Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4SOAW)

• Drug Name: URSOLIC ACID Drug Info
• Synonyms: Ursolic acid; Prunol; Malol; Urson; 77-52-1; 3beta-Hydroxyurs-12-en-28-oic acid; (3beta)-3-Hydroxyurs-12-en-28-oic acid; 3beta-Hydroxy-12-ursen-28-ic acid; UNII-P3M2575F3F; CHEBI:9908; CCRIS 7123; EINECS 201-034-0; CHEMBL169; Merotaine; AI3-03109; NSC4060; P3M2575F3F; NSC-4060; Urs-12-en-28-oic acid, 3-hydroxy-, (3beta)-; HNMR; .beta.-Ursolic acid; NSC 4060; NSC 167406

Indication

Disease Entry	ICD 11	Status	REF
Metabolic syndrome x	5C50-5D2Z	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 64945
  ChEBI ID: CHEBI:9908
  CAS Number: CAS 77-52-1
  TTD Drug ID: DM4SOAW

Molecule-Related Drug Atlas

Drug(s) Targeting Phospholipase A2 (PLA2G1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[14]
Miltefosine	DMND304	Chronic urticaria		Approved	[15]
Clocortolone	DM9ZMQH	Exanthem		Approved	[16]
Clobetasol	DMUXP52	Rosacea	ED90.0	Approved	[17]
Diflorasone	DMI9PRJ	Exanthem		Approved	[18]
AllerB	DM78DOT	Allergy	4A80-4A85	Phase 2b	[19]
MANOALIDE	DMB4A8I	Arthritis	FA20	Phase 2	[20]
MRX-4	DMQZWYE	Allergic rhinitis	CA08.0	Phase 2	[21]
MRX-6	DMLVQKF	Contact dermatitis	EK0Z	Phase 2	[22]
Varespladib	DM5JJ83	Snakebite	N.A.	Phase 2	[23]

Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[25]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[26]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[27]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[25]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[28]
Penciclovir	DMOUMDV	Herpes simplex labialis	1F00.01	Approved	[29]
Famciclovir	DMJHLSD	Meniere disease	AB31.0	Approved	[30]
Valacyclovir Hydrochloride	DM5I1CE	Herpes simplex virus infection	1F00	Approved	[25]
Foscavir	DM9KJLZ	Cytomegalovirus retinitis	9B72.00	Approved	[28]

Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GLYCYRRHIZIN	DM8M2N3	Influenza virus infection	1E30-1E32	Phase 3	[31]
BVT.2733	DM6RUKX	Lupus	4A40	Phase 3	[32]
INCB13739	DMLQ3PO	Type-2 diabetes	5A11	Phase 2a	[33]
JTT-654	DM50M2R	Type-2 diabetes	5A11	Phase 2	[34]
RG-4929	DMT4QRD	Metabolic disorder	5C50-5D2Z	Phase 2	[34]
BMS-770767	DMTVGY7	Hypercholesterolaemia	5C80.0	Phase 2	[34]
UE-2343	DMIERPK	Alzheimer disease	8A20	Phase 2	[35]
AZD-4017	DML9M5S	Ocular hypertension	9C61.01	Phase 2	[34]
Xanamem	DM580GT	Alzheimer disease	8A20	Phase 1/2	[36]
BMS-816336	DM2WMJ7	Lipid metabolism disorder	5C52.Z	Phase 1	[37]

Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
TRYPAN BLUE	DM4NTMO	Ophthalmic surgery injury	PK97	Approved	[39]
ISIS 113715	DMUPD4G	Type-2 diabetes	5A11	Phase 2	[40]
ISIS-PTP1Brx	DMJGVXT	Type-2 diabetes	5A11	Phase 2	[41]
ERTIPROTAFIB	DMJXEV7	Type-2 diabetes	5A11	Terminated	[42]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[14]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[14]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[14]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[14]
1,2-NAPHTHOQUINONE	DMYXELH	Discovery agent	N.A.	Investigative	[43]

Drug(s) Targeting Glycogen phosphorylase muscle form (GP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JTT-651	DMGP42Q	Type-2 diabetes	5A11	Discontinued in Phase 1	[44]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[14]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[14]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[14]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[14]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[14]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[14]
OLEANOLIC_ACID	DMWDMJ3	Discovery agent	N.A.	Investigative	[45]
Oleanonic acid	DMYPJC3	Discovery agent	N.A.	Investigative	[45]
Nojirimycine Tetrazole	DMYZRTB	Discovery agent	N.A.	Investigative	[46]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[48]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[49]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[50]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[51]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[52]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[53]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[52]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[48]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[54]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[61]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[58]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[69]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[70]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[75]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[76]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[56]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[61]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[86]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[87]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[88]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[88]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[90]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[93]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[94]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[95]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[96]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[97]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[98]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[99]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[100]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[101]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[102]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[103]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[104]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[102]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[112]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[113]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[117]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[118]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[119]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[118]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[120]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[123]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[125]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[126]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[127]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[128]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[129]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[130]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[133]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[134]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[135]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[138]

Drug(s) Affected By DNA topoisomerase 1 (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Selenium	DM25CGV	N. A.	N. A.	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[146]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[148]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[152]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[154]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[157]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[165]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[168]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[172]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[173]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[175]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[176]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[178]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[179]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[180]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[184]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[188]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[130]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[190]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[191]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Selenium	DM25CGV	N. A.	N. A.	Approved	[140]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[194]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[195]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[197]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[119]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[202]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[203]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[210]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[211]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[130]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[214]
Selenium	DM25CGV	N. A.	N. A.	Approved	[140]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[215]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[194]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[217]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[56]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[218]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[134]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[221]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[148]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[224]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[225]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[119]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[226]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[227]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[180]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[194]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[232]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[235]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[236]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[237]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[238]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[241]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[242]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[243]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[191]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[225]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[244]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[245]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[247]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[252]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[254]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[255]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[261]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[262]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[130]
Selenium	DM25CGV	N. A.	N. A.	Approved	[140]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[263]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[264]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[267]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[123]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[242]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[127]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[268]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[252]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[270]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[119]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[274]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[275]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[276]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[194]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[280]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[281]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[284]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[285]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[286]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[140]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[290]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[295]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[296]

Drug(s) Affected By Sigma non-opioid intracellular receptor 1 (SIGMAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[172]
Bortezomib	DMNO38U	Leukemia		Approved	[298]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[299]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[300]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[301]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[283]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[301]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[56]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[61]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[303]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[117]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[308]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[2]
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[3]
Herpes simplex virus DNA polymerase UL30 (HSV UL30)	TTIU7X1	DPOL_HHV11	Inhibitor	[4]
Phospholipase A2 (PLA2G1B)	TT9V5JH	PA21B_HUMAN	Inhibitor	[5]
PTPN1 messenger RNA (PTPN1 mRNA)	TTELIN2	PTN1_HUMAN	Inhibitor	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[7]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Post-Translational Modifications	[8]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[9]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[10]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Drug Response	[11]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[12]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[11]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[13]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[13]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Gene/Protein Processing	[8]

References

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• [2] 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.
• [3] Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8.
• [4] DNA polymerase beta inhibitors from Baeckea gunniana. J Nat Prod. 1999 Dec;62(12):1624-6.
• [5] Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.
• [6] Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
• [7] Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines. Toxicol In Vitro. 2011 Oct;25(7):1274-80. doi: 10.1016/j.tiv.2011.04.014. Epub 2011 Apr 20.
• [8] Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. Chem Biol Interact. 2014 Jul 25;218:28-41. doi: 10.1016/j.cbi.2014.04.017. Epub 2014 May 5.
• [9] Molecular mechanism of ursolic acid induced apoptosis in poorly differentiated endometrial cancer HEC108 cells. Oncol Rep. 2005 Aug;14(2):507-12.
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