Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9X2D0)

• Drug Name: Calphostin C Drug Info
• Synonyms: calphostin C; CHEMBL460433; UNII-I271P23G24; I271P23G24; CHEMBL1256495; Ucn 1028 C; UCN 1028C; BSPBio_001520; GTPL5156; SCHEMBL15185703; HSDB 7592; SRJYZPCBWDVSGO-NHCUHLMSSA-N; HMS1989L22; HMS3402L22; HMS1791L22; BDBM213748; Carbonic acid, 2-(12-(2-(benzoyloxy)propyl)-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl)-1-methylethyl 4-hydroxyphenyl ester; Carbonic acid, (1R)-2-(12-((2R)-2-(benzoyloxy)propyl)-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl)-1-methylethyl 4-hydroxy
• Cross-matching ID:
  PubChem CID: 2533
  CAS Number: CAS 121263-19-2
  TTD Drug ID: DM9X2D0
  VARIDT Drug ID: DR01427

Molecule-Related Drug Atlas

Drug(s) Targeting Protein kinase C (PRKC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Synthetic hypericin	DMXU4ON	Virus infection	1A24-1D9Z	Phase 3	[4]
APH-0812	DM756GE	Human immunodeficiency virus-1 infection	1C62	Phase 2	[5]
CYCLOPLATAM	DMXR8WN	Solid tumour/cancer	2A00-2F9Z	Phase 2	[6]
AEB07	DMJVN89	Transplant rejection	NE84	Phase 2	[7]
HO/03/03	DMA6HQJ	Diabetic foot ulcer	BD54	Phase 2	[8]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[9]
LXS196	DM65MEL	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[10]
SAFINGOL	DMBGUDR	Psoriasis vulgaris	EA90	Phase 1	[11]
GCC-1290K	DMJ7WRI	Parkinson disease	8A00.0	Phase 1	[12]
AEB701	DM8I4G0	Melanoma	2C30	Phase 1	[13]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[2]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[16]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[19]

Drug(s) Affected By B-cell CLL/lymphoma 9 protein (BCL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[24]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[26]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-1 (DVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[33]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[34]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[35]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[28]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-2 (DVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[36]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[38]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Axin-1 (AXIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[34]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[28]
Daporinad	DMCU74R	leukaemia	2A60-2B33	Phase 2	[44]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[48]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[59]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]

Drug(s) Affected By GSK-3-binding protein FRAT2 (FRAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[70]

Drug(s) Affected By CCN family member 4 (CCN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[71]
Indomethacin	DMSC4A7	Bursitis		Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]

Drug(s) Affected By BAG family molecular chaperone regulator 2 (BAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[82]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[88]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[89]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]

Drug(s) Affected By Gastrin (GAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Terbutaline	DMD4381	Asthma	CA23	Approved	[94]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[93]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[93]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[96]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[35]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[105]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[48]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[109]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[110]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[109]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[111]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[125]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[126]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[129]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[80]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[134]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[135]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[145]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[146]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[148]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[80]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[149]

Drug(s) Affected By Cysteine-rich secretory protein 2 (CRISP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[150]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[152]

Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[71]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[155]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[153]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[156]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[157]

Drug(s) Affected By Homeobox protein engrailed-2 (EN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[158]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[159]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[160]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[164]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[168]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Selenium	DM25CGV	N. A.	N. A.	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[180]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[183]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[46]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[49]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[186]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[110]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[187]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[190]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[191]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[192]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[193]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[194]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[195]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[196]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[197]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[186]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[204]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[205]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[139]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[211]

Drug(s) Affected By Cysteine-rich secretory protein 1 (CRISP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[212]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[213]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[214]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[215]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[48]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[218]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[219]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[220]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[226]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[227]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[231]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[228]

Drug(s) Affected By Frizzled-2 (FZD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[141]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[234]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[235]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[236]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]

Drug(s) Affected By Proto-oncogene FRAT1 (FRAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[70]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[240]

Drug(s) Affected By Frizzled-1 (FZD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[187]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[36]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[187]

Drug(s) Affected By F-box/WD repeat-containing protein 1A (BTRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[241]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[242]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[243]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[244]
Mepacrine	DMU8L7C	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By Axin-2 (AXIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[155]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[246]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[247]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein kinase C (PRKC)	TTYVX59	NOUNIPROTAC	Inhibitor	[1]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Axin-1 (AXIN1)	OTRGZGZ5	AXIN1_HUMAN	Gene/Protein Processing	[3]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Gene/Protein Processing	[3]
B-cell CLL/lymphoma 9 protein (BCL9)	OTRBIPR4	BCL9_HUMAN	Gene/Protein Processing	[3]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[3]
BAG family molecular chaperone regulator 2 (BAG2)	OTI6LD27	BAG2_HUMAN	Gene/Protein Processing	[3]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[3]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[3]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Protein Interaction/Cellular Processes	[3]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Protein Interaction/Cellular Processes	[3]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[3]

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