Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ391A)

• Drug Name: fMet-Leu-Phe Drug Info
• Synonyms: fMetLeuPhe; formyl-Met-Leu-Phe
• Cross-matching ID:
  PubChem CID: 443295
  ChEBI ID: CHEBI:53490
  CAS Number: CAS 59880-97-6
  TTD Drug ID: DMQ391A
  VARIDT Drug ID: DR01446

Molecule-Related Drug Atlas

Drug(s) Targeting N-formyl peptide receptor (FPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rebamipide	DM2GHCR	Peptic ulcer	DA61	Phase 3	[9]
PMID22607879CR-(-)-5f	DM7OJ5Q	Discovery agent	N.A.	Investigative	[10]
pyrazolone, 1	DMLFQKU	Discovery agent	N.A.	Investigative	[11]
group E 1682-2106	DMO6IM1	Discovery agent	N.A.	Investigative	[12]
BVT173187	DMULZOP	Discovery agent	N.A.	Investigative	[13]
CGEN-855	DM4FMPJ	Inflammation	1A00-CA43.1	Investigative	[14]
AG-11/03	DMZINUY	Discovery agent	N.A.	Investigative	[15]
methionine benzimidazole 6	DMEIP6H	Discovery agent	N.A.	Investigative	[16]
AG-09/1	DMW7H28	Discovery agent	N.A.	Investigative	[17]
diamide 7	DM4EX8Y	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting FMLP-related receptor I (FPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
humanin	DMUAPNF	Alzheimer disease	8A20	Preclinical	[18]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[19]
LXA4	DMGSVL0	Discovery agent	N.A.	Investigative	[19]
PMID22607879CR-(-)-5f	DM7OJ5Q	Discovery agent	N.A.	Investigative	[10]
aspirin-triggered resolvin D1	DMOP941	Discovery agent	N.A.	Investigative	[20]
RvD1-ME	DM8EZTM	Discovery agent	N.A.	Investigative	[20]
pyrazolone, 1	DMLFQKU	Discovery agent	N.A.	Investigative	[21]
quin-C7	DM1CYWB	Discovery agent	N.A.	Investigative	[22]
aspirin triggered lipoxin A4	DMLBSNP	Discovery agent	N.A.	Investigative	[23]
quin-C1	DMVQYWS	Discovery agent	N.A.	Investigative	[24]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[25]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[26]
Fructose	DM43AN2	Vomiting	MD90	Approved	[27]
Ketoprofen	DMRKXPT	Bursitis		Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[30]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[31]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[36]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[37]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[41]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[42]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[43]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[44]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[46]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[39]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[49]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[50]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[53]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[54]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[55]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[56]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[60]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[60]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[27]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[79]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[80]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[83]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]

Drug(s) Affected By Beta-glucuronidase (GUSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[93]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[96]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[97]

Drug(s) Affected By Neutrophil elastase (ELANE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Glyceryl trinitrate	DMF72W3	N. A.	N. A.	Phase 4	[98]
Lipoteichoic acid	DMEMRW0	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[100]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[101]
Aniline	DMLCAR9	N. A.	N. A.	Investigative	[102]

Drug(s) Affected By Cathepsin G (CTSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]
Y-40613	DM412IV	Discovery agent	N.A.	Investigative	[109]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[110]

Drug(s) Affected By Tyrosine-protein kinase HCK (HCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[60]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[115]

Drug(s) Affected By CD63 antigen (CD63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[118]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[62]

Drug(s) Affected By Tyrosine-protein kinase Fgr (FGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[122]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[60]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[124]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[125]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[46]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[128]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[37]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[132]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[133]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[134]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[75]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[135]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[136]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[140]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[141]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[142]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[148]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[149]

Drug(s) Affected By P-selectin (SELP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[152]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[117]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[154]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[156]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[161]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[162]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[163]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[164]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[167]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[169]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[170]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[173]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[165]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[174]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[175]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[176]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[164]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[167]

Drug(s) Affected By ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[181]
Bortezomib	DMNO38U	Leukemia		Approved	[182]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[178]
Novobiocin	DMRFWGK	Bacterial infection	1A00-1C4Z	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[184]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[185]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[186]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[188]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[191]
Selenium	DM25CGV	N. A.	N. A.	Approved	[192]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[193]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[194]

Drug(s) Affected By Phospholipase A2 group V (PLA2G5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[196]
Methamphetamine	DMPM4SK	Anxiety		Approved	[197]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[147]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[196]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
SB-203347	DM3AWMF	Discovery agent	N.A.	Investigative	[198]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[199]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[202]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[203]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[204]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[208]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[209]

Drug(s) Affected By Tyrosine-protein kinase Tec (TEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[211]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[212]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[213]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[214]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[215]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[218]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[219]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[220]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]

Drug(s) Affected By ADP-ribosylation factor 6 (ARF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[223]
Bortezomib	DMNO38U	Leukemia		Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By ADP-ribosylation factor 1 (ARF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[224]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[225]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[226]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[227]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[228]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[229]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[230]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[216]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[233]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[234]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[37]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
FMLP-related receptor I (FPR2)	TTOJ1NF	FPR2_HUMAN	Agonist	[1]
N-formyl peptide receptor (FPR1)	TT5Y4EM	FPR1_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)	OTGVC9MY	PLCG2_HUMAN	Post-Translational Modifications	[3]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Protein Interaction/Cellular Processes	[4]
ADP-ribosylation factor 1 (ARF1)	OT5C4C3L	ARF1_HUMAN	Protein Interaction/Cellular Processes	[5]
ADP-ribosylation factor 6 (ARF6)	OTVV7KJO	ARF6_HUMAN	Protein Interaction/Cellular Processes	[5]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[6]
Beta-glucuronidase (GUSB)	OT9N1DK3	BGLR_HUMAN	Protein Interaction/Cellular Processes	[7]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[6]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[6]
Cathepsin G (CTSG)	OT85ZMQG	CATG_HUMAN	Protein Interaction/Cellular Processes	[3]
CD63 antigen (CD63)	OT2UGZA9	CD63_HUMAN	Gene/Protein Processing	[8]

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