Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9LRKB)

• Drug Name: Nicotinamide-Adenine-Dinucleotide Drug Info
• Synonyms: NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM); AC1NRCGS; [[(2R,3S,4R,5R)-5-(6-amino-7H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
• Cross-matching ID:
  PubChem CID: 5892
  ChEBI ID: CHEBI:44215
  CAS Number: CAS 53-84-9
  TTD Drug ID: DM9LRKB

Molecule-Related Drug Atlas

Drug(s) Targeting Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[1]
3,5-dichlorosalicylic acid	DMQ45WH	Discovery agent	N.A.	Investigative	[10]
Cyclopropyl	DMGFEPJ	Discovery agent	N.A.	Investigative	[11]
Trifluoroethanol	DMAWTUL	Discovery agent	N.A.	Investigative	[12]
Cyclobutyl	DM35PIJ	Discovery agent	N.A.	Investigative	[11]

Drug(s) Targeting Bacterial Flavohemoglobin (Bact hmp)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[1]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[13]
2-(N-Morpholino)-Ethanesulfonic Acid	DMZVHSB	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Glutathione reductase (GR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[14]
Golden phosphorous acetyletic compound 2	DMYJ15A	N. A.	N. A.	Patented	[15]
Terpyridineplatinum(II) complexe 3	DM54EFD	N. A.	N. A.	Patented	[15]
Terpyridineplatinum(II) complexe 4	DMOV86T	N. A.	N. A.	Patented	[15]
Golden phosphorous acetyletic compound 1	DMVAKUI	N. A.	N. A.	Patented	[15]
Acyl oxymethyl acrylamide ester derivative 1	DMXTUE1	N. A.	N. A.	Patented	[15]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[1]
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[1]
1-(2'-chlorophenyl)penta-1,4-dien-3-one	DMKTZSY	Discovery agent	N.A.	Investigative	[16]
Trans-(R(S))-2-Hydroxy-1-phenylethyl nitrate	DMXC98D	Discovery agent	N.A.	Investigative	[17]

Drug(s) Targeting Biliverdin reductase A (BLVRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[18]

Drug(s) Targeting Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[19]
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[1]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[19]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[19]
4-ANDROSTENE-3-17-DIONE	DMSE8NU	Discovery agent	N.A.	Investigative	[1]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol	DMH8WA2	Discovery agent	N.A.	Investigative	[20]
7-(3-Hydroxy-phenyl)-naphthalen-2-ol	DM2I91C	Discovery agent	N.A.	Investigative	[21]
NSC-94258	DM6VY3P	Discovery agent	N.A.	Investigative	[19]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol	DM7ERYJ	Discovery agent	N.A.	Investigative	[22]
6-(4-Hydroxy-phenyl)-naphthalen-1-ol	DM2V9XI	Discovery agent	N.A.	Investigative	[21]

Drug(s) Targeting Mitochondrial aldehyde dehydrogenase (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALD-401	DM2U530	Cerebrovascular ischaemia	8B1Z	Phase 2	[23]
GS-6637	DMXG3T1	Substance use disorder	6C4Z	Phase 1	[24]
ANS-6637	DM39QWN	Substance use disorder	6C4Z	Phase 1	[25]
FP-045	DMV9FTH	Cardiovascular disease	BA00-BE2Z	Phase 1	[26]
Daidzin	DMFCMPS	N. A.	N. A.	Terminated	[1]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[1]
ISOFORMONENTIN	DM5CMA8	Discovery agent	N.A.	Investigative	[27]
prunetin	DMPD41Q	Discovery agent	N.A.	Investigative	[27]
CVT-10216	DMDH6PJ	Alcohol dependence	6C40.2	Investigative	[28]

Drug(s) Targeting HMG-CoA reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[29]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[30]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[31]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[32]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[33]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[30]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[30]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[35]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[34]

Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[36]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[37]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[1]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[38]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[38]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[38]
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[36]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[38]
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[39]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[38]

Drug(s) Targeting Estradiol 17 beta-dehydrogenase 4 (HSD17B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3r-Hydroxydecanoyl-Coa	DMV1HMX	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Sorbitoldehydrogenase (SORD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CP-470,711	DMS2RHE	Discovery agent	N.A.	Investigative	[40]

Drug(s) Targeting Alpha-glucosidase (GLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cipaglucosidase alfa	DMAPDH2	Glycogen storage disease type II	5C51.3	Approved in EU	[41]
Cipaglucosidase alfa	DMAPDH2	Glycogen storage disease type II	5C51.3	Approved in EU	[42]
Deoxynojirimycin	DM2ATZB	Pompe disease	5C51.3	Phase 3	[43]
Anamorelin	DM6HXTS	Carbohydrate metabolism disorder	5C51.Z	Phase 3	[44]
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[12]
AAV2/8-LSPhGAA	DMIX5HF	Pompe disease	5C51.3	Phase 1	[45]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[1]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[1]
POP-1	DMVTKCX	Solid tumour/cancer	2A00-2F9Z	Investigative	[46]
JBP-1	DM0KMPN	Solid tumour/cancer	2A00-2F9Z	Investigative	[46]

Drug(s) Targeting Deoxyhypusine synthase (DHPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-Guanidinium-7-Aminoheptane	DM42IY7	Discovery agent	N.A.	Investigative	[1]
N-guanyl-1,7-diaminoheptane	DMBG3ZF	Discovery agent	N.A.	Investigative	[47]
N1-guanyl-1,7-diaminoheptane	DMXE8CB	Discovery agent	N.A.	Investigative	[48]

Drug(s) Targeting Adenosylhomocysteinase (AHCY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARISTEROMYCIN	DMRXB74	N. A.	N. A.	Terminated	[49]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[13]
Neplanocin A	DMXULGK	Discovery agent	N.A.	Investigative	[50]
5'-deoxy-5'-ureidoadenosine	DM8IQX4	Discovery agent	N.A.	Investigative	[51]
5(E)-(5'-Deoxyadenosin-5'-ylidene)pentanoic acid	DM1IGOD	Discovery agent	N.A.	Investigative	[52]
5-methylenearisteromycin	DMIQ1X3	Discovery agent	N.A.	Investigative	[49]
NORARISTEROMYCIN	DMZ9024	Discovery agent	N.A.	Investigative	[53]
D-Eritadenine	DM2XT7S	N. A.	N. A.	Investigative	[1]
5'-S-ethyl-5'-thioadenosine	DM0PQH1	Discovery agent	N.A.	Investigative	[13]
FLUORO-NEPLANOCIN A	DM0LR7G	Discovery agent	N.A.	Investigative	[54]

Drug(s) Targeting Bacterial Fatty acid synthetase I (Bact inhA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[55]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[56]
Ethionamide	DM8K3EI	Pulmonary tuberculosis	1B10.Z	Approved	[57]
Prothionamide	DMX0EZJ	Tuberculosis	1B10-1B1Z	Approved	[57]
AFN-1720	DM6AJKC	Bacterial infection	1A00-1C4Z	Phase 2	[58]
MMV00/0053	DMF27BS	Malaria	1F40-1F45	Terminated	[59]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[1]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[60]
4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole	DMX681M	Discovery agent	N.A.	Investigative	[1]
Indole Naphthyridinone	DMB4ZNW	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Trypanosoma Dihydrolipoamide dehydrogenase (Trypano LPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[13]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[1]
Diphosphate	DMHY30B	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Bacterial Dehydroquinate synthase (Bact aroB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbaphosphonate	DMGFLI7	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting L-lactate dehydrogenase (LDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
OXAMATE	DMTYBC9	Discovery agent	N.A.	Investigative	[1]
3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID	DMJ0654	Discovery agent	N.A.	Investigative	[12]
4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid	DM6WJ4K	Discovery agent	N.A.	Investigative	[1]
3-Hydroxyisoxazole-4-Carboxylic Acid	DMKLZXV	Discovery agent	N.A.	Investigative	[1]
Naphthalene-2,6-disulfonic acid	DMLHWNG	Discovery agent	N.A.	Investigative	[13]
4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid	DME29PX	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DZ9	DM2HLGC	N. A.	N. A.	Patented	[61]
AC1LJNG0	DM9Q0EC	N. A.	N. A.	Patented	[61]
STK696827	DM19GAY	N. A.	N. A.	Patented	[61]
Deamido-NAD	DMDFRTI	N. A.	N. A.	Investigative	[62]

Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[63]
Urea and carbamate bioisostere derivative 1	DMEQFXZ	N. A.	N. A.	Patented	[64]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[1]
Mycophenolic hydroxamic acid	DM4YRAH	Discovery agent	N.A.	Investigative	[65]
Tiazofurin adenine dinucleotide	DMEFVPH	Discovery agent	N.A.	Investigative	[66]
Mycophenolic bis(sulfonamide)	DMUQP3J	Discovery agent	N.A.	Investigative	[67]
6-Chloropurine Riboside, 5'-Monophosphate	DMWB43U	Discovery agent	N.A.	Investigative	[1]
1-methyl-1H-indole-3-carboxamide	DMUKAH6	Discovery agent	N.A.	Investigative	[68]
6-phenyl-3-(pyridin-4-yl)-1H-indole	DM3UBR5	Discovery agent	N.A.	Investigative	[69]
C4-MAD	DMGA9U7	Discovery agent	N.A.	Investigative	[70]

Drug(s) Targeting Intestinal maltase-glucoamylase (MGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Voglibose	DMUBP9O	Diabetic complication	5A2Y	Approved	[71]
Acarbose	DMRM3AW	Diabetic complication	5A2Y	Approved	[72]
Miglitol	DMXBQAM	Diabetic complication	5A2Y	Approved	[73]
Rh-alphaglucosidase	DMNF0G8	Pompe disease	5C51.3	Approved	[74]
Deoxynojirimycin	DM2ATZB	Pompe disease	5C51.3	Phase 3	[43]
Alpha-glucosidase	DM2RTGP	Muscle disease	FB3Z	Phase 3	[75]
PAZ-320	DMU0812	Type-2 diabetes	5A11	Phase 2	[76]
SC-49483	DM180VX	Acquired immune deficiency syndrome	1C62.3	Phase 2	[77]
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[12]
SALACINOL	DMVKQT8	N. A.	N. A.	Phase 1/2	[78]

Drug(s) Targeting UDP-glucose 4-epimerase (GALE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PSAMMAPLIN A	DM6T0IQ	Discovery agent	N.A.	Investigative	[79]
UDP-glucose	DMLT4JA	Discovery agent	N.A.	Investigative	[1]
Uridine Diphosphate Galactose	DMPA0BJ	Discovery agent	N.A.	Investigative	[80]
Uridine-Diphosphate-N-Acetylgalactosamine	DMXHO6J	N. A.	N. A.	Investigative	[1]
Uridine-Diphosphate-N-Acetylglucosamine	DMEQSTP	Discovery agent	N.A.	Investigative	[12]
Tetramethylammonium Ion	DMLEPYN	Discovery agent	N.A.	Investigative	[1]
Uridine-5'-Diphosphate	DMDQKJB	Discovery agent	N.A.	Investigative	[1]
Phenyl-Uridine-5'-Diphosphate	DM7J0YG	Discovery agent	N.A.	Investigative	[1]
Uridine-5'-Diphosphate-Mannose	DMAYCQU	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By NAD kinase (NADK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[84]
Bortezomib	DMNO38U	Leukemia		Approved	[86]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]

Drug(s) Affected By Mucin-2 (MUC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[98]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[103]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
Nicotinamide mononucleotide	DMW1LKP	N. A.	N. A.	Preclinical	[105]

Drug(s) Affected By Sphingomyelin phosphodiesterase 2 (SMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[98]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[108]
27-hydroxycholesterol	DM2L6OZ	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[114]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[115]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[118]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[119]

Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[124]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[128]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[131]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[134]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[135]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[136]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[137]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[128]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[138]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[134]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[139]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[140]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[143]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[144]

Drug(s) Affected By Epidermal retinol dehydrogenase 2 (SDR16C5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[150]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[147]

Drug(s) Affected By Sphingosine kinase 1 (SPHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[152]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[153]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Bortezomib	DMNO38U	Leukemia		Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[156]

Drug(s) Affected By Chimeric ERCC6-PGBD3 protein (ERCC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[158]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[162]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[165]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[166]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[144]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[166]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[174]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[175]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[176]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP10 (PARP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[181]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[182]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[183]

Drug(s) Affected By Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[153]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[185]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[186]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[187]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[177]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[190]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[191]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[185]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[186]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[99]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[197]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[201]

Drug(s) Affected By NADH-cytochrome b5 reductase 3 (CYB5R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[186]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[204]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[184]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[209]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[209]

Drug(s) Affected By Protein DEK (DEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[186]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[177]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosylhomocysteinase (AHCY)	TTE2KUJ	SAHH_HUMAN	Inhibitor	[1]
Alpha-glucosidase (GLA)	TTHCF4J	LYAG_HUMAN; GANAB_HUMAN; GANC_HUMAN	Inhibitor	[1]
Bacterial Dehydroquinate synthase (Bact aroB)	TTPS7KA	AROB_ECOLI	Inhibitor	[1]
Bacterial Fatty acid synthetase I (Bact inhA)	TTVTX4N	INHA_MYCTU	Inhibitor	[1]
Bacterial Flavohemoglobin (Bact hmp)	TTNAW8S	HMP_ECOLI	Inhibitor	[1]
Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE)	TT8WCXO	NADE_ECOLI	Inhibitor	[1]
Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD)	TT1NFO3	NADD_ECOLI	Inhibitor	[1]
Biliverdin reductase A (BLVRA)	TTJBPN3	BIEA_HUMAN	Inhibitor	[1]
Deoxyhypusine synthase (DHPS)	TTBO2A9	DHYS_HUMAN	Inhibitor	[1]
Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2)	TTJS7O4	ADH2_ENTHI	Inhibitor	[1]
Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1)	TTIWB6L	DHB1_HUMAN	Inhibitor	[1]
Estradiol 17 beta-dehydrogenase 4 (HSD17B4)	TTL1WGS	DHB4_HUMAN	Inhibitor	[1]
Glutathione reductase (GR)	TTEP6RV	GSHR_HUMAN	Inhibitor	[1]
Haemophilus influenzae NadR protein (Hae-influ nadR)	TTWUDYC	NADR_HAEIN	Inhibitor	[1]
HMG-CoA reductase (HMGCR)	TTPADOQ	HMDH_HUMAN	Inhibitor	[1]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	TTTB4UP	IMDH2_HUMAN	Inhibitor	[1]
Intestinal maltase-glucoamylase (MGAM)	TTXWASR	MGA_HUMAN	Inhibitor	[1]
L-lactate dehydrogenase (LDH)	TTAZHU0	LDHA_HUMAN; LDHB_HUMAN; LDHC_HUMAN	Inhibitor	[1]
Mitochondrial aldehyde dehydrogenase (ALDH2)	TTFLN4T	ALDH2_HUMAN	Inhibitor	[1]
Plasmodium Enoyl-ACP reductase (Malaria fabI)	TTNX2CS	Q965D5_PLAFA	Inhibitor	[1]
Pseudomonas Nicotinate-nucleotide adenylyltransferase (Pseudo nadD)	TTKVNRF	NADD_PSEAE	Inhibitor	[1]
Sorbitoldehydrogenase (SORD)	TTLSRBZ	DHSO_HUMAN	Inhibitor	[1]
Trypanosoma Dihydrolipoamide dehydrogenase (Trypano LPD)	TTBKQL3	DLDH_TRYCR	Inhibitor	[1]
UDP-glucose 4-epimerase (GALE)	TTGRHIB	GALE_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Biotransformations	[2]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Drug Response	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[4]
Chimeric ERCC6-PGBD3 protein (ERCC6)	OT2QZKSF	ERPG3_HUMAN	Regulation of Drug Effects	[5]
Epidermal retinol dehydrogenase 2 (SDR16C5)	OT7BJD1M	RDHE2_HUMAN	Gene/Protein Processing	[6]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Regulation of Drug Effects	[7]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)	OTJDOL20	HCDH_HUMAN	Regulation of Drug Effects	[8]
Insulin-like growth factor-binding protein 1 (IGFBP1)	OT6UQV2K	IBP1_HUMAN	Gene/Protein Processing	[9]

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