Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXO6YH)

• Drug Name: PJ34 Drug Info
• Synonyms: PJ34; 344458-19-1; pj-34; N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE; CHEMBL372303; P34; 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide; Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-; UYJZZVDLGDDTCL-UHFFFAOYSA-N; PJ34(free base); 1xk9; SCHEMBL422317; ZINC8960; AC1L1J45; BDBM27497; CTK1B7701; MolPort-035-395-737; Ibrutinib (PCI32765 pound(c); HMS3651B06; BCP07990; HY-13688A; 2662AH; AKOS030229047; SB19292; DB08348; CS-1463; NCGC00370866-10; DA-42692; BC600341

Indication

Disease Entry	ICD 11	Status	REF
Coronavirus infection	1D92	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 4858
  TTD Drug ID: DMXO6YH

Molecule-Related Drug Atlas

Drug(s) Targeting Poly [ADP-ribose] polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[9]
KU-0058948	DMSA4HZ	Ovarian cancer	2C73	Approved	[10]
Niraparib Tosylate	DMLPSWQ	Fallopian tube cancer	2C74	Approved	[11]
CC-486	DMTNQB0	Acute myeloid leukaemia	2A60	Phase 3	[12]
Nicaraven	DMFBNA3	Cerebrovascular disease	8B2Z	Phase 3	[13]
PMID27841036-Compound-37	DM0OVZ2	Ovarian cancer	2C73	Phase 2	[14]
Stenoparib	DMKVBL8	Ovarian cancer	2C73	Phase 2	[15]
AG140699	DMA9FKY	Melanoma	2C30	Phase 2	[16]
AZD5305	DMW9R1C	Prostate cancer	2C82.0	Phase 2	[17]
AMXI 5001	DMR9H6B	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[18]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[22]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[23]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[25]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]

Drug(s) Affected By Diacylglycerol O-acyltransferase 1 (DGAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[35]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]

Drug(s) Affected By Transient receptor potential cation channel subfamily M member 2 (TRPM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[42]

Drug(s) Affected By Poly polymerase tankyrase-1 (TNKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[48]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[49]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[56]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[57]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[62]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[63]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[78]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[81]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[82]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[83]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[84]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[85]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[86]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[87]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[88]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[99]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[100]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[104]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[23]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[109]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[114]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[123]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[126]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[51]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[136]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[138]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[149]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[87]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[154]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[56]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[159]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[162]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[163]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[20]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[23]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[166]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[109]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[167]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[170]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[62]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[171]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[174]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[175]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[176]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[123]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[179]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[138]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[187]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[191]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[196]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[197]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[83]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[85]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[22]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[200]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[202]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[204]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[60]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[145]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[207]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[208]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[209]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[212]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[214]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[216]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[217]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[78]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[176]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[83]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[84]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[97]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[198]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[218]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[109]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[22]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[204]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[222]

Drug(s) Affected By Nuclear mitotic apparatus protein 1 (NUMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[225]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[226]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[227]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[228]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[230]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[231]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[232]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[232]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[233]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[234]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[232]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[232]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[237]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[238]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP15 (PARP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[42]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[240]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP14 (PARP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[242]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[243]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[228]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[244]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[245]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[246]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[48]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[247]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP16 (PARP16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[231]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[42]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[251]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[252]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[254]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[255]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[256]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[254]

Drug(s) Affected By Diacylglycerol O-acyltransferase 2 (DGAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[34]

Drug(s) Affected By Kinesin-like protein KIFC1 (KIFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[225]

Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[262]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]

Drug(s) Affected By Poly polymerase tankyrase-2 (TNKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[263]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[264]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[265]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[266]

Drug(s) Affected By Poly polymerase 2 (PARP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[267]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[268]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[243]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP4 (PARP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[270]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[225]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[228]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[271]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP3 (PARP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[42]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[264]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[272]

Drug(s) Affected By Chimeric ERCC6-PGBD3 protein (ERCC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[273]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[274]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[277]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[282]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[284]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[285]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[287]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[286]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[288]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Poly [ADP-ribose] polymerase 1 (PARP1)	TTVDSZ0	PARP1_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[3]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[6]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[6]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[6]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Gene/Protein Processing	[7]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[8]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[6]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Protein Interaction/Cellular Processes	[6]

References

• [1] Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
• [2] Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med. 2001 Jan;7(1):108-13.
• [3] PARP-1 inhibitor modulate -catenin signaling to enhance cisplatin sensitivity in cancer cervix. Oncotarget. 2019 Jul 2;10(42):4262-4275. doi: 10.18632/oncotarget.27008. eCollection 2019 Jul 2.
• [4] PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts. Cardiovasc Res. 2009 Jan 1;81(1):98-107. doi: 10.1093/cvr/cvn264. Epub 2008 Sep 24.
• [5] Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells. J Hematol Oncol. 2015 Oct 23;8:117. doi: 10.1186/s13045-015-0217-2.
• [6] PARP inhibitor activates the intrinsic pathway of apoptosis in primary lung cancer cells. Cancer Invest. 2014 Aug;32(7):339-48. doi: 10.3109/07357907.2014.919303. Epub 2014 Jun 4.
• [7] PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R. Int J Oncol. 2015 Jan;46(1):223-32. doi: 10.3892/ijo.2014.2726. Epub 2014 Oct 23.
• [8] Effects of PARP-1 inhibitor and ERK inhibitor on epithelial mesenchymal transitions of the ovarian cancer SKOV3 cells. Pharmacol Rep. 2016 Dec;68(6):1225-1229. doi: 10.1016/j.pharep.2016.08.001. Epub 2016 Aug 2.
• [9] beta-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics. Nucleosides Nucleotides Nucleic Acids. 2009 Mar;28(3):238-59.
• [10] Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem. 2009 May 14;52(9):3108-11.
• [11] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
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