Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLJ634)

• Drug Name: Sodium lauryl sulfate Drug Info
• Synonyms: Anticerumen; Dreft; Dupanal; Duponal; Duponol; Gardinol; Irium; NALS; Natriumlaurylsulfat; Neutrazyme; SDS; SLS; Syntapon; WAQE; Akyposal SDS; Aquarex ME; Aquarex methyl; Carsonol SLS; Carsonol SLS Paste B; Carsonol SLS Special; Conco Sulfate WAG; Conco Sulfate WAN; Conco Sulfate WAS; Conco sulfate WA; Conco sulfate WN; DODECYL SULFATE; Dupanol WAQ; Duponal WAQE; Duponol C; Duponol Me; Duponol QC; Duponol WA; Duponol WA dry; Duponol WAQ; Duponol WAQE; Duponol WAQM; Duponol methyl; Duponol qx; Duponol waqa; EMAL O; Empicol LPZ; Hexamol SLS; Incronol SLS; Laurylsiran sodny; Lauyl sodium sulfate; Maprobix NEU; Maprofix LK; Maprofix NEU; Maprofix WAC; Melanol CL; Montopol La Paste; Nikkol SLS; Orvus WA Paste; Perlandrol L; Perlankrol L; Richonol A; Richonol C; Richonol af; SDS Running Buffer; Sintapon L; Sipex OP; Sipex SP; Sipex UB; Sipex sb; Sipex sd; Sipon LS; Sipon LSB; Sipon PD; Sipon WD; Sodium Laurylsulfate; Solsol needles; Standapol WAQ; Stepanol ME; Stepanol ME Dry AW; Stepanol WA; Stepanol WA Paste; Stepanol me dry; Stepanol methyl; Stepanol wac; Stepanol waq; Sterling wa paste; Sulfotex wa; Texapon DL; Trepenol WA; Avirol 101; Avirol 118; Avirol 118 conc; Berol 452; CP 75424; Cycloryl 21; Cycloryl 31; Cycloryl 580; Cycloryl 585N; Detergent 66; Emal 10; Emersal 6400; Empicol LS 30; Empicol LX 28; Finasol osr2; MP SILICA RP 18; Maprofix 563; Melanol CL 30; Monagen Y 100; Monogen Y 100; Odoripon Al 95; Perklankrol ESD 60; Rewopol NLS 30; Sinnopon LS 100; Sinnopon LS 95; Sipon LS 100; Standapol 112; Standapol 112 conc; Standapol was 100; Steinapol NLS 90; Stepanol T 28; Sulfetal L 95; Sulfopon wa 1; Swascol 3L; Tarapon K 12; Tvm 474; Emulsifier no. 104; Finasol osr(sub 2); IPC-SDS;Jordanol SL-300; Lanette Wax-S; Maprofix WAC-LA; Product no. 161; Product no. 75; Quolac EX-UB; S-4600; Standapol wa-ac; Stepanol WA-100; Sterling WAQ-CH; Ultra sulfate sl-1

Indication

Disease Entry	ICD 11	Status	REF
Constipation	DD91.1	Approved	[1]

• Cross-matching ID:
  PubChem CID: 3423265
  ChEBI ID: CHEMBL8984
  CAS Number: CAS 151-21-3
  TTD Drug ID: DMLJ634

Molecule-Related Drug Atlas

Drug(s) Targeting Serum albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gadobenate Dimeglumine	DM4VAOG	Schizophrenia	6A20	Approved	[6]
Oxyphenbutazone	DMPZS7U	Arthritis	FA20	Approved	[7]
Iodipamide	DMXIQYS	Gallbladder disease	DC11.3	Approved	[8]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[9]
Gadofosveset	DM5V9U1	Imaging	QA0B	Approved	[10]
Albumin Human	DM5JTPU	Hypoalbuminemia	5C53.2	Approved	[11]
Bismuth	DMTKU46	Diarrhea	ME05.1	Approved	[12]
EVANS BLUE	DM5GT1M	Abdominal aortic aneurysm	BD50.4	Approved	[13]
Activated recombinant FVII-albumin fusion protein	DMKY9GI	Hemophilia	3B10.0	Phase 2/3	[14]
Vobarilizumab	DM9KNJT	Rheumatoid arthritis	FA20	Phase 2	[15]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[16]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[23]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[16]

Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[34]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[34]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[47]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[51]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[52]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[61]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[3]

Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[66]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[48]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[3]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[68]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[3]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[69]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[34]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[34]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[72]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[34]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[52]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[78]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[79]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[82]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[83]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[93]
Bortezomib	DMNO38U	Leukemia		Approved	[94]

Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[97]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[99]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[100]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[109]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[110]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[112]

Drug(s) Affected By Acyl-protein thioesterase 1 (LYPLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]

Drug(s) Affected By ATP synthase subunit d, mitochondrial (ATP5PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[124]

Drug(s) Affected By Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]

Drug(s) Affected By Ribose-phosphate pyrophosphokinase 2 (PRPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Nucleoside diphosphate kinase B (NME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[134]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[132]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[135]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[136]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[138]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Haloperidol	DM96SE0	Delirium		Approved	[141]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Proteasome subunit alpha type-2 (PSMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Keratin, type I cytoskeletal 9 (KRT9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
9-hydroxyoctadecadienoic acid	DM0FWNJ	Discovery agent	N.A.	Investigative	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[151]

Drug(s) Affected By Transaldolase (TALDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[152]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[48]

Drug(s) Affected By Phosphatidylinositol transfer protein beta isoform (PITPNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[153]

Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Bortezomib	DMNO38U	Leukemia		Approved	[156]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[156]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[157]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[162]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[163]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[167]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[173]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[175]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[175]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[175]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[175]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[179]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Haloperidol	DM96SE0	Delirium		Approved	[141]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[105]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[184]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[185]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[186]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[187]

Drug(s) Affected By Serpin B3 (SERPINB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[192]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[192]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[195]

Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[197]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[198]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[199]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[200]

Drug(s) Affected By Transcription factor E2F8 (E2F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]

Drug(s) Affected By Death-associated protein-like 1 (DAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Killer cell lectin-like receptor subfamily G member 2 (KLRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[204]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By Metallo-beta-lactamase domain-containing protein 1 (MBLAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By SH3 domain-containing protein 21 (SH3D21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By RCC1 domain-containing protein 1 (RCCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]

Drug(s) Affected By Calpain-14 (CAPN14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Hyaluronan synthase 3 (HAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[211]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[212]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[214]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[49]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[215]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[105]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[215]
Fructose	DM43AN2	Vomiting	MD90	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[215]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]

Drug(s) Affected By Late cornified envelope protein 2B (LCE2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Manganese	DMKT129	N. A.	N. A.	Investigative	[219]

Drug(s) Affected By Myosin regulatory light chain 12B (MYL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[220]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Bortezomib	DMNO38U	Leukemia		Approved	[221]

Drug(s) Affected By Period circadian protein homolog 2 (PER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[222]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[223]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[224]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[27]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By Sphingolipid delta(4)-desaturase DES1 (DEGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Forkhead box protein N1 (FOXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[229]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[232]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[233]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[235]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[236]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[237]

Drug(s) Affected By Kallikrein-10 (KLK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[238]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[175]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]

Drug(s) Affected By Synaptogyrin-3 (SYNGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[241]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By BMP/retinoic acid-inducible neural-specific protein 1 (BRINP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Plexin-C1 (PLXNC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]

Drug(s) Affected By Frizzled-7 (FZD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[242]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[243]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]

Drug(s) Affected By Protein NipSnap homolog 2 (NIPSNAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[33]

Drug(s) Affected By Jerky protein homolog (JRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[247]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[248]

Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[249]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[249]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[250]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[228]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[251]

Drug(s) Affected By Keratin, type I cuticular Ha7 (KRT37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Serine/threonine-protein kinase 10 (STK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[257]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[258]

Drug(s) Affected By Gap junction beta-6 protein (GJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[259]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[260]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Claudin-7 (CLDN7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[263]

Drug(s) Affected By CTD nuclear envelope phosphatase 1 (CTDNEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[264]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[265]

Drug(s) Affected By C-X-C motif chemokine 14 (CXCL14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[266]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Indomethacin	DMSC4A7	Bursitis		Approved	[267]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[268]

Drug(s) Affected By Cytotoxic and regulatory T-cell molecule (CRTAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[269]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]

Drug(s) Affected By Complement C1r subcomponent (C1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[274]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[244]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[274]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[275]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]

Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[251]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[279]
Indomethacin	DMSC4A7	Bursitis		Approved	[267]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[267]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[280]

Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[181]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[283]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[284]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[285]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[286]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]

Drug(s) Affected By Histone H2A type 1-B/E (H2AC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[290]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[293]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[296]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]

Drug(s) Affected By Fatty acid-binding protein, heart (FABP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[163]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[297]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Haloperidol	DM96SE0	Delirium		Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[48]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[141]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Methamphetamine	DMPM4SK	Anxiety		Approved	[298]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[299]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[302]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[303]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[304]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[305]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[307]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[308]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[309]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[310]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[311]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Histone H2B type 1-J (H2BC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[314]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[316]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[317]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[318]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[318]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[320]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[321]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[299]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[322]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[323]
Terbutaline	DMD4381	Asthma	CA23	Approved	[324]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[325]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[326]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[328]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[329]

Drug(s) Affected By Laminin subunit beta-1 (LAMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[331]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[105]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[333]

Drug(s) Affected By SLIT-ROBO Rho GTPase-activating protein 2C (SRGAP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[334]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[247]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[33]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[335]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[336]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[338]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[339]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[193]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[341]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[100]

Drug(s) Affected By Cation-independent mannose-6-phosphate receptor (IGF2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[285]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]

Drug(s) Affected By Collagen alpha-1(XI) chain (COL11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[225]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[342]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[343]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[344]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[345]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[346]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[347]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[348]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[349]

Drug(s) Affected By Hematopoietic lineage cell-specific protein (HCLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[350]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[352]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[353]
Haloperidol	DM96SE0	Delirium		Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By Fumarylacetoacetase (FAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[50]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[251]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[354]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[355]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[357]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[339]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[358]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[360]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[353]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[244]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[362]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[363]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[364]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[366]

Drug(s) Affected By Elafin (PI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Protachykinin-1 (TAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[369]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[370]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[371]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[369]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[372]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]

Drug(s) Affected By Filaggrin (FLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[318]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[321]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[283]

Drug(s) Affected By Galanin peptides (GAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[373]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[373]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[373]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Protein S100-A1 (S100A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By Glycine dehydrogenase (GLDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[242]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Loricrin (LORICRIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[321]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
SB 203580	DMAET6F	N. A.	N. A.	Terminated	[378]
PD98059	DMZC90M	Cardiac arrest	MC82	Investigative	[378]

Drug(s) Affected By Nuclear transcription factor Y subunit alpha (NFYA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[379]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[290]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[380]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[381]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[382]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[384]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[382]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[385]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Bortezomib	DMNO38U	Leukemia		Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[112]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[387]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[388]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[390]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[391]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[392]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[393]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[394]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[395]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]

Drug(s) Affected By G0/G1 switch protein 2 (G0S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[397]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Proteasome subunit beta type-9 (PSMB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[398]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[399]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[400]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[398]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[402]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[388]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[403]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[404]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[405]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[387]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[175]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[390]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[391]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[406]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[354]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[407]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[408]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[409]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By Flavin reductase (BLVRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[285]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Bortezomib	DMNO38U	Leukemia		Approved	[221]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[410]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[411]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[309]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[412]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[414]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[416]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[417]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]

Drug(s) Affected By Adenylosuccinate synthetase isozyme 2 (ADSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[418]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[419]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[420]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[421]

Drug(s) Affected By Protein S100-A7 (S100A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[181]

Drug(s) Affected By Peroxiredoxin-2 (PRDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[422]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[423]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[424]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[425]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Cytokine receptor common subunit beta (CSF2RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[33]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[426]

Drug(s) Affected By Protein S100-A5 (S100A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[427]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[428]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Trypsin-3 (PRSS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[429]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[354]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[430]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[244]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[431]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[432]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[433]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[434]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]

Drug(s) Affected By Keratin, type II cytoskeletal 2 epidermal (KRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[343]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[149]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[435]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Gap junction gamma-1 protein (GJC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[436]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Hippocalcin-like protein 1 (HPCAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[437]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]

Drug(s) Affected By Proteasome subunit beta type-10 (PSMB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[398]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[398]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[34]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[35]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[439]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[439]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[34]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[440]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[441]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[442]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[443]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[443]

Drug(s) Affected By Chemerin-like receptor 2 (CMKLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[445]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By Neuromedin-U (NMU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]

Drug(s) Affected By Adhesion G protein-coupled receptor E5 (ADGRE5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[447]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[448]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]

Drug(s) Affected By MARCKS-related protein (MARCKSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[251]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[449]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By Dual specificity protein kinase CLK3 (CLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[290]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[420]

Drug(s) Affected By DNA ligase 3 (LIG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[450]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[225]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[451]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[311]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[221]

Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[452]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[452]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[452]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[452]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[452]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[452]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[453]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[454]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[455]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[456]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[431]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[299]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[457]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[458]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[459]

Drug(s) Affected By Epithelial membrane protein 1 (EMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]

Drug(s) Affected By GTP-binding protein GEM (GEM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By RWD domain-containing protein 2B (RWDD2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Serine protease inhibitor Kazal-type 7 (SPINK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Proteasome activator complex subunit 3 (PSME3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[460]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[461]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[462]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[463]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]

Drug(s) Affected By Histone H2B type 1-C/E/F/G/I (H2BC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[290]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[314]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[342]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[465]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[466]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[467]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]

Drug(s) Affected By Iroquois-class homeodomain protein IRX-3 (IRX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]

Drug(s) Affected By Interferon-induced 35 kDa protein (IFI35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[468]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[469]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By Myosin light chain 5 (MYL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[471]

Drug(s) Affected By Desmoglein-1 (DSG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[472]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[473]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[349]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[474]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[436]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By Desmocollin-1 (DSC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[181]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[475]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[228]

Drug(s) Affected By Nexilin (NEXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[290]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Pejvakin (PJVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By Ecto-ADP-ribosyltransferase 3 (ART3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[476]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Ras-related protein Rab-33A (RAB33A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[477]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Growth factor receptor-bound protein 7 (GRB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[181]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[478]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[251]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[480]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[481]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[482]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[483]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[484]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[485]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[486]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[487]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[488]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[489]

Drug(s) Affected By Prostasin (PRSS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]

Drug(s) Affected By Histone H2B type 2-E (H2BC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[97]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[463]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[141]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[490]

Drug(s) Affected By Protein Dok-7 (DOK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[491]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[122]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[492]

Drug(s) Affected By MHC class I polypeptide-related sequence B (MICB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[493]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[285]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]

Drug(s) Affected By UPF0711 protein C18orf21 (C18ORF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]

Drug(s) Affected By Cytochrome c oxidase assembly protein COX19 (COX19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By tRNA wybutosine-synthesizing protein 2 homolog (TRMT12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[492]

Drug(s) Affected By Transmembrane protein 177 (TMEM177)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[290]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[495]

Drug(s) Affected By Filaggrin-2 (FLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[496]

Drug(s) Affected By Protein BEX5 (BEX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX60-like (DDX60L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[497]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[498]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Tetratricopeptide repeat protein 32 (TTC32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[499]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[33]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[27]

Drug(s) Affected By Sterile alpha motif domain-containing protein 9 (SAMD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[500]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[501]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Late cornified envelope protein 1E (LCE1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[33]

Drug(s) Affected By Proline-rich protein 9 (PRR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]

Drug(s) Affected By Protein FAM171A1 (FAM171A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[240]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[240]

Drug(s) Affected By Stabilizer of axonemal microtubules 2 (SAXO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Autophagy-related protein 9B (ATG9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[502]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Olfactomedin-like protein 2A (OLFML2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By LEM domain-containing protein 1 (LEMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[368]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[503]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[504]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD11 (KCTD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By Multiple C2 and transmembrane domain-containing protein 1 (MCTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]

Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[95]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[95]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Volume-regulated anion channel subunit LRRC8E (LRRC8E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]

Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[141]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Arylacetamide deacetylase-like 2 (AADACL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Uncharacterized protein C16orf46 (C16ORF46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[506]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[506]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[507]

Drug(s) Affected By Ribosomal protein eL22-like (RPL22L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[352]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]

Drug(s) Affected By Long-chain fatty acid transport protein 1 (SLC27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[508]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[509]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]

Drug(s) Affected By Spindle assembly abnormal protein 6 homolog (SASS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[510]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]

Drug(s) Affected By Sushi domain-containing protein 1 (SUSD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[225]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[499]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[511]

Drug(s) Affected By Serine protease inhibitor Kazal-type 6 (SPINK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Insulin growth factor-like family member 2 (IGFL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[512]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[513]

Drug(s) Affected By Protein disulfide isomerase CRELD2 (CRELD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[417]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[228]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[247]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[471]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[514]

Drug(s) Affected By Repetin (RPTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Rho-related GTP-binding protein RhoU (RHOU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[228]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[501]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]

Drug(s) Affected By Cytochrome b5 reductase 4 (CYB5R4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[515]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]

Drug(s) Affected By KRAB domain-containing protein 5 (KRBOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By L-xylulose reductase (DCXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[516]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]

Drug(s) Affected By tRNA-splicing endonuclease subunit Sen54 (TSEN54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]

Drug(s) Affected By Protein S100-A7A (S100A7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[517]

Drug(s) Affected By Glucosylceramide transporter ABCA12 (ABCA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 10 (NLRP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By GAS2-like protein 3 (GAS2L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]

Drug(s) Affected By Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[518]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[27]

Drug(s) Affected By Ceramide synthase 3 (CERS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Proline-rich protein 15 (PRR15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[519]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[520]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Sodium/hydrogen exchanger 9 (SLC9A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Methylmalonic aciduria type A protein, mitochondrial (MMAA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC6 (HERC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[180]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[180]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[180]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]

Drug(s) Affected By Inactive serine/threonine-protein kinase TEX14 (TEX14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[521]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[248]

Drug(s) Affected By Iron-sulfur cluster co-chaperone protein HscB (HSCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[471]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[33]

Drug(s) Affected By Cadherin-like protein 26 (CDH26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[342]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[522]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[523]

Drug(s) Affected By Polycomb group protein ASXL1 (ASXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[524]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[525]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[247]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[526]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX60 (DDX60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By Threonine synthase-like 1 (THNSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[501]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]

Drug(s) Affected By Adhesion G-protein coupled receptor G2 (ADGRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]

Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[527]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By CKLF-like MARVEL transmembrane domain-containing protein 8 (CMTM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[528]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[529]

Drug(s) Affected By Sesquipedalian-1 (PHETA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[506]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[506]

Drug(s) Affected By ADP-ribosylation factor GTPase-activating protein 2 (ARFGAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[151]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[248]

Drug(s) Affected By Uncharacterized protein KIAA1958 (KIAA1958)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By G patch domain-containing protein 11 (GPATCH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[205]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[401]

Drug(s) Affected By Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Liprin-beta-2 (PPFIBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[399]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]

Drug(s) Affected By Phosphatidylcholine:ceramide cholinephosphotransferase 2 (SGMS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Modulator of smoothened protein (MOSMO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[530]

Drug(s) Affected By Piwi-like protein 2 (PIWIL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]

Drug(s) Affected By Retinoic acid early transcript 1E (RAET1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[518]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Protein Shroom3 (SHROOM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]

Drug(s) Affected By Sodium-dependent phosphate transporter 1 (SLC20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[531]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[532]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[533]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By Solute carrier family 25 member 43 (SLC25A43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[476]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Soluble calcium-activated nucleotidase 1 (CANT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[495]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[205]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[534]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Bortezomib	DMNO38U	Leukemia		Approved	[221]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[477]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By SEC14-like protein 1 (SEC14L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[535]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[240]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[73]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[444]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[357]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]

Drug(s) Affected By Peroxidasin homolog (PXDN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[536]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[537]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By Rho-related GTP-binding protein Rho6 (RND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[538]

Drug(s) Affected By Protein RFT1 homolog (RFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[368]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]

Drug(s) Affected By Ras-related protein Rab-7b (RAB7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[290]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[27]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[477]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[539]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[513]

Drug(s) Affected By Transmembrane protein 125 (TMEM125)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]

Drug(s) Affected By Transmembrane protein 45B (TMEM45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[48]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]

Drug(s) Affected By Inactive rhomboid protein 1 (RHBDF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[540]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[540]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Mestranol	DMG3F94	Contraception	QA21	Approved	[540]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[540]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[541]

Drug(s) Affected By Large ribosomal subunit protein mL38 (MRPL38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Protein bicaudal D homolog 1 (BICD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[542]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[543]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]

Drug(s) Affected By Peroxisomal membrane protein 11C (PEX11G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By CUGBP Elav-like family member 6 (CELF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[399]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Calmin (CLMN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[540]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Mestranol	DMG3F94	Contraception	QA21	Approved	[540]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[540]

Drug(s) Affected By Calpain small subunit 2 (CAPNS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Adenylate kinase 8 (AK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[248]

Drug(s) Affected By Uncharacterized protein C5orf34 (C5ORF34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Retinol dehydrogenase 12 (RDH12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[544]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]
all-trans-retinal	DM6CEVB	Discovery agent	N.A.	Investigative	[544]

Drug(s) Affected By Small proline-rich protein 4 (SPRR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Erythroid membrane-associated protein (ERMAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[498]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[545]

Drug(s) Affected By Kinesin-like protein KIF20B (KIF20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[463]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[546]

Drug(s) Affected By Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[547]

Drug(s) Affected By Cysteine/serine-rich nuclear protein 1 (CSRNP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[548]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[290]

Drug(s) Affected By Protein FAM83C (FAM83C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[368]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Junctophilin-2 (JPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[520]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[549]

Drug(s) Affected By Vesicle-trafficking protein SEC22c (SEC22C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[33]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[550]

Drug(s) Affected By RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RHNO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]

Drug(s) Affected By Transcription factor SOX-7 (SOX7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Indomethacin	DMSC4A7	Bursitis		Approved	[551]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[492]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[354]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[73]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[552]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[553]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[354]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[417]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[552]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[554]

Drug(s) Affected By TNF receptor-associated factor 4 (TRAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[212]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[516]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[555]

Drug(s) Affected By Very long chain fatty acid elongase 1 (ELOVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[535]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[547]

Drug(s) Affected By Replication initiator 1 (REPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[556]

Drug(s) Affected By Cornifelin (CNFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[225]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[269]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[549]

Drug(s) Affected By Late cornified envelope protein 3D (LCE3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Small proline-rich protein 2G (SPRR2G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[516]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[221]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[557]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]

Drug(s) Affected By Tripartite motif-containing protein 6 (TRIM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[376]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Solute carrier family 22 member 4 (SLC22A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[558]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[532]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[559]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]

Drug(s) Affected By Kinesin light chain 2 (KLC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]

Drug(s) Affected By Coiled-coil domain-containing protein 8 (CCDC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[492]

Drug(s) Affected By PC-esterase domain-containing protein 1A (PCED1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[499]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Melanoma-associated antigen H1 (MAGEH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[547]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By RING finger protein 39 (RNF39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]

Drug(s) Affected By SPARC-related modular calcium-binding protein 1 (SMOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[560]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[350]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[27]

Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[25]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[110]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]

Drug(s) Affected By DENN domain-containing protein 2D (DENND2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[499]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Metal transporter CNNM2 (CNNM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[342]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[501]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]

Drug(s) Affected By Endogenous retroviral envelope protein HEMO (ERVMER34-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[110]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]

Drug(s) Affected By Plasminogen receptor (PLGRKT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[561]

Drug(s) Affected By UPF0606 protein KIAA1549 (KIAA1549)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]

Drug(s) Affected By Stromal cell-derived factor 2-like protein 1 (SDF2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[417]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Carbohydrate sulfotransferase 11 (CHST11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Bortezomib	DMNO38U	Leukemia		Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[352]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By Arf-GAP with dual PH domain-containing protein 2 (ADAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[562]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[563]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (B3GAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By Matrix-remodeling-associated protein 5 (MXRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[180]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[564]

Drug(s) Affected By SERTA domain-containing protein 4 (SERTAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]

Drug(s) Affected By E3 ubiquitin-protein ligase FANCL (FANCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[285]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[242]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[242]

Drug(s) Affected By Rhomboid-related protein 2 (RHBDL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[565]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[368]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[240]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[521]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP11 (FKBP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[420]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[566]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[240]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[228]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[567]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Grainyhead-like protein 1 homolog (GRHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By SH3 domain-binding protein 4 (SH3BP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[565]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[535]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]

Drug(s) Affected By Inhibitor of Bruton tyrosine kinase (IBTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[500]
Bortezomib	DMNO38U	Leukemia		Approved	[221]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[568]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[420]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Myelin expression factor 2 (MYEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[342]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[119]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[33]

Drug(s) Affected By Small proline-rich protein 3 (SPRR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[459]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[569]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Cornulin (CRNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Interleukin-36 receptor antagonist protein (IL36RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[475]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[465]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[570]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[354]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[73]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[571]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[444]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[354]

Drug(s) Affected By Pleckstrin homology domain-containing family B member 1 (PLEKHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[131]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Cysteine-rich C-terminal protein 1 (CRCT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[350]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[518]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[572]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[280]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[258]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By Kelch-like protein 21 (KLHL21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]

Drug(s) Affected By Phosphatidylcholine transfer protein (PCTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[187]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[574]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]

Drug(s) Affected By F-box only protein 5 (FBXO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[575]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[465]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]

Drug(s) Affected By Phospholipase A and acyltransferase 4 (PLAAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[299]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By Ankyrin repeat domain-containing protein 50 (ANKRD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[576]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Pleckstrin homology domain-containing family G member 1 (PLEKHG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[577]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Protein PHTF1 (PHTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Bortezomib	DMNO38U	Leukemia		Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[467]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Protein Smaug homolog 1 (SAMD4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[428]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]

Drug(s) Affected By DNA-binding protein SATB2 (SATB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Haloperidol	DM96SE0	Delirium		Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[578]

Drug(s) Affected By Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (DHDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 3 (LAMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[285]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[516]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[579]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[579]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[579]

Drug(s) Affected By Hepatocyte nuclear factor 3-beta (FOXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[443]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[580]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[580]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[581]

Drug(s) Affected By Heparan sulfate glucosamine 3-O-sulfotransferase 2 (HS3ST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[582]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[191]

Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[240]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[583]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Disco-interacting protein 2 homolog C (DIP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[466]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[258]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[466]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]

Drug(s) Affected By C-C motif chemokine 27 (CCL27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[584]

Drug(s) Affected By AP-4 complex subunit sigma-1 (AP4S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[131]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[258]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[226]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[27]

Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[585]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[586]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[539]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ alpha 2 chain (HLA-DQA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Protein PRRC2A (PRRC2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[587]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[588]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[589]

Drug(s) Affected By Complement C2 (C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[590]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[591]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[539]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serum albumin (ALB)	TTFNGC9	ALBU_HUMAN	Binder	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[3]
A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3)	OT2U6VF5	ATS3_HUMAN	Gene/Protein Processing	[4]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Gene/Protein Processing	[4]
Acyl-protein thioesterase 1 (LYPLA1)	OTENU47T	LYPA1_HUMAN	Gene/Protein Processing	[5]
Adenylate kinase 8 (AK8)	OT2UF6YM	KAD8_HUMAN	Gene/Protein Processing	[4]
Adenylosuccinate synthetase isozyme 2 (ADSS2)	OTW26XXB	PURA2_HUMAN	Gene/Protein Processing	[4]
Adhesion G protein-coupled receptor E5 (ADGRE5)	OTTSB84Q	AGRE5_HUMAN	Gene/Protein Processing	[4]
Adhesion G-protein coupled receptor G2 (ADGRG2)	OTPAD5S1	AGRG2_HUMAN	Gene/Protein Processing	[4]
ADP-ribosylation factor GTPase-activating protein 2 (ARFGAP2)	OTIP5ZJ7	ARFG2_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Gene/Protein Processing	[3]

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