. 2000 Nov-Dec;2(6):505-13. doi: 10.1038/sj.neo.7900120.
918 Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres. Int J Mol Sci. 2020 Aug 3;21(15):5564. doi: 10.3390/ijms21155564.
919 Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. Carcinogenesis. 2011 May;32(5):723-31. doi: 10.1093/carcin/bgr038. Epub 2011 Feb 28.
920 A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 2004 Dec 1;384(Pt 2):391-400. doi: 10.1042/BJ20041498.
921 Phosphorylation and stabilization of topoisomerase II protein by p38 mitogen-activated protein kinase sensitize breast cancer cells to its poisons. J Biol Chem. 2011 Oct 14;286(41):35883-35890. doi: 10.1074/jbc.M111.229260. Epub 2011 Aug 30.
922 Real-time monitoring of cisplatin-induced cell death. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.
923 Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry. 2008 Mar;65(3):345-55. doi: 10.1001/archpsyc.65.3.345.
924 trans-Resveratrol inhibits H2O2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis. Biochem Pharmacol. 2009 Feb 1;77(3):337-47. doi: 10.1016/j.bcp.2008.10.034. Epub 2008 Nov 6.
925 Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide. Int J Cancer. 2001 May 15;92(4):518-26. doi: 10.1002/ijc.1220.
926 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
927 Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. Biochem Biophys Res Commun. 2011 Feb 4;405(1):31-6. doi: 10.1016/j.bbrc.2010.12.111. Epub 2010 Dec 30.
928 Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
929 Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res. 2007 May 1;13(9):2795-803. doi: 10.1158/1078-0432.CCR-06-2077.
930 Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. Biochem Biophys Res Commun. 2008 Jul 25;372(2):356-61. doi: 10.1016/j.bbrc.2008.05.043. Epub 2008 May 19.
931 Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
932 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
933 Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions. Toxicol Sci. 2014 Oct;141(2):344-52. doi: 10.1093/toxsci/kfu133. Epub 2014 Jul 24.
934 Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone. Psychopharmacology (Berl). 1999 Dec;147(3):300-5. doi: 10.1007/s002130051171.
935 Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. J Toxicol Sci. 2016 Feb;41(1):143-6.
936 Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos. 2011 Nov;39(11):2049-56. doi: 10.1124/dmd.111.041384. Epub 2011 Aug 5.
937 Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biol Pharm Bull. 2005 Feb;28(2):328-34.
938 Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl. Eur J Clin Pharmacol. 2007 Feb;63(2):159-63.
939 Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. Clin Pharmacol Ther. 2001 Oct;70(4):327-35.
940 Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. Drug Metab Dispos. 2003 Jun;31(6):768-72.
941 Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression. Environ Toxicol. 2018 Dec;33(12):1237-1244. doi: 10.1002/tox.22630. Epub 2018 Sep 6.
942 [Indomethacin-induced HL-60 leukemic cell apoptosis and the activation of C-jun NH2- terminal kinase signal transduction pathway]. Hunan Yi Ke Da Xue Xue Bao. 2003 Dec;28(6):557-62.
943 Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells. J Signal Transduct. 2012;2012:204236. doi: 10.1155/2012/204236. Epub 2012 Oct 9.