Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5IHYP)

• Drug Name: Beta-D-Glucose Drug Info
• Synonyms: beta-D-glucose; beta-D-glucopyranose; 492-61-5; glucoside; b-D-Glucopyranose; beta-glucose; beta-Dextrose; b-Glucose; b-d-glucose; UNII-J4R00M814D; 28905-12-6; .beta.-D-Glucopyranose; 9001-37-0; (2R,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol; CHEMBL1614854; CHEBI:15903; WQZGKKKJIJFFOK-VFUOTHLCSA-N; J4R00M814D; Curdlan; (2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; .beta.-D-Glucose; BGC; ZYMOSAN; Glucose, (beta-D)-Isomer; Callose; b-Dextrose; beta-D-Glucopyranose, anhydrous

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 64689
  ChEBI ID: CHEBI:15903
  CAS Number: CAS 492-61-5
  TTD Drug ID: DM5IHYP

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[9]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[10]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[11]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[11]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[11]
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[9]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[11]
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[12]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[11]

Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[13]
Naproxen	DMZ5RGV	Bursitis		Approved	[14]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[15]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[16]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[17]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[18]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[19]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[18]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[20]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[21]

Drug(s) Targeting Alpha-glucosidase (GLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cipaglucosidase alfa	DMAPDH2	Glycogen storage disease type II	5C51.3	Approved in EU	[22]
Cipaglucosidase alfa	DMAPDH2	Glycogen storage disease type II	5C51.3	Approved in EU	[23]
Deoxynojirimycin	DM2ATZB	Pompe disease	5C51.3	Phase 3	[24]
Anamorelin	DM6HXTS	Carbohydrate metabolism disorder	5C51.Z	Phase 3	[25]
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[26]
AAV2/8-LSPhGAA	DMIX5HF	Pompe disease	5C51.3	Phase 1	[27]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[1]
POP-1	DMVTKCX	Solid tumour/cancer	2A00-2F9Z	Investigative	[28]
JBP-1	DM0KMPN	Solid tumour/cancer	2A00-2F9Z	Investigative	[28]

Drug(s) Targeting Bacterial Fatty acid synthetase I (Bact inhA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[29]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[30]
Ethionamide	DM8K3EI	Pulmonary tuberculosis	1B10.Z	Approved	[31]
Prothionamide	DMX0EZJ	Tuberculosis	1B10-1B1Z	Approved	[31]
AFN-1720	DM6AJKC	Bacterial infection	1A00-1C4Z	Phase 2	[32]
MMV00/0053	DMF27BS	Malaria	1F40-1F45	Terminated	[33]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[34]
4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole	DMX681M	Discovery agent	N.A.	Investigative	[1]
Indole Naphthyridinone	DMB4ZNW	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[35]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[36]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[37]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[38]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[39]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[40]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[41]
Procarbazine	DMIK367	Hodgkin lymphoma	2B30	Approved	[42]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[43]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[44]

Drug(s) Targeting Pancreatic alpha-amylase (AMY2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pancrecarb	DMOML9Q	Pancreatic malfunction	DC30-DC3Z	NDA filed	[45]
Liprotamase	DMNF4UH	Cystic fibrosis	CA25	Phase 3	[46]
Pyroglutamic Acid	DMROZUA	Discovery agent	N.A.	Investigative	[1]
Acanthus ilicifolius Linn	DMZDFRI	Discovery agent	N.A.	Investigative	[47]
6-Deoxy-Alpha-D-Glucose	DM9HBY5	Discovery agent	N.A.	Investigative	[1]
Acarbose Derived Hexasaccharide	DMS9COH	Discovery agent	N.A.	Investigative	[1]
Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam	DMMY542	Discovery agent	N.A.	Investigative	[26]
Hydroxycitric acid	DMY0A9E	Discovery agent	N.A.	Investigative	[48]
Alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen	DM4IXUQ	Discovery agent	N.A.	Investigative	[49]
Alpha-acarviosinyl-(1-->7)-3-alpha-D-glucopyranosylpropen	DMHV14R	Discovery agent	N.A.	Investigative	[49]

Drug(s) Targeting Glucokinase (GCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY-2599506	DMMI0RH	Diabetic complication	5A2Y	Phase 2	[50]
AMG 151	DMGOFL3	Type-2 diabetes	5A11	Phase 2	[50]
PF-04991532	DM94NBE	Diabetic complication	5A2Y	Phase 2	[51]
GK1-399	DMLFSMX	Diabetic complication	5A2Y	Phase 2	[52]
LY-2608204	DM4EF9Y	Type-2 diabetes	5A11	Phase 2	[53]
PF-04937319	DMQMF4O	Type-2 diabetes	5A11	Phase 2	[54]
AZD1656	DMUE90I	Diabetic complication	5A2Y	Phase 2	[55]
TTP399	DMBKQSZ	Type 2 diabetes	5A11	Phase 2	[56]
HMS5552	DMRYM03	Type-2 diabetes	5A11	Phase 1	[57]
BMS-820132	DMCX0H7	Type-2 diabetes	5A11	Phase 1	[58]

Drug(s) Targeting Glycogen phosphorylase muscle form (GP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[59]
JTT-651	DMGP42Q	Type-2 diabetes	5A11	Discontinued in Phase 1	[60]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[1]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[1]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[1]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[1]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[1]
OLEANOLIC_ACID	DMWDMJ3	Discovery agent	N.A.	Investigative	[61]
Oleanonic acid	DMYPJC3	Discovery agent	N.A.	Investigative	[61]
Nojirimycine Tetrazole	DMYZRTB	Discovery agent	N.A.	Investigative	[62]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]
Haloperidol	DM96SE0	Delirium		Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[68]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[75]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[76]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[78]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[79]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[80]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[81]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[82]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[85]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[86]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[93]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[95]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[97]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[101]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[90]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[103]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[104]
Fructose	DM43AN2	Vomiting	MD90	Approved	[65]
Ketoprofen	DMRKXPT	Bursitis		Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[106]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[107]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[108]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]

Drug(s) Affected By Platelet basic protein (PPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[111]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[112]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[113]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[115]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[117]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[118]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[128]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[133]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[137]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[138]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[139]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[65]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[142]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[145]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[98]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[146]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[148]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[149]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[77]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[150]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[157]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[158]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[159]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[160]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[148]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[163]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[76]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[164]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[165]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[167]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[168]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[169]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[106]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[170]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[149]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[172]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[173]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[176]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[139]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[184]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]

Drug(s) Affected By Neutrophil cytosol factor 2 (NCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[127]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[197]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[198]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[203]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[205]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[206]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[207]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[214]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[215]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[65]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[216]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[218]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[219]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[220]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]

Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[205]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[224]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[225]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[226]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[227]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[234]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[237]

Drug(s) Affected By Phospholipase A2 group V (PLA2G5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[239]
Methamphetamine	DMPM4SK	Anxiety		Approved	[240]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[241]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[242]
SB-203347	DM3AWMF	Discovery agent	N.A.	Investigative	[243]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[244]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[245]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[207]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[246]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[250]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[251]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[252]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[253]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[254]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[255]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[256]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[216]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[257]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[258]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[169]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[261]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[262]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[263]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[264]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[98]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[268]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[94]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[269]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[271]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[272]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[273]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[277]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[279]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[280]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[164]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[216]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[168]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[281]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[259]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[283]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[284]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[285]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[216]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[286]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[151]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[287]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[288]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[290]

Drug(s) Affected By C-type lectin domain family 7 member A (CLEC7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[292]
Bortezomib	DMNO38U	Leukemia		Approved	[293]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[294]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[242]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[296]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[297]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[298]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[76]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[288]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Selenium	DM25CGV	N. A.	N. A.	Approved	[78]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[287]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[76]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]

Drug(s) Affected By Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[301]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[302]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alpha-glucosidase (GLA)	TTHCF4J	LYAG_HUMAN; GANAB_HUMAN; GANC_HUMAN	Inhibitor	[1]
Bacterial Fatty acid synthetase I (Bact inhA)	TTVTX4N	INHA_MYCTU	Inhibitor	[1]
Glucokinase (GCK)	TTDLNGZ	HXK4_HUMAN	Inhibitor	[1]
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[1]
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Inhibitor	[1]
Pancreatic alpha-amylase (AMY2A)	TTCGSZ4	AMYP_HUMAN	Inhibitor	[1]
Plasmodium Enoyl-ACP reductase (Malaria fabI)	TTNX2CS	Q965D5_PLAFA	Inhibitor	[1]
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[2]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[3]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Protein Interaction/Cellular Processes	[4]
C-C motif chemokine 20 (CCL20)	OTUCJY4N	CCL20_HUMAN	Gene/Protein Processing	[5]
C-type lectin domain family 7 member A (CLEC7A)	OTRTBH27	CLC7A_HUMAN	Gene/Protein Processing	[6]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[2]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[2]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[7]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[8]

References

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• [3] Neisseria gonorrhoeae delays the onset of apoptosis in polymorphonuclear leukocytes. Cell Microbiol. 2006 Nov;8(11):1780-90. doi: 10.1111/j.1462-5822.2006.00748.x. Epub 2006 Jun 27.
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• [5] Activation of airway epithelial cells by toll-like receptor agonists. Am J Respir Cell Mol Biol. 2004 Sep;31(3):358-64. doi: 10.1165/rcmb.2003-0388OC. Epub 2004 Jun 10.
• [6] Fungal cell wall agents suppress the innate inflammatory cytokine responses of human peripheral blood mononuclear cells challenged with lipopolysaccharide in vitro. Int Immunopharmacol. 2011 Aug;11(8):939-47. doi: 10.1016/j.intimp.2011.02.006. Epub 2011 Feb 15.
• [7] Human alveolar macrophages and granulocyte-macrophage colony-stimulating factor-induced monocyte-derived macrophages are resistant to H2O2 via their high basal and inducible levels of catalase activity. J Biol Chem. 2001 Jun 29;276(26):24360-4.
• [8] Regulation and possible function of beta-catenin in human monocytes. J Immunol. 2001 Dec 15;167(12):6786-93. doi: 10.4049/jimmunol.167.12.6786.
• [9] Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
• [10] Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
• [11] Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
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