Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXZRW0)

• Drug Name: DTI-015 Drug Info
• Synonyms: Carmustine; carmustine; 154-93-8; 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin; Nitrumon; Carmubris; Gliadel; BiCNU; Bi CNU; Carmustinum; Bischlorethylnitrosurea; Bischlorethylnitrosourea; Carmustina; Becenun; Becenum; Bischloroethyl nitrosourea; N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA; Bis(2-chloroethyl)nitrosourea; Urea, N,N'-bis(2-chloroethyl)-N-nitroso-; Gliadel Wafer; FDA 0345; Bischloroethylnitrosourea; SRI 1720; 1,3-Bis(2-chloroethyl)nitrosourea; BiCNU (TN); Carmustinum [INN-Latin]; Carmustina [INN-Spanish]; DTI 015; NCI-C04773; SK; BCNU; Injectable carmustine, Direct Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Brain cancer	2A00	Approved	[1]
Glioblastoma of brain	2A00.00	Approved	[2]
Liver cancer	2C12	Approved	[3]
Malignant glioma	2A00.0	Approved	[4]
Plasma cell myeloma	2A83.1	Approved	[5]
Classic Hodgkin lymphoma		Investigative	[5]

• Cross-matching ID:
  PubChem CID: 2578
  ChEBI ID: CHEMBL513
  CAS Number: CAS 154-93-8
  TTD Drug ID: DMXZRW0
  INTEDE Drug ID: DR0278
  ACDINA Drug ID: D00918

Molecule-Related Drug Atlas

Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[11]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[12]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[14]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[15]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[16]
Procarbazine	DMIK367	Hodgkin lymphoma	2B30	Approved	[17]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[18]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[19]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[26]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[28]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[29]

Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[33]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[34]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[35]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[36]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[37]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[38]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[39]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[46]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[47]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[48]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]

Drug(s) Affected By Probable G-protein coupled receptor 25 (GPR25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]

Drug(s) Affected By Ladinin-1 (LAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Homeobox protein CDX-4 (CDX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[74]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-1 (DVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[80]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[76]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[82]

Drug(s) Affected By Tetraspanin-4 (TSPAN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 2 (ARPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[90]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[91]

Drug(s) Affected By Short stature homeobox protein (SHOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[95]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Prosaposin receptor GPR37 (GPR37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Protein phosphatase 1G (PPM1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[101]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
AMG 176	DM0Q7NO	Acute myeloid leukaemia	2A60	Phase 1	[108]
AZD5991	DM7QGHO	Haematological malignancy	2B33.Y	Phase 1	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[116]

Drug(s) Affected By Beta-1,4-galactosyltransferase 5 (B4GALT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[122]

Drug(s) Affected By NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Transcription factor 21 (TCF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By LIM homeobox transcription factor 1-beta (LMX1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[139]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[140]

Drug(s) Affected By Probable G-protein coupled receptor 32 (GPR32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[129]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[144]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]

Drug(s) Affected By Extracellular matrix protein 2 (ECM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[147]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Aquaporin-8 (AQP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[151]

Drug(s) Affected By BAI1-associated protein 3 (BAIAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Methamphetamine	DMPM4SK	Anxiety		Approved	[152]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[154]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 2 (SORBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[157]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]

Drug(s) Affected By Homeobox protein Nkx-2.2 (NKX2-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[161]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By Adenomatous polyposis coli protein 2 (APC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[164]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[165]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[124]

Drug(s) Affected By B-cell lymphoma/leukemia 10 (BCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[174]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[178]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[88]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]

Drug(s) Affected By Muellerian-inhibiting factor (AMH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[182]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[165]

Drug(s) Affected By Protamine-2 (PRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Non-histone chromosomal protein HMG-17 (HMGN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[186]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[188]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]

Drug(s) Affected By Creatine kinase M-type (CKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[192]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[193]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[194]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[192]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Carbimazole	DMULAI4	Hyperthyroidism	5A02	Approved	[196]

Drug(s) Affected By Acetylcholine receptor subunit gamma (CHRNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]

Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[201]
Haloperidol	DM96SE0	Delirium		Approved	[202]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[203]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, muscle type (PFKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[204]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[205]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[206]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[207]

Drug(s) Affected By U2 small nuclear ribonucleoprotein B'' (SNRPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Glycodelin (PAEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[210]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By B-cell antigen receptor complex-associated protein alpha chain (CD79A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Bortezomib	DMNO38U	Leukemia		Approved	[212]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[213]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[215]

Drug(s) Affected By Alpha-actinin-1 (ACTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By Platelet glycoprotein Ib beta chain (GP1BB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[221]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[223]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[226]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[227]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[231]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[232]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[233]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[234]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[235]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Haloperidol	DM96SE0	Delirium		Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[237]

Drug(s) Affected By Myoblast determination protein 1 (MYOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Myogenin (MYOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[244]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[245]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[246]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]

Drug(s) Affected By Pituitary adenylate cyclase-activating polypeptide (ADCYAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[251]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[60]

Drug(s) Affected By DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[253]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[208]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[254]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[255]

Drug(s) Affected By Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[256]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[256]

Drug(s) Affected By Protachykinin-1 (TAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[258]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[259]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[257]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[260]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[261]

Drug(s) Affected By Collagen alpha-1(IX) chain (COL9A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[262]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[264]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[265]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[266]

Drug(s) Affected By Macrophage scavenger receptor types I and II (MSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[267]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[268]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[269]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Calretinin (CALB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[271]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[262]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]

Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]

Drug(s) Affected By Carbonic anhydrase 6 (CA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[275]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]

Drug(s) Affected By Integrin alpha-3 (ITGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[277]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[278]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[280]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Elongation factor 1-gamma (EEF1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[282]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[283]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[210]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[284]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[207]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[285]

Drug(s) Affected By Cystatin-D (CST5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[287]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[288]

Drug(s) Affected By Cellular retinoic acid-binding protein 1 (CRABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[289]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[290]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[291]

Drug(s) Affected By ATP synthase subunit delta, mitochondrial (ATP5F1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Rab GDP dissociation inhibitor alpha (GDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[293]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[294]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[295]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[296]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[297]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[298]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[299]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[298]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[300]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[301]

Drug(s) Affected By Ribonuclease 4 (RNASE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[302]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By Macrosialin (CD68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[304]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[304]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]

Drug(s) Affected By Serine hydroxymethyltransferase, mitochondrial (SHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[307]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]

Drug(s) Affected By General transcription factor IIF subunit 1 (GTF2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[308]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[207]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]

Drug(s) Affected By Small proline-rich protein 2B (SPRR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[309]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Alpha-1B adrenergic receptor (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[311]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[312]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[314]
Terbutaline	DMD4381	Asthma	CA23	Approved	[315]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[311]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By Fibrillin-1 (FBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[316]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[212]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Monocarboxylate transporter 8 (SLC16A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[319]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[320]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[321]

Drug(s) Affected By Signal recognition particle 14 kDa protein (SRP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[203]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[322]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[323]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[324]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[325]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[325]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 2 (PBX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[74]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Selenium	DM25CGV	N. A.	N. A.	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[328]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]

Drug(s) Affected By Solute carrier organic anion transporter family member 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[329]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[330]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[331]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[332]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[333]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[334]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[335]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]

Drug(s) Affected By RPE-retinal G protein-coupled receptor (RGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[336]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Olfactory marker protein (OMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Neuropeptides B/W receptor type 2 (NPBWR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By CD151 antigen (CD151)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[337]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]

Drug(s) Affected By Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]

Drug(s) Affected By Choline-phosphate cytidylyltransferase A (PCYT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[340]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[207]

Drug(s) Affected By Rab GDP dissociation inhibitor beta (GDI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[341]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[293]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Potassium-transporting ATPase subunit beta (ATP4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[342]

Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Bortezomib	DMNO38U	Leukemia		Approved	[212]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[343]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[344]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[345]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[346]

Drug(s) Affected By Insulin-like 3 (INSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[347]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[347]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[348]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[349]
BADGE	DMCK5DG	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Host cell factor 1 (HCFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[352]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Clathrin heavy chain 2 (CLTCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[159]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[353]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[280]
Dicumarol	DMFQCB1	Bleeding disorder	GA20-GA21	Approved	[353]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[355]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[353]

Drug(s) Affected By UV excision repair protein RAD23 homolog A (RAD23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[356]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[357]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[358]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[359]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]

Drug(s) Affected By Eukaryotic translation initiation factor 6 (EIF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[202]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[202]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By Syntaxin-1B (STX1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]

Drug(s) Affected By Pterin-4-alpha-carbinolamine dehydratase (PCBD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[322]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[333]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[361]
Bortezomib	DMNO38U	Leukemia		Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Actin, gamma-enteric smooth muscle (ACTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[362]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Actin, alpha cardiac muscle 1 (ACTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[363]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[362]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[364]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Methamphetamine	DMPM4SK	Anxiety		Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[364]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[365]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Contactin-associated protein 1 (CNTNAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[367]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Homeobox protein Hox-A4 (HOXA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-1 (MAT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[194]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[210]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[369]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[42]

Drug(s) Affected By Mucin-2 (MUC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[371]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[372]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[302]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[373]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[163]

Drug(s) Affected By Transducin-like enhancer protein 3 (TLE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Sex-determining region Y protein (SRY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[374]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[375]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Neuronal acetylcholine receptor subunit beta-3 (CHRNB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[376]

Drug(s) Affected By Paired box protein Pax-8 (PAX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[378]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[379]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[380]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[381]

Drug(s) Affected By Golgin subfamily A member 2 (GOLGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[382]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[91]

Drug(s) Affected By Lysyl oxidase homolog 1 (LOXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[280]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[290]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[383]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[384]

Drug(s) Affected By Kinesin heavy chain isoform 5A (KIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[385]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[386]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[124]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[147]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[387]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[388]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[389]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[322]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[390]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[391]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[392]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[278]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]

Drug(s) Affected By Myosin-binding protein H (MYBPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[394]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[147]

Drug(s) Affected By Golgin subfamily A member 4 (GOLGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[395]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[396]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[395]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[397]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[308]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[308]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Laminin subunit beta-3 (LAMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[398]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[398]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[399]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[400]

Drug(s) Affected By Translation initiation factor eIF2B subunit alpha (EIF2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[341]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[401]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[402]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[182]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[401]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[403]

Drug(s) Affected By Guanidinoacetate N-methyltransferase (GAMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Ammonia	DMOEVK6	Coronary artery disease	BA80	Approved	[404]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By Growth factor receptor-bound protein 7 (GRB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[405]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[261]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[405]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]

Drug(s) Affected By Procollagen C-endopeptidase enhancer 1 (PCOLCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[318]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By Reticulocalbin-1 (RCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Haloperidol	DM96SE0	Delirium		Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[293]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[210]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]

Drug(s) Affected By Keratin, type I cuticular Ha1 (KRT31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Cytohesin-1 (CYTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 1 (MED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[406]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[407]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[408]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]

Drug(s) Affected By Striated muscle preferentially expressed protein kinase (SPEG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Haloperidol	DM96SE0	Delirium		Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]

Drug(s) Affected By Syntaxin-binding protein 2 (STXBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[410]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Naltrexone	DMUL45H	Alcohol dependence	6C40.2	Approved	[411]
Midazolam	DMXOELT	Agitation	6A70.3	Approved	[412]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]

Drug(s) Affected By snRNA-activating protein complex subunit 1 (SNAPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Alpha-sarcoglycan (SGCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[202]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]

Drug(s) Affected By Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[414]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Artemin (ARTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[415]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[416]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[416]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[418]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[418]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[322]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[324]

Drug(s) Affected By Psychosine receptor (GPR65)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[419]

Drug(s) Affected By Ataxin-2-like protein (ATXN2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[293]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[308]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]

Drug(s) Affected By Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[420]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[421]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[403]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[333]
cycloheximide	DMGDA3C	Discovery agent	N.A.	Investigative	[422]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[423]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Mestranol	DMG3F94	Contraception	QA21	Approved	[423]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[423]

Drug(s) Affected By Signal transducing adapter molecule 1 (STAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[286]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]

Drug(s) Affected By Deoxyribonuclease-1-like 2 (DNASE1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Forkhead box protein J1 (FOXJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[425]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[308]

Drug(s) Affected By snRNA-activating protein complex subunit 3 (SNAPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[395]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[426]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[254]

Drug(s) Affected By Transcription factor IIIB 90 kDa subunit (BRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[427]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[428]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[428]

Drug(s) Affected By Protein bicaudal D homolog 1 (BICD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[261]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[210]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[429]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[207]

Drug(s) Affected By GTP-binding protein Rit2 (RIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Cell cycle checkpoint control protein RAD9A (RAD9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[431]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[432]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[433]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[434]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[435]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[255]

Drug(s) Affected By Septin-5 (SEPTIN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]

Drug(s) Affected By Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[319]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[437]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Neuronal PAS domain-containing protein 1 (NPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[439]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Neurturin (NRTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[186]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[181]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[415]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By Chorion-specific transcription factor GCMa (GCM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[440]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[441]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[442]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[443]
T0070907	DMTKSVO	Discovery agent	N.A.	Investigative	[441]

Drug(s) Affected By Alpha-catulin (CTNNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[367]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Intercellular adhesion molecule 5 (ICAM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[220]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[446]

Drug(s) Affected By Protocadherin gamma-C3 (PCDHGC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[447]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[300]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[448]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[449]

Drug(s) Affected By NF-kappa-B essential modulator (IKBKG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[450]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[451]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[453]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[453]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[454]
Selenium	DM25CGV	N. A.	N. A.	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[398]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[455]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[456]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[458]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[459]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[461]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[462]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[463]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[464]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[465]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[466]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[467]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[468]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[469]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[470]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[468]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[471]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[472]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[473]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[474]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[475]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[474]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[476]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[477]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[478]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[479]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[480]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[481]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[482]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[483]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[484]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[485]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[475]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[486]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[487]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[488]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[489]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[486]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[490]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[491]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[492]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[473]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[493]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[277]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[494]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[495]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[356]

Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[497]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[391]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[498]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]

Drug(s) Affected By Three-prime repair exonuclease 1 (TREX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[499]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Fotemustine	DMV62ED	Solid tumour/cancer	2A00-2F9Z	Approved	[499]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By Eukaryotic initiation factor 4A-II (EIF4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[341]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[401]

Drug(s) Affected By Sodium channel protein type 8 subunit alpha (SCN8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[501]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[308]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Transmembrane protein 158 (TMEM158)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[502]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By Four and a half LIM domains protein 2 (FHL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[423]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]

Drug(s) Affected By Glutaminyl-peptide cyclotransferase (QPCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[503]

Drug(s) Affected By Rho-related BTB domain-containing protein 3 (RHOBTB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[504]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[418]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[233]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[505]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]

Drug(s) Affected By Nuclear factor 1 X-type (NFIX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[506]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By ATP-binding cassette sub-family G member 5 (ABCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[507]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[508]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[509]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[508]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[506]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Protein Lines homolog 1 (LINS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[510]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[511]

Drug(s) Affected By Protein ERGIC-53-like (LMAN1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[512]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Spermatogenesis-associated protein 12 (SPATA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[147]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[513]

Drug(s) Affected By Importin-4 (IPO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]

Drug(s) Affected By Msx2-interacting protein (SPEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[514]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[333]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[264]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By Probable RNA-binding protein 19 (RBM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[515]
Selenium	DM25CGV	N. A.	N. A.	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[398]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[405]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[516]

Drug(s) Affected By DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[497]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[362]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[157]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[517]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[447]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[518]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[519]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[520]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[356]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[521]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[522]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[523]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[523]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]

Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[524]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[525]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[341]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[526]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[374]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Leukocyte elastase inhibitor (SERPINB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[198]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[527]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[528]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[210]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By CCN family member 4 (CCN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[529]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[530]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[529]
Indomethacin	DMSC4A7	Bursitis		Approved	[531]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[415]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By ETS translocation variant 1 (ETV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[532]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[533]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[534]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[497]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[451]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[157]

Drug(s) Affected By Melanophilin (MLPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[186]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Golgin subfamily A member 8B (GOLGA8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[333]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[333]

Drug(s) Affected By Paired mesoderm homeobox protein 2 (PRRX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[265]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Serine/threonine-protein kinase LMTK2 (LMTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Doublesex- and mab-3-related transcription factor C2 (DMRTC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[535]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[536]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[537]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]

Drug(s) Affected By Secretory carrier-associated membrane protein 5 (SCAMP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Selenium	DM25CGV	N. A.	N. A.	Approved	[538]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[539]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[540]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[541]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[542]

Drug(s) Affected By N-acetylneuraminate lyase (NPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By DNA-3-methyladenine glycosylase (MPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[543]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[42]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By Transcriptional and immune response regulator (TCIM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[544]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[545]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[405]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[212]

Drug(s) Affected By Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[135]

Drug(s) Affected By Bone morphogenetic protein 5 (BMP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[286]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Organic cation/carnitine transporter 2 (SLC22A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[546]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[547]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[319]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[548]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[549]

Drug(s) Affected By Synaptopodin-2 (SYNPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[362]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[265]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[550]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[254]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By 3-mercaptopyruvate sulfurtransferase (MPST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[551]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By Protein naked cuticle homolog 2 (NKD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[552]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By Cadherin-13 (CDH13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[553]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Methamphetamine	DMPM4SK	Anxiety		Approved	[555]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[556]

Drug(s) Affected By Notch homolog 2 N-terminal-like protein A (NOTCH2NLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[333]

Drug(s) Affected By DNA polymerase subunit gamma-2 (POLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[557]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[323]

Drug(s) Affected By Maturin (MTURN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[265]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By Cysteine and glycine-rich protein 3 (CSRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[558]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[559]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[560]

Drug(s) Affected By Testis development-related protein (TDRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[561]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[333]

Drug(s) Affected By Glycine receptor subunit beta (GLRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[562]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[159]

Drug(s) Affected By CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[290]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[447]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[563]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[564]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[565]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By Polyhomeotic-like protein 2 (PHC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[566]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[567]

Drug(s) Affected By Voltage-gated potassium channel subunit beta-2 (KCNAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[86]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By Ankyrin repeat domain-containing protein 1 (ANKRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[568]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[569]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[233]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[570]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[571]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[447]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[572]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[573]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[574]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[575]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[576]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]

Drug(s) Affected By Phosphopentomutase (PGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[578]

Drug(s) Affected By Differentially expressed in FDCP 6 homolog (DEF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[163]

Drug(s) Affected By Protocadherin beta-2 (PCDHB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[579]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Alpha-(1,6)-fucosyltransferase (FUT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[580]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Nuclear factor of activated T-cells 5 (NFAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[514]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[581]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[396]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[582]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[341]

Drug(s) Affected By Transmembrane protein 19 (TMEM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Pleckstrin homology domain-containing family G member 5 (PLEKHG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[356]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[583]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[584]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]

Drug(s) Affected By Splicing factor 1 (SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[203]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[202]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[585]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[586]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[587]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[588]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[589]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[590]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[591]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Probable ATP-dependent RNA helicase DHX37 (DHX37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[116]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[116]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By T-box transcription factor TBX3 (TBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[227]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[409]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[592]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[227]

Drug(s) Affected By Neuronal PAS domain-containing protein 2 (NPAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[365]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[428]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By Exostosin-like 1 (EXTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[280]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[497]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[485]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[593]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[594]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[595]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[596]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[597]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[598]

Drug(s) Affected By Popeye domain-containing protein 3 (POPDC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[599]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[458]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[401]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[600]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[601]

Drug(s) Affected By Anterior gradient protein 3 (AGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[163]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[254]

Drug(s) Affected By Histone-lysine N-methyltransferase MECOM (MECOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]

Drug(s) Affected By Ras-related protein Rab-27B (RAB27B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[530]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[365]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]

Drug(s) Affected By Plakophilin-3 (PKP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[602]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[603]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[603]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[174]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[604]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[318]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[605]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[606]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[607]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[608]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[606]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[606]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[609]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[608]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[606]

Drug(s) Affected By Prolyl 3-hydroxylase 3 (P3H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[322]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 2 (CHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[610]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[212]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]

Drug(s) Affected By Cell adhesion molecule 1 (CADM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[611]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[157]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[612]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[613]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[173]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[116]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]

Drug(s) Affected By Neuroblastoma suppressor of tumorigenicity 1 (NBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[614]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[101]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[415]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[615]

Drug(s) Affected By Fanconi anemia group C protein (FANCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[497]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[616]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[401]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[447]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[617]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[618]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[619]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[620]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[620]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[157]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[501]

Drug(s) Affected By RAB6A-GEF complex partner protein 2 (RGP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Protein Mdm4 (MDM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[168]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[621]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[622]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[623]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[624]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Transcription factor AP-2 gamma (TFAP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[423]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Mestranol	DMG3F94	Contraception	QA21	Approved	[423]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[318]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[423]

Drug(s) Affected By F-box only protein 32 (FBXO32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[535]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[328]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[535]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[328]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[362]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]

Drug(s) Affected By Syntaxin-binding protein 6 (STXBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[625]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[626]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[627]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[627]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[627]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[627]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[627]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[627]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[627]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[627]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[628]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[629]

Drug(s) Affected By Forkhead box protein F2 (FOXF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[86]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[630]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[480]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[631]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[632]

Drug(s) Affected By Arrestin domain-containing protein 2 (ARRDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[293]

Drug(s) Affected By Ninein (NIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[633]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[634]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[635]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[342]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[636]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[520]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[636]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[637]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[638]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[636]

Drug(s) Affected By Ankyrin-2 (ANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[192]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[192]

Drug(s) Affected By Mannan-binding lectin serine protease 1 (MASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[281]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[256]

Drug(s) Affected By Nuclear factor 1 B-type (NFIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[639]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[640]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM50 (TRIM50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[256]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[256]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[398]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[146]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[641]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[642]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By Engulfment and cell motility protein 1 (ELMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]

Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[62]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[643]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[261]

Drug(s) Affected By GTPase-activating Rap/Ran-GAP domain-like protein 3 (GARNL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[138]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By AP-1 complex subunit sigma-2 (AP1S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[333]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[643]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[142]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[537]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[644]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[645]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Binder	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Glutathione S-transferase alpha-1 (GSTA1)	DE4ZHS1	GSTA1_HUMAN	Substrate	[6]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein eta	OTP8NJFJ	1433F_HUMAN	Gene/Protein Processing	[8]
2-hydroxyacylsphingosine 1-beta-galactosyltransferase	OT17ST61	CGT_HUMAN	Gene/Protein Processing	[8]
3-mercaptopyruvate sulfurtransferase (MPST)	OTCDPH5D	THTM_HUMAN	Drug Response	[9]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Drug Response	[9]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2)	OTG7NW98	F262_HUMAN	Gene/Protein Processing	[8]
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)	OT4CA13K	ATS4_HUMAN	Gene/Protein Processing	[8]
Acetylcholine receptor subunit gamma (CHRNG)	OTXC2UR7	ACHG_HUMAN	Gene/Protein Processing	[8]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Gene/Protein Processing	[8]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Gene/Protein Processing	[8]
Actin-binding protein WASF2	OTRT4F55	WASF2_HUMAN	Drug Response	[9]

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