Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSC4A7)

Drug Name
Indomethacin Drug Info
Synonyms
Aconip; Amuno; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Catlep; Confortid; Dolcidium; Dolovin; Durametacin; Elmetacin; Hicin; IMN; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indocid; Indocin; Indomecol; Indomed; Indomee; Indometacin; Indometacina; Indometacine; Indometacinum; Indometacyna; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethegan; Indomethine; Indometicina; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Mezolin; Miametan; Mikametan; Mobilan; Novomethacin; Reumacide; Sadoreum; Tannex; Vonum; Bonidon Gel; DESMETHYL INDOMETHACIN; Dolcidium PL;Flexin continus; Indocid Pda; Indocid Sr; Indocin Sr; Indolar SR; Indometacyna [Polish]; Indometicina [Spanish]; Inteban sp; Rhemacin LA; Rheumacin LA; I 7378; IN1454; Indomet 140; Aconip (TN); Apo-Indomethacin; Chibro-amuno; Chrono-indicid; Chrono-indocid; Indo-Lemmon; Indo-Spray; Indo-phlogont; Indo-rectolmin; Indo-tablinen; Indocid (TN); Indocid (pharmaceutical); Indocin (TN); Indocin I.V; Indometacina [INN-Spanish]; Indometacine [INN-French]; Indometacinum [INN-Latin]; Indomethacin (USP); Indomethacin [USAN:BAN]; Novo-Methacin; Indochron E-R (TN); Indocin I.V.; Indocin-SR (TN); Indometacin (JP15/INN); Indomethacin & MAP-30; Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
Indication
Disease Entry ICD 11 Status REF
Bursitis Approved [1]
Gout FA25 Approved [1]
Osteoarthritis FA00-FA05 Approved [1]
Patent ductus arteriosus Approved [1]
Rheumatic disorder Approved [1]
Rheumatoid arthritis FA20 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 1/2 [3]
Synovitis Investigative [1]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
3715
ChEBI ID
CHEBI:49662
CAS Number
CAS 53-86-1
TTD Drug ID
DMSC4A7
VARIDT Drug ID
DR00267
INTEDE Drug ID
DR0875
ACDINA Drug ID
D00329

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [16]
Naproxen DMZ5RGV Bursitis Approved [17]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [18]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [19]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [20]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [21]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [22]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [23]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [4]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [24]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [25]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Folic Acid DMEMBJC Colorectal carcinoma Approved [28]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [38]
Metronidazole DMTIVEN Abscess Approved [39]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [40]
Ethanol DMDRQZU Chronic pain MG30 Approved [41]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [47]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [48]
Estrone DM5T6US Acne vulgaris ED80 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [51]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [52]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [56]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [57]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [58]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [59]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [61]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [62]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [66]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [67]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [6]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [69]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [6]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [6]
Haloperidol DM96SE0 Delirium Approved [6]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [71]
Fructose DM43AN2 Vomiting MD90 Approved [15]
Ketoprofen DMRKXPT Bursitis Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [73]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [74]
Gefitinib DM15F0X Colon adenocarcinoma Approved [75]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [78]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [80]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [83]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
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Drug(s) Affected By Integrin alpha-M (ITGAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [91]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [92]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [93]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [95]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [96]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [97]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [100]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [101]
Gefitinib DM15F0X Colon adenocarcinoma Approved [102]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [104]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [105]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [106]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
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Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [108]
Folic Acid DMEMBJC Colorectal carcinoma Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [111]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [112]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [113]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [114]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [115]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [116]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [116]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [121]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [123]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [124]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [125]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [133]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [134]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [135]
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Drug(s) Affected By Plasma kallikrein (KLKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Testosterone DM7HUNW Hot flushes GA30 Approved [139]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [137]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [142]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [140]
Chondroitin sulfate DM0N19Y N. A. N. A. Phase 4 [143]
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Drug(s) Affected By B2 bradykinin receptor (BDKRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [142]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [147]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [148]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [149]
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Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [156]
Ethanol DMDRQZU Chronic pain MG30 Approved [157]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [158]
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Drug(s) Affected By Carbonic anhydrase 1 (CA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [124]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [159]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [160]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [161]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [162]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [159]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [164]
GUAIACOL DMN4E7T N. A. N. A. Phase 3 [161]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [166]
Epinephrine DM3KJBC Acute asthma CA23 Approved [167]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [170]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [171]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [172]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
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Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [174]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [175]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [175]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [176]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [177]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [176]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [178]
Trospium chloride DM32XZT Discovery agent N.A. Approved [179]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [180]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
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Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [180]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [174]
Trospium chloride DM32XZT Discovery agent N.A. Approved [179]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [182]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [177]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [178]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [184]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [178]
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Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [185]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [178]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [186]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [178]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [178]
Succinic acid DMDWICP Malnutrition 5B50-5B71 Approved [187]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [178]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [188]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [178]
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Drug(s) Affected By Organic anion transporter 7 (SLC22A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [178]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [189]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [190]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [178]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [137]
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Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [178]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [178]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [178]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [191]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [178]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [192]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [178]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [193]
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Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [178]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [189]
Paclitaxel DMLB81S Breast carcinoma Approved [194]
Allopurinol DMLPAOB Gout FA25 Approved [194]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [194]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [194]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [194]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [194]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [176]
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Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [195]
Diazepam DM08E9O Alcohol withdrawal Approved [196]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Benzbromarone DMC3YUA Gout FA25 Approved [197]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [197]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [196]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [196]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [198]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [200]
Diazepam DM08E9O Alcohol withdrawal Approved [196]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [202]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [203]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [200]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [204]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [206]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [200]
Diazepam DM08E9O Alcohol withdrawal Approved [196]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [207]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [200]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [200]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [209]
Ethacrynic acid DM60QMR Edema MG29 Approved [207]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [210]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [211]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [212]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [212]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [214]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [215]
Quercetin DM3NC4M Obesity 5B81 Approved [216]
Fluoxetine DM3PD2C Bipolar depression Approved [212]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [217]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [218]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [220]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [123]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [222]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [221]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Selenium DM25CGV N. A. N. A. Approved [104]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [225]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [227]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [227]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Importin-5 (IPO5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [230]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E2F3 (E2F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [233]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [131]
Menthol DMG2KW7 Back pain ME84.Z Approved [236]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By AT-rich interactive domain-containing protein 1A (ARID1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [238]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [240]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [241]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [242]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [243]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [244]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [245]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [246]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 1 (CHD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [249]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mothers against decapentaplegic homolog 7 (SMAD7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [253]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Praja-2 (PJA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [256]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [258]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
Milchsaure DM462BT Pruritus EC90 Investigative [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 4 (KLF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [261]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [262]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [260]
Testosterone DM7HUNW Hot flushes GA30 Approved [263]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid-transporting ATPase IC (ATP8B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [265]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [269]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NUAK family SNF1-like kinase 1 (NUAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [270]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cAMP-responsive element-binding protein-like 2 (CREBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [271]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [94]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Thiamine transporter 1 (SLC19A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [189]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [273]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily A member 2 (DNAJA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [275]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [148]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [275]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [276]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [277]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [278]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [266]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Frizzled-7 (FZD7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Selenium DM25CGV N. A. N. A. Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [279]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [275]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-associated protein kinase 2 (ROCK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [281]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [218]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [275]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Suppressor of cytokine signaling 5 (SOCS5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Bortezomib DMNO38U Leukemia Approved [282]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [273]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
AMEP DMFELMQ Melanoma 2C30 Phase 1 [283]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [286]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [269]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutaminase kidney isoform, mitochondrial (GLS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [288]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [290]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Bortezomib DMNO38U Leukemia Approved [282]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [288]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [291]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [288]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [292]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-nerve growth factor (NGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [294]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [295]
MCI-186 DM8ZHP1 Amyotrophic lateral sclerosis 8B60.0 Approved [296]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [297]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [298]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [299]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transferrin receptor protein 1 (TFRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [301]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [302]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [303]
Quercetin DM3NC4M Obesity 5B81 Approved [304]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [305]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [306]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [308]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Quercetin DM3NC4M Obesity 5B81 Approved [311]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [312]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [313]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [314]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [315]
Acetylcholine DMDF79Z Cataract 9B10 Approved [316]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [318]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [319]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [320]
Methotrexate DM2TEOL Anterior urethra cancer Approved [321]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [322]
Quercetin DM3NC4M Obesity 5B81 Approved [323]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [325]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [326]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [329]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [330]
Quercetin DM3NC4M Obesity 5B81 Approved [331]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [332]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [333]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [334]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [335]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [336]
Fructose DM43AN2 Vomiting MD90 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [337]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [338]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [301]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [339]
Methotrexate DM2TEOL Anterior urethra cancer Approved [340]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombomodulin (THBD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [341]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [344]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [345]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [346]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [290]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [347]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombospondin-1 (THBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [319]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Quercetin DM3NC4M Obesity 5B81 Approved [349]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [350]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [221]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [290]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [351]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [352]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [353]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [354]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [338]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [355]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [356]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [357]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [358]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding protein RO60 (RO60)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Selenium DM25CGV N. A. N. A. Approved [104]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [270]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-7 (IL7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [360]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [361]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Ethanol DMDRQZU Chronic pain MG30 Approved [361]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [362]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Isoproterenol DMK7MEY Atrioventricular block Approved [363]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor JunB (JUNB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [338]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [364]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [365]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By S-adenosylmethionine decarboxylase proenzyme (AMD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [366]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein SON (SON)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Selenium DM25CGV N. A. N. A. Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [238]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [270]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-11 (IL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [319]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [368]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ethanol DMDRQZU Chronic pain MG30 Approved [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By COUP transcription factor 2 (NR2F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [264]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [370]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [371]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [372]
Methotrexate DM2TEOL Anterior urethra cancer Approved [373]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [246]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [374]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Guanylate-binding protein 1 (GBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [375]
Selenium DM25CGV N. A. N. A. Approved [104]
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [350]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-18 (SOX18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [247]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [376]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
Arsenic DMTL2Y1 N. A. N. A. Approved [377]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [140]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [378]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Selenium DM25CGV N. A. N. A. Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [381]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [135]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [135]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C iota type (PRKCI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [382]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [275]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [275]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [271]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [383]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [102]
Prednisone DM2HG4X Acute asthma CA23 Approved [384]
Methotrexate DM2TEOL Anterior urethra cancer Approved [385]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [386]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [387]
Quercetin DM3NC4M Obesity 5B81 Approved [388]
Fluoxetine DM3PD2C Bipolar depression Approved [389]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [390]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [391]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [392]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [275]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [393]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein Tob1 (TOB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [394]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [218]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [282]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [395]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocarboxylate transporter 1 (SLC16A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [189]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [221]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [394]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [396]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By UV excision repair protein RAD23 homolog B (RAD23B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Menthol DMG2KW7 Back pain ME84.Z Approved [236]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [397]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [224]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [398]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP synthase subunit e, mitochondrial (ATP5ME)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Selenium DM25CGV N. A. N. A. Approved [104]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [265]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [399]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [400]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor-like protein 4C (ARL4C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [401]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [344]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [402]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Folic Acid DMEMBJC Colorectal carcinoma Approved [403]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Bortezomib DMNO38U Leukemia Approved [282]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein BTG1 (BTG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [404]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [405]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [290]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [406]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [347]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [221]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [407]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [392]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [408]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [409]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dystonin (DST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [238]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [411]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Folic Acid DMEMBJC Colorectal carcinoma Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 12 (PTPN12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [238]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/arginine-rich splicing factor 6 (SRSF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [413]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Ethanol DMDRQZU Chronic pain MG30 Approved [414]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [415]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [393]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [416]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [417]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [418]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [419]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [420]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PRP4 homolog (PRP4K)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [393]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [422]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G/T mismatch-specific thymine DNA glycosylase (TDG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [393]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [148]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [271]
Paclitaxel DMLB81S Breast carcinoma Approved [271]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein EFR3 homolog A (EFR3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [423]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [221]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [270]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By AT-rich interactive domain-containing protein 5B (ARID5B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [424]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Folic Acid DMEMBJC Colorectal carcinoma Approved [412]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Arsenic DMTL2Y1 N. A. N. A. Approved [425]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TSC22 domain family protein 1 (TSC22D1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [426]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-G2 (CCNG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [427]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Fluoxetine DM3PD2C Bipolar depression Approved [419]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Estrone DM5T6US Acne vulgaris ED80 Approved [427]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cleavage and polyadenylation specificity factor subunit 6 (CPSF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [275]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [393]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [428]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [430]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein D53 (TPD52L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [270]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centrosome and spindle pole-associated protein 1 (CSPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Selenium DM25CGV N. A. N. A. Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [223]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [431]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein LBH (LBH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [137]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [415]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NHS-like protein 1 (NHSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [149]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Putative uncharacterized protein C6orf52 (C6ORF52)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [423]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [94]
Drug(s) Affected By PX domain-containing protein 1 (PXDC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [370]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [255]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [223]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein AEBP2 (AEBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [432]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [433]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [238]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [434]
Hexadecanoic acid DMWUXDZ Discovery agent N.A. Investigative [435]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Folic Acid DMEMBJC Colorectal carcinoma Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FMR1-interacting protein NUFIP2 (NUFIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [238]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [437]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [438]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase RNF144B (RNF144B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [305]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [273]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuroepithelial cell-transforming gene 1 protein (NET1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphoterin-induced protein 2 (AMIGO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [350]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [439]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [350]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-arginine methyltransferase METTL23 (METTL23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [437]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [440]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
Milchsaure DM462BT Pruritus EC90 Investigative [259]
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Drug(s) Affected By Protein O-mannosyl-transferase TMTC1 (TMTC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [441]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coiled-coil domain-containing protein 50 (CCDC50)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [406]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Arsenic DMTL2Y1 N. A. N. A. Approved [442]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase HACE1 (HACE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [443]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Ankyrin repeat domain-containing protein 13C (ANKRD13C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [444]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [445]
Milchsaure DM462BT Pruritus EC90 Investigative [259]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [446]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Hemicentin-2 (HMCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Arsenic DMTL2Y1 N. A. N. A. Approved [447]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [378]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [149]
APR-246 DMNFADH Ovarian cancer 2C73 Phase 2 [448]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [449]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Acrosin-binding protein (ACRBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Arsenic DMTL2Y1 N. A. N. A. Approved [450]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [142]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
Piperazinyl methyl quinazolinone derivative 2 DM913KS N. A. N. A. Patented [451]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Mitochondria-eating protein (SPATA18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [288]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [223]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [288]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [376]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pantothenate kinase 1 (PANK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [270]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [137]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rap guanine nucleotide exchange factor 6 (RAPGEF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [238]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Arsenic DMTL2Y1 N. A. N. A. Approved [450]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [104]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuronal cell adhesion molecule (NRCAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [452]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor GATA-6 (GATA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [375]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [375]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [253]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [375]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [375]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein TMEPAI (PMEPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [344]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [270]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [454]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arrestin domain-containing protein 3 (ARRDC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [394]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BTB/POZ domain-containing protein KCTD12 (KCTD12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Ethanol DMDRQZU Chronic pain MG30 Approved [455]
Benzatropine DMF7EXL Parkinsonian disorder Approved [456]
Clozapine DMFC71L Schizophrenia 6A20 Approved [456]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RING finger protein 145 (RNF145)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [266]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [457]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [458]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 237 (TMEM237)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Ethanol DMDRQZU Chronic pain MG30 Approved [414]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [370]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [224]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trimethylguanosine synthase (TGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [437]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [238]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [229]
Forskolin DM6ITNG Solid tumour/cancer 2A00-2F9Z Investigative [459]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [460]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By RNA-binding protein 15 (RBM15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Quercetin DM3NC4M Obesity 5B81 Approved [238]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [461]
Arsenic DMTL2Y1 N. A. N. A. Approved [462]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [441]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plakophilin-4 (PKP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Nkx-3.1 (NKX3-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [463]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [444]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [465]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [466]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [467]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [468]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [401]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [218]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-7 (SOX7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [469]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [446]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [279]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [229]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [460]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [446]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death-inducer obliterator 1 (DIDO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [446]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [423]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [244]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [270]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [399]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein Q1 (FOXQ1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [140]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Activity-dependent neuroprotector homeobox protein (ADNP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [470]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [422]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [404]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [404]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [404]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [404]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [404]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [224]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [404]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retroelement silencing factor 1 (RESF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [423]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [423]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [422]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily C member 4 (DNAJC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Bortezomib DMNO38U Leukemia Approved [282]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [277]
Okadaic acid DM47CO1 Discovery agent N.A. Investigative [471]
L-serine DM6WPIS Pulmonary tuberculosis 1B10.Z Investigative [472]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Muscleblind-like protein 1 (MBNL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Bortezomib DMNO38U Leukemia Approved [282]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [113]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [473]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sperm protein associated with the nucleus on the X chromosome A (SPANXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [474]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [271]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [475]
Drug(s) Affected By Sal-like protein 1 (SALL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [370]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [165]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [441]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BMP-2-inducible protein kinase (BMP2K)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [476]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [393]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [350]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [270]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK2 (PLK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [477]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ]-phosphatase 1, mitochondrial (PDP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [402]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [400]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [478]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair protein REV1 (REV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [479]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [480]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
Guanine DMIWLJE N. A. N. A. Phase 3 [481]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [422]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [460]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Translocation protein SEC63 homolog (SEC63)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [456]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Benzatropine DMF7EXL Parkinsonian disorder Approved [456]
Clozapine DMFC71L Schizophrenia 6A20 Approved [456]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [224]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [482]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [452]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [402]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tomoregulin-2 (TMEFF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [483]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [423]
Folic Acid DMEMBJC Colorectal carcinoma Approved [484]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Arsenic DMTL2Y1 N. A. N. A. Approved [450]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [423]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [485]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [423]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By F-box/WD repeat-containing protein 2 (FBXW2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Arsenic DMTL2Y1 N. A. N. A. Approved [450]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [486]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [104]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
Nickel chloride DMI12Y8 Discovery agent N.A. Investigative [487]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Scrapie-responsive protein 1 (SCRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [223]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [443]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [394]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [189]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [419]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [488]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [488]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [394]
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [489]
Fluoxetine DM3PD2C Bipolar depression Approved [488]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamine synthetase (GLUL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [244]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [218]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Clozapine DMFC71L Schizophrenia 6A20 Approved [490]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystathionine gamma-lyase (CTH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [491]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [492]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [260]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystathionine beta-synthase (CBS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [493]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [494]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ethanol DMDRQZU Chronic pain MG30 Approved [414]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [137]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine--tRNA ligase, cytoplasmic (SARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Haloperidol DM96SE0 Delirium Approved [456]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [270]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Benzatropine DMF7EXL Parkinsonian disorder Approved [456]
Clozapine DMFC71L Schizophrenia 6A20 Approved [456]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stanniocalcin-1 (STC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [349]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [269]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ethanol DMDRQZU Chronic pain MG30 Approved [495]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoserine phosphatase (PSPH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [269]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [218]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [418]
Methotrexate DM2TEOL Anterior urethra cancer Approved [496]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [497]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [498]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [123]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Fluoxetine DM3PD2C Bipolar depression Approved [499]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [244]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [244]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [500]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [439]
Arsenic DMTL2Y1 N. A. N. A. Approved [450]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [501]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [502]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Spermatogenesis-associated serine-rich protein 1 (SPATS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
Drug(s) Affected By Tribbles homolog 3 (TRIB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [419]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [503]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [374]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [419]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [504]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [505]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [260]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [500]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [504]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Racecadotril DMFOTZ7 Diarrhea ME05.1 Approved [506]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein DEPP1 (DEPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [488]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [489]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [355]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [488]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [488]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Fluoxetine DM3PD2C Bipolar depression Approved [488]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [489]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [489]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell cycle progression protein 1 (CCPG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [507]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ampicillin DMHWE7P Acute epiglottitis Approved [168]
Bortezomib DMNO38U Leukemia Approved [507]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [508]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [356]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [356]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [356]
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [509]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Fluoxetine DM3PD2C Bipolar depression Approved [419]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenosine receptor A3 (ADORA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [510]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [344]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [511]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [476]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [512]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [513]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5'-nucleotidase (NT5E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Quercetin DM3NC4M Obesity 5B81 Approved [514]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [137]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [200]
Diazepam DM08E9O Alcohol withdrawal Approved [196]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [515]
Desogestrel DM27U4Y Contraception QA21 Approved [515]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [200]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [200]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [516]
Quercetin DM3NC4M Obesity 5B81 Approved [517]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [518]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [519]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [519]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [520]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [518]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [519]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [521]
Gefitinib DM15F0X Colon adenocarcinoma Approved [518]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [522]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [518]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [523]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [524]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [525]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [73]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [526]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [527]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [528]
Gefitinib DM15F0X Colon adenocarcinoma Approved [529]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [530]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [531]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [532]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [524]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [533]
Paclitaxel DMLB81S Breast carcinoma Approved [534]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [535]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [523]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [73]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [526]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leukocyte cell-derived chemotaxin 1 (CNMD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [536]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [537]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [253]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [149]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [223]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [223]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [446]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By ABC-type organic anion transporter ABCA8 (ABCA8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [190]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [137]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [140]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [423]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [149]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [538]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAS guanyl-releasing protein 1 (RASGRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [445]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [512]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [539]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 14 (CXCL14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [279]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [540]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [541]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [482]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [426]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [279]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [542]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [13]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [543]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Hox-D4 (HOXD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [512]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [423]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [149]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [423]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [238]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Hox-D3 (HOXD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [544]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [512]
Arsenic DMTL2Y1 N. A. N. A. Approved [447]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [423]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [423]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [545]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
Rutin DMEHRAJ Discovery agent N.A. Investigative [546]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [547]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [548]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [549]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [550]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [551]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [374]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [552]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [423]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Excitatory amino acid transporter 4 (SLC1A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [554]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [89]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
Milchsaure DM462BT Pruritus EC90 Investigative [259]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [446]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By LIM/homeobox protein Lhx1 (LHX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [13]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
PHENCYCLIDINE DMQBEYX Discovery agent N.A. Investigative [555]
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Drug(s) Affected By Ras association domain-containing protein 2 (RASSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [439]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [556]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired mesoderm homeobox protein 1 (PRRX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [305]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [557]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [13]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [558]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein delta homolog 1 (DLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [319]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [428]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [559]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [255]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Runt-related transcription factor 1 (RUNX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [270]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [270]
Cotinine DMCEZ1B Insecticide N.A. Approved [560]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myosin light chain kinase, smooth muscle (MYLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [407]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [561]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth/differentiation factor 6 (GDF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Arsenic DMTL2Y1 N. A. N. A. Approved [562]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [543]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [149]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
Nitrobenzanthrone DMN6L70 N. A. N. A. Investigative [563]
crotylaldehyde DMTWRQI Discovery agent N.A. Investigative [564]
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Drug(s) Affected By Epidermal growth factor-like protein 6 (EGFL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [552]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [476]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [223]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [565]
Methotrexate DM2TEOL Anterior urethra cancer Approved [566]
Paclitaxel DMLB81S Breast carcinoma Approved [566]
Topotecan DMP6G8T Central nervous system neoplasm Approved [566]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rhomboid-related protein 4 (RHBDD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [370]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Arsenic DMTL2Y1 N. A. N. A. Approved [450]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [163]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [433]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SOSS complex subunit B2 (NABP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosomal protein eL39-like 2 (RPL39L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [567]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [441]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [181]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [278]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Hox-D1 (HOXD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Ethanol DMDRQZU Chronic pain MG30 Approved [414]
Ampicillin DMHWE7P Acute epiglottitis Approved [168]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [370]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [273]
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Drug(s) Affected By Band 4.1-like protein 4B (EPB41L4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [344]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [444]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [223]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [440]
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Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [402]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ampicillin DMHWE7P Acute epiglottitis Approved [168]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [568]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [279]
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Drug(s) Affected By Homeobox protein NANOG (NANOG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [569]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [268]
Quercetin DM3NC4M Obesity 5B81 Approved [570]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [571]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [261]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [572]
Testosterone DM7HUNW Hot flushes GA30 Approved [573]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [574]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Armadillo repeat-containing X-linked protein 1 (ARMCX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [415]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [422]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [272]
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Drug(s) Affected By Dickkopf-related protein 2 (DKK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [446]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [165]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [142]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [575]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [378]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [440]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [229]
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Drug(s) Affected By Histone deacetylase 9 (HDAC9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [576]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [576]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [399]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [256]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [142]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 3 (NFE2L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [419]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [419]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [282]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [370]
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Drug(s) Affected By Calpain-6 (CAPN6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Menthol DMG2KW7 Back pain ME84.Z Approved [236]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [512]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [577]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [575]
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Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [508]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [578]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [579]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [580]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [581]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [582]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [582]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [305]
Fluoxetine DM3PD2C Bipolar depression Approved [582]
Fructose DM43AN2 Vomiting MD90 Approved [583]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [582]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [584]
Gefitinib DM15F0X Colon adenocarcinoma Approved [585]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [586]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [418]
Etretinate DM2CZFA Keratosis ED56 Approved [587]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [394]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [588]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [589]
Quercetin DM3NC4M Obesity 5B81 Approved [590]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [591]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [592]
Diazepam DM08E9O Alcohol withdrawal Approved [592]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Selenium DM25CGV N. A. N. A. Approved [104]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [592]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [592]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [592]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [592]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [592]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [592]
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Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [593]
Methotrexate DM2TEOL Anterior urethra cancer Approved [594]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [595]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [596]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [508]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [597]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Prednisone DM2HG4X Acute asthma CA23 Approved [598]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [599]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [600]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 2 (TLR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [303]
Quercetin DM3NC4M Obesity 5B81 Approved [601]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [350]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [507]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [602]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [603]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [303]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [604]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [605]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [606]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [607]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [608]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [14]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [609]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [270]
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Drug(s) Affected By ATP-binding cassette sub-family C member 6 (ABCC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzbromarone DMC3YUA Gout FA25 Approved [610]
Verapamil DMA7PEW Angina pectoris BA40 Approved [610]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [611]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [189]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [190]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [612]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 4 (CCN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [403]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [498]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [344]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [552]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Folic Acid DMEMBJC Colorectal carcinoma Approved [403]
Arsenic DMTL2Y1 N. A. N. A. Approved [613]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [614]
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Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [615]
Haloperidol DM96SE0 Delirium Approved [15]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [375]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [301]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [357]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [616]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [617]
Methotrexate DM2TEOL Anterior urethra cancer Approved [618]
Epinephrine DM3KJBC Acute asthma CA23 Approved [619]
Quercetin DM3NC4M Obesity 5B81 Approved [620]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [621]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [622]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [623]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [624]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [625]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [626]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [627]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [628]
Epinephrine DM3KJBC Acute asthma CA23 Approved [629]
Chlorthalidone DM4DMBT Edema MG29 Approved [630]
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Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [631]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [632]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [624]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [633]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [634]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [627]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [635]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [636]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [637]
Verapamil DMA7PEW Angina pectoris BA40 Approved [638]
Selenium DM25CGV N. A. N. A. Approved [547]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [638]
Quercetin DM3NC4M Obesity 5B81 Approved [639]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [292]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [640]
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Drug(s) Affected By Kininogen-1 (KNG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Mepyramine DMB4SFH Allergic rhinitis CA08.0 Approved [641]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [641]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [642]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Olanzapine DMPFN6Y Bipolar depression Approved [643]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [224]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [142]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [644]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [597]
Gefitinib DM15F0X Colon adenocarcinoma Approved [645]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [247]
Selenium DM25CGV N. A. N. A. Approved [646]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [105]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [83]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [647]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
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Drug(s) Affected By Low-density lipoprotein receptor (LDLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [648]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Desogestrel DM27U4Y Contraception QA21 Approved [648]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [649]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [650]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [244]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
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Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [651]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [652]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [653]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [654]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [655]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [635]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [656]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [657]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [658]
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Drug(s) Affected By Vasopressin-neurophysin 2-copeptin (AVP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [659]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [660]
Oxprenolol DM51OQW Anxiety Approved [661]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [662]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [663]
Luvox DMJKROX Anxiety disorder 6B00-6B0Z Approved [664]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [665]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [660]
Chlorpropamide DMPHZQE Non-insulin dependent diabetes 5A11 Approved [666]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [667]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Epinephrine DM3KJBC Acute asthma CA23 Approved [668]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [669]
Fructose DM43AN2 Vomiting MD90 Approved [670]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [671]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [672]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [673]
Propranolol DM79NTF Angina pectoris BA40 Approved [674]
Testosterone DM7HUNW Hot flushes GA30 Approved [675]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [355]
Gefitinib DM15F0X Colon adenocarcinoma Approved [676]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [356]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [357]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [356]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [677]
Selenium DM25CGV N. A. N. A. Approved [678]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [679]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [680]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein C-III (APOC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [681]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein B-100 (APOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [682]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [683]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [14]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [684]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [685]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [686]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [687]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [688]
Paclitaxel DMLB81S Breast carcinoma Approved [689]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [690]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [691]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [692]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [693]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [104]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [694]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [695]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [696]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [503]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [697]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [698]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [699]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [700]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [701]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [702]
Prednisone DM2HG4X Acute asthma CA23 Approved [703]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [704]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [705]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [706]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [350]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [707]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [354]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [708]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [355]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [677]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [709]
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C beta type (PRKCB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [710]
Quercetin DM3NC4M Obesity 5B81 Approved [711]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [401]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [712]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [710]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleophosmin (NPM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Etretinate DM2CZFA Keratosis ED56 Approved [713]
Methotrexate DM2TEOL Anterior urethra cancer Approved [714]
Quercetin DM3NC4M Obesity 5B81 Approved [304]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [715]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [716]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione peroxidase 1 (GPX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [717]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [718]
Selenium DM25CGV N. A. N. A. Approved [719]
Methotrexate DM2TEOL Anterior urethra cancer Approved [720]
Quercetin DM3NC4M Obesity 5B81 Approved [721]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [413]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [722]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [723]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein disulfide-isomerase (P4HB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [14]
Etretinate DM2CZFA Keratosis ED56 Approved [713]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [724]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [14]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [375]
Selenium DM25CGV N. A. N. A. Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [725]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [726]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [727]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [728]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [729]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [730]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [731]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [732]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [733]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [734]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [734]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [735]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [736]
Capsaicin DMGMF6V Back pain ME84.Z Approved [737]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [738]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A5 (ANXA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [491]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [739]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [740]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Benzatropine DMF7EXL Parkinsonian disorder Approved [456]
Clozapine DMFC71L Schizophrenia 6A20 Approved [456]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [300]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [354]
Verapamil DMA7PEW Angina pectoris BA40 Approved [741]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [355]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [371]
Selenium DM25CGV N. A. N. A. Approved [742]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [743]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [744]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Gefitinib DM15F0X Colon adenocarcinoma Approved [745]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [746]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [418]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [747]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [748]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [747]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [749]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [750]
Methotrexate DM2TEOL Anterior urethra cancer Approved [751]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [752]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Gefitinib DM15F0X Colon adenocarcinoma Approved [676]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Selenium DM25CGV N. A. N. A. Approved [104]
Etretinate DM2CZFA Keratosis ED56 Approved [713]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [753]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [754]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [755]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [756]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Verapamil DMA7PEW Angina pectoris BA40 Approved [757]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [758]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [73]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [759]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [760]
Etretinate DM2CZFA Keratosis ED56 Approved [713]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [761]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [762]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [763]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [764]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [765]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [766]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [580]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [224]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [393]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [767]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [759]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Etretinate DM2CZFA Keratosis ED56 Approved [713]
Quercetin DM3NC4M Obesity 5B81 Approved [711]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [413]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [768]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [740]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [769]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [770]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [771]
Selenium DM25CGV N. A. N. A. Approved [646]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [772]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [773]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [774]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [597]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Selenium DM25CGV N. A. N. A. Approved [646]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [775]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [776]
Meloxicam DM2AR7L Arthritis FA20 Approved [777]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Epinephrine DM3KJBC Acute asthma CA23 Approved [778]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [375]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [779]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [780]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [781]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [782]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [783]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By L-selectin (SELL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [784]
Meloxicam DM2AR7L Arthritis FA20 Approved [784]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [785]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [784]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [786]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [784]
Phenylbutazone DMAYL0T Chronic pain MG30 Approved [784]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [294]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [787]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [301]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Selenium DM25CGV N. A. N. A. Approved [646]
Etretinate DM2CZFA Keratosis ED56 Approved [587]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [748]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [788]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [394]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [305]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [789]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [306]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [790]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [305]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [791]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [792]
Capsaicin DMGMF6V Back pain ME84.Z Approved [793]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [305]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [794]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [10]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase A (NME1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [584]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Quercetin DM3NC4M Obesity 5B81 Approved [795]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [306]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [796]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [392]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Ethanol DMDRQZU Chronic pain MG30 Approved [797]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [14]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [798]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [799]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [800]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [801]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [399]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [802]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Early growth response protein 1 (EGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [803]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [123]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [428]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [288]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [740]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [305]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [350]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [794]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [312]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [804]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [805]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [607]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [806]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [326]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [14]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [807]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [808]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [300]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [809]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Gefitinib DM15F0X Colon adenocarcinoma Approved [810]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [811]
Methotrexate DM2TEOL Anterior urethra cancer Approved [618]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [812]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [813]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [78]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [701]
Methotrexate DM2TEOL Anterior urethra cancer Approved [373]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [814]
Quercetin DM3NC4M Obesity 5B81 Approved [815]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [816]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [817]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [360]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [818]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [374]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [819]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C eta type (PRKCH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [477]
Panobinostat DM58WKG Chronic graft versus host disease Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [223]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [149]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [444]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [294]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [787]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [820]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [821]
Selenium DM25CGV N. A. N. A. Approved [646]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [748]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [822]
Methotrexate DM2TEOL Anterior urethra cancer Approved [823]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [773]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenomatous polyposis coli protein (APC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [411]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Folic Acid DMEMBJC Colorectal carcinoma Approved [824]
Menthol DMG2KW7 Back pain ME84.Z Approved [236]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Selenium DM25CGV N. A. N. A. Approved [646]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [825]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [826]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [827]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [828]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [829]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [830]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [691]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [100]
Gefitinib DM15F0X Colon adenocarcinoma Approved [831]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [832]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [833]
Selenium DM25CGV N. A. N. A. Approved [104]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [775]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [337]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [834]
Quercetin DM3NC4M Obesity 5B81 Approved [795]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [835]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [836]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [837]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [838]
Testosterone DM7HUNW Hot flushes GA30 Approved [839]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [840]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [841]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [842]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [843]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [844]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [219]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [845]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [846]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [356]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [847]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [848]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [849]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [761]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [850]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [844]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [851]
Quercetin DM3NC4M Obesity 5B81 Approved [852]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [789]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [853]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [854]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [855]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [856]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [857]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [827]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [858]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [301]
Gefitinib DM15F0X Colon adenocarcinoma Approved [585]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Etretinate DM2CZFA Keratosis ED56 Approved [587]
Prednisone DM2HG4X Acute asthma CA23 Approved [384]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [748]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [404]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [859]
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [812]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [860]
Quercetin DM3NC4M Obesity 5B81 Approved [803]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [861]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [350]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [402]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [862]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [863]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [864]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [688]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [865]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [866]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [867]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [868]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [869]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [417]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin E2 receptor EP2 subtype (PTGER2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [558]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [870]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [871]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [872]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [812]
Quercetin DM3NC4M Obesity 5B81 Approved [873]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Menthol DMG2KW7 Back pain ME84.Z Approved [236]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [874]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [875]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [812]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [508]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [371]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [709]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [581]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [599]
Quercetin DM3NC4M Obesity 5B81 Approved [876]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [877]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [492]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [508]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [274]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [581]
Quercetin DM3NC4M Obesity 5B81 Approved [878]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [131]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [503]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [401]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [879]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [880]
Selenium DM25CGV N. A. N. A. Approved [104]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [775]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [881]
Quercetin DM3NC4M Obesity 5B81 Approved [349]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [882]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [883]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C chemokine receptor type 3 (CCR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [884]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [885]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [886]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [887]
Arsenic DMTL2Y1 N. A. N. A. Approved [613]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [888]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
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Drug(s) Affected By ATP-citrate synthase (ACLY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [795]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [889]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [890]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [426]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [891]
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Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [14]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [892]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [14]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [892]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [800]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [650]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [893]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [894]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [758]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [895]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [418]
Meloxicam DM2AR7L Arthritis FA20 Approved [896]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [897]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [898]
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Drug(s) Affected By Caspase-6 (CASP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Methotrexate DM2TEOL Anterior urethra cancer Approved [899]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [712]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [900]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [901]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [902]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [418]
Selenium DM25CGV N. A. N. A. Approved [903]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [904]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [905]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [906]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thymosin beta-4 (TMSB4X)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [290]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [406]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [907]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [908]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [909]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [910]
Gefitinib DM15F0X Colon adenocarcinoma Approved [745]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [895]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [760]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [911]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [912]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [913]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [914]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [915]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [915]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [916]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [917]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [915]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [915]
Ethacrynic acid DM60QMR Edema MG29 Approved [915]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [915]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C epsilon type (PRKCE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [712]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [223]
Arsenic DMTL2Y1 N. A. N. A. Approved [450]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [558]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [918]
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Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [919]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [920]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [920]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [221]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [920]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [920]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [920]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [508]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [921]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [922]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [429]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [923]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [924]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [399]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [104]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [925]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [813]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [712]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [926]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [927]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Focal adhesion kinase 1 (PTK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [527]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [928]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Quercetin DM3NC4M Obesity 5B81 Approved [929]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [557]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [930]
Testosterone DM7HUNW Hot flushes GA30 Approved [931]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [932]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tight junction protein ZO-1 (TJP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [933]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Ethanol DMDRQZU Chronic pain MG30 Approved [934]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [935]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [753]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [417]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Verapamil DMA7PEW Angina pectoris BA40 Approved [757]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [375]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [895]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Meloxicam DM2AR7L Arthritis FA20 Approved [777]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [748]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [691]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [936]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [418]
Selenium DM25CGV N. A. N. A. Approved [104]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [937]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [938]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [939]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [940]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [941]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [856]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [942]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [943]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [924]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [944]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [795]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [883]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [790]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [945]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor HES-1 (HES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [946]
Selenium DM25CGV N. A. N. A. Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Verapamil DMA7PEW Angina pectoris BA40 Approved [741]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [357]
Selenium DM25CGV N. A. N. A. Approved [104]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [947]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [948]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [949]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [950]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [951]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [350]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [794]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [828]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [952]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [953]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [350]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [273]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [954]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [955]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [956]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [957]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [901]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [958]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [959]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Occludin (OCLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [960]
Methotrexate DM2TEOL Anterior urethra cancer Approved [618]
Quercetin DM3NC4M Obesity 5B81 Approved [961]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [962]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [963]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [344]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ethanol DMDRQZU Chronic pain MG30 Approved [934]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [964]
Quercetin DM3NC4M Obesity 5B81 Approved [964]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [964]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [965]
Sulfinpyrazone DMEV954 Gout FA25 Approved [966]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [967]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [968]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [969]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [970]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [114]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [593]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [971]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [417]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [379]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [972]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [973]
Quercetin DM3NC4M Obesity 5B81 Approved [974]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [975]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [418]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [394]
Methotrexate DM2TEOL Anterior urethra cancer Approved [496]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [976]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [123]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [977]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [978]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [979]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Perilipin-2 (PLIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [980]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [306]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [270]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [981]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [399]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid-transporting ATPase ABCA3 (ABCA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [189]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [344]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [402]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Arsenic DMTL2Y1 N. A. N. A. Approved [450]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [142]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth/differentiation factor 15 (GDF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [404]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [394]
Quercetin DM3NC4M Obesity 5B81 Approved [873]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [982]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [983]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [809]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [604]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [984]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [607]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [608]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [985]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiopoietin-related protein 3 (ANGPTL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [14]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [892]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Allopurinol DMLPAOB Gout FA25 Approved [14]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [892]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [198]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [142]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin D2 receptor 2 (PTGDR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Arsenic DMTL2Y1 N. A. N. A. Approved [613]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [986]
Urethane DM7NSI0 N. A. N. A. Phase 4 [257]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [165]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [987]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Acetylcholinesterase (ACHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [988]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [989]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [990]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [991]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [990]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [992]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [993]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [994]
Testosterone DM7HUNW Hot flushes GA30 Approved [205]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome b5 (CYB5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [307]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [162]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [254]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-1-antitrypsin (SERPINA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [508]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [344]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Folic Acid DMEMBJC Colorectal carcinoma Approved [551]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [995]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [326]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [996]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [486]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [997]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 12A (HSPA12A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [348]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [376]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Arsenic DMTL2Y1 N. A. N. A. Approved [450]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By p21 protein (HRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [15]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [15]
NVP-LAQ824 DM8JWNA Mood disorder 6A60-6E23 Phase 3 [15]
Drug(s) Affected By Transcriptional activator Myb (MYB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [427]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [825]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Estrone DM5T6US Acne vulgaris ED80 Approved [427]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [998]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [999]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [1000]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [1000]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [637]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [1001]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [1002]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [1003]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [1004]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [743]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH-cytochrome b5 reductase 3 (CYB5R3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [456]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [401]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [231]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [282]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [237]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By P-selectin (SELP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [1005]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1006]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [799]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [1007]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [802]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [1008]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1009]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1010]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Modulator [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [6]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [6]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [6]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Substrate [7]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [8]
14-3-3 protein epsilon OT3WQXNA 1433E_HUMAN Gene/Protein Processing [9]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Gene/Protein Processing [10]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Gene/Protein Processing [11]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Gene/Protein Processing [12]
ABC-type organic anion transporter ABCA8 (ABCA8) OTCWLX6N ABCA8_HUMAN Gene/Protein Processing [13]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [14]
Acetylcholinesterase (ACHE) OT2H8HG6 ACES_HUMAN Drug Response [15]
Acrosin-binding protein (ACRBP) OT0MK3L1 ACRBP_HUMAN Gene/Protein Processing [12]
Activity-dependent neuroprotector homeobox protein (ADNP) OTEGICWR ADNP_HUMAN Gene/Protein Processing [12]

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803 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
804 Indomethacin and ibuprofen effect on IL-1ra production by mononuclear cells of preterm newborns and adults. Biol Neonate. 2002 Aug;82(2):73-7. doi: 10.1159/000063090.
805 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
806 Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res. 2009 Sep;50(9):1814-23. doi: 10.1194/jlr.M800343-JLR200. Epub 2009 Apr 21.
807 Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Exp Eye Res. 2007 Dec;85(6):825-35. doi: 10.1016/j.exer.2007.08.018. Epub 2007 Aug 29.
808 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
809 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
810 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
811 The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res. 2008 Oct 15;68(20):8269-77. doi: 10.1158/0008-5472.CAN-08-2010.
812 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
813 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
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816 The effects of 1 month antihypertensive treatment with perindopril, bisoprolol or both on the ex vivo ability of monocytes to secrete inflammatory cytokines. Int J Clin Pharmacol Ther. 2009 Nov;47(11):686-94. doi: 10.5414/cpp47686.
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818 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
819 Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicol Sci. 2022 Sep 24;189(2):216-224. doi: 10.1093/toxsci/kfac073.
820 Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
821 Down-regulation and decreased activity of cyclin-dependent kinase 2 in H2O2-induced premature senescence. Int J Biochem Cell Biol. 2003 Feb;35(2):246-54. doi: 10.1016/s1357-2725(02)00129-2.
822 Nonsteroidal anti-inflammatory drugs inhibit growth of human neuroendocrine tumor cells via G1 cell-cycle arrest. Int J Cancer. 2003 Dec 10;107(5):844-53. doi: 10.1002/ijc.11446.
823 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
824 Folic acid enforces DNA methylation-mediated transcriptional silencing of PTEN, APC and RARbeta2 tumour suppressor genes in breast cancer. Biochem Biophys Res Commun. 2013 Jan 11;430(2):623-8. doi: 10.1016/j.bbrc.2012.11.103. Epub 2012 Dec 3.
825 Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. doi: 10.1124/jpet.103.049098. Epub 2003 Mar 20.
826 Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
827 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
828 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
829 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
830 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
831 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
832 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
833 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
834 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
835 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
836 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
837 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
838 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
839 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
840 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
841 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
842 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
843 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
844 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
845 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
846 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
847 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
848 Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
849 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
850 Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
851 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
852 The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-). Food Funct. 2015 Apr;6(4):1098-107. doi: 10.1039/c5fo00076a.
853 Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. J Rheumatol. 2012 Mar;39(3):635-44. doi: 10.3899/jrheum.110621. Epub 2011 Nov 15.
854 Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. Toxicol Appl Pharmacol. 2013 Dec 15;273(3):435-41. doi: 10.1016/j.taap.2013.10.005. Epub 2013 Oct 12.
855 Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
856 Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomed Pharmacother. 2010 Feb;64(2):118-23. doi: 10.1016/j.biopha.2009.04.033. Epub 2009 Oct 17.
857 Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antivir Ther. 2003 Aug;8(4):323-31.
858 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
859 Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem. 1999 Jun 18;274(25):17580-6. doi: 10.1074/jbc.274.25.17580.
860 Molecular mechanisms underlying the inhibition of IFN--induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J Cell Biochem. 2011 Feb;112(2):675-83. doi: 10.1002/jcb.22976.
861 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
862 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
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864 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
865 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
866 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
867 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
868 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
869 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
870 Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. Hum Mol Genet. 2004 Dec 15;13(24):3203-17. doi: 10.1093/hmg/ddh332. Epub 2004 Oct 20.
871 Suppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes. Biochem Pharmacol. 2006 Aug 14;72(4):463-73. doi: 10.1016/j.bcp.2006.05.001. Epub 2006 Jun 19.
872 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
873 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
874 Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression. Environ Toxicol. 2018 Dec;33(12):1237-1244. doi: 10.1002/tox.22630. Epub 2018 Sep 6.
875 Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells. J Signal Transduct. 2012;2012:204236. doi: 10.1155/2012/204236. Epub 2012 Oct 9.
876 Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med. 2002 Mar 1;32(5):386-93. doi: 10.1016/s0891-5849(01)00812-7.
877 Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
878 Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun. 2009 Sep 11;387(1):109-14. doi: 10.1016/j.bbrc.2009.06.136. Epub 2009 Jul 1.
879 An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Toxicol In Vitro. 2017 Apr;40:11-25. doi: 10.1016/j.tiv.2016.12.005. Epub 2016 Dec 10.
880 Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
881 Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
882 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
883 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
884 Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Blood. 2009 Dec 24;114(27):5512-21. doi: 10.1182/blood-2009-02-204834. Epub 2009 Oct 14.
885 Association of the CCR3 gene polymorphism with aspirin exacerbated respiratory disease. Respir Med. 2010 May;104(5):626-32. doi: 10.1016/j.rmed.2009.11.024. Epub 2009 Dec 21.
886 Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1. Life Sci. 2006 Aug 22;79(13):1293-300. doi: 10.1016/j.lfs.2006.03.046. Epub 2006 Apr 22.
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888 Tacrolimus decreases the expression of eotaxin, CCR3, RANTES and interleukin-5 in atopic dermatitis. Br J Dermatol. 2005 Jun;152(6):1173-81. doi: 10.1111/j.1365-2133.2005.06474.x.
889 Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies. Arch Toxicol. 2018 Sep;92(9):2829-2844. doi: 10.1007/s00204-018-2263-3. Epub 2018 Jul 13.
890 Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBP-SIRT1 pathway. Toxicology. 2019 Apr 1;417:23-34. doi: 10.1016/j.tox.2019.02.008. Epub 2019 Feb 15.
891 Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer. Environ Toxicol. 2023 Oct;38(10):2352-2360. doi: 10.1002/tox.23871. Epub 2023 Jun 22.
892 Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
893 Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
894 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
895 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
896 Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
897 Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
898 Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
899 A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
900 Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria. Biochem J. 2001 Nov 1;359(Pt 3):537-46. doi: 10.1042/0264-6021:3590537.
901 Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
902 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
903 Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
904 Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int. 2011 Aug;35(8):803-10. doi: 10.1042/CBI20100739.
905 Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
906 p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
907 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
908 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
909 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
910 Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
911 Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
912 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
913 Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
914 NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11.
915 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
916 Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
917 Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
918 Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
919 Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine. Toxicol In Vitro. 2009 Oct;23(7):1259-67.
920 Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
921 Functional characterization of peroxisome proliferator-activated receptor-/ expression in colon cancer. Mol Carcinog. 2011 Nov;50(11):884-900. doi: 10.1002/mc.20757. Epub 2011 Mar 11.
922 Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta. Mol Cell Biochem. 2004 Nov;266(1-2):57-63. doi: 10.1023/b:mcbi.0000049138.67699.7b.
923 (9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.
924 Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. Anticancer Res. 2009 Sep;29(9):3647-58.
925 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
926 Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
927 Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
928 Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chem Biol Interact. 2008 Jan 10;171(1):57-66. doi: 10.1016/j.cbi.2007.08.009. Epub 2007 Aug 19.
929 Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013 May;33(5):1941-50.
930 Activation of cannabinoid receptors promote periodontal cell adhesion and migration. J Clin Periodontol. 2019 Dec;46(12):1264-1272. doi: 10.1111/jcpe.13190. Epub 2019 Oct 22.
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