General Information of Disease (ID: DIS7WI98)

Disease Name Essential hypertension
Synonyms primary hypertension; idiopathic hypertension
Disease Class BA00: Essential hypertension
Definition Hypertension that presents without an identifiable cause.
Disease Hierarchy
DISR4QMU: Increase blood pressure
DIS7WI98: Essential hypertension
ICD Code
ICD-11
ICD-11: BA00
ICD-10
ICD-10: I10
ICD-9
ICD-9: 401
Expand ICD-11
'BA00
Expand ICD-10
'I10
Expand ICD-9
401
Disease Identifiers
MONDO ID
MONDO_0001134
MESH ID
D000075222
UMLS CUI
C0085580
OMIM ID
145500
MedGen ID
88442
Orphanet ID
243761
SNOMED CT ID
59621000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Mecamylamine DMGQFYB Approved Small molecular drug [1]
Seractide Acetate DMQNLNI Approved NA [1]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ACT-280778 DMTXRGU Phase 2 NA [2]
RMJH-111b DM0961C Phase 1/2 NA [3]
MK-8266 DM5HFY4 Phase 1 NA [4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 83 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
APOL1 TTDB8PW Limited Genetic Variation [5]
ATP1A1 TTWK8D0 Limited Genetic Variation [6]
AVPR1A TT4TFGN Limited Genetic Variation [7]
BDKRB1 TTG5QIA Limited Altered Expression [8]
CTH TTLQUZS Limited Genetic Variation [9]
DBH TTYIP79 Limited Genetic Variation [10]
GCK TTDLNGZ Limited Genetic Variation [11]
HCRT TTU5HJP Limited Biomarker [12]
HMGCR TTPADOQ Limited Biomarker [13]
HTR2A TTJQOD7 Limited Genetic Variation [14]
OLR1 TTKSND3 Limited Altered Expression [15]
PDE5A TTJ0IQB Limited Biomarker [16]
PNMT TT0NZIC Limited Genetic Variation [17]
ROCK2 TTGWKQJ Limited Altered Expression [18]
SLC6A2 TTAWNKZ Limited Biomarker [19]
SLC8A1 TTCF82X Limited Altered Expression [20]
ADORA1 TTK25J1 Strong Biomarker [21]
ADRA1B TTBRKXS Strong Genetic Variation [22]
ADRB2 TTG8ZWP Strong Genetic Variation [23]
APLNR TTJ8E43 Strong Genetic Variation [24]
BDKRB2 TTGY8IW Strong Genetic Variation [25]
BLVRA TTJBPN3 Strong Biomarker [26]
CALCRL TTY6O0Q Strong Genetic Variation [27]
CALY TT0R12H Strong Biomarker [28]
CCL23 TTHAPJK Strong Biomarker [29]
CLCNKA TT823N1 Strong Biomarker [30]
CLCNKB TTR68GQ Strong Genetic Variation [31]
CTF1 TTXGTZU Strong Biomarker [32]
CYP11B1 TTIQUX7 Strong Biomarker [33]
CYP2D6 TTVG215 Strong Genetic Variation [34]
CYP2J2 TTNE1C7 Strong Genetic Variation [35]
DRD1 TTZFYLI Strong Genetic Variation [36]
DRD3 TT4C8EA Strong Genetic Variation [37]
ECE1 TTQ9RYT Strong Genetic Variation [38]
ECE2 TT5U914 Strong Genetic Variation [38]
EDN2 TTMR0OP Strong Biomarker [39]
ENPEP TT9PBIL Strong Biomarker [40]
EPHX2 TT7WVHI Strong Genetic Variation [41]
ERAP1 TT60XFL Strong Altered Expression [42]
ERAP2 TTVGS1C Strong Biomarker [43]
FABP2 TTS4YLO Strong Genetic Variation [44]
FABP3 TT3TGLR Strong Genetic Variation [45]
FSHR TTZFDBT Strong Genetic Variation [46]
FURIN TTH9WF6 Strong Genetic Variation [47]
GCGR TT9O6WS Strong Genetic Variation [48]
GJA4 TTQO1VY Strong Genetic Variation [49]
GJA5 TTFQKZ7 Strong Genetic Variation [50]
HMOX2 TTWZRL4 Strong Biomarker [51]
KCNJ11 TT329V4 Strong Genetic Variation [52]
KLKB1 TTN0PCX Strong Genetic Variation [53]
KYNU TTWQM3J Strong Biomarker [54]
LPA TTU9LGY Strong Genetic Variation [55]
LPL TTOF3WZ Strong Genetic Variation [56]
LSS TT7O8ZA Strong Genetic Variation [57]
NOS2 TTF10I9 Strong Biomarker [58]
NPPC TTRK0B9 Strong Biomarker [59]
NPR1 TTM9IYA Strong Biomarker [60]
NPR3 TTWVLS6 Strong Genetic Variation [61]
NR3C2 TT26PHO Strong Biomarker [62]
OXSR1 TT7ZY03 Strong Biomarker [63]
PCSK1 TTED9LZ Strong Genetic Variation [64]
PRCP TTTJZ4M Strong Genetic Variation [65]
PRKCH TTONI0R Strong Genetic Variation [66]
PRSS8 TTT4N0Q Strong Genetic Variation [67]
PTGER2 TT1ZAVI Strong Genetic Variation [68]
PTGFR TTT2ZAR Strong Biomarker [69]
RGS2 TTKB7T3 Strong Genetic Variation [70]
SCN10A TT90XZ8 Strong Biomarker [71]
SELE TT1PL7M Strong Altered Expression [72]
SLC12A1 TTS087L Strong Genetic Variation [73]
SLC22A12 TTA592U Strong Genetic Variation [74]
SLC22A2 TT0XOJN Strong Biomarker [75]
SLC6A9 TTHJTF7 Strong Genetic Variation [76]
SMAD9 TTX8EBV Strong Genetic Variation [77]
STK39 TTYQTIU Strong Genetic Variation [78]
TRPC3 TTNVC34 Strong Biomarker [79]
UTS2 TTERU0T Strong Genetic Variation [80]
VKORC1 TTEUC8H Strong Genetic Variation [81]
WNK1 TTJ9UMX Strong Genetic Variation [82]
ADIPOQ TTXKA7D Definitive Genetic Variation [83]
ADRB3 TTMXGCW Definitive Genetic Variation [84]
AGTR2 TTQVOEI Definitive Genetic Variation [85]
KNG1 TTDJ4MY Definitive Altered Expression [86]
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⏷ Show the Full List of 83 DTT(s)
This Disease Is Related to 5 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC9C1 DT9J8DO Limited Altered Expression [87]
SLC35A1 DTVZIRG Strong Biomarker [88]
SLC3A1 DTBCKVM Strong Genetic Variation [89]
SLC6A18 DTGQ7FH Strong Biomarker [90]
SLCO6A1 DTIFXNS Strong Genetic Variation [44]
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This Disease Is Related to 8 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CYP2C8 DES5XRU Limited Genetic Variation [91]
CHST3 DEQIZP2 Strong Altered Expression [92]
CYP2C18 DEZMWRE Strong Genetic Variation [91]
CYP4F2 DE3GT9C Strong Biomarker [93]
FMO3 DEP76YL Strong Genetic Variation [94]
HSD3B1 DERDQWN Strong Genetic Variation [95]
HSD3B2 DEN0GVQ Strong Genetic Variation [95]
CYP4A11 DE2XQGW Definitive Genetic Variation [96]
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⏷ Show the Full List of 8 DME(s)
This Disease Is Related to 82 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACSM3 OT0AE1IV Limited Genetic Variation [97]
ATP2B2 OT1NPZ9T Limited Biomarker [98]
BSND OTYWZWPD Limited Genetic Variation [99]
DBP OTE0W7LN Limited Biomarker [96]
GPX3 OT6PK94R Limited Genetic Variation [100]
HAP1 OT6SG0JQ Limited Genetic Variation [101]
KCNMB1 OTO4KNJ4 Limited Genetic Variation [52]
LPCAT3 OTWI96P4 Limited Genetic Variation [102]
NFYA OTWFFOVH Limited Genetic Variation [101]
OR10A4 OTYYB8SY Limited Biomarker [103]
SCNN1A OTE2KVZV Limited Genetic Variation [104]
SCNN1B OT61QQTL Limited Genetic Variation [105]
TBX1 OTQLBPRA Limited Genetic Variation [106]
GATA5 OTO81B63 moderate Biomarker [107]
ACADSB OTDO6HBG Strong Genetic Variation [108]
ACSM1 OT1TS9M9 Strong Biomarker [97]
ADD2 OTRCPCD2 Strong Biomarker [109]
AMPD1 OTU17BCI Strong Genetic Variation [110]
ARNT OTMSIEZY Strong Genetic Variation [111]
ASIC5 OT1KWTC1 Strong Biomarker [112]
ATF1 OT251CI0 Strong Genetic Variation [113]
ATP1B1 OTTO6ZP4 Strong Genetic Variation [114]
ATP2B3 OT9DIEOP Strong Genetic Variation [115]
ATP6 OTPHOGLX Strong Genetic Variation [116]
C4BPA OTHNH6Y8 Strong Altered Expression [117]
CAMK1D OTU24HAU Strong Biomarker [118]
CAPN10 OTS9LJW4 Strong Biomarker [119]
CARD8 OTXXZYWU Strong Biomarker [120]
CCHCR1 OT22C116 Strong Biomarker [121]
CD164L2 OT0LZOPP Strong Genetic Variation [122]
CHGA OTXYX5JH Strong Biomarker [88]
CYBA OT16N9ZO Strong Biomarker [123]
DROSHA OTCE68KZ Strong Genetic Variation [124]
EMILIN1 OT94R6M1 Strong Biomarker [125]
FCN3 OTPRENLS Strong Genetic Variation [122]
FGF5 OTQXGHBY Strong Altered Expression [126]
FKBP1B OT8CMPB2 Strong Genetic Variation [127]
GAL3ST1 OTSFFZRD Strong Biomarker [88]
GCA OTAJ7ZHG Strong Biomarker [128]
GNAI2 OTTLGRGH Strong Genetic Variation [129]
GNG5 OT5LR7MB Strong Genetic Variation [130]
GOSR2 OTYHIYN2 Strong Biomarker [131]
GRHL1 OTZ4MNEW Strong Genetic Variation [132]
GSTK1 OTDNGWAF Strong Genetic Variation [44]
GSTT2B OTCMRDLE Strong Genetic Variation [133]
GUCA2B OTZERX04 Strong Biomarker [134]
HJV OT4235J2 Strong Genetic Variation [135]
HLA-DRB3 OT5PM9N7 Strong Biomarker [136]
INPPL1 OTCDAVBQ Strong Genetic Variation [137]
KIAA1755 OT1FCGEW Strong Genetic Variation [138]
KIR2DS5 OTXLEN11 Strong Biomarker [139]
LCN1 OT8BWXTV Strong Altered Expression [140]
MEX3C OT8AJG1I Strong Biomarker [141]
MFN2 OTPYN8A3 Strong Posttranslational Modification [142]
MTPN OT5N60RU Strong Biomarker [143]
ND2 OTG9OHOX Strong Genetic Variation [144]
NEDD4L OT1B19RU Strong Genetic Variation [145]
NEFH OTMSCW5I Strong Biomarker [146]
NFYB OTXSE7KW Strong Genetic Variation [65]
NLRP6 OTEREN4W Strong Genetic Variation [147]
NOX5 OTHTH59G Strong Altered Expression [148]
NPPA OTMQNTNX Strong Genetic Variation [149]
OGN OTKP5S4L Strong Biomarker [150]
POU2F2 OTPV0J0C Strong Biomarker [75]
RAMP1 OT7UT2XB Strong Biomarker [151]
RAPGEF5 OT53VS75 Strong Genetic Variation [152]
RGS5 OTUY0Q2I Strong Genetic Variation [153]
RNASE2 OT8Z4FNE Strong Biomarker [154]
RRAS OTBBF28C Strong Genetic Variation [155]
SCN7A OTK05PXY Strong Genetic Variation [156]
SELENBP1 OT3NZNTR Strong Biomarker [121]
SHBG OTPWU5IW Strong Biomarker [121]
SHMT1 OTIINA3J Strong Posttranslational Modification [157]
SMTN OT4R2TYK Strong Genetic Variation [158]
SNX1 OTXQSJ1J Strong Biomarker [159]
SPRR2A OT62ZU6B Strong Genetic Variation [160]
STK24 OTGUHOIL Strong Biomarker [63]
TESC OTI8C76M Strong Genetic Variation [161]
TGFBRAP1 OT80QNR5 Strong Biomarker [162]
TMEM38A OT7336MZ Strong Biomarker [163]
TOR2A OT1EGCDU Strong Altered Expression [164]
GRK4 OTUU8V2S Definitive Genetic Variation [165]
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⏷ Show the Full List of 82 DOT(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 ClinicalTrials.gov (NCT01264692) Essential Hypertension. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 ClinicalTrials.gov (NCT01263314) Safety, Tolerability and Pharmacokinetics of MK-8266 in Elderly Subjects With High Blood Pressure (MK-8266-003 AM1). U.S. National Institutes of Health.
5 The Impact of APOL1 on Chronic Kidney Disease and Hypertension.Adv Chronic Kidney Dis. 2019 Mar;26(2):131-136. doi: 10.1053/j.ackd.2019.01.003.
6 Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects.Circ Res. 2007 May 25;100(10):1522-9. doi: 10.1161/01.RES.0000267716.96196.60. Epub 2007 Apr 19.
7 Association of novel promoter single nucleotide polymorphisms in vasopressin V1a receptor gene with essential hypertension in nonobese Japanese.J Hum Hypertens. 2007 Oct;21(10):825-7. doi: 10.1038/sj.jhh.1002227. Epub 2007 Jul 26.
8 Differential gene expression of bradykinin receptors 1 and 2 in peripheral monocytes from patients with essential hypertension.J Hum Hypertens. 2014 Jul;28(7):450-5. doi: 10.1038/jhh.2013.133. Epub 2014 Jan 9.
9 Functional promoter polymorphisms direct the expression of cystathionine gamma-lyase gene in mouse models of essential hypertension.J Mol Cell Cardiol. 2017 Jan;102:61-73. doi: 10.1016/j.yjmcc.2016.11.005. Epub 2016 Nov 16.
10 Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.J Hypertens. 2010 Jan;28(1):76-86. doi: 10.1097/HJH.0b013e328332bc87.
11 Aberrant methylation of the GCK gene body is associated with the risk of essential hypertension.Mol Med Rep. 2015 Aug;12(2):2390-4. doi: 10.3892/mmr.2015.3631. Epub 2015 Apr 16.
12 The Orexin System and Hypertension.Cell Mol Neurobiol. 2018 Mar;38(2):385-391. doi: 10.1007/s10571-017-0487-z. Epub 2017 Mar 27.
13 Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study.J Renin Angiotensin Aldosterone Syst. 2019 Jul-Sep;20(3):1470320319868890. doi: 10.1177/1470320319868890.
14 Is there an association between T102C polymorphism of the serotonin receptor 2A gene and urinary incontinence?.Braz J Med Biol Res. 2007 Oct;40(10):1315-22. doi: 10.1590/s0100-879x2006005000151. Epub 2007 Jul 31.
15 The gene polymorphism of LOX1 predicts the incidence of LVH in patients with essential hypertension.Cell Physiol Biochem. 2014;33(1):88-96. doi: 10.1159/000356652. Epub 2014 Jan 17.
16 Chronic administration of sildenafil improves endothelial function in spontaneously hypertensive rats by decreasing COX-2 expression and oxidative stress.Life Sci. 2019 May 15;225:29-38. doi: 10.1016/j.lfs.2019.03.074. Epub 2019 Mar 30.
17 Phenylethanolamine N-methyltransferase gene promoter haplotypes and risk of essential hypertension.Am J Hypertens. 2011 Nov;24(11):1222-6. doi: 10.1038/ajh.2011.124. Epub 2011 Aug 25.
18 Polymorphisms and haplotype of ROCK2 associate with high altitude essential hypertension in native high altitude Ladakhi Indian population: a preliminary study.Clin Exp Hypertens. 2016;38(2):238-44. doi: 10.3109/10641963.2015.1081231. Epub 2016 Jan 28.
19 A polymorphism in the norepinephrine transporter gene is associated with affective and cardiovascular disease through a microRNA mechanism.Mol Psychiatry. 2017 Jan;22(1):134-141. doi: 10.1038/mp.2016.40. Epub 2016 Apr 5.
20 Cross talk between plasma membrane Na(+)/Ca (2+) exchanger-1 and TRPC/Orai-containing channels: key players in arterial hypertension.Adv Exp Med Biol. 2013;961:365-74. doi: 10.1007/978-1-4614-4756-6_31.
21 The role of adenosine-related genes variants in susceptibility to essential hypertension.J Hypertens. 2004 Aug;22(8):1519-22. doi: 10.1097/01.hjh.0000133723.16947.6d.
22 Variability in phenylephrine response and essential hypertension: a search for human alpha(1B)-adrenergic receptor polymorphisms.J Pharmacol Exp Ther. 1999 Nov;291(2):793-8.
23 Genetic determinants of essential hypertension in the population of Tatars from Russia.J Hypertens. 2017 May;35 Suppl 1:S16-S23. doi: 10.1097/HJH.0000000000001332.
24 Polymorphisms of APLN-APLNR system are associated with essential hypertension in Mexican-Mestizo individuals.Exp Mol Pathol. 2016 Aug;101(1):105-9. doi: 10.1016/j.yexmp.2016.07.007. Epub 2016 Jul 20.
25 Association and interaction of -58C>T and 9 bp polymorphisms of BDKRB2 gene causing susceptibility to essential hypertension.Clin Exp Hypertens. 2012;34(3):230-5. doi: 10.3109/10641963.2011.631653. Epub 2012 Apr 2.
26 Association of a BLVRA common polymorphism with essential hypertension and blood pressure in Kazaks.Clin Exp Hypertens. 2011;33(5):294-8. doi: 10.3109/10641963.2010.531854. Epub 2011 Jul 1.
27 Association study of calcitonin-receptor-like receptor gene in essential hypertension.Am J Hypertens. 2005 Mar;18(3):403-8. doi: 10.1016/j.amjhyper.2004.10.016.
28 Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain. PLoS One. 2019 Feb 12;14(2):e0211903. doi: 10.1371/journal.pone.0211903. eCollection 2019.
29 CXCL13 polymorphism is associated with essential hypertension in Tatars from Russia.Mol Biol Rep. 2018 Oct;45(5):1557-1564. doi: 10.1007/s11033-018-4257-x. Epub 2018 Jul 17.
30 Associations between CLCNKA_B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China.Clin Exp Hypertens. 2015;37(7):519-25. doi: 10.3109/10641963.2015.1013124. Epub 2015 Apr 28.
31 Association of CLCNKB haplotypes and hypertension in Mongolian and Han populations.Clin Exp Hypertens. 2012;34(7):482-7. doi: 10.3109/10641963.2012.666602. Epub 2012 May 11.
32 Protective effect of the 1742(C/G) polymorphism of human cardiotrophin-1 against left ventricular hypertrophy in essential hypertension.J Hypertens. 2010 Nov;28(11):2219-26. doi: 10.1097/HJH.0b013e32833da326.
33 Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.Hypertension. 2013 Jan;61(1):232-9. doi: 10.1161/HYPERTENSIONAHA.112.200741. Epub 2012 Nov 12.
34 Associations between ADRB1 and CYP2D6 gene polymorphisms and the response to -blocker therapy in hypertension.J Int Med Res. 2015 Jun;43(3):424-34. doi: 10.1177/0300060514563151. Epub 2015 Mar 30.
35 A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.Hypertens Res. 2019 Feb;42(2):257-272. doi: 10.1038/s41440-018-0142-1. Epub 2018 Dec 5.
36 Investigation of the association between dopamine D1 receptor gene polymorphisms and essential hypertension in a group of Turkish subjects.Clin Exp Hypertens. 2011;33(6):418-21. doi: 10.3109/10641963.2011.561898. Epub 2011 Jul 28.
37 Ser9Gly polymorphism in the dopamine D3 receptor gene is not associated with essential hypertension in the Japanese.Med Sci Monit. 2002 Jan;8(1):CR1-4.
38 Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension.J Hum Hypertens. 2007 Nov;21(11):883-92. doi: 10.1038/sj.jhh.1002234. Epub 2007 May 24.
39 Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension.J Hypertens. 1999 Sep;17(9):1281-7. doi: 10.1097/00004872-199917090-00007.
40 Speckle-Tracking Echocardiographic Layer-Specific Strain Analysis on Subclinical Left Ventricular Dysfunction in Patients With Primary Aldosteronism.Am J Hypertens. 2019 Jan 15;32(2):155-162. doi: 10.1093/ajh/hpy175.
41 Relationship between EPHX2 gene polymorphisms and essential hypertension in Uygur, Kazakh, and Han.Genet Mol Res. 2015 Apr 15;14(2):3474-80. doi: 10.4238/2015.April.15.11.
42 Association of single nucleotide polymorphisms in the 3'UTR of ERAP1 gene with essential hypertension in the Northeastern Han Chinese.Gene. 2015 Apr 15;560(2):211-6. doi: 10.1016/j.gene.2015.02.005. Epub 2015 Feb 7.
43 The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.Hum Genet. 2009 Nov;126(5):655-66. doi: 10.1007/s00439-009-0714-x. Epub 2009 Jul 4.
44 Association of ACE, FABP2 and GST genes polymorphism with essential hypertension risk among a North Indian population.Ann Hum Biol. 2015;42(5):461-9. doi: 10.3109/03014460.2014.968206. Epub 2014 Oct 30.
45 Association between fatty acid binding protein 3 gene variants and essential hypertension in humans.Am J Hypertens. 2008 Jun;21(6):691-5. doi: 10.1038/ajh.2008.40. Epub 2008 Apr 10.
46 Mutation of the follicle-stimulating hormone receptor gene 5'-untranslated region associated with female hypertension.Hypertension. 2006 Sep;48(3):512-8. doi: 10.1161/01.HYP.0000233877.84343.d7. Epub 2006 Jul 24.
47 Associations between genetic variations in the FURIN gene and hypertension.BMC Med Genet. 2010 Aug 13;11:124. doi: 10.1186/1471-2350-11-124.
48 Screening for the Gly40Ser mutation in the glucagon receptor gene among patients with type 2 diabetes or essential hypertension in Taiwan.Pancreas. 1999 Mar;18(2):151-5. doi: 10.1097/00006676-199903000-00006.
49 Association between 1019C/T polymorphism in the connexin 37 gene and essential hypertension.Heart Lung Circ. 2014 Oct;23(10):924-9. doi: 10.1016/j.hlc.2014.02.016. Epub 2014 Mar 12.
50 Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men.J Hypertens. 2006 Feb;24(2):325-30. doi: 10.1097/01.hjh.0000200512.40818.47.
51 Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population.Clin Exp Hypertens. 2009 Oct;31(7):534-43. doi: 10.3109/10641960902825461.
52 The dominant models of KCNJ11 E23K and KCNMB1 E65K are associated with essential hypertension (EH) in Asian: Evidence from a meta-analysis.Medicine (Baltimore). 2019 Jun;98(23):e15828. doi: 10.1097/MD.0000000000015828.
53 Common variation in KLKB1 and essential hypertension risk: tagging-SNP haplotype analysis in a case-control study.Hum Genet. 2007 May;121(3-4):327-35. doi: 10.1007/s00439-007-0340-4. Epub 2007 Feb 23.
54 A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.Circ Cardiovasc Genet. 2011 Dec;4(6):687-94. doi: 10.1161/CIRCGENETICS.110.959064. Epub 2011 Oct 19.
55 Apolipoprotein(a) gene polymorphism in the Korean population: is there any relevance to essential hypertension?.Med Princ Pract. 2002 Apr-Jun;11(2):69-74. doi: 10.1159/000058010.
56 A study of lipoprotein lipase gene intron 8 polymorphisms in Chinese Han race essential hypertension patients.Int J Cardiol. 2005 Mar 18;99(2):263-7. doi: 10.1016/j.ijcard.2004.01.015.
57 Lanosterol Synthase Gene Polymorphisms and Changes in Endogenous Ouabain in the Response to Low Sodium Intake.Hypertension. 2016 Feb;67(2):342-8. doi: 10.1161/HYPERTENSIONAHA.115.06415. Epub 2015 Dec 14.
58 Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension.Hum Genet. 2001 Oct;109(4):408-15. doi: 10.1007/s004390100565.
59 Chronic treatment with C-type natriuretic peptide impacts differently in the aorta of normotensive and hypertensive rats.Pflugers Arch. 2019 Aug;471(8):1103-1115. doi: 10.1007/s00424-019-02287-y. Epub 2019 Jun 11.
60 Association of NPRA and NPRC gene variants and hypertension in Mongolian population.Genet Mol Res. 2015 Dec 28;14(4):18494-502. doi: 10.4238/2015.December.23.37.
61 Association of NPR3 polymorphism with risk of essential hypertension in a Chinese population.J Clin Pharm Ther. 2017 Oct;42(5):554-560. doi: 10.1111/jcpt.12549. Epub 2017 May 11.
62 Risk of new-onset autoimmune diseases in primary aldosteronism: a nation-wide population-based study.J Hypertens. 2020 Apr;38(4):745-754. doi: 10.1097/HJH.0000000000002300.
63 Cotransporters, WNKs and hypertension: an update.Curr Opin Nephrol Hypertens. 2008 Mar;17(2):186-92. doi: 10.1097/MNH.0b013e3282f5244e.
64 The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population.Hypertens Res. 2012 Oct;35(10):994-9. doi: 10.1038/hr.2012.79. Epub 2012 May 17.
65 Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population.J Renin Angiotensin Aldosterone Syst. 2013 Sep;14(3):263-70. doi: 10.1177/1470320312448949. Epub 2012 Jun 7.
66 Influence of PRKCH gene polymorphism on antihypertensive response to amlodipine and telmisartan.Clin Exp Hypertens. 2017;39(8):726-731. doi: 10.1080/10641963.2017.1324475. Epub 2017 Jun 22.
67 Association of genetic variations of the prostasin gene with essential hypertension in the Xinjiang Kazakh population.Chin Med J (Engl). 2011 Jul;124(14):2107-12.
68 Association between prostaglandin E2 receptor gene and essential hypertension.Prostaglandins Leukot Essent Fatty Acids. 2007 Jul;77(1):15-20. doi: 10.1016/j.plefa.2007.04.004. Epub 2007 Jul 20.
69 Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2 Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1687-95. doi: 10.1161/ATVBAHA.115.305445. Epub 2015 May 14.
70 The RGS2 (-391, C>G) genetic variation correlates to antihypertensive drug responses in Chinese patients with essential hypertension.PLoS One. 2015 Apr 7;10(4):e0121483. doi: 10.1371/journal.pone.0121483. eCollection 2015.
71 Sympathetic nervous system, genes and human essential hypertension.Curr Neurovasc Res. 2005 Oct;2(4):303-17. doi: 10.2174/156720205774322575.
72 E-selectin gene in essential hypertension: a case-control study.Eur J Clin Invest. 2018 Jan;48(1). doi: 10.1111/eci.12868. Epub 2017 Dec 13.
73 Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension.Hypertension. 2001 Aug;38(2):204-9. doi: 10.1161/01.hyp.38.2.204.
74 Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension.Kidney Blood Press Res. 2012;35(6):477-82. doi: 10.1159/000337370. Epub 2012 Jun 8.
75 Lower prevalence of the OCT2 Ser270 allele in patients with essential hypertension.Clin Exp Hypertens. 2006 Oct;28(7):645-53. doi: 10.1080/10641960600946411.
76 Association of SLC6A9 gene variants with human essential hypertension.J Atheroscler Thromb. 2009 Jun;16(3):201-6. doi: 10.5551/jat.e125. Epub 2009 Jun 25.
77 Association of the gene polymorphisms of BMPR2, ACVRL1, SMAD9 and their interactions with the risk of essential hypertension in the Chinese Han population.Biosci Rep. 2019 Jan 25;39(1):BSR20181217. doi: 10.1042/BSR20181217. Print 2019 Jan 31.
78 Association of with-no-lysine kinase 1 and Serine/Threonine kinase 39 gene polymorphisms and haplotypes with essential hypertension in Tibetans.Environ Mol Mutagen. 2018 Mar;59(2):151-160. doi: 10.1002/em.22140. Epub 2017 Sep 25.
79 Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension.J Physiol. 2017 Mar 1;595(5):1497-1513. doi: 10.1113/JP273327. Epub 2016 Dec 29.
80 Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China.J Int Med Res. 2006 May-Jun;34(3):272-83. doi: 10.1177/147323000603400306.
81 Susceptiveness of Vitamin K epOxide Reductase Complex Subunit 1 Gene Polymorphism in Essential Hypertension.Genet Test Mol Biomarkers. 2017 May;21(5):292-297. doi: 10.1089/gtmb.2016.0311. Epub 2017 Mar 10.
82 Association of WNK1 exon 1 polymorphisms with essential hypertension in Hani and Yi minorities of China.J Genet Genomics. 2011 Apr 20;38(4):165-71. doi: 10.1016/j.jgg.2011.03.004. Epub 2011 Apr 13.
83 Single nucleotide polymorphism of adiponectin +276 G/T is associated with the susceptibility to essential hypertension in a Turkish population.Clin Exp Hypertens. 2016;38(8):686-690. doi: 10.1080/10641963.2016.1200607. Epub 2016 Dec 9.
84 ADRB3 Gene Trp64Arg Polymorphism and Essential Hypertension: A Meta-Analysis Including 9,555 Subjects.Front Genet. 2018 Apr 4;9:106. doi: 10.3389/fgene.2018.00106. eCollection 2018.
85 Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals.Hypertens Res. 2014 Dec;37(12):1068-74. doi: 10.1038/hr.2014.124. Epub 2014 Aug 7.
86 Neprilysin Inhibitors and Bradykinin.Front Med (Lausanne). 2018 Sep 19;5:257. doi: 10.3389/fmed.2018.00257. eCollection 2018.
87 GNB3 C825T and ACE I/D polymorphisms on the sodium-proton exchanger and the prevalence of essential hypertension in males.Arch Med Res. 2006 Jan;37(1):150-7. doi: 10.1016/j.arcmed.2005.05.012.
88 Catestatin: A Master Regulator of Cardiovascular Functions.Curr Med Chem. 2018;25(11):1352-1374. doi: 10.2174/0929867324666170425100416.
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91 The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population.Clin Exp Hypertens. 2017;39(4):306-311. doi: 10.1080/10641963.2016.1246562. Epub 2017 May 17.
92 Endothelin 1 type a receptor antagonism prevents vascular dysfunction and hypertension induced by 11beta-hydroxysteroid dehydrogenase inhibition: role of nitric oxide.Circulation. 2001 Jun 26;103(25):3129-35. doi: 10.1161/01.cir.103.25.3129.
93 Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects.Hypertens Res. 2008 Sep;31(9):1719-26. doi: 10.1291/hypres.31.1719.
94 Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians.BMC Med Genet. 2005 Dec 2;6:41. doi: 10.1186/1471-2350-6-41.
95 Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.Eur J Endocrinol. 2010 Oct;163(4):671-80. doi: 10.1530/EJE-10-0428. Epub 2010 Jul 21.
96 Associations of CYP4A11 gene-gene and gene-smoking interactions with essential hypertension in the male eastern Chinese Han population.Clin Exp Hypertens. 2017;39(5):448-453. doi: 10.1080/10641963.2016.1267201. Epub 2017 May 23.
97 Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension.J Hypertens. 2004 Oct;22(10):1903-7. doi: 10.1097/00004872-200410000-00012.
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99 CLCNKB-T481S and essential hypertension in a Ghanaian population.J Hypertens. 2009 Feb;27(2):298-304. doi: 10.1097/hjh.0b013e3283140c9e.
100 The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension.Hypertens Res. 2012 May;35(5):507-12. doi: 10.1038/hr.2011.213. Epub 2011 Dec 8.
101 Novel genetic variation in exon 28 of FBN1 gene is associated with essential hypertension.Am J Hypertens. 2011 Jun;24(6):687-93. doi: 10.1038/ajh.2011.21. Epub 2011 Feb 17.
102 Association between the C3F-gene and essential hypertension.Clin Sci (Lond). 1981 Dec;61 Suppl 7:363s-365s. doi: 10.1042/cs061363s.
103 Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery.Atherosclerosis. 1997 Jul 25;132(2):215-9. doi: 10.1016/s0021-9150(97)00089-0.
104 Lack of association of functional variants in alpha-ENaC gene and essential hypertension in two ethnic groups in China.Kidney Blood Press Res. 2008;31(4):268-73. doi: 10.1159/000151286. Epub 2008 Aug 15.
105 Association of SCNN1B promoter methylation with essential hypertension.Mol Med Rep. 2016 Dec;14(6):5422-5428. doi: 10.3892/mmr.2016.5905. Epub 2016 Oct 31.
106 Genetic association of rs1800780 (AG) polymorphism of the eNOS gene with susceptibility to essential hypertension in a Chinese Han population.Biochem Genet. 2014 Feb;52(1-2):71-8. doi: 10.1007/s10528-013-9628-3. Epub 2013 Nov 29.
107 Endothelial Gata5 transcription factor regulates blood pressure.Nat Commun. 2015 Nov 30;6:8835. doi: 10.1038/ncomms9835.
108 Association of genetic polymorphisms of ACADSB and COMT with human hypertension.J Hypertens. 2007 Jan;25(1):103-10. doi: 10.1097/HJH.0b013e3280103a40.
109 Polymorphisms in four candidate genes in young patients with essential hypertension.Acta Paediatr. 2006 Mar;95(3):353-8. doi: 10.1080/08035250500434777.
110 Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients.Genet Mol Res. 2016 Jun 20;15(2). doi: 10.4238/gmr.15026241.
111 A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility.Pharmacogenet Genomics. 2017 Feb;27(2):57-69. doi: 10.1097/FPC.0000000000000261.
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113 The human ATF1 rs11169571 polymorphism increases essential hypertension risk through modifying miRNA binding.FEBS Lett. 2015 Jul 22;589(16):2087-93. doi: 10.1016/j.febslet.2015.06.029. Epub 2015 Jul 3.
114 Association of ATP1B1 single-nucleotide polymorphisms with blood pressure and hypertension in a Chinese population.Clin Chim Acta. 2009 Sep;407(1-2):47-50. doi: 10.1016/j.cca.2009.06.026. Epub 2009 Jun 27.
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116 Mitochondrial DNA 7908-8816 region mutations in maternally inherited essential hypertensive subjects in China.BMC Med Genomics. 2018 Oct 16;11(1):89. doi: 10.1186/s12920-018-0408-0.
117 Association of single nucleotide polymorphisms in the 5' upstream region of the C4BPA gene with essential hypertension in a northeastern Han Chinese population.Mol Med Rep. 2017 Aug;16(2):1289-1297. doi: 10.3892/mmr.2017.6736. Epub 2017 Jun 9.
118 Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study.Pharmacogenomics. 2014 Sep;15(13):1643-52. doi: 10.2217/pgs.14.119.
119 Association of CAPN10 gene with insulin sensitivity, glucose tolerance and renal function in essential hypertensive patients.Clin Chim Acta. 2010 Aug 5;411(15-16):1126-31. doi: 10.1016/j.cca.2010.04.012. Epub 2010 Apr 18.
120 High sodium-low potassium environment and hypertension.Am J Cardiol. 1976 Nov 23;38(6):768-85. doi: 10.1016/0002-9149(76)90356-8.
121 Effects of sodium nitrite on renal function and blood pressure in hypertensive vs. healthy study participants: a randomized, placebo-controlled, crossover study.J Hypertens. 2018 Mar;36(3):666-679. doi: 10.1097/HJH.0000000000001598.
122 A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese population.Clin Exp Hypertens. 2012;34(5):377-82. doi: 10.3109/10641963.2012.665538. Epub 2012 Apr 3.
123 A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension.J Hypertens. 2007 Aug;25(8):1620-6. doi: 10.1097/HJH.0b013e3281ac211d.
124 rs10719 Polymorphism Located within DROSHA 3'-Untranslated Region is Responsible for Development of Primary Hypertension by Disrupting Binding with microRNA-27b.Med Sci Monit. 2017 Feb 19;23:911-918. doi: 10.12659/msm.897607.
125 Association of intronic single-nucleotide polymorphisms in the EMILIN1 gene with essential hypertension in a Chinese population.J Hum Hypertens. 2012 Sep;26(9):553-61. doi: 10.1038/jhh.2011.68. Epub 2011 Jul 14.
126 Expression level of fibroblast growth factor 5 (FGF5) in the peripheral blood of primary hypertension and its clinical significance.Saudi J Biol Sci. 2018 Mar;25(3):469-473. doi: 10.1016/j.sjbs.2017.11.043. Epub 2017 Nov 16.
127 Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension.Clin Genet. 2003 Nov;64(5):433-8. doi: 10.1034/j.1399-0004.2003.00148.x.
128 Association of TSC gene variants and hypertension in Mongolian and Han populations.Genet Mol Res. 2011 May 17;10(2):902-9. doi: 10.4238/vol10-2gmr1227.
129 The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy.J Am Soc Nephrol. 2006 Apr;17(4 Suppl 2):S115-9. doi: 10.1681/ASN.2005121340.
130 Association between single nucleotide polymorphisms of the G-protein 5 subunit and the risk of essential hypertension in the population of Poland.Pol Arch Med Wewn. 2015;125(12):903-9. doi: 10.20452/pamw.3207. Epub 2015 Nov 16.
131 A haplotype of the GOSR2 gene is associated with essential hypertension in Japanese men.Clin Biochem. 2013 Jun;46(9):760-5. doi: 10.1016/j.clinbiochem.2012.12.021. Epub 2013 Jan 11.
132 Effects of high and low sodium diet on blood pressure and heart rate in mice lacking the functional grainyhead-like 1 gene.Physiol Res. 2017 Mar 31;66(1):163-165. doi: 10.33549/physiolres.933298. Epub 2016 Oct 26.
133 Explorative genetic association study of GSTT2B copy number variant in complex disease risks.Ann Hum Biol. 2016 May;43(3):279-84. doi: 10.3109/03014460.2015.1049206. Epub 2015 Jul 24.
134 Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension.Hypertens Res. 2007 Sep;30(9):789-96. doi: 10.1291/hypres.30.789.
135 Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study.Medicine (Baltimore). 2017 Feb;96(5):e6052. doi: 10.1097/MD.0000000000006052.
136 Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain).J Hum Hypertens. 2005 Aug;19(8):615-22. doi: 10.1038/sj.jhh.1001872.
137 Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.J Med Genet. 2007 Sep;44(9):603-5. doi: 10.1136/jmg.2007.049718. Epub 2007 Jun 8.
138 Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics.BMC Genomics. 2019 May 21;20(1):395. doi: 10.1186/s12864-019-5772-4.
139 Association between killer cell immunoglobulin-like receptor 2DS5 gene with essential hypertension in the Chinese Han patients.Int J Immunogenet. 2017 Dec;44(6):343-349. doi: 10.1111/iji.12342. Epub 2017 Nov 3.
140 Global DNA methylation changes in blood of patients with essential hypertension.Med Sci Monit. 2010 Mar;16(3):CR149-155.
141 Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene.Hypertension. 2006 Nov;48(5):883-91. doi: 10.1161/01.HYP.0000244085.52918.a0. Epub 2006 Oct 2.
142 Association of mitofusin 2 methylation and essential hypertension: a case-control study in a Chinese population.Hypertens Res. 2018 Aug;41(8):605-613. doi: 10.1038/s41440-018-0057-x. Epub 2018 Jun 7.
143 The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension.PLoS One. 2015 Aug 14;10(8):e0135526. doi: 10.1371/journal.pone.0135526. eCollection 2015.
144 Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population.BMC Med Genet. 2019 Jul 5;20(1):121. doi: 10.1186/s12881-019-0838-3.
145 Gender difference in association of NEDD4L gene variants among southern Han Chinese with essential hypertension - a population-based case-control study.Clin Exp Hypertens. 2014;36(5):309-14. doi: 10.3109/10641963.2013.827693. Epub 2013 Sep 18.
146 beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine.J Hypertens. 2004 Oct;22(10):1917-25. doi: 10.1097/00004872-200410000-00014.
147 Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population.PLoS One. 2013 Oct 11;8(10):e77562. doi: 10.1371/journal.pone.0077562. eCollection 2013.
148 Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells.Redox Biol. 2014 Feb 22;2:570-9. doi: 10.1016/j.redox.2014.01.020. eCollection 2014.
149 Association of Polymorphisms in the Atrial Natriuretic Factor Gene with the Risk of Essential Hypertension: A Systematic Review and Meta-Analysis.Int J Environ Res Public Health. 2016 Apr 29;13(5):458. doi: 10.3390/ijerph13050458.
150 Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients.J Hum Hypertens. 2018 Sep;32(8-9):564-571. doi: 10.1038/s41371-018-0077-7. Epub 2018 Jun 5.
151 Haplotype-based, case-control study of the receptor (calcitonin) activity-modifying protein (RAMP) 1 gene in essential hypertension.J Hum Hypertens. 2017 May;31(5):361-365. doi: 10.1038/jhh.2016.96. Epub 2017 Feb 9.
152 Predisposition to essential hypertension and renal hemodynamics in recent-onset insulin-dependent diabetic patients.J Am Soc Nephrol. 1992 Oct;3(4 Suppl):S34-40. doi: 10.1681/ASN.V34s34.
153 Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations.Genet Mol Res. 2015 Dec 21;14(4):17641-50. doi: 10.4238/2015.December.21.37.
154 Association of genetic polymorphisms of endothelin-converting enzyme-1 gene with hypertension in a Japanese population and rare missense mutation in preproendothelin-1 in Japanese hypertensives.Hypertens Res. 2007 Jun;30(6):513-20. doi: 10.1291/hypres.30.513.
155 Serum concentration of renin-angiotensin system components in association with ACE I/D polymorphism among hypertensive subjects in response to ACE inhibitor therapy.Clin Exp Hypertens. 2019;41(7):662-669. doi: 10.1080/10641963.2018.1529782. Epub 2018 Oct 11.
156 The association between the polymorphisms in a sodium channel gene SCN7A and essential hypertension: a case-control study in the Northern Han Chinese.Ann Hum Genet. 2015 Jan;79(1):28-36. doi: 10.1111/ahg.12085. Epub 2014 Nov 13.
157 Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.J Clin Lab Anal. 2019 Mar;33(3):e22712. doi: 10.1002/jcla.22712. Epub 2018 Nov 9.
158 Haplotype of smoothelin gene associated with essential hypertension.Hereditas. 2012 Oct;149(5):178-85. doi: 10.1111/j.1601-5223.2012.02242.x. Epub 2012 Oct 18.
159 Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.J Biol Chem. 2013 Jan 4;288(1):152-63. doi: 10.1074/jbc.M112.428458. Epub 2012 Nov 14.
160 Association of two well-defined polymorphisms in leptin and leptin receptor genes with hypertension and circulating leptin: a meta-analysis.Arch Med Res. 2015 Jan;46(1):38-46. doi: 10.1016/j.arcmed.2014.11.012. Epub 2014 Dec 2.
161 Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis.Genet Mol Res. 2012 Sep 26;11(3):3511-7. doi: 10.4238/2012.September.26.7.
162 Polymorphisms of the TGFBRAP1 gene in relation to blood pressure variability and plasma TGF-1.Clin Exp Hypertens. 2015;37(5):420-5. doi: 10.3109/10641963.2015.1013113. Epub 2015 Apr 9.
163 TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance.Cell Metab. 2011 Aug 3;14(2):231-41. doi: 10.1016/j.cmet.2011.05.011.
164 Correlation of Salusin Beta with hs-CRP and ADMA in Hypertensive Children and Adolescents.Curr Pharm Des. 2018;24(30):3551-3557. doi: 10.2174/1381612824666180607124531.
165 Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade.Pharmacogenomics J. 2016 Feb;16(1):3-9. doi: 10.1038/tpj.2015.6. Epub 2015 Mar 3.