Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRICNP)

Drug Name
Vandetanib Drug Info
Synonyms
Zactima; Vandetanib [INN]; CH 331; ZD 6474; ZD6474; AZD-6474; CH-331; F9995-0087; ZD-6474; Zactima, ZD6474; Vandetanib (JAN/INN); Vandetanib, Zactima, ZD6474; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; Vandetanib (Pan-TK inhibitor)
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
3081361
ChEBI ID
CHEBI:49960
CAS Number
CAS 443913-73-3
TTD Drug ID
DMRICNP
VARIDT Drug ID
DR00618
INTEDE Drug ID
DR1669
ACDINA Drug ID
D00720

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [10]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [11]
Gefitinib DM15F0X Colon adenocarcinoma Approved [12]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [13]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [14]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [15]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [16]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [14]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [17]
Nitroglycerin DMQ2491 Angina pectoris BA40 Approved [18]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [110]
Gefitinib DM15F0X Colon adenocarcinoma Approved [111]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [112]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [113]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [114]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [115]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Selenium DM25CGV N. A. N. A. Approved [118]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [119]
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Drug(s) Targeting Proto-oncogene c-Ret (RET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [19]
Regorafenib DMHSY1I Gastrointestinal stromal tumour 2B5B Approved [20]
Ponatinib DMYGJQO Acute lymphoblastic leukaemia 2A85 Approved [20]
Selpercatinib DMZR15V Non-small-cell lung cancer 2C25.Y Approved [21]
Pralsetinib DMWU0I2 Non-small-cell lung cancer 2C25.Y Approved [22]
MGCD516 DM752PU Solid tumour/cancer 2A00-2F9Z Phase 2/3 [23]
CEP-32496 DMAO04B Solid tumour/cancer 2A00-2F9Z Phase 1/2 [24]
TPX-0046 DMIVE67 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [25]
GSK3179106 DM2KCIP Inflammatory bowel disease DD72 Phase 1 [26]
BOS172738 DM9L0D8 Solid tumour/cancer 2A00-2F9Z Phase 1 [27]
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Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [28]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [29]
Regorafenib DMHSY1I Gastrointestinal stromal tumour 2B5B Approved [20]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [30]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [31]
Pazopanib HCl DM6U9CQ Renal cell carcinoma 2C90 Approved [32]
Fruquintinib DMHOSCQ Colorectal cancer 2B91.Z Approved [33]
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [34]
Tivozanib DMUKC5L Renal cell carcinoma 2C90 Approved [35]
Lenvatinib DMB1IU4 Thyroid cancer 2D10 Approved [36]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Folic Acid DMEMBJC Colorectal carcinoma Approved [39]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
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Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [47]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [4]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [48]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [4]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [49]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [50]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [51]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [52]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [49]
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Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [4]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [54]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [55]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [4]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [56]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [50]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [52]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [57]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [52]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [58]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [59]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [60]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [63]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [64]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [59]
Verapamil DMA7PEW Angina pectoris BA40 Approved [66]
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Drug(s) Affected By Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [70]
Estrone DM5T6US Acne vulgaris ED80 Approved [68]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [67]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Panobinostat DM58WKG Chronic graft versus host disease Approved [77]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Testosterone enanthate DMB6871 N. A. N. A. Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [81]
Ethanol DMDRQZU Chronic pain MG30 Approved [78]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [82]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [83]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [85]
Fluoxetine DM3PD2C Bipolar depression Approved [83]
Fructose DM43AN2 Vomiting MD90 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [83]
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Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Fluoxetine DM3PD2C Bipolar depression Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [92]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [94]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [96]
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Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [101]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [94]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [72]
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Drug(s) Affected By Protein FAM13A (FAM13A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [106]
Ethanol DMDRQZU Chronic pain MG30 Approved [107]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [108]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [109]
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Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Etretinate DM2CZFA Keratosis ED56 Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [124]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [125]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
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Drug(s) Affected By Calbindin (CALB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [81]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [130]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [132]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [133]
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Drug(s) Affected By Prothymosin alpha (PTMA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [137]
Haloperidol DM96SE0 Delirium Approved [138]
Testosterone enanthate DMB6871 N. A. N. A. Approved [79]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [81]
Clozapine DMFC71L Schizophrenia 6A20 Approved [138]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trypsin-2 (PRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [140]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [141]
Bortezomib DMNO38U Leukemia Approved [142]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [143]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [144]
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Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [145]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [146]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [147]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [148]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
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Drug(s) Affected By Gamma-enolase (ENO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Estrone DM5T6US Acne vulgaris ED80 Approved [151]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [152]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [153]
Leflunomide DMR8ONJ Arthritis FA20 Approved [149]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [96]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [155]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [157]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [158]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [157]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [157]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Fluoxetine DM3PD2C Bipolar depression Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [159]
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Drug(s) Affected By Mucin-1 (MUC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [93]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [161]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [162]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [161]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Folic Acid DMEMBJC Colorectal carcinoma Approved [163]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [108]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [164]
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Drug(s) Affected By Histone H1.2 (H1-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [93]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [96]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Selenium DM25CGV N. A. N. A. Approved [166]
Methotrexate DM2TEOL Anterior urethra cancer Approved [167]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [170]
Panobinostat DM58WKG Chronic graft versus host disease Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [172]
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Drug(s) Affected By DNA mismatch repair protein Msh3 (MSH3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [142]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [130]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [173]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [174]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [174]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [175]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [176]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [177]
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Drug(s) Affected By Alanine aminotransferase 1 (GPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [178]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [179]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [180]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [178]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [178]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [178]
Gefitinib DM15F0X Colon adenocarcinoma Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [6]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [6]
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Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [184]
Methotrexate DM2TEOL Anterior urethra cancer Approved [185]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [148]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [187]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [188]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [189]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [190]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [191]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [192]
Gefitinib DM15F0X Colon adenocarcinoma Approved [193]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [194]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [195]
Selenium DM25CGV N. A. N. A. Approved [74]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [196]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-adrenomedullin (ADM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [198]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [199]
Methotrexate DM2TEOL Anterior urethra cancer Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [200]
Leflunomide DMR8ONJ Arthritis FA20 Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [201]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [202]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [203]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [204]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [205]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [206]
Testosterone DM7HUNW Hot flushes GA30 Approved [207]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [208]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-3(IV) chain (COL4A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [212]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [213]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [214]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [215]
Quinidine DMLPICK N. A. N. A. Approved [216]
Verapamil DMA7PEW Angina pectoris BA40 Approved [217]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [218]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [218]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [219]
Propranolol DM79NTF Angina pectoris BA40 Approved [220]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [221]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [222]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [218]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [223]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [197]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [225]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [104]
Testosterone DM7HUNW Hot flushes GA30 Approved [207]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [227]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [229]
Testosterone DM7HUNW Hot flushes GA30 Approved [230]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [149]
Testosterone enanthate DMB6871 N. A. N. A. Approved [79]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [231]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [212]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein NDRG1 (NDRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [233]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [234]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [235]
Quercetin DM3NC4M Obesity 5B81 Approved [236]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [228]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [237]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [239]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [242]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [106]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [243]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [142]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [96]
Leflunomide DMR8ONJ Arthritis FA20 Approved [149]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [96]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-17 (SOX17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [128]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [128]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [128]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [245]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [128]
Ziprasidone DMM58JY Bipolar disorder 6A60 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [246]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [247]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [248]
Leflunomide DMR8ONJ Arthritis FA20 Approved [149]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [96]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [249]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [249]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [93]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [250]
Leflunomide DMR8ONJ Arthritis FA20 Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-induced gene 2 protein (INSIG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [96]
Ethanol DMDRQZU Chronic pain MG30 Approved [107]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [96]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [130]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [251]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [2]
Proto-oncogene c-Ret (RET) TT4DXQT RET_HUMAN Inhibitor [2]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [3]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [4]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [6]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Gene/Protein Processing [7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Gene/Protein Processing [7]
Calbindin (CALB1) OTM7IXDG CALB1_HUMAN Gene/Protein Processing [7]
Collagen alpha-3(IV) chain (COL4A3) OT6SB8X5 CO4A3_HUMAN Gene/Protein Processing [7]
DNA mismatch repair protein Msh3 (MSH3) OTD3YPVL MSH3_HUMAN Gene/Protein Processing [7]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Gene/Protein Processing [7]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Gene/Protein Processing [8]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [9]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Gene/Protein Processing [7]

References

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