General Information of Drug (ID: DMS3GX2)

Drug Name
Telmisartan Drug Info
Synonyms
Kinzal; Kinzalmono; Micardis; Pritor; Abbott brand of telmisartan; Boehringer Ingelheim brand of telmisartan; Glaxo Wellcome brand of telmisartan; GlaxoSmithKline brand of telmisartan; BIBR 277; BIBR 277SE; BIBR-277; BIBR-277SE; Bay 68-9291; Micardis (TN); Telmisartan [USAN:INN]; YM-086; BIBR-277-SE; Telmisartan (JAN/USAN/INN); Micardis, Targit, Temax, BIBR277, Telmisartan; 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid; 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid; 4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid; 4'-((4-mehtyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimmidazolyl)methyl)-2-biphenylcarboxylic acid; 4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid; 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid; 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [1]
Malignant essential hypertension BA00 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Stroke 8B20 Investigative [2]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
65999
ChEBI ID
CHEBI:9434
CAS Number
CAS 144701-48-4
TTD Drug ID
DMS3GX2
VARIDT Drug ID
DR00248
INTEDE Drug ID
DR1545
ACDINA Drug ID
D00657

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [19]
Olmesartan medoxomil DMWBHRY High blood pressure BA00 Approved [20]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [19]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [19]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [21]
ANGIOTENSIN II DMLWQ27 Increase blood pressure BA04 Approved [22]
SARALASIN DMKS1DV Hypertension BA00-BA04 Approved [23]
Tasosartan DMM13DI Hypertension BA00-BA04 Approved [24]
Eprosartan DM07K2I Hypertension BA00-BA04 Approved [25]
Sparsentan DMMP51W IgA nephropathy MF8Y Approved [26]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [27]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [5]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [31]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [32]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [33]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [34]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [35]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [36]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [37]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [39]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [40]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [41]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [39]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [42]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [43]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [44]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [45]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [44]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [46]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [47]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [48]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [49]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [50]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [51]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [52]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [53]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [54]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [55]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [62]
Metronidazole DMTIVEN Abscess Approved [63]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [64]
Ethanol DMDRQZU Chronic pain MG30 Approved [65]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [67]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [68]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [69]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [71]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [73]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [67]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [13]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [74]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [74]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [75]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [13]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [74]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [76]
Gefitinib DM15F0X Colon adenocarcinoma Approved [13]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [77]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [13]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [78]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [81]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [83]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [86]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [84]
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Drug(s) Affected By Cytochrome P450 2J2 (CYP2J2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [90]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [15]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [15]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [92]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Epinephrine DM3KJBC Acute asthma CA23 Approved [96]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [97]
Fructose DM43AN2 Vomiting MD90 Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [100]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [101]
Propranolol DM79NTF Angina pectoris BA40 Approved [102]
Testosterone DM7HUNW Hot flushes GA30 Approved [103]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [104]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [105]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [107]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [108]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [109]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [110]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [111]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [112]
Testosterone DM7HUNW Hot flushes GA30 Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [114]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [104]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [115]
Diazepam DM08E9O Alcohol withdrawal Approved [116]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [117]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [118]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [119]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [122]
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Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [123]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [124]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [125]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [126]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [129]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [130]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [131]
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Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [135]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [136]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [137]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [138]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [140]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [141]
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Drug(s) Affected By Natriuretic peptides B (NPPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [142]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [145]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [146]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [149]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [150]
Ethanol DMDRQZU Chronic pain MG30 Approved [151]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [154]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [155]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [145]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [156]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [159]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [161]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [145]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [162]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [163]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [164]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [164]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [166]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [167]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [168]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [169]
Panobinostat DM58WKG Chronic graft versus host disease Approved [170]
Estrone DM5T6US Acne vulgaris ED80 Approved [167]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [172]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [174]
Methotrexate DM2TEOL Anterior urethra cancer Approved [175]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [163]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [176]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [177]
Ethanol DMDRQZU Chronic pain MG30 Approved [178]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [104]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [180]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [181]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Meloxicam DM2AR7L Arthritis FA20 Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [185]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [176]
Retigabine DMGNYIH Behcet disease 4A62 Approved [187]
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Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [188]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [188]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [189]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [190]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [188]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [188]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [193]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [194]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin II receptor type-1 (AGTR1) TT8DBY3 AGTR1_HUMAN Antagonist [4]
HUMAN type-1 angiotensin II receptor (AGTR1) TTPKMXQ AGTR1_HUMAN Blocker [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [6]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [7]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [8]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [10]
Albumin (ALB) OTVMM513 ALBU_HUMAN Gene/Protein Processing [11]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Gene/Protein Processing [12]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [13]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Protein Interaction/Cellular Processes [14]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [10]
Cytochrome P450 2J2 (CYP2J2) OTJBTEH8 CP2J2_HUMAN Gene/Protein Processing [15]
Insulin (INS) OTZ85PDU INS_HUMAN Gene/Protein Processing [16]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [17]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Gene/Protein Processing [18]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 592).
2 Telmisartan FDA Label
3 ClinicalTrials.gov (NCT04359953) Efficacy of Hydroxychloroquine, Telmisartan and Azithromycin on the Survival of Hospitalized Elderly Patients With COVID-19. U.S. National Institutes of Health.
4 Deletion of angiotensin II type I receptor reduces hepatic steatosis. J Hepatol. 2009 Jun;50(6):1226-35.
5 Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. Nat Rev Nephrol. 2020 Apr 3.
6 Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide. Drug Metab Dispos. 2008 Apr;36(4):796-805.
7 Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug Metab Dispos. 2006 Jul;34(7):1109-15.
8 The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers. Pharmacogenet Genomics. 2011 Sep;21(9):523-30.
9 Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: comparison with liver and intestinal glucuronidation and impact of albumin. Drug Metab Dispos. 2012 Apr;40(4):825-35.
10 Improvement of endothelial function in patients with hypertension and type 2 diabetes after treatment with telmisartan. Hypertens Res. 2010 Aug;33(8):796-801. doi: 10.1038/hr.2010.107. Epub 2010 Jun 17.
11 Effect of telmisartan on ambulatory blood pressure monitoring, plasma brain natriuretic peptide, and oxidative status of serum albumin in hemodialysis patients. Hypertens Res. 2005 Dec;28(12):987-94. doi: 10.1291/hypres.28.987.
12 Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor- activation in human monocytes. J Hypertens. 2012 Jan;30(1):87-96. doi: 10.1097/HJH.0b013e32834dde5f.
13 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
14 Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma. Hypertension. 2008 Feb;51(2):259-66. doi: 10.1161/HYPERTENSIONAHA.107.099028. Epub 2007 Dec 24.
15 Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine. Chem Biol Interact. 2019 Jun 1;306:1-9.
16 Metabolic effect of telmisartan and losartan in hypertensive patients with metabolic syndrome. Cardiovasc Diabetol. 2005 May 15;4:6. doi: 10.1186/1475-2840-4-6.
17 Toxicological evaluation of acyl glucuronides utilizing half-lives, peptide adducts, and immunostimulation assays. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):241-9.
18 Comparison of the effects of telmisartan and olmesartan on home blood pressure, glucose, and lipid profiles in patients with hypertension, chronic heart failure, and metabolic syndrome. Hypertens Res. 2008 May;31(5):921-9. doi: 10.1291/hypres.31.921.
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