Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ4Z6E)

Drug Name
ISORHAMNETIN Drug Info
Synonyms
Isorhamnetin; 480-19-3; 3-Methylquercetin; Isorhamnetol; 3'-Methoxyquercetin; 3'-Methoxy-3,4',5,7-tetrahydroxyflavone; isorhamnetine; 3'-Methylquercetin; C.I. 75680; 3-Methylquercetine; UNII-07X3IB4R4Z; CCRIS 3791; C16H12O7; EINECS 207-545-5; Flavone, 3'-methoxy-3,4',5,7-tetrahydroxy-; BRN 0044723; 3,5,7,4'-Tetrahydroxy-3'-methoxyflavone; CHEMBL379064; CHEBI:6052; 07X3IB4R4Z
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281654
ChEBI ID
CHEBI:6052
CAS Number
CAS 480-19-3
TTD Drug ID
DMQ4Z6E

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [7]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [8]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [9]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [9]
MORIN DM2OGZ5 Discovery agent N.A. Investigative [2]
3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 Discovery agent N.A. Investigative [2]
(-)-CATECHINGALLATE DMZOGSK Discovery agent N.A. Investigative [2]
Thiolactomycin DMBAWDG Malaria 1F40-1F45 Investigative [7]
GALLOCATECHIN GALLATE DMX2084 Discovery agent N.A. Investigative [2]
Diazaborines DM5UFZX Discovery agent N.A. Investigative [10]
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Drug(s) Targeting Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [2]
Chrysin DM7V2LG Discovery agent N.A. Investigative [2]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [2]
MORIN DM2OGZ5 Discovery agent N.A. Investigative [2]
3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 Discovery agent N.A. Investigative [2]
(-)-CATECHINGALLATE DMZOGSK Discovery agent N.A. Investigative [2]
2-Hexadecynoic acid DMTFIPZ Discovery agent N.A. Investigative [11]
GALLOCATECHIN GALLATE DMX2084 Discovery agent N.A. Investigative [2]
NADPH DM75Q34 Discovery agent N.A. Investigative [12]
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Drug(s) Targeting Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PINOCEMBRIN DM96VWD N. A. N. A. Phase 2 [1]
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [1]
Chrysin DM7V2LG Discovery agent N.A. Investigative [1]
APIGENIN DMI3491 Discovery agent N.A. Investigative [1]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [1]
ACACETIN DMQOB0X Discovery agent N.A. Investigative [1]
TRISMETHOXYRESVERATROL DM6USPC Discovery agent N.A. Investigative [13]
Galangin DM5TQ2O Discovery agent N.A. Investigative [1]
CHRYSOERIOL DM96ECL Discovery agent N.A. Investigative [1]
DIOSMETIN DM4KXIM Discovery agent N.A. Investigative [1]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [183]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [184]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [185]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [186]
Estrone DM5T6US Acne vulgaris ED80 Approved [187]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [188]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [189]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [190]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [191]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [70]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [14]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [15]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [18]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [19]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [20]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [21]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
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Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [26]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Panobinostat DM58WKG Chronic graft versus host disease Approved [30]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [31]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [32]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [24]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [33]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [34]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [35]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [36]
Cepharanthine DM9Y5JB N. A. N. A. Approved [37]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [38]
Clozapine DMFC71L Schizophrenia 6A20 Approved [39]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [40]
Trifluoperazine DMKBYWI Anxiety Approved [41]
Olanzapine DMPFN6Y Bipolar depression Approved [39]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [44]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [45]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [46]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [47]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [48]
Capsaicin DMGMF6V Back pain ME84.Z Approved [49]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [50]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [55]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [54]
Estrone DM5T6US Acne vulgaris ED80 Approved [59]
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Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [6]
Estrone DM5T6US Acne vulgaris ED80 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [62]
Testosterone DM7HUNW Hot flushes GA30 Approved [65]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [66]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [67]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [70]
Verapamil DMA7PEW Angina pectoris BA40 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [74]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [75]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Gefitinib DM15F0X Colon adenocarcinoma Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [81]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [82]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [83]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [82]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [87]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [88]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [89]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [90]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Verapamil DMA7PEW Angina pectoris BA40 Approved [92]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [93]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [95]
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Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [99]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [100]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [101]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [102]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [103]
Folic Acid DMEMBJC Colorectal carcinoma Approved [104]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [105]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [106]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [108]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Selenium DM25CGV N. A. N. A. Approved [111]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [112]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [113]
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Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [114]
Folic Acid DMEMBJC Colorectal carcinoma Approved [115]
Methotrexate DM2TEOL Anterior urethra cancer Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [117]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [118]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [119]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [120]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [121]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [122]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [122]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [123]
Quercetin DM3NC4M Obesity 5B81 Approved [124]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [126]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [127]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [129]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [130]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [131]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [132]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [133]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [134]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [135]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [136]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [137]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [138]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [139]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [140]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [141]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [142]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [143]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [93]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [144]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [81]
Meloxicam DM2AR7L Arthritis FA20 Approved [146]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [147]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [148]
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Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [149]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [153]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [155]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
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Drug(s) Affected By Protein kinase C delta type (PRKCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [159]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [160]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [161]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [162]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [163]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [164]
Testosterone DM7HUNW Hot flushes GA30 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [167]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [168]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [169]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [81]
Selenium DM25CGV N. A. N. A. Approved [111]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [170]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [171]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [172]
Quercetin DM3NC4M Obesity 5B81 Approved [173]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [174]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Verapamil DMA7PEW Angina pectoris BA40 Approved [71]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Selenium DM25CGV N. A. N. A. Approved [111]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [178]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [179]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [180]
Quercetin DM3NC4M Obesity 5B81 Approved [181]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [182]
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Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [21]
Gefitinib DM15F0X Colon adenocarcinoma Approved [192]
Quercetin DM3NC4M Obesity 5B81 Approved [193]
Estrone DM5T6US Acne vulgaris ED80 Approved [194]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [195]
Testosterone DM7HUNW Hot flushes GA30 Approved [196]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [197]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [198]
Mestranol DMG3F94 Contraception QA21 Approved [199]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [200]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cytochrome P450 1B1 (CYP1B1) TTI84H7 CP1B1_HUMAN Inhibitor [1]
Plasmodium Enoyl-ACP reductase (Malaria fabI) TTNX2CS Q965D5_PLAFA Inhibitor [2]
Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) TTBE4IR Q965D6_PLAFA Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [3]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [3]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [5]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [4]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Protein Interaction/Cellular Processes [6]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Protein Interaction/Cellular Processes [6]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [3]

References

1 Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5.
2 Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
3 Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor activation pathway in gastric cancer. J Biol Chem. 2012 Nov 2;287(45):38028-40. doi: 10.1074/jbc.M112.388702. Epub 2012 Sep 19.
4 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease. Pharmacol Res. 2015 Oct;100:64-72.
5 Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells. Can J Physiol Pharmacol. 2009 Sep;87(9):674-83. doi: 10.1139/y09-061.
6 Estrogenic activities of Ginkgo biloba extracts. Life Sci. 2004 Jan 30;74(11):1325-35. doi: 10.1016/j.lfs.2003.06.045.
7 Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
8 Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
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