Details of the Drug Combination

General Information of Drug Combination (ID: DCZ1OBE)

Drug Combination Name
Acetic Acid, Glacial Proflavine
Indication
Disease Entry Status REF
Cervical Cancer Phase 1 [1]
Component Drugs Acetic Acid, Glacial   DM4SJ5Y Proflavine   DMF1X5P
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Acetic Acid, Glacial
Disease Entry ICD 11 Status REF
infection in the ear canal AA0Y Approved [2]
Acetic Acid, Glacial Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [5]
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Acetic Acid, Glacial Interacts with 148 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Activator of apoptosis harakiri (HRK) OTR4GWJ0 HRK_HUMAN Increases Expression [4]
Transcription factor E2F3 (E2F3) OT5VQMWY E2F3_HUMAN Increases Expression [4]
Programmed cell death protein 5 (PDCD5) OT6T2DDL PDCD5_HUMAN Decreases Expression [4]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [4]
Transcription regulator protein BACH1 (BACH1) OTY8004K BACH1_HUMAN Increases Expression [4]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Increases Expression [4]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [4]
Death-associated protein kinase 3 (DAPK3) OTLV7EKW DAPK3_HUMAN Increases Expression [4]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Increases Expression [4]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [4]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) OT5GR4Z2 SMCA5_HUMAN Decreases Expression [4]
HMG box-containing protein 1 (HBP1) OTDPGGDV HBP1_HUMAN Increases Expression [4]
DnaJ homolog subfamily B member 6 (DNAJB6) OTMHIIAN DNJB6_HUMAN Increases Expression [4]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Increases Expression [4]
E3 SUMO-protein ligase PIAS1 (PIAS1) OTZVAHZI PIAS1_HUMAN Increases Expression [4]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Decreases Expression [4]
Glutaminase kidney isoform, mitochondrial (GLS) OTGOZG2M GLSK_HUMAN Decreases Expression [4]
Elongator complex protein 1 (ELP1) OTYEWBF7 ELP1_HUMAN Decreases Expression [4]
RCC1 and BTB domain-containing protein 2 (RCBTB2) OTECBF4R RCBT2_HUMAN Decreases Expression [4]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Decreases Expression [4]
NAD kinase (NADK) OTYN9GX0 NADK_HUMAN Increases Expression [4]
Heat shock 70 kDa protein 4L (HSPA4L) OT181WZB HS74L_HUMAN Increases Expression [4]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [4]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [4]
Phosphoglycerate kinase 1 (PGK1) OT6V1ICH PGK1_HUMAN Increases Expression [4]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [4]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [4]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [4]
Metallothionein-1F (MT1F) OTZVUYG1 MT1F_HUMAN Increases Expression [4]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Increases Expression [4]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [4]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Increases Expression [4]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Increases Expression [4]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [4]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Increases Expression [4]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [4]
Metallothionein 1H-like protein 1 (MT1HL1) OTTB2N9F M1BL1_HUMAN Increases Expression [4]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [4]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Increases Expression [4]
Metallothionein-1G (MT1G) OTAV1OCR MT1G_HUMAN Increases Expression [4]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Increases Expression [4]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [4]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [4]
Neurofibromin (NF1) OTC29NHH NF1_HUMAN Increases Expression [4]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Increases Expression [4]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Increases Expression [4]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Decreases Expression [4]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Increases Expression [4]
Cell division cycle protein 27 homolog (CDC27) OTDT45XJ CDC27_HUMAN Increases Expression [4]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Increases Expression [4]
High affinity cationic amino acid transporter 1 (SLC7A1) OTR2ZVA8 CTR1_HUMAN Increases Expression [4]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [4]
Tumor necrosis factor ligand superfamily member 8 (TNFSF8) OTDYGDJ3 TNFL8_HUMAN Increases Expression [4]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [4]
Glycogen debranching enzyme (AGL) OTWBM7WY GDE_HUMAN Decreases Expression [4]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [4]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [4]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [4]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [4]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Decreases Expression [4]
Transcription activator BRG1 (SMARCA4) OT68WOPQ SMCA4_HUMAN Decreases Expression [4]
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) OTF3TBTK SSDH_HUMAN Increases Expression [4]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Increases Expression [4]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [4]
Selenoprotein W (SELENOW) OTVSKPAN SELW_HUMAN Increases Expression [4]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Increases Expression [4]
Metallothionein-1H (MT1H) OT0MVBM6 MT1H_HUMAN Increases Expression [4]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Increases Expression [4]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [4]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [4]
Transcription factor RelB (RELB) OTU3QYEF RELB_HUMAN Increases Expression [4]
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) OT1YFEP1 TNR17_HUMAN Decreases Expression [4]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Increases Expression [4]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Increases Expression [4]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Decreases Expression [4]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [4]
Cell division cycle protein 16 homolog (CDC16) OTB914M7 CDC16_HUMAN Decreases Expression [4]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [4]
DnaJ homolog subfamily C member 3 (DNAJC3) OT7ROIJF DNJC3_HUMAN Increases Expression [4]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Expression [4]
Serine/threonine-protein kinase ATR (ATR) OTH0OP1J ATR_HUMAN Decreases Expression [4]
Cullin-3 (CUL3) OTDNOAPM CUL3_HUMAN Decreases Expression [4]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [4]
Core-binding factor subunit beta (CBFB) OTIAC6W4 PEBB_HUMAN Increases Expression [4]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) OT5VYOSM IKKE_HUMAN Increases Expression [4]
Helicase-like transcription factor (HLTF) OTRX2OSF HLTF_HUMAN Decreases Expression [4]
Protein RRP5 homolog (PDCD11) OTS1NJK2 RRP5_HUMAN Decreases Expression [4]
Nuclear receptor subfamily 1 group D member 2 (NR1D2) OT9CVF41 NR1D2_HUMAN Increases Expression [4]
Metal cation symporter ZIP14 (SLC39A14) OTGR686L S39AE_HUMAN Increases Expression [4]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [4]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) OT25JBA3 F263_HUMAN Increases Expression [4]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) OTQYEXL2 F264_HUMAN Increases Expression [4]
S-adenosylmethionine sensor upstream of mTORC1 (BMT2) OTSMVQCU SAMTR_HUMAN Increases Expression [4]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Increases Expression [4]
Cyclin-J (CCNJ) OTCR4WVV CCNJ_HUMAN Decreases Expression [4]
Rho GTPase-activating protein 17 (ARHGAP17) OTEABPLV RHG17_HUMAN Decreases Expression [4]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [4]
Interferon regulatory factor 2-binding protein 2 (IRF2BP2) OTSSRRCA I2BP2_HUMAN Increases Expression [4]
Homeodomain-interacting protein kinase 1 (HIPK1) OTSEA8RS HIPK1_HUMAN Increases Expression [4]
T-cell activation Rho GTPase-activating protein (TAGAP) OTHJNNO2 TAGAP_HUMAN Increases Expression [4]
Protein PHTF2 (PHTF2) OTBLTYRJ PHTF2_HUMAN Increases Expression [4]
TNFAIP3-interacting protein 2 (TNIP2) OTDQWTUB TNIP2_HUMAN Decreases Expression [4]
Alanine aminotransferase 2 (GPT2) OTS5VF7N ALAT2_HUMAN Increases Expression [4]
General transcription factor 3C polypeptide 2 (GTF3C2) OTWDANLJ TF3C2_HUMAN Increases Expression [4]
DNA-binding death effector domain-containing protein 2 (DEDD2) OT0WXRWT DEDD2_HUMAN Increases Expression [4]
Heat shock protein 105 kDa (HSPH1) OTVRR73T HS105_HUMAN Increases Expression [4]
Protein FAM162A (FAM162A) OT882DND F162A_HUMAN Increases Expression [4]
Probable G-protein coupled receptor 146 (GPR146) OTFDR1WJ GP146_HUMAN Increases Expression [4]
Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) OTWE5G4T P3IP1_HUMAN Increases Expression [4]
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) OTALABSK S38A2_HUMAN Increases Expression [4]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [4]
Cell division cycle 5-like protein (CDC5L) OTTPFUU5 CDC5L_HUMAN Decreases Expression [4]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Decreases Expression [4]
Cyclin-dependent kinase 19 (CDK19) OTVMM0CP CDK19_HUMAN Increases Expression [4]
Serine/threonine-protein kinase D2 (PRKD2) OTIFSVI8 KPCD2_HUMAN Decreases Expression [4]
Egl nine homolog 1 (EGLN1) OT5QODDK EGLN1_HUMAN Increases Expression [4]
MOB kinase activator 1A (MOB1A) OTSPBZ4Z MOB1A_HUMAN Increases Expression [4]
Zinc transporter ZIP9 (SLC39A9) OTBVVFSK S39A9_HUMAN Increases Expression [4]
Fas apoptotic inhibitory molecule 1 (FAIM) OTR67PGU FAIM1_HUMAN Decreases Expression [4]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [4]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Decreases Expression [4]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Increases Expression [4]
NADH-cytochrome b5 reductase 1 (CYB5R1) OTMDHMLA NB5R1_HUMAN Increases Expression [4]
Zinc transporter ZIP10 (SLC39A10) OT04411Q S39AA_HUMAN Affects Expression [4]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [4]
Nischarin (NISCH) OTTMT8UD NISCH_HUMAN Decreases Expression [4]
Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) OTBU39Q1 PTH2_HUMAN Decreases Expression [4]
Lysine-specific demethylase 3A (KDM3A) OTZYJ8VN KDM3A_HUMAN Increases Expression [4]
Hypoxia-inducible lipid droplet-associated protein (HILPDA) OTEID3ZM HLPDA_HUMAN Increases Expression [4]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Increases Expression [4]
High affinity copper uptake protein 1 (SLC31A1) OTXLRTUB COPT1_HUMAN Increases Expression [6]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [7]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Secretion [8]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Increases Expression [9]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Increases Expression [6]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Increases Expression [7]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Increases Secretion [8]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [9]
Interleukin-7 (IL7) OTT6YSKM IL7_HUMAN Increases Secretion [8]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Secretion [8]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Degradation [8]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Decreases Expression [10]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [7]
Reelin (RELN) OTLKMW1O RELN_HUMAN Increases Expression [10]
Histone deacetylase 2 (HDAC2) OTUYVFKN HDAC2_HUMAN Increases Expression [7]
Glutamate decarboxylase 1 (GAD1) OT52Z39J DCE1_HUMAN Increases Expression [10]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Increases Metabolism [11]
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⏷ Show the Full List of 148 DOT(s)
Indication(s) of Proflavine
Disease Entry ICD 11 Status REF
Sepsis 1G40-1G41 Approved [3]
Proflavine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Deoxyribonucleic acid (Bact DNA) TTS1W4A NOUNIPROTAC Binder [12]
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Proflavine Interacts with 4 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Increases Activity [13]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [13]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [14]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Activity [13]
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References

1 ClinicalTrials.gov (NCT02335372) Cervical Cancer Screening Study in Brazil
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Drug information of Proflavine, 2008. eduDrugs.
4 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
5 Kinetics of cytochrome P450 2E1-catalyzed oxidation of ethanol to acetic acid via acetaldehyde. J Biol Chem. 1999 Aug 20;274(34):23833-40.
6 Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. J Biol Inorg Chem. 2014 Jan;19(1):17-27. doi: 10.1007/s00775-013-1051-z. Epub 2013 Oct 17.
7 Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
8 Zinc induces chemokine and inflammatory cytokine release from human promonocytes. J Hazard Mater. 2011 Nov 30;196:335-41. doi: 10.1016/j.jhazmat.2011.09.035. Epub 2011 Sep 19.
9 Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells. Toxicol Appl Pharmacol. 2013 Dec 15;273(3):492-9. doi: 10.1016/j.taap.2013.09.014. Epub 2013 Sep 29.
10 DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol. 2007 Mar;71(3):644-53. doi: 10.1124/mol.106.030635. Epub 2006 Oct 25.
11 Kinetics of trihalogenated acetic acid metabolism and isoform specificity in liver microsomes. Int J Toxicol. 2011 Oct;30(5):551-61. doi: 10.1177/1091581811414213. Epub 2011 Sep 20.
12 Interaction of small molecules with double-stranded RNA: spectroscopic, viscometric, and calorimetric study of hoechst and proflavine binding to PolyCG structures. DNA Cell Biol. 2009 Apr;28(4):209-19.
13 Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays. Molecules. 2019 Feb 27;24(5):841. doi: 10.3390/molecules24050841.
14 Why are most phospholipidosis inducers also hERG blockers?. Arch Toxicol. 2017 Dec;91(12):3885-3895. doi: 10.1007/s00204-017-1995-9. Epub 2017 May 27.