Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLPAOB)

• Drug Name: Allopurinol Drug Info
• Synonyms: Adenock; Ailural; Ailurial; Allohexal; Allohexan; Alloprin; Allopur; Allopurin; Allopurinolum; Allorin; Allozym; Allpargin; Allural; Aloprim; Alopurinol; Aloral; Alositol; Aluline; Anoprolin; Anzief; Apulonga; Apurin; Apurol; Atisuril; Bleminol; Bloxanth; Caplenal; Capurate; Cellidrin; Cosuric; Dabrosin; Dabroson; Embarin; Epidropal; Epuric; Foligan; Geapur; Gichtex; Gotax; Hamarin; Hexanuret; Jenapurinol; Ketanrift; Ledopur; Lopurin; Lysuron; Milurit; Milurite; Miniplanor; Monarch; Nektrohan; Novopurol; Progout; Pureduct; Purinol; Remid; Riball; Rimapurinol; Roucol; Sigapurol; Suspendol; Takanarumin; Tipuric; Urbol; Uribenz; Uricemil; Uridocid; Uriprim; Uripurinol; Uritas; Urobenyl; Urolit; Urosin; Urtias; Xanthomax; Xanturat; Xanturic; Zygout; Zyloprim; Zyloric; Dura Al; Pan Quimica; A 8003; BW 56158; Urtias 100; AL-100; Allo-Puren; Allohexal (TN); Allopurinol(I); Allosig (TN); Apo-Allopurinol; BW 56-158; Ketobun-A; Progout (TN); Puricos (TN); Quimica, Pan; Zyloprim (TN); Zyloric (TN); BW-56-158; B. W. 56-158; 4-HPP

Indication

Disease Entry	ICD 11	Status	REF
Gout	FA25	Approved	[1]
Hyperuricaemia	5C55.Y	Approved	[2]
Recurrent adult burkitt lymphoma	2A85.6	Approved	[1]

• Therapeutic Class: Antimetabolites
• Cross-matching ID:
  PubChem CID: 135401907
  ChEBI ID: CHEBI:40279
  CAS Number: CAS 315-30-0
  TTD Drug ID: DMLPAOB
  VARIDT Drug ID: DR00074
  INTEDE Drug ID: DR0066
  ACDINA Drug ID: D00020

Molecule-Related Drug Atlas

Drug(s) Targeting Xanthine dehydrogenase/oxidase (XDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[12]
Fosdenopterin	DMR0TYK	Molybdenum cofactor deficiency	5B5K.A	Approved	[13]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
Oxypurinol	DMURH4X	Heart failure	BD10-BD13	Phase 2/3	[15]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[16]
Topiroxostat	DMA04DE	Gout	FA25	Phase 2	[17]
TMX-049	DME8PFQ	Diabetic nephropathy	GB61.Z	Phase 2	[18]
LC-350189	DMHT3CB	Gout	FA25	Phase 1	[19]
Azaindole derivative 5	DMD2BL3	N. A.	N. A.	Patented	[20]
Fused heterocyclic compound 3	DM2QVHY	N. A.	N. A.	Patented	[20]

Drug(s) Transported By Organic anion transporter 2 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[25]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[26]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[27]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[28]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[29]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[25]

Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[31]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[32]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[33]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[34]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[35]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[36]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[37]

Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[38]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[39]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[40]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[41]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[42]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[43]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[44]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[45]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[46]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[47]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[50]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[22]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[22]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[22]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[22]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[28]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[48]

Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[51]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[55]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[56]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[57]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[58]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]

Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[61]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]

Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[69]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[59]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[62]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[56]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[56]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[56]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[72]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[56]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[74]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[56]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[75]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[75]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[75]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[75]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[75]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[75]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[82]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[83]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[7]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[86]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[78]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[86]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[91]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[92]
Fructose	DM43AN2	Vomiting	MD90	Approved	[10]
Ketoprofen	DMRKXPT	Bursitis		Approved	[10]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[95]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[96]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]

Drug(s) Affected By Apolipoprotein C-III (APOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[103]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[105]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[7]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[106]

Drug(s) Affected By Protein disulfide-isomerase (P4HB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[107]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[110]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[112]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[117]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[120]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[121]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[112]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[126]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[124]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[107]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[129]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[130]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[131]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[133]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[137]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[138]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[143]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[144]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[149]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[82]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[152]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[153]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[155]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[157]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[161]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[162]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[165]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[157]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[166]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[167]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[10]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[78]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[171]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[129]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[7]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[7]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[175]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[176]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[177]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[179]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[178]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[178]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[178]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[182]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[188]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[103]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[189]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[190]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[191]

Drug(s) Affected By Angiopoietin-related protein 3 (ANGPTL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[7]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[175]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[192]
Indomethacin	DMSC4A7	Bursitis		Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]

Drug(s) Affected By Glycophorin-A (GYPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[195]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[196]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[197]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[198]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[199]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[200]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[201]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[202]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[203]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[204]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[10]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[206]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[210]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[211]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[211]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[10]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[213]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[216]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[217]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[117]

Drug(s) Affected By HLA class I histocompatibility antigen protein P5 (HCP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[58]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[218]
Pazopanib	DMF57DM	N. A.	N. A.	Approved	[219]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Xanthine dehydrogenase/oxidase (XDH)	TT7RJY8	XDH_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporter 2 (SLC22A7)	DT0OC1Q	S22A7_HUMAN	Substrate	[4]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
RNA cytidine acetyltransferase (hALP) Main DME	DEZV4AP	NAT10_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Angiopoietin-related protein 3 (ANGPTL3)	OTCD5Z9W	ANGL3_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein C-III (APOC3)	OTW3520C	APOC3_HUMAN	Gene/Protein Processing	[7]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[8]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Gene/Protein Processing	[7]
Cytochrome P450 4A11 (CYP4A11)	OTPU5J0S	CP4AB_HUMAN	Gene/Protein Processing	[9]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[7]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Gene/Protein Processing	[7]
Glycophorin-A (GYPA)	OTABU4YV	GLPA_HUMAN	Drug Response	[10]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Gene/Protein Processing	[11]

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