Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLJ634)

• Drug Name: Sodium lauryl sulfate Drug Info
• Synonyms: Anticerumen; Dreft; Dupanal; Duponal; Duponol; Gardinol; Irium; NALS; Natriumlaurylsulfat; Neutrazyme; SDS; SLS; Syntapon; WAQE; Akyposal SDS; Aquarex ME; Aquarex methyl; Carsonol SLS; Carsonol SLS Paste B; Carsonol SLS Special; Conco Sulfate WAG; Conco Sulfate WAN; Conco Sulfate WAS; Conco sulfate WA; Conco sulfate WN; DODECYL SULFATE; Dupanol WAQ; Duponal WAQE; Duponol C; Duponol Me; Duponol QC; Duponol WA; Duponol WA dry; Duponol WAQ; Duponol WAQE; Duponol WAQM; Duponol methyl; Duponol qx; Duponol waqa; EMAL O; Empicol LPZ; Hexamol SLS; Incronol SLS; Laurylsiran sodny; Lauyl sodium sulfate; Maprobix NEU; Maprofix LK; Maprofix NEU; Maprofix WAC; Melanol CL; Montopol La Paste; Nikkol SLS; Orvus WA Paste; Perlandrol L; Perlankrol L; Richonol A; Richonol C; Richonol af; SDS Running Buffer; Sintapon L; Sipex OP; Sipex SP; Sipex UB; Sipex sb; Sipex sd; Sipon LS; Sipon LSB; Sipon PD; Sipon WD; Sodium Laurylsulfate; Solsol needles; Standapol WAQ; Stepanol ME; Stepanol ME Dry AW; Stepanol WA; Stepanol WA Paste; Stepanol me dry; Stepanol methyl; Stepanol wac; Stepanol waq; Sterling wa paste; Sulfotex wa; Texapon DL; Trepenol WA; Avirol 101; Avirol 118; Avirol 118 conc; Berol 452; CP 75424; Cycloryl 21; Cycloryl 31; Cycloryl 580; Cycloryl 585N; Detergent 66; Emal 10; Emersal 6400; Empicol LS 30; Empicol LX 28; Finasol osr2; MP SILICA RP 18; Maprofix 563; Melanol CL 30; Monagen Y 100; Monogen Y 100; Odoripon Al 95; Perklankrol ESD 60; Rewopol NLS 30; Sinnopon LS 100; Sinnopon LS 95; Sipon LS 100; Standapol 112; Standapol 112 conc; Standapol was 100; Steinapol NLS 90; Stepanol T 28; Sulfetal L 95; Sulfopon wa 1; Swascol 3L; Tarapon K 12; Tvm 474; Emulsifier no. 104; Finasol osr(sub 2); IPC-SDS;Jordanol SL-300; Lanette Wax-S; Maprofix WAC-LA; Product no. 161; Product no. 75; Quolac EX-UB; S-4600; Standapol wa-ac; Stepanol WA-100; Sterling WAQ-CH; Ultra sulfate sl-1

Indication

Disease Entry	ICD 11	Status	REF
Constipation	DD91.1	Approved	[1]

• Cross-matching ID:
  PubChem CID: 3423265
  ChEBI ID: CHEBI:8984
  CAS Number: CAS 151-21-3
  TTD Drug ID: DMLJ634

Molecule-Related Drug Atlas

Drug(s) Targeting Serum albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gadobenate Dimeglumine	DM4VAOG	Schizophrenia	6A20	Approved	[7]
Oxyphenbutazone	DMPZS7U	Arthritis	FA20	Approved	[8]
Iodipamide	DMXIQYS	Gallbladder disease	DC11.3	Approved	[9]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[10]
Gadofosveset	DM5V9U1	Imaging	QA0B	Approved	[11]
Albumin Human	DM5JTPU	Hypoalbuminemia	5C53.2	Approved	[12]
Bismuth	DMTKU46	Diarrhea	ME05.1	Approved	[13]
EVANS BLUE	DM5GT1M	Abdominal aortic aneurysm	BD50.4	Approved	[14]
Activated recombinant FVII-albumin fusion protein	DMKY9GI	Hemophilia	3B10.0	Phase 2/3	[15]
Vobarilizumab	DM9KNJT	Rheumatoid arthritis	FA20	Phase 2	[16]

Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[22]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[25]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[32]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[25]

Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By Metallothionein-1A (MT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[41]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[46]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[47]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[48]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[53]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[54]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[59]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[60]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[64]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[65]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[65]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[76]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[79]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Ketoprofen	DMRKXPT	Bursitis		Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[97]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[98]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[100]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[101]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[105]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[111]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[3]

Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[116]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[3]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[117]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[127]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[3]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[128]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[65]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[65]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[130]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[65]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[80]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[136]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[137]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[140]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[141]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[150]
Bortezomib	DMNO38U	Leukemia		Approved	[151]

Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[152]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[154]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[158]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[161]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[163]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[164]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[164]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[171]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[172]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[173]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[174]

Drug(s) Affected By ATP-binding cassette sub-family A member 6 (ABCA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[178]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[180]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[181]

Drug(s) Affected By Acyl-protein thioesterase 1 (LYPLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]

Drug(s) Affected By ATP synthase subunit d, mitochondrial (ATP5PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[190]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[191]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[192]
Haloperidol	DM96SE0	Delirium		Approved	[84]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[194]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]

Drug(s) Affected By Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]

Drug(s) Affected By Ribose-phosphate pyrophosphokinase 2 (PRPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[204]

Drug(s) Affected By Nucleoside diphosphate kinase B (NME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[207]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[205]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[208]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[210]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[211]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Haloperidol	DM96SE0	Delirium		Approved	[109]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]

Drug(s) Affected By Proteasome subunit alpha type-2 (PSMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By Keratin, type I cytoskeletal 9 (KRT9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[220]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
9-hydroxyoctadecadienoic acid	DM0FWNJ	Discovery agent	N.A.	Investigative	[221]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[222]

Drug(s) Affected By Transaldolase (TALDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[55]

Drug(s) Affected By Phosphatidylinositol transfer protein beta isoform (PITPNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[224]

Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[227]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[227]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[228]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[184]

Drug(s) Affected By Biliverdin reductase A (BLVRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[235]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[240]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[243]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[244]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[245]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[84]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[84]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[84]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[248]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[249]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Haloperidol	DM96SE0	Delirium		Approved	[109]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[252]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[253]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[254]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[255]

Drug(s) Affected By Interleukin-1 receptor type 2 (IL1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[258]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[261]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[262]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]

Drug(s) Affected By Serpin B3 (SERPINB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[266]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[267]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[268]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[269]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[271]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[273]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[276]

Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[277]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[278]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[245]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[279]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[280]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[281]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[164]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]

Drug(s) Affected By Transcription factor E2F8 (E2F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By Death-associated protein-like 1 (DAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By Killer cell lectin-like receptor subfamily G member 2 (KLRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[287]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[286]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Metallo-beta-lactamase domain-containing protein 1 (MBLAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By SH3 domain-containing protein 21 (SH3D21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By RCC1 domain-containing protein 1 (RCCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Calpain-14 (CAPN14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Sulfotransferase 2B1 (SULT2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[291]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Hyaluronan synthase 3 (HAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[294]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[295]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[297]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[77]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[298]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[64]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[298]
Fructose	DM43AN2	Vomiting	MD90	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[298]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]

Drug(s) Affected By Late cornified envelope protein 2B (LCE2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Manganese	DMKT129	N. A.	N. A.	Investigative	[302]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[303]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[309]

Drug(s) Affected By Myosin regulatory light chain 12B (MYL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[310]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[311]

Drug(s) Affected By Period circadian protein homolog 2 (PER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[312]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[314]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[35]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Sphingolipid delta(4)-desaturase DES1 (DEGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[228]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[317]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[17]

Drug(s) Affected By Forkhead box protein N1 (FOXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[318]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[319]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[320]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[321]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[322]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[324]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[118]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[325]

Drug(s) Affected By Kallikrein-10 (KLK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[326]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[328]
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[84]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]

Drug(s) Affected By Synaptogyrin-3 (SYNGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[329]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[287]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]

Drug(s) Affected By BMP/retinoic acid-inducible neural-specific protein 1 (BRINP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Plexin-C1 (PLXNC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[332]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[330]

Drug(s) Affected By Frizzled-7 (FZD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[333]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[334]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]

Drug(s) Affected By Protein NipSnap homolog 2 (NIPSNAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Jerky protein homolog (JRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[337]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[338]

Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[339]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[339]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[339]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[340]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[317]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[341]

Drug(s) Affected By Keratin, type I cuticular Ha7 (KRT37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]

Drug(s) Affected By Serine/threonine-protein kinase 10 (STK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[344]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[346]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[347]

Drug(s) Affected By Gap junction beta-6 protein (GJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[348]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[349]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Claudin-7 (CLDN7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[350]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[351]

Drug(s) Affected By CTD nuclear envelope phosphatase 1 (CTDNEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[352]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[353]

Drug(s) Affected By C-X-C motif chemokine 14 (CXCL14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Indomethacin	DMSC4A7	Bursitis		Approved	[355]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[356]

Drug(s) Affected By Cytotoxic and regulatory T-cell molecule (CRTAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Interleukin-33 (IL33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[357]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[358]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[359]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[360]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[361]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[362]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[363]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Coagulation factor VIII (F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[364]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[366]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[367]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[368]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Complement C1r subcomponent (C1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[371]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]

Drug(s) Affected By Carbonic anhydrase 2 (CA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[372]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[374]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[375]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[376]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[377]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[378]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[379]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[379]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[380]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[382]

Drug(s) Affected By Gastrin (GAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Terbutaline	DMD4381	Asthma	CA23	Approved	[384]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[383]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[383]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[385]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[386]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[84]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[387]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[388]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[389]
Fructose	DM43AN2	Vomiting	MD90	Approved	[84]
Ketoprofen	DMRKXPT	Bursitis		Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[390]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[391]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[392]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[393]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[394]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[164]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[395]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[396]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[164]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[397]
Selenium	DM25CGV	N. A.	N. A.	Approved	[163]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[398]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[399]

Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[341]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[401]
Indomethacin	DMSC4A7	Bursitis		Approved	[355]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[355]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[402]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[404]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[406]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[407]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[295]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[409]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[414]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[415]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[416]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[417]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[418]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[419]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[420]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[421]

Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[422]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[238]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[423]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[424]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[425]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[426]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[293]

Drug(s) Affected By Histone H2A type 1-B/E (H2AC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[429]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[430]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[431]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[433]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[434]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[435]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[100]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[137]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[397]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[436]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[437]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[438]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[439]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[440]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[441]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[442]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[443]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[443]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[445]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[446]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[414]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[447]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[448]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[105]

Drug(s) Affected By Fatty acid-binding protein, heart (FABP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[449]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Haloperidol	DM96SE0	Delirium		Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[55]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[109]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Methamphetamine	DMPM4SK	Anxiety		Approved	[450]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[451]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[452]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[453]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[454]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[455]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[456]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[457]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[84]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[458]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[455]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[459]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[460]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[459]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[461]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[462]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[463]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[464]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[465]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[466]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[467]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[468]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[470]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[471]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By Histone H2B type 1-J (H2BC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[472]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[473]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[474]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[475]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[476]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[475]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[477]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[478]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[155]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[479]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[480]
Terbutaline	DMD4381	Asthma	CA23	Approved	[481]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[482]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[483]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[484]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[485]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[486]

Drug(s) Affected By Laminin subunit beta-1 (LAMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[487]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[488]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[490]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[491]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[490]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[492]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[493]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[490]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[494]

Drug(s) Affected By Pro-cathepsin H (CTSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[491]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By SLIT-ROBO Rho GTPase-activating protein 2C (SRGAP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[495]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[337]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[496]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[497]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[498]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[100]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[499]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[500]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[164]

Drug(s) Affected By Cation-independent mannose-6-phosphate receptor (IGF2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]

Drug(s) Affected By Collagen alpha-1(XI) chain (COL11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[293]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[501]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[502]

Drug(s) Affected By Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[503]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[504]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[503]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[505]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[506]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[409]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[135]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[507]

Drug(s) Affected By Hematopoietic lineage cell-specific protein (HCLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[508]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[509]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[510]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[511]
Haloperidol	DM96SE0	Delirium		Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[512]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[513]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[514]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[515]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[261]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[516]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[517]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[518]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[519]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[519]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[520]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[521]

Drug(s) Affected By Fumarylacetoacetase (FAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[341]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[522]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[523]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[499]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[524]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[525]

Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[526]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[527]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[341]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[526]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[528]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[529]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[530]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[531]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[492]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[532]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[98]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[511]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[533]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[534]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[535]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[536]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[395]

Drug(s) Affected By Follistatin (FST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[537]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[538]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Elafin (PI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[540]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[328]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[541]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[542]

Drug(s) Affected By Protachykinin-1 (TAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[543]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[544]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[545]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[543]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[546]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]

Drug(s) Affected By Filaggrin (FLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[475]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[475]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[478]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[424]

Drug(s) Affected By Galanin peptides (GAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[547]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[547]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[547]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Protein S100-A1 (S100A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]

Drug(s) Affected By Glycine dehydrogenase (GLDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[548]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[333]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[549]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[218]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]

Drug(s) Affected By Loricrin (LORICRIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[551]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[478]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
SB 203580	DMAET6F	N. A.	N. A.	Terminated	[552]
PD98059	DMZC90M	Cardiac arrest	MC82	Investigative	[552]

Drug(s) Affected By Nuclear transcription factor Y subunit alpha (NFYA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[553]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[554]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[555]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]

Drug(s) Affected By Tenascin (TNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[556]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[557]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[558]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[559]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[560]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[561]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Bortezomib	DMNO38U	Leukemia		Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[174]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[562]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[563]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[518]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[391]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[564]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[565]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[566]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[567]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[568]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[569]

Drug(s) Affected By G0/G1 switch protein 2 (G0S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[163]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[570]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]

Drug(s) Affected By Proteasome subunit beta type-9 (PSMB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[571]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[572]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[573]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[574]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[571]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[575]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[563]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[576]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[577]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[578]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[562]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[391]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[564]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 6 (PCSK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[579]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[99]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[580]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[152]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[581]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[582]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Flavin reductase (BLVRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Bortezomib	DMNO38U	Leukemia		Approved	[311]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[583]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[584]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[467]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[585]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[309]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[587]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[587]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[548]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[279]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[588]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Heme oxygenase 2 (HMOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[589]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[591]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[592]

Drug(s) Affected By Adenylosuccinate synthetase isozyme 2 (ADSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[593]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[594]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[178]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[595]

Drug(s) Affected By Protein S100-A7 (S100A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[371]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[110]

Drug(s) Affected By Peroxiredoxin-2 (PRDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[597]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[598]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[599]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]

Drug(s) Affected By Cytokine receptor common subunit beta (CSF2RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[600]

Drug(s) Affected By Protein S100-A5 (S100A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[601]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[602]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]

Drug(s) Affected By Trypsin-3 (PRSS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[603]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[328]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[604]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[605]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[606]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[607]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[608]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[609]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[610]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[611]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[612]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[613]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[614]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[615]

Drug(s) Affected By Keratin, type II cytoskeletal 2 epidermal (KRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[502]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[220]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[616]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Gap junction gamma-1 protein (GJC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[617]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Hippocalcin-like protein 1 (HPCAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[618]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[619]

Drug(s) Affected By Proteasome subunit beta type-10 (PSMB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[571]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[571]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[620]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[408]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[621]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[621]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[621]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[622]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[623]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[624]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[622]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[65]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[66]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[625]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[625]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[65]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[626]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[627]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[628]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[629]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[293]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[629]

Drug(s) Affected By Chemerin-like receptor 2 (CMKLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[630]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[631]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Cytosolic phospholipase A2 (PLA2G4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[632]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[633]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[634]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[635]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[636]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By P2Y purinoceptor 1 (P2RY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[637]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Neuromedin-U (NMU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[287]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]

Drug(s) Affected By Adhesion G protein-coupled receptor E5 (ADGRE5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[638]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[639]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By MARCKS-related protein (MARCKSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[341]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]

Drug(s) Affected By Dual specificity protein kinase CLK3 (CLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[178]

Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[640]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[640]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[641]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[642]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[640]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[642]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[643]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[644]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[642]

Drug(s) Affected By DNA ligase 3 (LIG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[645]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[646]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]

Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[647]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[647]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[647]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[647]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[647]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[647]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[648]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[649]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[650]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[651]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[605]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[652]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[653]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[344]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[654]

Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[506]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[655]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[656]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[657]
I3C	DMIGFOR	Breast cancer	2C60-2C65	Phase 3	[658]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[659]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[660]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[657]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[661]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[662]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[663]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[664]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[665]

Drug(s) Affected By Potassium-transporting ATPase alpha chain 2 (ATP12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[666]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Epithelial membrane protein 1 (EMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[152]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]

Drug(s) Affected By GTP-binding protein GEM (GEM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[525]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By RWD domain-containing protein 2B (RWDD2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[17]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Serine protease inhibitor Kazal-type 7 (SPINK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Proteasome activator complex subunit 3 (PSME3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[667]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[668]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[669]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[492]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[670]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]

Drug(s) Affected By Histone H2B type 1-C/E/F/G/I (H2BC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[472]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[501]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[671]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[672]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[673]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]

Drug(s) Affected By Iroquois-class homeodomain protein IRX-3 (IRX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[574]

Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[674]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[675]

Drug(s) Affected By Interferon-induced 35 kDa protein (IFI35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[676]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]

Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[677]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]

Drug(s) Affected By Interleukin-1 receptor-like 1 (IL1RL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[678]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[360]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[178]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[263]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[679]

Drug(s) Affected By Myosin light chain 5 (MYL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[541]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[680]

Drug(s) Affected By Desmoglein-1 (DSG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[310]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[681]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[682]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[515]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[683]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[684]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[685]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[686]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[687]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[507]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[688]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[617]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[279]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By Desmocollin-1 (DSC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[689]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[317]

Drug(s) Affected By Nexilin (NEXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By Pejvakin (PJVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[164]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[164]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[164]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[690]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]

Drug(s) Affected By Phospholipase D1 (PLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[341]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[691]

Drug(s) Affected By Ecto-ADP-ribosyltransferase 3 (ART3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[692]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Ras-related protein Rab-33A (RAB33A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[693]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Growth factor receptor-bound protein 7 (GRB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[110]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[386]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]

Drug(s) Affected By Semaphorin-3A (SEMA3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[694]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[341]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[695]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[696]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[697]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[698]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[699]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[410]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By Cullin-7 (CUL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[700]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[289]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[701]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[702]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[261]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[703]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[704]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[705]

Drug(s) Affected By Dihydropyrimidinase-related protein 2 (DPYSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[706]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[109]

Drug(s) Affected By Prostasin (PRSS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]

Drug(s) Affected By Histone H2B type 2-E (H2BC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[154]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[574]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[492]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[109]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[707]

Drug(s) Affected By Protein Dok-7 (DOK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[708]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[189]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[709]

Drug(s) Affected By MHC class I polypeptide-related sequence B (MICB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[710]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]

Drug(s) Affected By UPF0711 protein C18orf21 (C18ORF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[289]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]

Drug(s) Affected By Cytochrome c oxidase assembly protein COX19 (COX19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By tRNA wybutosine-synthesizing protein 2 homolog (TRMT12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[709]

Drug(s) Affected By Transmembrane protein 177 (TMEM177)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[712]

Drug(s) Affected By Filaggrin-2 (FLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[713]

Drug(s) Affected By Protein BEX5 (BEX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX60-like (DDX60L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[714]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[715]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]

Drug(s) Affected By Tetratricopeptide repeat protein 32 (TTC32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[218]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[716]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[35]

Drug(s) Affected By Sterile alpha motif domain-containing protein 9 (SAMD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[717]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[718]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By Late cornified envelope protein 1E (LCE1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Proline-rich protein 9 (PRR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]

Drug(s) Affected By Protein FAM171A1 (FAM171A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[619]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[328]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[328]

Drug(s) Affected By Stabilizer of axonemal microtubules 2 (SAXO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Autophagy-related protein 9B (ATG9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[719]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Olfactomedin-like protein 2A (OLFML2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[218]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By LEM domain-containing protein 1 (LEMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[540]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[720]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[218]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[721]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD11 (KCTD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[722]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Multiple C2 and transmembrane domain-containing protein 1 (MCTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[218]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]

Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[152]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[152]

Drug(s) Affected By Volume-regulated anion channel subunit LRRC8E (LRRC8E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]

Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[109]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By Arylacetamide deacetylase-like 2 (AADACL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Uncharacterized protein C16orf46 (C16ORF46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[723]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[723]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[724]

Drug(s) Affected By Ribosomal protein eL22-like (RPL22L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[293]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[509]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]

Drug(s) Affected By Long-chain fatty acid transport protein 1 (SLC27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[725]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[726]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By Spindle assembly abnormal protein 6 homolog (SASS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[727]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[727]

Drug(s) Affected By Sushi domain-containing protein 1 (SUSD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[293]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[716]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[728]

Drug(s) Affected By Serine protease inhibitor Kazal-type 6 (SPINK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Insulin growth factor-like family member 2 (IGFL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[729]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[631]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[730]

Drug(s) Affected By Protein disulfide isomerase CRELD2 (CRELD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[588]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[619]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[317]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[337]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[680]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By Repetin (RPTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Rho-related GTP-binding protein RhoU (RHOU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[317]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[718]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Cytochrome b5 reductase 4 (CYB5R4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[678]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]

Drug(s) Affected By KRAB domain-containing protein 5 (KRBOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By L-xylulose reductase (DCXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[732]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]

Drug(s) Affected By tRNA-splicing endonuclease subunit Sen54 (TSEN54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Protein S100-A7A (S100A7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[733]

Drug(s) Affected By Glucosylceramide transporter ABCA12 (ABCA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 10 (NLRP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By GAS2-like protein 3 (GAS2L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[574]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[734]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[317]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[35]

Drug(s) Affected By Ceramide synthase 3 (CERS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]

Drug(s) Affected By Proline-rich protein 15 (PRR15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[735]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[736]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Sodium/hydrogen exchanger 9 (SLC9A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]

Drug(s) Affected By Methylmalonic aciduria type A protein, mitochondrial (MMAA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC6 (HERC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[156]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[156]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]

Drug(s) Affected By Inactive serine/threonine-protein kinase TEX14 (TEX14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[722]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[737]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[338]

Drug(s) Affected By Iron-sulfur cluster co-chaperone protein HscB (HSCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[680]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Cadherin-like protein 26 (CDH26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[501]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[738]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[739]

Drug(s) Affected By Polycomb group protein ASXL1 (ASXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[740]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[741]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[337]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[742]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX60 (DDX60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[371]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]

Drug(s) Affected By Threonine synthase-like 1 (THNSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[718]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Adhesion G-protein coupled receptor G2 (ADGRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]

Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[743]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]

Drug(s) Affected By CKLF-like MARVEL transmembrane domain-containing protein 8 (CMTM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[619]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[744]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[631]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[745]

Drug(s) Affected By Mucin-15 (MUC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[35]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[746]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Sesquipedalian-1 (PHETA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[723]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[723]

Drug(s) Affected By ADP-ribosylation factor GTPase-activating protein 2 (ARFGAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[222]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[338]

Drug(s) Affected By Uncharacterized protein KIAA1958 (KIAA1958)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[722]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By G patch domain-containing protein 11 (GPATCH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[287]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[574]

Drug(s) Affected By Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Liprin-beta-2 (PPFIBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[572]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]

Drug(s) Affected By Phosphatidylcholine:ceramide cholinephosphotransferase 2 (SGMS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Modulator of smoothened protein (MOSMO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[122]

Drug(s) Affected By Piwi-like protein 2 (PIWIL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]

Drug(s) Affected By Ceramide kinase (CERK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Retinoic acid early transcript 1E (RAET1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[734]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[722]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[631]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By Protein Shroom3 (SHROOM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[279]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]

Drug(s) Affected By Sodium-dependent phosphate transporter 1 (SLC20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[747]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[748]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[749]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Solute carrier family 25 member 43 (SLC25A43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[692]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Soluble calcium-activated nucleotidase 1 (CANT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[712]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[287]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[557]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[311]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[693]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[289]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By SEC14-like protein 1 (SEC14L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[750]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[328]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[262]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Peroxidasin homolog (PXDN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[751]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[752]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]

Drug(s) Affected By Rho-related GTP-binding protein Rho6 (RND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[753]

Drug(s) Affected By CREB-binding protein (CREBBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[754]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[492]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[755]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[688]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[756]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[757]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Bortezomib	DMNO38U	Leukemia		Approved	[758]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[759]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[760]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[761]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[762]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[763]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[764]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[765]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[766]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[319]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Protein RFT1 homolog (RFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[540]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]

Drug(s) Affected By Ras-related protein Rab-7b (RAB7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[154]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[35]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[693]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[767]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[730]

Drug(s) Affected By Transmembrane protein 125 (TMEM125)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]

Drug(s) Affected By Transmembrane protein 45B (TMEM45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[287]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]

Drug(s) Affected By Inactive rhomboid protein 1 (RHBDF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[515]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[515]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Mestranol	DMG3F94	Contraception	QA21	Approved	[515]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[515]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[768]

Drug(s) Affected By Large ribosomal subunit protein mL38 (MRPL38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]

Drug(s) Affected By Protein bicaudal D homolog 1 (BICD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[694]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[769]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]

Drug(s) Affected By Peroxisomal membrane protein 11C (PEX11G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[218]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]

Drug(s) Affected By CUGBP Elav-like family member 6 (CELF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[572]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[154]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[501]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]

Drug(s) Affected By Calmin (CLMN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[515]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Mestranol	DMG3F94	Contraception	QA21	Approved	[515]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[515]

Drug(s) Affected By Calpain small subunit 2 (CAPNS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Adenylate kinase 8 (AK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[631]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[338]

Drug(s) Affected By Uncharacterized protein C5orf34 (C5ORF34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[378]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[574]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By Retinol dehydrogenase 12 (RDH12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[770]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]
all-trans-retinal	DM6CEVB	Discovery agent	N.A.	Investigative	[770]

Drug(s) Affected By Small proline-rich protein 4 (SPRR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By Erythroid membrane-associated protein (ERMAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[715]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[771]

Drug(s) Affected By Kinesin-like protein KIF20B (KIF20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[492]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[772]

Drug(s) Affected By Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[773]

Drug(s) Affected By Cysteine/serine-rich nuclear protein 1 (CSRNP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[774]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By Protein arginine N-methyltransferase 1 (PRMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[775]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[776]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[344]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[777]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[333]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[333]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[190]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[728]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[289]

Drug(s) Affected By Protein FAM83C (FAM83C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[540]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Junctophilin-2 (JPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[736]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[778]

Drug(s) Affected By Vesicle-trafficking protein SEC22c (SEC22C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[217]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[287]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[779]

Drug(s) Affected By RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RHNO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[574]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[287]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[631]

Drug(s) Affected By Transcription factor SOX-7 (SOX7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[487]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Indomethacin	DMSC4A7	Bursitis		Approved	[780]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[709]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[781]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[782]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[588]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[781]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[783]

Drug(s) Affected By TNF receptor-associated factor 4 (TRAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[295]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[732]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[784]

Drug(s) Affected By Very long chain fatty acid elongase 1 (ELOVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[750]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[773]

Drug(s) Affected By Replication initiator 1 (REPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[501]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[31]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[631]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[785]

Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[548]

Drug(s) Affected By Cornifelin (CNFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[363]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[778]

Drug(s) Affected By Late cornified envelope protein 3D (LCE3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Small proline-rich protein 2G (SPRR2G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[732]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[786]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[722]

Drug(s) Affected By Tripartite motif-containing protein 6 (TRIM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[550]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Solute carrier family 22 member 4 (SLC22A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[787]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[748]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[788]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]

Drug(s) Affected By Kinesin light chain 2 (KLC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]

Drug(s) Affected By Coiled-coil domain-containing protein 8 (CCDC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[709]

Drug(s) Affected By PC-esterase domain-containing protein 1A (PCED1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[716]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Melanoma-associated antigen H1 (MAGEH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[773]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By RING finger protein 39 (RNF39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]

Drug(s) Affected By SPARC-related modular calcium-binding protein 1 (SMOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[789]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[508]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[35]

Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[17]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]

Drug(s) Affected By DENN domain-containing protein 2D (DENND2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[716]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Metal transporter CNNM2 (CNNM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[501]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[718]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]

Drug(s) Affected By Endogenous retroviral envelope protein HEMO (ERVMER34-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[631]

Drug(s) Affected By Plasminogen receptor (PLGRKT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[790]

Drug(s) Affected By UPF0606 protein KIAA1549 (KIAA1549)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]

Drug(s) Affected By Stromal cell-derived factor 2-like protein 1 (SDF2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[588]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By Cytochrome P450 4F12 (CYP4F12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[791]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By ATP-binding cassette sub-family B member 6 (ABCB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[792]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Carbohydrate sulfotransferase 11 (CHST11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Bortezomib	DMNO38U	Leukemia		Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[619]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[509]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]

Drug(s) Affected By Arf-GAP with dual PH domain-containing protein 2 (ADAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[793]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[631]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[794]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (B3GAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Transcription factor 7-like 2 (TCF7L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[795]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[688]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[217]
Bortezomib	DMNO38U	Leukemia		Approved	[796]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[718]

Drug(s) Affected By Matrix-remodeling-associated protein 5 (MXRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[156]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[797]

Drug(s) Affected By SERTA domain-containing protein 4 (SERTAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[154]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]

Drug(s) Affected By E3 ubiquitin-protein ligase FANCL (FANCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[333]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[228]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[333]

Drug(s) Affected By Rhomboid-related protein 2 (RHBDL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[798]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[540]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[328]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[737]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP11 (FKBP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[178]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[799]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[328]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[317]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[800]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Interleukin-36 gamma (IL36G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[540]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[801]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Grainyhead-like protein 1 homolog (GRHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[548]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[200]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By SH3 domain-binding protein 4 (SH3BP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[798]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[750]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]

Drug(s) Affected By Inhibitor of Bruton tyrosine kinase (IBTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[717]
Bortezomib	DMNO38U	Leukemia		Approved	[311]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[802]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[178]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[289]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[289]

Drug(s) Affected By Myelin expression factor 2 (MYEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[501]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[39]

Drug(s) Affected By Small proline-rich protein 3 (SPRR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[654]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[803]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Cardiotrophin-like cytokine factor 1 (CLCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[804]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By Cornulin (CRNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Interleukin-36 receptor antagonist protein (IL36RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[689]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[671]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[805]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[245]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[262]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[99]

Drug(s) Affected By Pleckstrin homology domain-containing family B member 1 (PLEKHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[204]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Solute carrier family 23 member 2 (SLC23A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[748]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[792]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[806]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[311]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Cysteine-rich C-terminal protein 1 (CRCT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[508]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[734]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[807]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[341]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[402]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[328]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[347]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Kelch-like protein 21 (KLHL21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[410]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Heat shock protein beta-8 (HSPB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[808]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Phosphatidylcholine transfer protein (PCTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[255]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[809]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]

Drug(s) Affected By F-box only protein 5 (FBXO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[810]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[671]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By Phospholipase A and acyltransferase 4 (PLAAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Ankyrin repeat domain-containing protein 50 (ANKRD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[811]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[722]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Pleckstrin homology domain-containing family G member 1 (PLEKHG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[812]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Protein PHTF1 (PHTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Bortezomib	DMNO38U	Leukemia		Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[673]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Protein Smaug homolog 1 (SAMD4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[602]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By DNA-binding protein SATB2 (SATB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Haloperidol	DM96SE0	Delirium		Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[109]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[813]

Drug(s) Affected By Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (DHDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 3 (LAMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[732]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[814]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[814]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[814]

Drug(s) Affected By Hepatocyte nuclear factor 3-beta (FOXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[629]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[815]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[815]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[218]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[816]

Drug(s) Affected By Heparan sulfate glucosamine 3-O-sulfotransferase 2 (HS3ST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[817]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[328]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[818]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Disco-interacting protein 2 homolog C (DIP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[672]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[347]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[672]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]

Drug(s) Affected By C-C motif chemokine 27 (CCL27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[819]

Drug(s) Affected By AP-4 complex subunit sigma-1 (AP4S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[204]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[347]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[35]

Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[820]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[687]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[574]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[203]

Drug(s) Affected By Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[370]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[767]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ alpha 2 chain (HLA-DQA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Acetyl-CoA carboxylase 2 (ACACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Fructose	DM43AN2	Vomiting	MD90	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[548]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[256]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]

Drug(s) Affected By Protein PRRC2A (PRRC2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[821]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[229]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[822]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[823]

Drug(s) Affected By BDNF/NT-3 growth factors receptor (NTRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[824]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[598]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[329]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[549]

Drug(s) Affected By Allograft inflammatory factor 1 (AIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[126]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[825]

Drug(s) Affected By Complement C2 (C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[345]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[826]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[827]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[767]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serum albumin (ALB)	TTFNGC9	ALBU_HUMAN	Binder	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[3]
A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3)	OT2U6VF5	ATS3_HUMAN	Gene/Protein Processing	[4]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Gene/Protein Processing	[4]
Acetyl-CoA carboxylase 2 (ACACB)	OT96UIP1	ACACB_HUMAN	Drug Response	[5]
Acyl-protein thioesterase 1 (LYPLA1)	OTENU47T	LYPA1_HUMAN	Gene/Protein Processing	[6]
Adenylate kinase 8 (AK8)	OT2UF6YM	KAD8_HUMAN	Gene/Protein Processing	[4]
Adenylosuccinate synthetase isozyme 2 (ADSS2)	OTW26XXB	PURA2_HUMAN	Gene/Protein Processing	[4]
Adhesion G protein-coupled receptor E5 (ADGRE5)	OTTSB84Q	AGRE5_HUMAN	Gene/Protein Processing	[4]
Adhesion G-protein coupled receptor G2 (ADGRG2)	OTPAD5S1	AGRG2_HUMAN	Gene/Protein Processing	[4]
ADP-ribosylation factor GTPase-activating protein 2 (ARFGAP2)	OTIP5ZJ7	ARFG2_HUMAN	Gene/Protein Processing	[4]

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