Details of the Drug-Related molecule(s) Interaction Atlas

L-thyroxine Drug Info

DL-Thyroxin; L-3,5,3',5'-Tetraiodothyronine; L-Thyroxin; L-thyroxine; Laevothyroxinum; Laevothyroxinum (acid); Levothyroxin; Levothyroxinum (acid); T4 (Hormone); Tetraiodothyronine; Tetramet; Thyratabs; Thyrax; Thyreoideum; Thyroxinal; Thyroxine (VAN); Thyroxine (l); Thyroxine I 125; Thyroxine iodine; levothyroxine; thyroxin; thyroxine; (-)-Thyroxine; 3,3',5,5'-Tetraiodo-L-thyronine; 3,5,3',5'-Tetraiodo-L-thyronine; 3,5,3',5'-Tetraiodothyronine; 51-48-9; L-T4; t4

Cross-matching ID

PubChem CID

5819

ChEBI ID

CHEBI:18332

CAS Number

CAS 51-48-9

TTD Drug ID

DM83HWL

INTEDE Drug ID

DR1950

General Information of Drug (ID: DM83HWL)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[10]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[13]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[14]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[15]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[16]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[17]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[20]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
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Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[5]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[25]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[5]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[25]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[26]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[5]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[5]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[5]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[27]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[28]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[8]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[8]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[31]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[8]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[8]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[33]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[39]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[40]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
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Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[46]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[47]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[51]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[52]
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Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[35]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[54]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[55]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[56]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[57]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[58]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
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Drug(s) Affected By Thyroxine-binding globulin (SERPINA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprolide	DM5XPIJ	Plasma cell myeloma	2A83.1	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
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Drug(s) Affected By Thyroid hormone receptor alpha (THRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[68]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[73]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[74]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[75]
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Drug(s) Affected By Thyroid hormone receptor beta (THRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[77]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[84]
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Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[91]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[98]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[102]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[103]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[104]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[105]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[107]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[108]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[110]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[105]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[115]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[116]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[104]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[107]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[108]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[118]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[119]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[122]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[123]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[124]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[128]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[131]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[134]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[135]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[141]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[146]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[148]
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Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[142]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
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Drug(s) Affected By Sulfotransferase 4A1 (SULT4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[154]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[156]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[156]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[158]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[159]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[160]
Mononitrophenol	DM4QO9G	N. A.	N. A.	Investigative	[156]
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Drug(s) Affected By Somatotropin (GH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[161]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[162]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[163]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Sodium oxybate	DMBOV5P	Narcolepsy	7A20	Approved	[165]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[161]
Connexyn	DMF29Q5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[166]
Gamma Hydroxybutyric Acid	DMGBKVD	Narcolepsy	7A20	Approved	[167]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[168]
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Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[172]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[76]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[172]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[66]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[173]
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Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[68]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[172]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[179]
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⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sulfotransferase 1A1 (SULT1A1)	DEYWLRK	ST1A1_HUMAN	Substrate	[1]
Thyroxine 5-deiodinase (DIO3)	DET89OV	IOD3_HUMAN	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[3]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Gene/Protein Processing	[5]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Gene/Protein Processing	[6]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Gene/Protein Processing	[6]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[6]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[6]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	OTAYZMOY	SIR1_HUMAN	Gene/Protein Processing	[7]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Gene/Protein Processing	[8]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Gene/Protein Processing	[9]

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