Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM60QMR)

Drug Name
Ethacrynic acid Drug Info
Synonyms
Crinuryl; Edecril; Edecrina; Endecril; Ethacrynate; Hidromedin; Hydromedin; Mingit; Otacril; Reomax; Taladren; Uregit; Acide etacrynique; Acido etacrinico; Acidum etacrynicum; Etacrinic acid; Etacrynic Acid; Etakrinic acid; Ethacrinic acid; Ethacryinic Acid; Kyselina ethakrynova; Kyselina ethakrynova [Czech]; Methylenebutyryl phenoxyacetic acid; Methylenebutyrylphenoxyacetic acid; E0526; MK 595; Acide etacrynique [INN-French]; Acido etacrinico [INN-Spanish]; Acidum etacrynicum [INN-Latin]; Edecrin (TN); Ethacrinique (acide); Ethacrynic Acid, Sodium Salt; Ethacrynic acid (USP); Ethacrynic acid [USAN:BAN]; MK-595; Etacrynic acid (JP15/INN); [2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid; [2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid; [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid; [4-(2-Methylenebutyryl)-2,3-dichlorophenoxy]acetic acid; Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova; Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova [Czech]; [2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid; (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid; (2,3-Dichloro-4-(2-methylenebutyryl)phenoxy)acetic acid; (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid; (4-(2-Methylenebutyryl)-2,3-dichlorophenoxy)acetic acid; 2,3-Dichloro-4(2-methylene-butyryl)phenoxy] acetic acid; 2,3-Dichloro-4-(2-methylenebutyl)phenoxyacetic acid; 2,3-Dichloro-4-(2-methylenebutyryl)phenoxy acetic acid; 2,3-Dichloro-4-(2-methylenebutyryl)phenoxyacetic acid; 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
Indication
Disease Entry ICD 11 Status REF
Edema MG29 Approved [1]
High blood pressure BA00 Approved [2]
Therapeutic Class
Diuretics
Cross-matching ID
PubChem CID
3278
ChEBI ID
CHEBI:4876
CAS Number
CAS 58-54-8
TTD Drug ID
DM60QMR
VARIDT Drug ID
DR00548
INTEDE Drug ID
DR0653
ACDINA Drug ID
D00251

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Solute carrier family 12 member 1 (SLC12A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [12]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [13]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [14]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [15]
Torasemide DMXKJ6C Congestive heart failure BD10 Approved [16]
Bendroflumethiazide DM7EVLC High blood pressure BA00 Approved [17]
Trichlormethiazide DMHAQCO Hypertension BA00-BA04 Approved [18]
Hydroflumethiazide DMVPUQI Congestive heart failure BD10 Approved [17]
Methyclothiazide DMN7SDE Edema MG29 Approved [17]
Chlorthalidone DM4DMBT Edema MG29 Approved [19]
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Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [26]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [27]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [28]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [72]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [73]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [74]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [75]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [76]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [76]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [31]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [33]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [34]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [35]
Estrone DM5T6US Acne vulgaris ED80 Approved [36]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [37]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [38]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [39]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [50]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [51]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [52]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [57]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [58]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [59]
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Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [42]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [43]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [44]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [45]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [46]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [47]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [48]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [49]
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Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [47]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [60]
Thiotepa DMIZKOP Breast cancer 2C60-2C65 Approved [61]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [62]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [77]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [78]
Diazepam DM08E9O Alcohol withdrawal Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [7]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [78]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [80]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [81]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [78]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [82]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [83]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [84]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [86]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [87]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [88]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [89]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [99]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [100]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [106]
Testosterone DM7HUNW Hot flushes GA30 Approved [107]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [109]
Menthol DMG2KW7 Back pain ME84.Z Approved [110]
Capsaicin DMGMF6V Back pain ME84.Z Approved [111]
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Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [116]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [118]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [119]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [120]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [121]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [122]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [123]
Verapamil DMA7PEW Angina pectoris BA40 Approved [124]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [126]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [127]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [129]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Verapamil DMA7PEW Angina pectoris BA40 Approved [124]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Selenium DM25CGV N. A. N. A. Approved [132]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [133]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [134]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [136]
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Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [140]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
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Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [146]
Methotrexate DM2TEOL Anterior urethra cancer Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [148]
Aripiprazole DM3NUMH Bipolar I disorder Approved [149]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [150]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [155]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [156]
Methotrexate DM2TEOL Anterior urethra cancer Approved [147]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [159]
Paclitaxel DMLB81S Breast carcinoma Approved [160]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [161]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [163]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [164]
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Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [165]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [166]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [167]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [167]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [168]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Selenium DM25CGV N. A. N. A. Approved [132]
Etretinate DM2CZFA Keratosis ED56 Approved [171]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [172]
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Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [173]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [174]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [176]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [173]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [178]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [173]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [179]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [180]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [181]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [182]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [183]
Gefitinib DM15F0X Colon adenocarcinoma Approved [184]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [185]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [186]
Selenium DM25CGV N. A. N. A. Approved [132]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [187]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [188]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [122]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [189]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [130]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [190]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [191]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [192]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [193]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Methotrexate DM2TEOL Anterior urethra cancer Approved [195]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [196]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [197]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [198]
Gefitinib DM15F0X Colon adenocarcinoma Approved [199]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [185]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [192]
Etretinate DM2CZFA Keratosis ED56 Approved [200]
Prednisone DM2HG4X Acute asthma CA23 Approved [201]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [202]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [203]
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Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [176]
Estrone DM5T6US Acne vulgaris ED80 Approved [204]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [205]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [206]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [109]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [207]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [204]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [204]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [208]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [209]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [174]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [210]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [211]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [212]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [213]
Meloxicam DM2AR7L Arthritis FA20 Approved [214]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [215]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [216]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [217]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [218]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [218]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [219]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [220]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [176]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [218]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [218]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [219]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [221]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [213]
Selenium DM25CGV N. A. N. A. Approved [132]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [222]
Methotrexate DM2TEOL Anterior urethra cancer Approved [129]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [223]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [86]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [137]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [224]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [225]
Quercetin DM3NC4M Obesity 5B81 Approved [226]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [228]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Frizzled-5 (FZD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [152]
Panobinostat DM58WKG Chronic graft versus host disease Approved [230]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Testosterone DM7HUNW Hot flushes GA30 Approved [231]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [231]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [233]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [206]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [234]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [235]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [236]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [237]
Gefitinib DM15F0X Colon adenocarcinoma Approved [238]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [239]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [213]
Selenium DM25CGV N. A. N. A. Approved [132]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [215]
Methotrexate DM2TEOL Anterior urethra cancer Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfiredoxin-1 (SRXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [240]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [241]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [242]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [243]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [243]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [244]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [155]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [245]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [206]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [246]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [247]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [248]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [249]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [250]
Thymoquinone DMVDTR2 Polycystic ovarian syndrome 5A80.1 Phase 2/3 [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [252]
Sulfinpyrazone DMEV954 Gout FA25 Approved [253]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [254]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [255]
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [256]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [257]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [74]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [258]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Maleylacetoacetate isomerase (GSTZ1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [260]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [261]
Testosterone DM7HUNW Hot flushes GA30 Approved [262]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [263]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [233]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [264]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [109]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [265]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Solute carrier family 12 member 1 (SLC12A1) TTS087L S12A1_HUMAN Blocker [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [5]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [7]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Regulation of Drug Effects [8]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [9]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Gene/Protein Processing [9]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [9]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [9]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Protein Interaction/Cellular Processes [10]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [10]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [7]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [11]

References

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88 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
89 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
90 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
91 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
92 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
93 Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
94 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
95 Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
96 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
97 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
98 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
99 Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
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