Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0N634)

Drug Name
CITCO Drug Info
Synonyms
CITCO; 338404-52-7; UNII-D77H8321PB; 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE O-(3,4-DICHLOROBENZYL)OXIME; CHEMBL458603; D77H8321PB; 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime; 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; CITCO cpd; Spectrum5_001974; BSPBio_001028; SCHEMBL241281; DTXSID4040761; CHEBI:92928; BCBcMAP01_000217; 6-[4-Chlorophenyl]imidazo[2,1-b][1,3]thiazole-5-carbaldehydeo-[3,4-dichlorobenzyl]oxime
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9600409
ChEBI ID
CHEBI:92928
CAS Number
CAS 338404-52-7
TTD Drug ID
DM0N634

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Orphan nuclear receptor NR1I3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclizine DMS7T13 Dizziness MB48 Approved [7]
(5BETA)-PREGNANE-3,20-DIONE DMVQ6RN Discovery agent N.A. Investigative [8]
TCPOBOP DMKVF5Q Discovery agent N.A. Investigative [9]
androstenol DM7RXQ6 Discovery agent N.A. Investigative [10]
androstanol DMPXF5I Discovery agent N.A. Investigative [10]
Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [11]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [12]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [11]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [12]
Sulfinpyrazone DMEV954 Gout FA25 Approved [13]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [11]
Zafirlukast DMHNQOG Asthma CA23 Approved [11]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [11]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [14]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [15]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [18]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [19]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [20]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [21]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [22]
Capsaicin DMGMF6V Back pain ME84.Z Approved [23]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [24]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [26]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [27]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [28]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [29]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [30]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [31]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [32]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [33]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [34]
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Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [35]
Methoxsalen DME8FZ9 Cutaneous T-cell lymphoma 2B01 Approved [36]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [43]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [44]
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Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [20]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [19]
Capsaicin DMGMF6V Back pain ME84.Z Approved [46]
Zafirlukast DMHNQOG Asthma CA23 Approved [47]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [20]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [48]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [19]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [20]
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Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
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Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [54]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [60]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [60]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [62]
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Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [64]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [71]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [71]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [72]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [74]
Etidronic acid DM1XHYJ Bone Paget disease Approved [71]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [71]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [71]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [76]
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Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [78]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [80]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [81]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [82]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [83]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [84]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
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Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [88]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [89]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [89]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Testosterone enanthate DMB6871 N. A. N. A. Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
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Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [92]
Selenium DM25CGV N. A. N. A. Approved [93]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [94]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [95]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [99]
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Drug(s) Affected By Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [103]
Clozapine DMFC71L Schizophrenia 6A20 Approved [104]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [105]
Bortezomib DMNO38U Leukemia Approved [106]
Arsenic DMTL2Y1 N. A. N. A. Approved [107]
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Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [108]
Testosterone DM7HUNW Hot flushes GA30 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [110]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [111]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [112]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [105]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
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Drug(s) Affected By Short-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [93]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [114]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Arsenic DMTL2Y1 N. A. N. A. Approved [107]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Urethane DM7NSI0 N. A. N. A. Phase 4 [115]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [93]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [116]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [117]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [118]
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Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [119]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [120]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [121]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [125]
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Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
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Drug(s) Affected By Acyl-coenzyme A thioesterase 6 (ACOT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [107]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [129]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [130]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [116]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [100]
Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [133]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [89]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [89]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [134]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [135]
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Drug(s) Affected By Acyl-coenzyme A thioesterase 1 (ACOT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [135]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [111]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [112]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [136]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [137]
Urethane DM7NSI0 N. A. N. A. Phase 4 [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [138]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [117]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [139]
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Drug(s) Affected By Peroxisomal succinyl-coenzyme A thioesterase (ACOT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Arsenic DMTL2Y1 N. A. N. A. Approved [107]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [141]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [58]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [142]
GW7647 DM9RD0C Discovery agent N.A. Investigative [3]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [143]
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Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Arsenic DMTL2Y1 N. A. N. A. Approved [107]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [144]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [58]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [145]
GW7647 DM9RD0C Discovery agent N.A. Investigative [3]
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Drug(s) Affected By Very long chain fatty acid elongase 1 (ELOVL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [146]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [147]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [136]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [148]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [149]
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Drug(s) Affected By Very long chain fatty acid elongase 6 (ELOVL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [150]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [151]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [112]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [152]
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Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [156]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [99]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [157]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [128]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [158]
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Drug(s) Affected By Thyroid hormone-inducible hepatic protein (THRSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [159]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [146]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [60]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [60]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [160]
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Drug(s) Affected By Carbohydrate-responsive element-binding protein (MLXIPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [146]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [112]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [161]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [163]
Urethane DM7NSI0 N. A. N. A. Phase 4 [115]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [164]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [165]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [146]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [166]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Orphan nuclear receptor NR1I3 (NR1I3) TTRANFM NR1I3_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1) OTX65INE PLCA_HUMAN Gene/Protein Processing [3]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) OT5I4Y9K PLCB_HUMAN Gene/Protein Processing [3]
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) OTR4990X PLPL3_HUMAN Gene/Protein Processing [4]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [4]
Acyl-coenzyme A thioesterase 1 (ACOT1) OTXFL7WM ACOT1_HUMAN Gene/Protein Processing [3]
Acyl-coenzyme A thioesterase 6 (ACOT6) OTDE5QKC ACOT6_HUMAN Gene/Protein Processing [3]
Carbohydrate-responsive element-binding protein (MLXIPL) OTR9MLLW MLXPL_HUMAN Gene/Protein Processing [4]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) OTIN6G20 CPT2_HUMAN Gene/Protein Processing [3]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Gene/Protein Processing [6]

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119 Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis. Toxicol Sci. 2017 Sep 1;159(1):159-169. doi: 10.1093/toxsci/kfx121.
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124 Comparative study of the effects of ziram and disulfiram on human monocyte-derived macrophage functions and polarization: involvement of zinc. Cell Biol Toxicol. 2021 Jun;37(3):379-400. doi: 10.1007/s10565-020-09540-6. Epub 2020 Jul 25.
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127 Activation of the constitutive androstane receptor by monophthalates. Chem Res Toxicol. 2016 Oct 17;29(10):1651-1661.
128 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
129 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
130 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
131 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
132 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
133 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
134 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
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136 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
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