Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXZRW0)

• Drug Name: DTI-015 Drug Info
• Synonyms: Carmustine; carmustine; 154-93-8; 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin; Nitrumon; Carmubris; Gliadel; BiCNU; Bi CNU; Carmustinum; Bischlorethylnitrosurea; Bischlorethylnitrosourea; Carmustina; Becenun; Becenum; Bischloroethyl nitrosourea; N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA; Bis(2-chloroethyl)nitrosourea; Urea, N,N'-bis(2-chloroethyl)-N-nitroso-; Gliadel Wafer; FDA 0345; Bischloroethylnitrosourea; SRI 1720; 1,3-Bis(2-chloroethyl)nitrosourea; BiCNU (TN); Carmustinum [INN-Latin]; Carmustina [INN-Spanish]; DTI 015; NCI-C04773; SK; BCNU; Injectable carmustine, Direct Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Brain cancer	2A00	Approved	[1]
Glioblastoma of brain	2A00.00	Approved	[2]
Liver cancer	2C12	Approved	[3]
Malignant glioma	2A00.0	Approved	[4]
Plasma cell myeloma	2A83.1	Approved	[5]
Classic Hodgkin lymphoma		Investigative	[5]

• Cross-matching ID:
  PubChem CID: 2578
  ChEBI ID: CHEBI:3423
  CAS Number: CAS 154-93-8
  TTD Drug ID: DMXZRW0
  INTEDE Drug ID: DR0278
  ACDINA Drug ID: D00918

Molecule-Related Drug Atlas

Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[11]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[12]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[14]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[15]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[16]
Procarbazine	DMIK367	Hodgkin lymphoma	2B30	Approved	[17]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[18]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[19]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[26]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[28]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[29]

Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[33]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[34]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[35]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[36]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[37]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[38]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[39]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[46]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[47]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[48]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]

Drug(s) Affected By Probable G-protein coupled receptor 25 (GPR25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]

Drug(s) Affected By Ladinin-1 (LAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Homeobox protein CDX-4 (CDX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[74]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-1 (DVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[80]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[76]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[82]

Drug(s) Affected By Tetraspanin-4 (TSPAN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 2 (ARPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[90]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[91]

Drug(s) Affected By Short stature homeobox protein (SHOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[95]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Prosaposin receptor GPR37 (GPR37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Protein phosphatase 1G (PPM1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[101]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
AMG 176	DM0Q7NO	Acute myeloid leukaemia	2A60	Phase 1	[108]
AZD5991	DM7QGHO	Haematological malignancy	2B33.Y	Phase 1	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[116]

Drug(s) Affected By Beta-1,4-galactosyltransferase 5 (B4GALT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[122]

Drug(s) Affected By NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Transcription factor 21 (TCF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By LIM homeobox transcription factor 1-beta (LMX1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]

Drug(s) Affected By Sphingomyelin phosphodiesterase 2 (SMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
27-hydroxycholesterol	DM2L6OZ	Discovery agent	N.A.	Investigative	[136]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[137]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[141]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[142]

Drug(s) Affected By Probable G-protein coupled receptor 32 (GPR32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[129]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[143]

Drug(s) Affected By Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[146]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]

Drug(s) Affected By Gamma-synuclein (SNCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[149]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[150]

Drug(s) Affected By Extracellular matrix protein 2 (ECM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Aquaporin-8 (AQP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By BAI1-associated protein 3 (BAIAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Methamphetamine	DMPM4SK	Anxiety		Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[159]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 2 (SORBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[162]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]

Drug(s) Affected By Homeobox protein Nkx-2.2 (NKX2-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[166]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]

Drug(s) Affected By Adenomatous polyposis coli protein 2 (APC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[168]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[169]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[124]

Drug(s) Affected By B-cell lymphoma/leukemia 10 (BCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[173]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[174]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[176]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[178]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[179]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[180]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[181]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[182]

Drug(s) Affected By Gastrin (GAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Terbutaline	DMD4381	Asthma	CA23	Approved	[184]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[183]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[185]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[183]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[186]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[187]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[188]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[191]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[88]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]

Drug(s) Affected By Muellerian-inhibiting factor (AMH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[203]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By Protamine-2 (PRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Non-histone chromosomal protein HMG-17 (HMGN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[205]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[207]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]

Drug(s) Affected By Creatine kinase M-type (CKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[211]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[212]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[213]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[214]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Carbimazole	DMULAI4	Hyperthyroidism	5A02	Approved	[215]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[217]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By Acetylcholine receptor subunit gamma (CHRNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[224]
Haloperidol	DM96SE0	Delirium		Approved	[225]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By Muscarinic acetylcholine receptor M4 (CHRM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALCURONIUM	DM2U4XQ	Anaesthesia	9A78.6	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[228]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[229]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
brucine	DM50RUD	Discovery agent	N.A.	Investigative	[227]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, muscle type (PFKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[231]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[232]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]

Drug(s) Affected By U2 small nuclear ribonucleoprotein B'' (SNRPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[234]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[235]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[237]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[236]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[235]

Drug(s) Affected By Glycodelin (PAEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[239]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[242]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[245]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[246]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[247]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[248]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[249]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[250]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[251]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[253]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[250]

Drug(s) Affected By B-cell antigen receptor complex-associated protein alpha chain (CD79A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[254]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[255]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[256]

Drug(s) Affected By Alpha-actinin-1 (ACTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[259]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By Platelet glycoprotein Ib beta chain (GP1BB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[261]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[262]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[147]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[265]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[267]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[268]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[272]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[273]

Drug(s) Affected By Delta-aminolevulinic acid dehydratase (ALAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[276]
Mestranol	DMG3F94	Contraception	QA21	Approved	[274]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[274]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[187]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[279]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[280]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Haloperidol	DM96SE0	Delirium		Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]

Drug(s) Affected By Myoblast determination protein 1 (MYOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[282]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[283]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Myogenin (MYOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[284]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[286]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[288]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[290]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[291]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[292]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[294]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[297]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[300]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]

Drug(s) Affected By Bone morphogenetic protein 7 (BMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[208]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[301]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[302]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[303]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Pituitary adenylate cyclase-activating polypeptide (ADCYAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[304]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[60]

Drug(s) Affected By DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[234]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[307]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[308]

Drug(s) Affected By Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[309]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]

Drug(s) Affected By Protachykinin-1 (TAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[310]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[311]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[312]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[310]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[313]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[185]

Drug(s) Affected By Hepatocyte nuclear factor 1-alpha (HNF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[314]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[316]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[126]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[315]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]

Drug(s) Affected By Collagen alpha-1(IX) chain (COL9A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[317]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[321]

Drug(s) Affected By Macrophage scavenger receptor types I and II (MSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[322]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[324]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Iduronate 2-sulfatase (IDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[116]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[116]

Drug(s) Affected By Calretinin (CALB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[327]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[317]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]

Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[225]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]

Drug(s) Affected By Carbonic anhydrase 6 (CA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[330]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[331]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[263]

Drug(s) Affected By Sodium-dependent noradrenaline transporter (SLC6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[332]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[333]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[334]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[332]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[336]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]

Drug(s) Affected By Integrin alpha-3 (ITGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[340]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[342]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[343]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Elongation factor 1-gamma (EEF1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[344]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[345]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[346]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[347]

Drug(s) Affected By Cystatin-D (CST5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[348]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[349]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[350]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[296]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[352]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]

Drug(s) Affected By Cellular retinoic acid-binding protein 1 (CRABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[353]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[354]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[355]

Drug(s) Affected By ATP synthase subunit delta, mitochondrial (ATP5F1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[356]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Gonadotropin-releasing hormone receptor (GNRHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[357]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[358]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[359]

Drug(s) Affected By Rab GDP dissociation inhibitor alpha (GDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[296]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[360]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[363]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[361]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[364]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[365]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[366]

Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[367]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[368]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[370]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[371]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[372]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[371]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[373]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[374]

Drug(s) Affected By Ribonuclease 4 (RNASE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[301]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By Macrosialin (CD68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[375]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[376]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[376]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]

Drug(s) Affected By Serine hydroxymethyltransferase, mitochondrial (SHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[379]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]

Drug(s) Affected By General transcription factor IIF subunit 1 (GTF2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[380]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]

Drug(s) Affected By Small proline-rich protein 2B (SPRR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[381]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[382]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Alpha-1B adrenergic receptor (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[383]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[386]
Terbutaline	DMD4381	Asthma	CA23	Approved	[387]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[383]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[387]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By Apelin receptor (APLNR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By Fibrillin-1 (FBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[388]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[390]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[392]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]

Drug(s) Affected By Monocarboxylate transporter 8 (SLC16A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[334]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[393]

Drug(s) Affected By Signal recognition particle 14 kDa protein (SRP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[394]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[395]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[396]

Drug(s) Affected By Vasopressin V1a receptor (AVPR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[213]
Vasopressin	DMQ2FPC	Diabetes insipidus	5A61.5	Approved	[397]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[398]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[399]
Insulin	DMB7CE0	Diabetic complication	5A2Y	Approved	[187]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[187]
Alprostadil	DMWH7NQ	Aorta coarctation		Approved	[187]
Dinoprost Tromethamine	DMXQKSL	Abortion	JA00	Approved	[187]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[400]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[401]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[401]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 2 (PBX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[74]

Drug(s) Affected By Carnitine O-acetyltransferase (CRAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[187]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[142]
BENZOQUINONE	DMNBA0G	Discovery agent	N.A.	Investigative	[402]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Selenium	DM25CGV	N. A.	N. A.	Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[300]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]

Drug(s) Affected By Solute carrier organic anion transporter family member 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[404]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[405]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[406]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[407]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[408]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[409]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[410]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]

Drug(s) Affected By RPE-retinal G protein-coupled receptor (RGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[411]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Olfactory marker protein (OMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Neuropeptides B/W receptor type 2 (NPBWR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By CD151 antigen (CD151)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[413]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]

Drug(s) Affected By Cyclin-dependent kinase 8 (CDK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[415]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[76]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[416]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[417]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[418]

Drug(s) Affected By Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]

Drug(s) Affected By Choline-phosphate cytidylyltransferase A (PCYT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[419]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]

Drug(s) Affected By Rab GDP dissociation inhibitor beta (GDI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[258]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[420]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[296]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Potassium-transporting ATPase subunit beta (ATP4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[421]

Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[422]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[423]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[424]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[425]

Drug(s) Affected By Insulin-like 3 (INSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[426]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[426]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[427]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[428]
BADGE	DMCK5DG	Discovery agent	N.A.	Investigative	[429]

Drug(s) Affected By Host cell factor 1 (HCFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[430]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Diphosphomevalonate decarboxylase (MVD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[363]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[431]

Drug(s) Affected By Beta-crystallin B1 (CRYBB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[301]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Clathrin heavy chain 2 (CLTCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[343]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[164]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[432]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[433]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[342]
Dicumarol	DMFQCB1	Bleeding disorder	GA20-GA21	Approved	[432]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[434]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[432]

Drug(s) Affected By UV excision repair protein RAD23 homolog A (RAD23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[436]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[437]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[438]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]

Drug(s) Affected By Eukaryotic translation initiation factor 6 (EIF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[225]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[225]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By Syntaxin-1B (STX1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By Pterin-4-alpha-carbinolamine dehydratase (PCBD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[394]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[408]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[439]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Actin, gamma-enteric smooth muscle (ACTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Actin, alpha cardiac muscle 1 (ACTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[441]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[442]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Methamphetamine	DMPM4SK	Anxiety		Approved	[157]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[443]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Contactin-associated protein 1 (CNTNAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[445]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Homeobox protein Hox-A4 (HOXA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[446]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-1 (MAT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[213]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[399]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[42]

Drug(s) Affected By Mucin-2 (MUC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[447]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[448]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[449]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[301]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[450]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[148]

Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[451]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[452]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[453]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[453]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[451]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[453]

Drug(s) Affected By Transducin-like enhancer protein 3 (TLE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Sex-determining region Y protein (SRY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[454]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[455]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Neuronal acetylcholine receptor subunit beta-3 (CHRNB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[343]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[301]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[456]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[458]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[459]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[460]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[461]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[462]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]

Drug(s) Affected By Paired box protein Pax-8 (PAX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[463]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[464]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[465]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[466]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[467]

Drug(s) Affected By Golgin subfamily A member 2 (GOLGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[468]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[91]

Drug(s) Affected By Lysyl oxidase homolog 1 (LOXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[342]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[354]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[469]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[470]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[471]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[472]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[473]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[474]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[474]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[475]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[476]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[477]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[478]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[474]

Drug(s) Affected By Kinesin heavy chain isoform 5A (KIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[479]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[480]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[124]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[481]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[482]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[483]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[394]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[484]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[485]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[486]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[340]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]

Drug(s) Affected By Myosin-binding protein H (MYBPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[487]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[488]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]

Drug(s) Affected By Golgin subfamily A member 4 (GOLGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[489]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[490]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[489]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[491]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[380]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[380]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Laminin subunit beta-3 (LAMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[235]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[492]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[493]

Drug(s) Affected By Translation initiation factor eIF2B subunit alpha (EIF2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[420]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[494]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[315]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[495]

Drug(s) Affected By Guanidinoacetate N-methyltransferase (GAMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Ammonia	DMOEVK6	Coronary artery disease	BA80	Approved	[496]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]

Drug(s) Affected By Growth factor receptor-bound protein 7 (GRB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[453]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[453]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[185]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[453]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[497]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[498]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[499]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[500]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[501]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[502]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[503]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[504]

Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[505]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[506]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[507]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[217]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[508]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[509]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[510]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Procollagen C-endopeptidase enhancer 1 (PCOLCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[390]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By Reticulocalbin-1 (RCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Haloperidol	DM96SE0	Delirium		Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[296]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]

Drug(s) Affected By Keratin, type I cuticular Ha1 (KRT31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Cytohesin-1 (CYTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 1 (MED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[511]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[512]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[513]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]

Drug(s) Affected By Striated muscle preferentially expressed protein kinase (SPEG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Haloperidol	DM96SE0	Delirium		Approved	[225]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By Syntaxin-binding protein 2 (STXBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[361]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[343]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Histone-lysine N-methyltransferase EZH2 (EZH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[514]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[515]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[516]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[517]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Naltrexone	DMUL45H	Alcohol dependence	6C40.2	Approved	[518]
Midazolam	DMXOELT	Agitation	6A70.3	Approved	[519]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By snRNA-activating protein complex subunit 1 (SNAPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Alpha-sarcoglycan (SGCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[225]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Cardiotrophin-1 (CTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[520]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[521]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]

Drug(s) Affected By Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[522]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[77]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Artemin (ARTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[523]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[524]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[524]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[525]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[526]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[526]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[394]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[396]

Drug(s) Affected By Psychosine receptor (GPR65)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[527]

Drug(s) Affected By Ataxin-2-like protein (ATXN2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[296]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[380]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[263]

Drug(s) Affected By Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[398]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[520]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[495]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[408]
cycloheximide	DMGDA3C	Discovery agent	N.A.	Investigative	[528]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[274]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Mestranol	DMG3F94	Contraception	QA21	Approved	[274]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[274]

Drug(s) Affected By Signal transducing adapter molecule 1 (STAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[348]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]

Drug(s) Affected By Growth hormone secretagogue receptor type 1 (GHSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zithromax	DMN4H2O	Syphilis infection	1A6Z	Approved	[529]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By Deoxyribonuclease-1-like 2 (DNASE1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Forkhead box protein J1 (FOXJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[530]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[380]

Drug(s) Affected By snRNA-activating protein complex subunit 3 (SNAPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[489]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[531]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[307]

Drug(s) Affected By Transcription factor IIIB 90 kDa subunit (BRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[532]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[533]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[533]

Drug(s) Affected By Protein bicaudal D homolog 1 (BICD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[534]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]

Drug(s) Affected By GTP-binding protein Rit2 (RIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Cell cycle checkpoint control protein RAD9A (RAD9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[535]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[536]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[537]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[538]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[539]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[540]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[308]

Drug(s) Affected By Septin-5 (SEPTIN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[541]

Drug(s) Affected By Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[334]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[542]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Neuronal PAS domain-containing protein 1 (NPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[543]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Neurturin (NRTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[205]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[200]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[523]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]

Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[545]

Drug(s) Affected By Chorion-specific transcription factor GCMa (GCM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[546]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[547]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[548]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[549]
T0070907	DMTKSVO	Discovery agent	N.A.	Investigative	[547]

Drug(s) Affected By Alpha-catulin (CTNNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[452]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[445]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Intercellular adhesion molecule 5 (ICAM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[261]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[551]

Drug(s) Affected By Protocadherin gamma-C3 (PCDHGC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[552]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[343]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[373]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[553]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[554]

Drug(s) Affected By NF-kappa-B essential modulator (IKBKG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[555]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[556]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[557]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[558]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[558]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[559]
Haloperidol	DM96SE0	Delirium		Approved	[187]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[552]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[560]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[561]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[562]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[563]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[564]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[565]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[566]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[567]
Selenium	DM25CGV	N. A.	N. A.	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[235]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[568]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[565]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[569]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[363]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[570]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[571]

Drug(s) Affected By Suppressor of cytokine signaling 1 (SOCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[453]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[453]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[572]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[453]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[573]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[573]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[494]
Ketoprofen	DMRKXPT	Bursitis		Approved	[187]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[574]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[575]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[505]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[576]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[577]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[578]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[579]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[580]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[581]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[582]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[581]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[321]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[583]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[584]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[585]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[586]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[587]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[588]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[589]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[590]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[591]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[592]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[360]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[453]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[453]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[594]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[595]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[552]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[560]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[596]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[452]
Fructose	DM43AN2	Vomiting	MD90	Approved	[597]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[598]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[599]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[600]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[601]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[602]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[603]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[604]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[605]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[606]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[607]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[608]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[606]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[609]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[610]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[611]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[612]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[613]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[612]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[614]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[615]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[616]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[617]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[618]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[619]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[620]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[187]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[621]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[622]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[623]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[624]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[625]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[626]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[560]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[627]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[628]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[629]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[630]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[613]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[631]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[632]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[633]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[634]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[586]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[635]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[636]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[637]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[638]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[639]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[640]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[641]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[642]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[643]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[631]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[644]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[452]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[617]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[640]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[621]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[552]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[645]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[628]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[646]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[613]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[589]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[647]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[611]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[648]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[649]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[650]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[651]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]

Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[485]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[652]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]

Drug(s) Affected By Three-prime repair exonuclease 1 (TREX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[343]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[653]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Fotemustine	DMV62ED	Solid tumour/cancer	2A00-2F9Z	Approved	[653]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[654]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[643]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Selenium	DM25CGV	N. A.	N. A.	Approved	[655]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[656]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[657]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[658]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[659]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[660]

Drug(s) Affected By Eukaryotic initiation factor 4A-II (EIF4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[420]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[661]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]

Drug(s) Affected By Sodium channel protein type 8 subunit alpha (SCN8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[662]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[663]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[380]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Transmembrane protein 158 (TMEM158)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[352]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By Four and a half LIM domains protein 2 (FHL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[361]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[274]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]

Drug(s) Affected By Glutaminyl-peptide cyclotransferase (QPCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[664]

Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[665]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[556]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[666]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]

Drug(s) Affected By Rho-related BTB domain-containing protein 3 (RHOBTB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[667]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[526]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[187]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[668]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]

Drug(s) Affected By Nuclear factor 1 X-type (NFIX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[669]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[670]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[671]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[672]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[673]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[674]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[675]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[676]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[677]

Drug(s) Affected By Neurotrypsin (PRSS12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[678]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[239]

Drug(s) Affected By ATP-binding cassette sub-family G member 5 (ABCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[505]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[509]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[679]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[509]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[669]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Protein Lines homolog 1 (LINS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[680]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[681]

Drug(s) Affected By Protein ERGIC-53-like (LMAN1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[682]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Spermatogenesis-associated protein 12 (SPATA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[683]

Drug(s) Affected By Importin-4 (IPO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]

Drug(s) Affected By Msx2-interacting protein (SPEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[268]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[684]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[408]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By Protein-cysteine N-palmitoyltransferase HHAT (HHAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]

Drug(s) Affected By Probable RNA-binding protein 19 (RBM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[263]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[685]
Selenium	DM25CGV	N. A.	N. A.	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[453]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[235]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[453]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[686]

Drug(s) Affected By DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[162]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[687]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[552]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[688]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[689]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[690]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[691]

Drug(s) Affected By Microsomal glutathione S-transferase 2 (MGST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[692]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[693]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[694]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[694]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]

Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[695]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[696]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[420]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[697]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[454]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By ADP-ribosylation factor 1 (ARF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[430]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[698]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Leukocyte elastase inhibitor (SERPINB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[221]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[699]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[700]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By CCN family member 4 (CCN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[701]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[702]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[701]
Indomethacin	DMSC4A7	Bursitis		Approved	[703]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[523]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By ETS translocation variant 1 (ETV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[698]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[704]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[705]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[651]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[556]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[162]

Drug(s) Affected By Melanophilin (MLPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[205]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[706]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[626]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[707]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[708]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[709]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[710]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[711]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[712]

Drug(s) Affected By Golgin subfamily A member 8B (GOLGA8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[408]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[408]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[713]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[714]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[589]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[624]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[715]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[716]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[717]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[360]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[718]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[719]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[720]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[624]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[721]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[722]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[628]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[723]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[718]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[724]

Drug(s) Affected By Glial cell line-derived neurotrophic factor (GDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[725]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[726]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[727]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[317]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[728]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[729]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[726]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[730]

Drug(s) Affected By Paired mesoderm homeobox protein 2 (PRRX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Thrombomodulin (THBD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[731]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[732]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Serine/threonine-protein kinase LMTK2 (LMTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Doublesex- and mab-3-related transcription factor C2 (DMRTC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[733]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[734]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]

Drug(s) Affected By Secretory carrier-associated membrane protein 5 (SCAMP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Selenium	DM25CGV	N. A.	N. A.	Approved	[735]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[736]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[737]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[738]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[739]

Drug(s) Affected By N-acetylneuraminate lyase (NPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[740]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[685]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[741]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[740]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[701]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[740]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[740]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[742]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[741]

Drug(s) Affected By DNA-3-methyladenine glycosylase (MPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[743]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[42]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By Transcriptional and immune response regulator (TCIM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[744]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[452]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[453]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[453]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]

Drug(s) Affected By Enteropeptidase (TMPRSS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
biotin	DMKMCE1	Discovery agent	N.A.	Investigative	[745]

Drug(s) Affected By Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[135]

Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[746]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[747]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[748]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[749]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[750]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[751]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[752]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[753]

Drug(s) Affected By Bone morphogenetic protein 5 (BMP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[348]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Organic cation/carnitine transporter 2 (SLC22A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[754]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[755]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[756]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[757]

Drug(s) Affected By Synaptopodin-2 (SYNPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[758]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[307]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By 3-mercaptopyruvate sulfurtransferase (MPST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[759]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By Protein naked cuticle homolog 2 (NKD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[760]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By Cadherin-13 (CDH13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[761]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[762]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Methamphetamine	DMPM4SK	Anxiety		Approved	[763]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[764]

Drug(s) Affected By Notch homolog 2 N-terminal-like protein A (NOTCH2NLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[408]

Drug(s) Affected By DNA polymerase subunit gamma-2 (POLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[727]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[395]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[765]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[766]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[767]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]

Drug(s) Affected By Solute carrier family 15 member 2 (SLC15A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[95]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[768]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]

Drug(s) Affected By Maturin (MTURN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]

Drug(s) Affected By Cysteine and glycine-rich protein 3 (CSRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[769]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[770]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[771]

Drug(s) Affected By Testis development-related protein (TDRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[772]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[408]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Selenium	DM25CGV	N. A.	N. A.	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[760]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[773]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]

Drug(s) Affected By Glycine receptor subunit beta (GLRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[774]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[164]

Drug(s) Affected By CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[354]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[187]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[640]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[775]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[567]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[776]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[777]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[778]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[779]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[552]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[780]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[781]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[782]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By DNA mismatch repair protein Mlh1 (MLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[783]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[784]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[785]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[786]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[787]

Drug(s) Affected By Polyhomeotic-like protein 2 (PHC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[75]

Drug(s) Affected By Stanniocalcin-1 (STC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[788]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[789]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[514]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[790]

Drug(s) Affected By Voltage-gated potassium channel subunit beta-2 (KCNAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[86]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[791]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[791]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[792]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[793]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[363]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]

Drug(s) Affected By Urea transporter 1 (SLC14A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[663]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[382]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[772]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[794]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[772]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[406]

Drug(s) Affected By Ankyrin repeat domain-containing protein 1 (ANKRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[795]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[796]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[797]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[798]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[799]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[378]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[187]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[800]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[707]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[552]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[801]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[802]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[803]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[804]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[805]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[806]

Drug(s) Affected By Phosphopentomutase (PGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[807]

Drug(s) Affected By Differentially expressed in FDCP 6 homolog (DEF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[148]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[592]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[453]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[788]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[808]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[809]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[408]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[810]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]

Drug(s) Affected By N-glycosylase/DNA lyase (OGG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[811]
Selenium	DM25CGV	N. A.	N. A.	Approved	[812]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[811]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[813]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[814]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[815]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[787]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[816]

Drug(s) Affected By Protocadherin beta-2 (PCDHB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[817]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Alpha-(1,6)-fucosyltransferase (FUT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[818]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[819]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[820]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[821]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[822]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[823]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[824]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[509]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[825]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[826]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By Tenascin (TNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[707]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[827]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[308]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]

Drug(s) Affected By Endothelin-1 receptor (EDNRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Fructose	DM43AN2	Vomiting	MD90	Approved	[597]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[828]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]

Drug(s) Affected By Nuclear factor of activated T-cells 5 (NFAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[684]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[433]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[709]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Indomethacin	DMSC4A7	Bursitis		Approved	[564]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[829]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[830]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[831]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[832]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[833]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[511]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[651]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[490]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[834]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[420]

Drug(s) Affected By Transmembrane protein 19 (TMEM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Pleckstrin homology domain-containing family G member 5 (PLEKHG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[833]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[835]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]

Drug(s) Affected By Splicing factor 1 (SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[225]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[836]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[837]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[838]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[839]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[839]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[840]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[221]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[841]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[499]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[842]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[843]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[844]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Probable ATP-dependent RNA helicase DHX37 (DHX37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[116]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[116]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By T-box transcription factor TBX3 (TBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[268]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[845]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[268]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[268]

Drug(s) Affected By Neuronal PAS domain-containing protein 2 (NPAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[443]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[533]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By Exostosin-like 1 (EXTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[342]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[630]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[846]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[651]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[847]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[584]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[848]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[849]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[850]

Drug(s) Affected By Popeye domain-containing protein 3 (POPDC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[571]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[851]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]

Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[852]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[164]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[853]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[854]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[855]

Drug(s) Affected By Anterior gradient protein 3 (AGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[148]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[307]

Drug(s) Affected By Histone-lysine N-methyltransferase MECOM (MECOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]

Drug(s) Affected By Ras-related protein Rab-27B (RAB27B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[702]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[443]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]

Drug(s) Affected By Plakophilin-3 (PKP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[856]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[857]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[857]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[858]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[390]

Drug(s) Affected By Semaphorin-3A (SEMA3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[185]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[859]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[860]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[861]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[862]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[860]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[860]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[452]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[863]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[862]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[860]

Drug(s) Affected By Lipopolysaccharide-binding protein (LBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Prolyl 3-hydroxylase 3 (P3H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[394]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[864]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[865]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[866]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 2 (CHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[867]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[244]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]

Drug(s) Affected By Cell adhesion molecule 1 (CADM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[868]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[162]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[869]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[870]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[192]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[116]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]

Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[453]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[453]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[557]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[871]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[838]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[872]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[873]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[453]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[453]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[874]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[691]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[526]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[445]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[301]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[758]

Drug(s) Affected By Neuroblastoma suppressor of tumorigenicity 1 (NBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[875]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[101]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[523]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[876]

Drug(s) Affected By cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[877]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Tadalafil	DMJZHT1	Benign prostatic hyperplasia	GA90	Approved	[878]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Vardenafil	DMTBGW8	Cystic fibrosis	CA25	Approved	[878]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[879]

Drug(s) Affected By Fanconi anemia group C protein (FANCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[852]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[552]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[880]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[881]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[552]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[882]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[883]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[883]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[884]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[884]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[162]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[663]

Drug(s) Affected By RAB6A-GEF complex partner protein 2 (RGP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Protein Mdm4 (MDM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[885]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[886]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[887]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[888]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Transcription factor AP-2 gamma (TFAP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[274]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Mestranol	DMG3F94	Contraception	QA21	Approved	[274]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[390]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[274]

Drug(s) Affected By F-box only protein 32 (FBXO32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[733]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[733]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[343]

Drug(s) Affected By Syntaxin-binding protein 6 (STXBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[889]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[890]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[891]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[891]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[891]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[891]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[891]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[891]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[891]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[891]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[235]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[892]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[893]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[775]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[894]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[895]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[235]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[896]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[897]

Drug(s) Affected By Forkhead box protein F2 (FOXF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[86]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[898]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[626]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[899]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[385]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[900]

Drug(s) Affected By Arrestin domain-containing protein 2 (ARRDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[296]

Drug(s) Affected By Ninein (NIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[766]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[901]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[902]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[421]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[903]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[690]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[903]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[904]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[905]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[903]

Drug(s) Affected By Ankyrin-2 (ANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[552]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[211]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[211]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[906]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[907]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[908]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[376]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[909]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[910]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[890]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[382]

Drug(s) Affected By Syndecan-1 (SDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[631]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[760]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[911]

Drug(s) Affected By Mannan-binding lectin serine protease 1 (MASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[343]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[309]

Drug(s) Affected By Nuclear factor 1 B-type (NFIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[912]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[913]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM50 (TRIM50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[309]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[162]

Drug(s) Affected By Sphingosine 1-phosphate receptor 3 (S1PR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[914]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[319]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[235]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[268]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[915]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[827]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By Engulfment and cell motility protein 1 (ELMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]

Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[62]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[916]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[185]

Drug(s) Affected By GTPase-activating Rap/Ran-GAP domain-like protein 3 (GARNL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[408]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[140]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Drug(s) Affected By Chloride intracellular channel protein 1 (CLIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[678]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[917]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[918]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By AP-1 complex subunit sigma-2 (AP1S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[408]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[377]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[106]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[916]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[919]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[920]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Binder	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Glutathione S-transferase alpha-1 (GSTA1)	DE4ZHS1	GSTA1_HUMAN	Substrate	[6]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein eta	OTP8NJFJ	1433F_HUMAN	Gene/Protein Processing	[8]
2-hydroxyacylsphingosine 1-beta-galactosyltransferase	OT17ST61	CGT_HUMAN	Gene/Protein Processing	[8]
3-mercaptopyruvate sulfurtransferase (MPST)	OTCDPH5D	THTM_HUMAN	Drug Response	[9]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Drug Response	[9]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2)	OTG7NW98	F262_HUMAN	Gene/Protein Processing	[8]
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)	OT4CA13K	ATS4_HUMAN	Gene/Protein Processing	[8]
Acetylcholine receptor subunit gamma (CHRNG)	OTXC2UR7	ACHG_HUMAN	Gene/Protein Processing	[8]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Gene/Protein Processing	[8]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Gene/Protein Processing	[8]
Actin-binding protein WASF2	OTRT4F55	WASF2_HUMAN	Drug Response	[9]

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